MiMeDB: Showing metabocard for N-Methylproline (MMDBc0000829)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2020-12-10 23:04:43 UTC

Update Date

2025-10-07 16:04:22 UTC

Metabolite ID

MMDBc0000829

Metabolite Identification

Common Name

N-Methylproline

Description

N-Methylproline is a secondary amine and a derivative of proline, classified as an amino acid metabolite. Its chemical structure features a methyl group attached to the nitrogen atom of proline, which influences its biochemical pathways. N-Methylproline is involved in various metabolic processes, including mediating associations between gut microbiota, such as Bacteroides salyersiae, and conditions like bladder cancer (BCa), accounting for significant effects in mediation analyses (PMID:40937009 ). It also plays a role in the dietary context, where it has been linked to potassium intake and various serum metabolites (PMID:40067387 ). In inflammatory conditions, N-methylproline has shown a mediated effect in uveitis related to specific gut microbiota (PMID:39686482 ). Furthermore, its levels are indicative of dietary impacts on collagen metabolism, with lower concentrations suggesting reduced collagen breakdown (PMID:37369569 ). In clinical studies, associations between N-methylproline and blood pressure regulation have been observed, particularly in dietary interventions (PMID:37161796 ). Additionally, it is correlated with hepatic injury biomarkers, suggesting its involvement in metabolic remodeling (PMID:37023648 ). Overall, N-methylproline serves as a significant metabolite within various biochemical and physiological contexts.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Molecular Formula

C₆H₁₁NO₂

Average Mass

129.159

Monoisotopic Mass

129.078978598

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

Not Available

InChI Identifier

InChI=1S/C6H11NO2/c1-7-4-2-3-5(7)6(8)9/h5H,2-4H2,1H3,(H,8,9)

InChI Key

CWLQUGTUXBXTLF-UHFFFAOYSA-N

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Not Available

Predicted Properties

Not Available

Spectra

Not Available

Chromatographic Retention Times and Retention Indices

Retention Times

Chromatography Type	Technique	Column	Deposition Date	Retention Time (s)
Liquid Chromatography	HILIC	Waters Acquity UPLC-BEH Amide column (eluted)	2025-10-23	448.3
Liquid Chromatography	HILIC	Accucore 150 Amide HILIC (eluted)	2025-10-23	372.3
Liquid Chromatography	Reversed-phase	Hypersil Gold 1.9 µm C18 (void)	2025-10-23	39.2
Liquid Chromatography	Reversed-phase	Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) (eluted)	2025-10-23	233.7
Liquid Chromatography	Reversed-phase	XBridge C18 3.5u 2.1x50 mm (eluted)	2025-10-23	263.8
Liquid Chromatography	Reversed-phase	Ascentis Express C18 (void)	2025-10-23	286.7
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (void)	2025-10-23	432.5
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-23	802.9
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC (eluted)	2025-10-23	526.9
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	164.5
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-23	449.6
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (void)	2025-10-23	179.5
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	66.0
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-23	321.4
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-23	781.7
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	46.5
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (void)	2025-10-23	201.2
Liquid Chromatography	Reversed-phase	Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex (eluted)	2025-10-23	630.5
Liquid Chromatography	Reversed-phase	Waters Atlantis T3 (2.1 x 150 mm, 5 um) (eluted)	2025-10-23	555.4

Retention Indices

Chromatography Type	Peak Label	SMILES	Stationary Phase	Deposition Date	Retention Index
Gas Chromatography	N-Methylproline_TMS_1	CN1CCCC1C(=O)O[Si](C)(C)C	standard non polar	2025-10-23	1978.13
Gas Chromatography	N-Methylproline_TMS_1	CN1CCCC1C(=O)O[Si](C)(C)C	standard polar	2025-10-23	2570.44

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria/Eubacteria	Firmicutes	2		Indirect association between microbiota composition and metabolites measured in host biospecimen

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

Not Available

General References

Kong SW, Hernandez-Ferrer C: Assessment of coverage for endogenous metabolites and exogenous chemical compounds using an untargeted metabolomics platform. Pac Symp Biocomput. 2020;25:587-598. [PubMed:31797630 ]

Showing metabocard for N-Methylproline (MMDBc0000829)

MOL for #<Metabolite:0x00007f9ab50e4c80>

3D MOL for #<Metabolite:0x00007f9ab50e4c80>

3D SDF for #<Metabolite:0x00007f9ab50e4c80>

3D-SDF for #<Metabolite:0x00007f9ab50e4c80>

PDB for #<Metabolite:0x00007f9ab50e4c80>

3D PDB for #<Metabolite:0x00007f9ab50e4c80>

SMILES for #<Metabolite:0x00007f9ab50e4c80>

INCHI for #<Metabolite:0x00007f9ab50e4c80>

Structure for #<Metabolite:0x00007f9ab50e4c80>

3D Structure for #<Metabolite:0x00007f9ab50e4c80>