MiMeDB: Showing metabocard for 5-Hydroxylysine (MMDBc0000344)

Plant

Animal

Xenobiotic

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2020-12-10 18:35:47 UTC

Update Date

2024-10-17 18:45:36 UTC

Metabolite ID

MMDBc0000344

Metabolite Identification

Common Name

5-Hydroxylysine

Description

5-Hydroxylysine (Hyl), also known as hydroxylysine or 5-Hydroxy-L-lysine, belongs to the class of organic compounds known as L-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom. Amino acids are organic compounds that contain amino (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid. 5-Hydroxylysine is a hydroxylated derivative of the amino acid lysine that is present in certain collagens, the chief structural protein of mammalian skin and connective tissue. 5-Hydroxylysine arises from a post-translational hydroxy modification of lysine and is biosynthesized from lysine via oxidation by lysyl hydroxylase enzymes. 5-Hydroxylysine can then undergo further modification by glycosylation, giving rise to galactosyl hydroxylysine (GH) and glucosylgalactosyl hydroxylysine (GGH). These glycosylated forms of hydroxylysine contribute to collagen‚Äôs unusual toughness and resiliency. The monoglycosylated, galactosyl-hydroxylysine is enriched in bone compared with the disaccharide form, glucosyl-galactosyl-hydroxylysine, which is the major form in skin. 5-Hydroxylysine exists in all eukaryotes, ranging from yeast to humans. It was first discovered in 1921 by Donald Van Slyke. Free forms of hydroxylysine arise through proteolytic degradation of collagen. Urinary excretion of 5-Hydroxylysine and its glycosides can be used as an index of collagen degradation, with high levels being indicative of more rapid or extensive collagen degradation (often seen in patients with thermal burns, Paget's disease of bone or hyperphosphatasia) (PMID: 404321 ).

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Molecular Formula

C₆H₁₄N₂O₃

Average Mass

162.187

Monoisotopic Mass

162.100442324

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

Not Available

InChI Identifier

InChI=1S/C6H14N2O3/c7-3-4(9)1-2-5(8)6(10)11/h4-5,9H,1-3,7-8H2,(H,10,11)/t4-,5+/m1/s1

InChI Key

YSMODUONRAFBET-UHNVWZDZSA-N

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Not Available

Spectra

Not Available

Chromatographic Retention Times and Retention Indices

Retention Times

Chromatography Type	Technique	Column	Deposition Date	Retention Time (s)
Liquid Chromatography	HILIC	Waters Acquity UPLC-BEH Amide column (retained)	2025-10-23	562.9
Liquid Chromatography	HILIC	Accucore 150 Amide HILIC (eluted)	2025-10-23	488.2
Liquid Chromatography	Reversed-phase	Hypersil Gold 1.9 µm C18 (void)	2025-10-23	40.7
Liquid Chromatography	Reversed-phase	Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) (eluted)	2025-10-23	227.5
Liquid Chromatography	Reversed-phase	XBridge C18 3.5u 2.1x50 mm (eluted)	2025-10-23	286.8
Liquid Chromatography	Reversed-phase	Ascentis Express C18 (void)	2025-10-23	285.5
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (void)	2025-10-23	372.5
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-23	1008.4
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC (eluted)	2025-10-23	692.8
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	169.7
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-23	750.2
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (void)	2025-10-23	177.7
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (void)	2025-10-23	33.5
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (retained)	2025-10-23	459.9
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-23	992.4
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (void)	2025-10-23	70.6
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (void)	2025-10-23	298.7
Liquid Chromatography	Reversed-phase	Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex (eluted)	2025-10-23	581.8
Liquid Chromatography	Reversed-phase	Waters Atlantis T3 (2.1 x 150 mm, 5 um) (eluted)	2025-10-23	557.4

