MiMeDB: Showing metabocard for 6-epi-Ophiobolin A (MMDBc0001196)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-05-14 19:31:41 UTC

Update Date

2025-10-07 16:04:26 UTC

Metabolite ID

MMDBc0001196

Metabolite Identification

Common Name

6-epi-Ophiobolin A

Description

6-epi-Ophiobolin A is a member of the ophiobolin chemical class, which consists of bioactive metabolites produced by certain fungi. Its chemical structure features a complex arrangement of carbon rings and functional groups that contribute to its biological activity. This compound has been shown to exhibit phytotoxic effects, particularly in bioassays involving green foxtail, where it ranked second in toxicity after 3-anhydro-ophiobolin A, indicating its role in plant-pathogen interactions (PMID:37090018 ). Additionally, 6-epi-Ophiobolin A has demonstrated cytotoxicity against various human cancer cell lines, including colon adenocarcinoma (HCT-8), liver cancer (Bel-7402), gastric cancer (BGC-823), lung adenocarcinoma (A549), and ovarian adenocarcinoma (A2780) cells (PMID:37090018 ). The compound was isolated alongside other ophiobolins, revealing its significance within this metabolite family (PMID:33074690 ). Furthermore, synthetic approaches to access 6-epi-Ophiobolin A highlighted its structural complexity and the potential for further chemical modifications (PMID:32202757 ). Overall, 6-epi-Ophiobolin A is implicated in both phytotoxic and anticancer pathways, marking it as a compound of interest in both agricultural and medicinal research.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652305142121312D          

 35 38  0  0  1  0            999 V2000
    1.1811    0.8973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2787   -0.0177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0482   -3.4127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6763   -3.4477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1256   -3.3407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5681   -0.7204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9196   -1.2304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8726   -3.3835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0788   -3.1587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9375   -0.5107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7630   -1.9705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1509   -2.7960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1089   -2.0270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7912   -0.0990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4657    0.1230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2730   -2.6190    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.3872   -0.8183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2221   -1.2851    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.7994   -2.2860    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.7066   -1.3067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8217   -2.0496    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.8973   -1.4668    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.3317   -2.6981    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.5482   -2.6322    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.0474   -2.3343    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.6161   -0.0891    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0528   -0.5579    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2087   -3.1266    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0159   -1.5099    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3450    0.0739    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4637   -2.7790    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7828   -0.6799    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0800   -1.8820    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6160   -1.8266    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1837   -0.6931    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  7  6  1  0  0  0  0
  9  8  1  0  0  0  0
 15  1  1  0  0  0  0
 15  2  1  0  0  0  0
 15 10  2  0  0  0  0
 16  3  1  1  0  0  0
 16 11  1  0  0  0  0
 17  6  2  0  0  0  0
 17 14  1  0  0  0  0
 18 10  1  6  0  0  0
 18 11  1  0  0  0  0
 19 12  1  0  0  0  0
 20 13  1  0  0  0  0
 21  7  1  0  0  0  0
 22 17  1  0  0  0  0
 22 19  1  0  0  0  0
 22 20  1  0  0  0  0
 23  4  1  6  0  0  0
 23  8  1  0  0  0  0
 23 12  1  0  0  0  0
 23 21  1  0  0  0  0
 24  5  1  6  0  0  0
 24 13  1  0  0  0  0
 24 19  1  0  0  0  0
 25  9  1  0  0  0  0
 25 16  1  0  0  0  0
 25 21  1  0  0  0  0
 26 14  2  0  0  0  0
 27 20  2  0  0  0  0
 24 28  1  1  0  0  0
 29 18  1  0  0  0  0
 25 29  1  1  0  0  0
 30  6  1  0  0  0  0
 16 31  1  6  0  0  0
 18 32  1  1  0  0  0
 19 33  1  6  0  0  0
 21 34  1  1  0  0  0
 22 35  1  1  0  0  0
M  END