Retention Indices

Chromatography Type	Peak Label	SMILES	Stationary Phase	Deposition Date	Retention Index
Gas Chromatography	5-Hydroxylysine_TMS_1	C[Si](C)(C)O[C@@H](CN)CC[C@H](N)C(=O)O	standard non polar	2025-10-23	2158.1
Gas Chromatography	5-Hydroxylysine_TMS_2	C[Si](C)(C)OC(=O)[C@@H](N)CC[C@@H](O)CN	standard non polar	2025-10-23	1863.32
Gas Chromatography	5-Hydroxylysine_TMS_3	C[Si](C)(C)NC[C@H](O)CC[C@H](N)C(=O)O	standard non polar	2025-10-23	1662.77
Gas Chromatography	5-Hydroxylysine_TMS_4	C[Si](C)(C)N[C@@H](CC[C@@H](O)CN)C(=O)O	standard non polar	2025-10-23	1725.78
Gas Chromatography	5-Hydroxylysine_TMS_5	C[Si](C)(C)OC(=O)[C@@H](N)CC[C@H](CN)O[Si](C)(C)C	standard non polar	2025-10-23	1850.11
Gas Chromatography	5-Hydroxylysine_TMS_6	C[Si](C)(C)NC[C@@H](CC[C@H](N)C(=O)O)O[Si](C)(C)C	standard non polar	2025-10-23	2004.18
Gas Chromatography	5-Hydroxylysine_TMS_7	C[Si](C)(C)N[C@@H](CC[C@H](CN)O[Si](C)(C)C)C(=O)O	standard non polar	2025-10-23	1468.15
Gas Chromatography	5-Hydroxylysine_TMS_8	C[Si](C)(C)N[C@@H](CC[C@@H](O)CN)C(=O)O[Si](C)(C)C	standard non polar	2025-10-23	1480.71
Gas Chromatography	5-Hydroxylysine_TMS_9	C[Si](C)(C)NC[C@H](O)CC[C@H](N)C(=O)O[Si](C)(C)C	standard non polar	2025-10-23	2397.81
Gas Chromatography	5-Hydroxylysine_TMS_10	C[Si](C)(C)NC[C@H](O)CC[C@H](N[Si](C)(C)C)C(=O)O	standard non polar	2025-10-23	1751.49
Gas Chromatography	5-Hydroxylysine_TMS_11	C[Si](C)(C)N(C[C@H](O)CC[C@H](N)C(=O)O)[Si](C)(C)C	standard non polar	2025-10-23	2267.83
Gas Chromatography	5-Hydroxylysine_TMS_12	C[Si](C)(C)N([C@@H](CC[C@@H](O)CN)C(=O)O)[Si](C)(C)C	standard non polar	2025-10-23	1804.62
Gas Chromatography	5-Hydroxylysine_TMS_13	C[Si](C)(C)N[C@@H](CC[C@H](CN)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-23	2023.65
Gas Chromatography	5-Hydroxylysine_TMS_14	C[Si](C)(C)NC[C@@H](CC[C@H](N)C(=O)O[Si](C)(C)C)O[Si](C)(C)C	standard non polar	2025-10-23	2592.94
Gas Chromatography	5-Hydroxylysine_TMS_15	C[Si](C)(C)NC[C@@H](CC[C@H](N[Si](C)(C)C)C(=O)O)O[Si](C)(C)C	standard non polar	2025-10-23	1912.67
Gas Chromatography	5-Hydroxylysine_TMS_16	C[Si](C)(C)O[C@H](CC[C@H](N)C(=O)O)CN([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-23	2092.79
Gas Chromatography	5-Hydroxylysine_TMS_17	C[Si](C)(C)O[C@@H](CN)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-23	2654.35
Gas Chromatography	5-Hydroxylysine_TMS_18	C[Si](C)(C)NC[C@H](O)CC[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-23	1903.91
Gas Chromatography	5-Hydroxylysine_TMS_19	C[Si](C)(C)OC(=O)[C@H](CC[C@@H](O)CN)N([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-23	1973.82
Gas Chromatography	5-Hydroxylysine_TMS_20	C[Si](C)(C)OC(=O)[C@@H](N)CC[C@@H](O)CN([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-23	2378.01
Gas Chromatography	5-Hydroxylysine_TMS_21	C[Si](C)(C)N[C@@H](CC[C@@H](O)CN([Si](C)(C)C)[Si](C)(C)C)C(=O)O	standard non polar	2025-10-23	2466.99
Gas Chromatography	5-Hydroxylysine_TMS_22	C[Si](C)(C)NC[C@H](O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-23	2414.13
Gas Chromatography	5-Hydroxylysine_TMS_23	C[Si](C)(C)NC[C@@H](CC[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)O[Si](C)(C)C	standard non polar	2025-10-23	1966.4
Gas Chromatography	5-Hydroxylysine_TMS_24	C[Si](C)(C)OC(=O)[C@H](CC[C@H](CN)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-23	1897.75
Gas Chromatography	5-Hydroxylysine_TMS_25	C[Si](C)(C)OC(=O)[C@@H](N)CC[C@H](CN([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C	standard non polar	2025-10-23	1884.04
Gas Chromatography	5-Hydroxylysine_TMS_26	C[Si](C)(C)N[C@@H](CC[C@H](CN([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C)C(=O)O	standard non polar	2025-10-23	2270.12
Gas Chromatography	5-Hydroxylysine_TMS_27	C[Si](C)(C)NC[C@@H](CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C	standard non polar	2025-10-23	1981.25
Gas Chromatography	5-Hydroxylysine_TMS_28	C[Si](C)(C)N[C@@H](CC[C@@H](O)CN([Si](C)(C)C)[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-23	1660.85
Gas Chromatography	5-Hydroxylysine_TMS_29	C[Si](C)(C)NC[C@H](O)CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-23	2263.68
Gas Chromatography	5-Hydroxylysine_TMS_30	C[Si](C)(C)N(C[C@H](O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-23	1579.56
Gas Chromatography	5-Hydroxylysine_TMS_31	C[Si](C)(C)N[C@@H](CC[C@H](CN([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-23	1748.91
Gas Chromatography	5-Hydroxylysine_TMS_32	C[Si](C)(C)NC[C@@H](CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C	standard non polar	2025-10-23	2436.78
Gas Chromatography	5-Hydroxylysine_TMS_33	C[Si](C)(C)O[C@H](CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)CN([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-23	1587.84
Gas Chromatography	5-Hydroxylysine_TMS_34	C[Si](C)(C)OC(=O)[C@H](CC[C@@H](O)CN([Si](C)(C)C)[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-23	2257.88
Gas Chromatography	5-Hydroxylysine_TMS_35	C[Si](C)(C)OC(=O)[C@H](CC[C@H](CN([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-23	1401.21
Gas Chromatography	5-Hydroxylysine_TMS_1	C[Si](C)(C)O[C@@H](CN)CC[C@H](N)C(=O)O	standard polar	2025-10-23	1889.23
Gas Chromatography	5-Hydroxylysine_TMS_2	C[Si](C)(C)OC(=O)[C@@H](N)CC[C@@H](O)CN	standard polar	2025-10-23	1999.78
Gas Chromatography	5-Hydroxylysine_TMS_3	C[Si](C)(C)NC[C@H](O)CC[C@H](N)C(=O)O	standard polar	2025-10-23	1860.76
Gas Chromatography	5-Hydroxylysine_TMS_4	C[Si](C)(C)N[C@@H](CC[C@@H](O)CN)C(=O)O	standard polar	2025-10-23	2080.72
Gas Chromatography	5-Hydroxylysine_TMS_5	C[Si](C)(C)OC(=O)[C@@H](N)CC[C@H](CN)O[Si](C)(C)C	standard polar	2025-10-23	2051.53
Gas Chromatography	5-Hydroxylysine_TMS_6	C[Si](C)(C)NC[C@@H](CC[C@H](N)C(=O)O)O[Si](C)(C)C	standard polar	2025-10-23	1407.85
Gas Chromatography	5-Hydroxylysine_TMS_7	C[Si](C)(C)N[C@@H](CC[C@H](CN)O[Si](C)(C)C)C(=O)O	standard polar	2025-10-23	2434.18
Gas Chromatography	5-Hydroxylysine_TMS_8	C[Si](C)(C)N[C@@H](CC[C@@H](O)CN)C(=O)O[Si](C)(C)C	standard polar	2025-10-23	2244.71
Gas Chromatography	5-Hydroxylysine_TMS_9	C[Si](C)(C)NC[C@H](O)CC[C@H](N)C(=O)O[Si](C)(C)C	standard polar	2025-10-23	2570.75
Gas Chromatography	5-Hydroxylysine_TMS_10	C[Si](C)(C)NC[C@H](O)CC[C@H](N[Si](C)(C)C)C(=O)O	standard polar	2025-10-23	2274.82
Gas Chromatography	5-Hydroxylysine_TMS_11	C[Si](C)(C)N(C[C@H](O)CC[C@H](N)C(=O)O)[Si](C)(C)C	standard polar	2025-10-23	2073.01
Gas Chromatography	5-Hydroxylysine_TMS_12	C[Si](C)(C)N([C@@H](CC[C@@H](O)CN)C(=O)O)[Si](C)(C)C	standard polar	2025-10-23	2057.98
Gas Chromatography	5-Hydroxylysine_TMS_13	C[Si](C)(C)N[C@@H](CC[C@H](CN)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-23	1408.63