  Mrv1652305142121312D          

 35 38  0  0  1  0            999 V2000
    1.1811    0.8973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2787   -0.0177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0482   -3.4127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6763   -3.4477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1256   -3.3407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5681   -0.7204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9196   -1.2304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8726   -3.3835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0788   -3.1587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9375   -0.5107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7630   -1.9705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1509   -2.7960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1089   -2.0270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7912   -0.0990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4657    0.1230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2730   -2.6190    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.3872   -0.8183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2221   -1.2851    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.7994   -2.2860    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.7066   -1.3067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8217   -2.0496    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.8973   -1.4668    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.3317   -2.6981    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.5482   -2.6322    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.0474   -2.3343    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.6161   -0.0891    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0528   -0.5579    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2087   -3.1266    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0159   -1.5099    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3450    0.0739    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4637   -2.7790    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7828   -0.6799    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0800   -1.8820    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6160   -1.8266    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1837   -0.6931    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  7  6  1  0  0  0  0
  9  8  1  0  0  0  0
 15  1  1  0  0  0  0
 15  2  1  0  0  0  0
 15 10  2  0  0  0  0
 16  3  1  1  0  0  0
 16 11  1  0  0  0  0
 17  6  2  0  0  0  0
 17 14  1  0  0  0  0
 18 10  1  6  0  0  0
 18 11  1  0  0  0  0
 19 12  1  0  0  0  0
 20 13  1  0  0  0  0
 21  7  1  0  0  0  0
 22 17  1  0  0  0  0
 22 19  1  0  0  0  0
 22 20  1  0  0  0  0
 23  4  1  6  0  0  0
 23  8  1  0  0  0  0
 23 12  1  0  0  0  0
 23 21  1  0  0  0  0
 24  5  1  6  0  0  0
 24 13  1  0  0  0  0
 24 19  1  0  0  0  0
 25  9  1  0  0  0  0
 25 16  1  0  0  0  0
 25 21  1  0  0  0  0
 26 14  2  0  0  0  0
 27 20  2  0  0  0  0
 24 28  1  1  0  0  0
 29 18  1  0  0  0  0
 25 29  1  1  0  0  0
 30  6  1  0  0  0  0
 16 31  1  6  0  0  0
 18 32  1  1  0  0  0
 19 33  1  6  0  0  0
 21 34  1  1  0  0  0
 22 35  1  1  0  0  0
M  END
> <DATABASE_ID>
MMDBc0001196

> <DATABASE_NAME>
MIME

> <SMILES>
[H]\C1=C(C=O)\[C@]2([H])C(=O)C[C@@](C)(O)[C@@]2([H])C[C@@]2(C)CC[C@@]3(O[C@]([H])(C[C@]3([H])C)C=C(C)C)[C@]2([H])C1

> <INCHI_IDENTIFIER>
InChI=1S/C25H36O4/c1-15(2)10-18-11-16(3)25(29-18)9-8-23(4)12-19-22(20(27)13-24(19,5)28)17(14-26)6-7-21(23)25/h6,10,14,16,18-19,21-22,28H,7-9,11-13H2,1-5H3/b17-6-/t16-,18-,19-,21+,22-,23+,24+,25-/m0/s1

> <INCHI_KEY>
MWYYLZRWWNBROW-RXAKKKFQSA-N

> <FORMULA>
C25H36O4

> <MOLECULAR_WEIGHT>
400.559

> <EXACT_MASS>
400.261359639

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
65

> <JCHEM_AVERAGE_POLARIZABILITY>
46.23616996867605

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1'S,2S,3S,3'R,5R,7'R,9'E,11'R,14'R)-14'-hydroxy-3,3',14'-trimethyl-5-(2-methylprop-1-en-1-yl)-12'-oxospiro[oxolane-2,6'-tricyclo[9.3.0.0^{3,7}]tetradecan]-9'-ene-10'-carbaldehyde