Gas Chromatography	5-Hydroxylysine_TMS_14	C[Si](C)(C)NC[C@@H](CC[C@H](N)C(=O)O[Si](C)(C)C)O[Si](C)(C)C	standard polar	2025-10-23	2073.31
Gas Chromatography	5-Hydroxylysine_TMS_15	C[Si](C)(C)NC[C@@H](CC[C@H](N[Si](C)(C)C)C(=O)O)O[Si](C)(C)C	standard polar	2025-10-23	1947.56
Gas Chromatography	5-Hydroxylysine_TMS_16	C[Si](C)(C)O[C@H](CC[C@H](N)C(=O)O)CN([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-23	2458.2
Gas Chromatography	5-Hydroxylysine_TMS_17	C[Si](C)(C)O[C@@H](CN)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-23	2113.78
Gas Chromatography	5-Hydroxylysine_TMS_18	C[Si](C)(C)NC[C@H](O)CC[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-23	1942.05
Gas Chromatography	5-Hydroxylysine_TMS_19	C[Si](C)(C)OC(=O)[C@H](CC[C@@H](O)CN)N([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-23	2829.65
Gas Chromatography	5-Hydroxylysine_TMS_20	C[Si](C)(C)OC(=O)[C@@H](N)CC[C@@H](O)CN([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-23	2407.12
Gas Chromatography	5-Hydroxylysine_TMS_21	C[Si](C)(C)N[C@@H](CC[C@@H](O)CN([Si](C)(C)C)[Si](C)(C)C)C(=O)O	standard polar	2025-10-23	1975.02
Gas Chromatography	5-Hydroxylysine_TMS_22	C[Si](C)(C)NC[C@H](O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-23	2587.08
Gas Chromatography	5-Hydroxylysine_TMS_23	C[Si](C)(C)NC[C@@H](CC[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)O[Si](C)(C)C	standard polar	2025-10-23	2283.78
Gas Chromatography	5-Hydroxylysine_TMS_24	C[Si](C)(C)OC(=O)[C@H](CC[C@H](CN)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-23	1457.32
Gas Chromatography	5-Hydroxylysine_TMS_25	C[Si](C)(C)OC(=O)[C@@H](N)CC[C@H](CN([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C	standard polar	2025-10-23	1884.45
Gas Chromatography	5-Hydroxylysine_TMS_26	C[Si](C)(C)N[C@@H](CC[C@H](CN([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C)C(=O)O	standard polar	2025-10-23	1299.73
Gas Chromatography	5-Hydroxylysine_TMS_27	C[Si](C)(C)NC[C@@H](CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C	standard polar	2025-10-23	2198.65
Gas Chromatography	5-Hydroxylysine_TMS_28	C[Si](C)(C)N[C@@H](CC[C@@H](O)CN([Si](C)(C)C)[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-23	2583.7
Gas Chromatography	5-Hydroxylysine_TMS_29	C[Si](C)(C)NC[C@H](O)CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-23	1579.79
Gas Chromatography	5-Hydroxylysine_TMS_30	C[Si](C)(C)N(C[C@H](O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-23	2281.6
Gas Chromatography	5-Hydroxylysine_TMS_31	C[Si](C)(C)N[C@@H](CC[C@H](CN([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-23	1322.25
Gas Chromatography	5-Hydroxylysine_TMS_32	C[Si](C)(C)NC[C@@H](CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C	standard polar	2025-10-23	2492.55
Gas Chromatography	5-Hydroxylysine_TMS_33	C[Si](C)(C)O[C@H](CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)CN([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-23	3054.39
Gas Chromatography	5-Hydroxylysine_TMS_34	C[Si](C)(C)OC(=O)[C@H](CC[C@@H](O)CN([Si](C)(C)C)[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-23	2787.69
Gas Chromatography	5-Hydroxylysine_TMS_35	C[Si](C)(C)OC(=O)[C@H](CC[C@H](CN([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-23	1781.67

Biological Properties

Cellular Locations

Cytoplasm

Biospecimen Locations

Blood
Cerebrospinal Fluid (CSF)
Feces
Placenta
Urine

Tissue Locations

Placenta

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species
MMDBp0192119	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Unknown	Q02809	Homo sapiens
MMDBp0192120	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Unknown	O00469	Homo sapiens
MMDBp0192121	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	Unknown	O60568	Homo sapiens
MMDBp0196680	Hydroxylysine kinase	Unknown	A2RU49

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference
Alzheimer's disease		Association	Human Blood	HMDB	17031479
Eosinophilic esophagitis		Association	Human Urine	HMDB	Slae, M., Huynh, H., Wishart, D.S. (2014). Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria/Eubacteria	Actinobacteria	1	Human ; Human feces; Human saliva; Human supragingival plaque	Indirect association between microbiota composition and metabolites measured in host biospecimen
Bacteria/Eubacteria	Firmicutes	2	Human feces; Human sputum; Human ; Human subgingival plaque; Human saliva; Human mucosa; Human supragingival plaque	Indirect association between microbiota composition and metabolites measured in host biospecimen
Eukaryota/Fungi	Ascomycota	1	Human feces; Human saliva	Unknown

Exposure Sources

Other Exposures

Source Type	Data Source	Reference
Cosmetics	U.S. Environmental Protection Agency	CompTox
Domestics	U.S. Environmental Protection Agency	CompTox
Domestics	U.S. Environmental Protection Agency	CompTox