> <ALOGPS_LOGP>
3.85

> <JCHEM_LOGP>
3.535256972666666

> <ALOGPS_LOGS>
-4.66

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.948071183160895

> <JCHEM_PKA_STRONGEST_ACIDIC>
10.615091202879062

> <JCHEM_PKA_STRONGEST_BASIC>
-2.989416208149593

> <JCHEM_POLAR_SURFACE_AREA>
63.60000000000001

> <JCHEM_REFRACTIVITY>
115.04379999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
8.76e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1'S,2S,3S,3'R,5R,7'R,9'E,11'R,14'R)-14'-hydroxy-3,3',14'-trimethyl-5-(2-methylprop-1-en-1-yl)-12'-oxospiro[oxolane-2,6'-tricyclo[9.3.0.0^{3,7}]tetradecan]-9'-ene-10'-carbaldehyde

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 14-MAY-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   14-MAY-21         0                                  
HETATM    1  C   UNK     0       2.205   1.675   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       4.253  -0.033   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       1.957  -6.370   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       6.862  -6.436   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       9.568  -6.236   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       6.660  -1.345   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       5.450  -2.297   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       5.362  -6.316   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       3.880  -5.896   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       1.750  -0.953   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       1.424  -3.678   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       7.748  -5.219   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      11.403  -3.784   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       8.943  -0.185   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       2.736   0.230   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       2.376  -4.889   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       8.190  -1.528   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       2.281  -2.399   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       8.959  -4.267   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      10.652  -2.439   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       5.267  -3.826   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       9.142  -2.738   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       6.219  -5.036   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      10.357  -4.913   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       3.822  -4.357   0.000  0.00  0.00           C+0
HETATM   26  O   UNK     0      10.483  -0.166   0.000  0.00  0.00           O+0
HETATM   27  O   UNK     0      11.299  -1.041   0.000  0.00  0.00           O+0
HETATM   28  O   UNK     0      11.590  -5.836   0.000  0.00  0.00           O+0
HETATM   29  O   UNK     0       3.763  -2.818   0.000  0.00  0.00           O+0
HETATM   30  H   UNK     0       6.244   0.138   0.000  0.00  0.00           H+0
HETATM   31  H   UNK     0       0.866  -5.187   0.000  0.00  0.00           H+0
HETATM   32  H   UNK     0       3.328  -1.269   0.000  0.00  0.00           H+0
HETATM   33  H   UNK     0       7.616  -3.513   0.000  0.00  0.00           H+0
HETATM   34  H   UNK     0       6.750  -3.410   0.000  0.00  0.00           H+0
HETATM   35  H   UNK     0       9.676  -1.294   0.000  0.00  0.00           H+0
CONECT    1   15                                                            
CONECT    2   15                                                            
CONECT    3   16                                                            
CONECT    4   23                                                            
CONECT    5   24                                                            
CONECT    6    7   17   30                                                  
CONECT    7    6   21                                                       
CONECT    8    9   23                                                       
CONECT    9    8   25                                                       
CONECT   10   15   18                                                       
CONECT   11   16   18                                                       
CONECT   12   19   23                                                       
CONECT   13   20   24                                                       
CONECT   14   17   26                                                       
CONECT   15    1    2   10                                                  
CONECT   16    3   11   25   31                                             
CONECT   17    6   14   22                                                  
CONECT   18   10   11   29   32                                             
CONECT   19   12   22   24   33                                             
CONECT   20   13   22   27                                                  
CONECT   21    7   23   25   34                                             
CONECT   22   17   19   20   35                                             
CONECT   23    4    8   12   21                                             
CONECT   24    5   13   19   28                                             
CONECT   25    9   16   21   29                                             
CONECT   26   14                                                            
CONECT   27   20                                                            
CONECT   28   24                                                            
CONECT   29   18   25                                                       
CONECT   30    6                                                            
CONECT   31   16                                                            
CONECT   32   18                                                            
CONECT   33   19                                                            
CONECT   34   21                                                            
CONECT   35   22                                                            
MASTER        0    0    0    0    0    0    0    0   35    0   76    0
END