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified									HMDB
Human Blood	Detected and Quantified	0.50	0.028			uM	Elderly (>65 years old)	Both	Alzheimer's disease	HMDB	17031479
Human Urine	Detected and Quantified	20.963				umol/mmol creatinine	Adolescent (13-18 years old)	Male	Hydroxylysinuria	HMDB	4194840
Human Urine	Detected and Quantified			5.507	7.110	umol/mmol creatinine	Adolescent (13-18 years old)	Male	Hydroxylysinuria	HMDB	4194840
Human Urine	Detected and Quantified	0.11				umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	19309105
Human Urine	Detected and Quantified	0.35	0.62			umol/mmol creatinine	Infant (0-1 year old)	Both	Normal	HMDB	2026685
Human Urine	Detected and Quantified			0.78	1.2	umol/mmol creatinine	Adult (>18 years old)	Female	Normal	HMDB	27012787
Human Urine	Detected and Quantified			0.82	1.2	umol/mmol creatinine	Adult (>18 years old)	Male	Normal	HMDB	27012787
Human Urine	Detected and Quantified	1.0		0.45	2.26	umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	5472370
Human Urine	Detected and Quantified	7.262	2.023			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Eosinophilic esophagitis	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Urine	Detected and Quantified			0	8.03	umol/mmol creatinine	Children (2 - 4 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Urine	Detected and Quantified			0	8.03	umol/mmol creatinine	Children (4 - 13 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Urine	Detected and Quantified			0	8.03	umol/mmol creatinine	Adolescent (13 - 21 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Urine	Detected and Quantified			0	8.03	umol/mmol creatinine	Adult (>21 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Cerebrospinal fluid (csf)	Detected and Quantified			0	0.8	uM	Children (0 - 10 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Cerebrospinal fluid (csf)	Detected and Quantified			0	0.8	uM	Adolescent (>11 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Blood	Detected and Quantified			0	2.5	uM	Newborn (0-30 days old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Blood	Detected and Quantified			0	2.5	uM	Infant (1 - 3 months old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Blood	Detected and Quantified			0	2.5	uM	Children (3 months - 6 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Blood	Detected and Quantified			0	2.5	uM	Children (6 - 18 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Urine	Detected and Quantified			2.04	71.91	umol/mmol creatinine	Infant (1 - 6 months old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Urine	Detected and Quantified			2.04	71.91	umol/mmol creatinine	Infant (6 months - <1 year old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Urine	Detected and Quantified			2.04	71.91	umol/mmol creatinine	Children (1 - 2 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Urine	Detected and Quantified			4.97	116.90	umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Blood	Detected and Quantified	2.5		1.8	3.2	uM	Adult (>18 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Urine	Detected and Quantified	<1.36				umol/mmol creatinine	Adult (>18 years old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human Urine	Detected and Quantified	<16.97				umol/mmol creatinine	Infant (0-1 year old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human Urine	Detected and Quantified	<2.94				umol/mmol creatinine	Children (1-13 years old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human Urine	Detected and Quantified	<3.51				umol/mmol creatinine	Adolescent (13-18 years old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human Urine	Detected and Quantified	<3.85				umol/mmol creatinine	Children (1-13 years old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human Urine	Detected and Quantified	<6.45				umol/mmol creatinine	Children (1-13 years old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human Placenta	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Feces	Detected but not Quantified						Adult (>18 years old)	Female	Normal	HMDB	26709303
Human Feces	Detected but not Quantified						Not Specified	Both	Normal	HMDB	25486321
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	27543620
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	25037050
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	29808030

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General References

Krane SM, Kantrowitz FG, Byrne M, Pinnell SR, Singer FR: Urinary excretion of hydroxylysine and its glycosides as an index of collagen degradation. J Clin Invest. 1977 May;59(5):819-27. doi: 10.1172/JCI108704. [PubMed:404321 ]
Schor DS, Verhoeven NM, Struys EA, ten Brink HJ, Jakobs C: Quantification of 3-hydroxyglutaric acid in urine, plasma, cerebrospinal fluid and amniotic fluid by stable-isotope dilution negative chemical ionization gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Nov 15;780(1):199-204. doi: 10.1016/s1570-0232(02)00406-3. [PubMed:12383496 ]
Ohdoi C, Nyhan WL, Kuhara T: Chemical diagnosis of Lesch-Nyhan syndrome using gas chromatography-mass spectrometry detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 15;792(1):123-30. doi: 10.1016/s1570-0232(03)00277-0. [PubMed:12829005 ]
Boulat O, Gradwohl M, Matos V, Guignard JP, Bachmann C: Organic acids in the second morning urine in a healthy Swiss paediatric population. Clin Chem Lab Med. 2003 Dec;41(12):1642-58. doi: 10.1515/CCLM.2003.248. [PubMed:14708889 ]
Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]

Showing metabocard for 5-Hydroxylysine (MMDBc0000344)

MOL for #<Metabolite:0x00007f9accdac2d0>

3D MOL for #<Metabolite:0x00007f9accdac2d0>

3D SDF for #<Metabolite:0x00007f9accdac2d0>

3D-SDF for #<Metabolite:0x00007f9accdac2d0>

PDB for #<Metabolite:0x00007f9accdac2d0>

3D PDB for #<Metabolite:0x00007f9accdac2d0>

SMILES for #<Metabolite:0x00007f9accdac2d0>

INCHI for #<Metabolite:0x00007f9accdac2d0>

Structure for #<Metabolite:0x00007f9accdac2d0>

3D Structure for #<Metabolite:0x00007f9accdac2d0>