Synonyms

Not Available

Molecular Formula

C₂₅H₃₆O₄

Average Mass

400.559

Monoisotopic Mass

400.261359639

IUPAC Name

(1'S,2S,3S,3'R,5R,7'R,9'E,11'R,14'R)-14'-hydroxy-3,3',14'-trimethyl-5-(2-methylprop-1-en-1-yl)-12'-oxospiro[oxolane-2,6'-tricyclo[9.3.0.0^{3,7}]tetradecan]-9'-ene-10'-carbaldehyde

Traditional Name

(1'S,2S,3S,3'R,5R,7'R,9'E,11'R,14'R)-14'-hydroxy-3,3',14'-trimethyl-5-(2-methylprop-1-en-1-yl)-12'-oxospiro[oxolane-2,6'-tricyclo[9.3.0.0^{3,7}]tetradecan]-9'-ene-10'-carbaldehyde

CAS Registry Number

Not Available

SMILES

[H]\C1=C(C=O)\[C@]2([H])C(=O)C[C@@](C)(O)[C@@]2([H])C[C@@]2(C)CC[C@@]3(O[C@]([H])(C[C@]3([H])C)C=C(C)C)[C@]2([H])C1

InChI Identifier

InChI=1S/C25H36O4/c1-15(2)10-18-11-16(3)25(29-18)9-8-23(4)12-19-22(20(27)13-24(19,5)28)17(14-26)6-7-21(23)25/h6,10,14,16,18-19,21-22,28H,7-9,11-13H2,1-5H3/b17-6-/t16-,18-,19-,21+,22-,23+,24+,25-/m0/s1

InChI Key

MWYYLZRWWNBROW-RXAKKKFQSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as ophiobolane sesterterpenoids. These are sesterterpnoids with a structure based on the ophiobolane backbone. Ophiobolane is a tricyclic compound consisting of two cyclopentane rings joined by a cyclooctane ring, and carries a methyl group at the 1-, 4-, and 8-position, as well as a 6-methylheptane group at the 12-position.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Sesterterpenoids

Direct Parent

Ophiobolane sesterterpenoids

Alternative Parents

Substituents

Ophiobolane sesterterpenoid
Cyclic alcohol
Tertiary alcohol
Tetrahydrofuran
Ketone
Organoheterocyclic compound
Ether
Dialkyl ether
Oxacycle
Aldehyde
Organooxygen compound
Organic oxygen compound
Alcohol
Carbonyl group
Hydrocarbon derivative
Organic oxide
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.0088 g/L	ALOGPS
logP	3.85	ALOGPS
logP	3.54	ChemAxon
logS	-4.7	ALOGPS
pKa (Strongest Acidic)	10.62	ChemAxon
pKa (Strongest Basic)	-3	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	63.6 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	115.04 m³·mol⁻¹	ChemAxon
Polarizability	46.24 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_1) - 70eV, Positive	Not Available	2022-08-08	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	Not Available	2022-08-09	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-23	View Spectrum

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

This table shows at most 5 pathways. For the full list of associated pathways:

See All Associated Bacterial Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria/Eubacteria	Proteobacteria	1	Human ; Human sputum; Human subgingival plaque; Human feces	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

31118877

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

12303079

PDB ID

Not Available

ChEBI ID

Not Available

CMMC Knowledgebase

Not Available

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for 6-epi-Ophiobolin A (MMDBc0001196)

MOL for #<Metabolite:0x00007fd42a12b5c8>

3D MOL for #<Metabolite:0x00007fd42a12b5c8>

3D SDF for #<Metabolite:0x00007fd42a12b5c8>

3D-SDF for #<Metabolite:0x00007fd42a12b5c8>

PDB for #<Metabolite:0x00007fd42a12b5c8>

3D PDB for #<Metabolite:0x00007fd42a12b5c8>

SMILES for #<Metabolite:0x00007fd42a12b5c8>

INCHI for #<Metabolite:0x00007fd42a12b5c8>

Structure for #<Metabolite:0x00007fd42a12b5c8>

3D Structure for #<Metabolite:0x00007fd42a12b5c8>