MiMeDB: Showing metabocard for 4-epi-8Î±-hydroxy-15-epi-brefeldin C (MMDBc0002041)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-05-14 20:36:18 UTC

Update Date

2025-10-07 16:04:33 UTC

Metabolite ID

MMDBc0002041

Metabolite Identification

Common Name

4-epi-8Î±-hydroxy-15-epi-brefeldin C

Description

4-epi-8α-hydroxy-15-epi-brefeldin C is a natural product belonging to the class of macrolide compounds, specifically a derivative of brefeldin C, which is known for its role in inhibiting protein transport and secretion in eukaryotic cells. This compound has garnered interest due to its potential biological activities, including effects on cellular processes and pathways related to vesicular trafficking and Golgi apparatus function. However, there is limited literature available on 4-epi-8α-hydroxy-15-epi-brefeldin C, with few studies detailing its specific biochemical properties or biological implications. Notably, research has highlighted its structural similarities to other brefeldin derivatives, suggesting potential for further exploration in drug development and therapeutic applications (PMID: 15082712 , PMID: 21112926 ). Overall, while the compound shows promise, more comprehensive studies are necessary to elucidate its full biological significance and mechanisms of action.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652305142122362D          

 29 30  0  0  1  0            999 V2000
    9.0803   -0.6589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5709   -2.3521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2491   -1.7562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7787   -2.1218    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0737   -1.7304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -1.3206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7704   -0.2285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4586   -0.9923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9809    0.0516    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5765    0.6225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3040   -0.9382    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.7898   -1.0903    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.5932   -0.2891    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.0886   -1.5249    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.1887    0.2819    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    7.3687    0.3922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0280   -2.3477    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9921    1.0831    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9517    0.9759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6217   -0.4744    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1831   -2.6927    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.1776   -0.7497    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.7731   -0.1787    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.3798    1.4237    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.9053   -1.5031    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9017   -1.9077    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.3854   -0.5194    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3280   -1.8445    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7843    0.8528    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  3  2  1  0  0  0  0
  4  2  1  0  0  0  0
  5  3  1  0  0  0  0
  6  4  2  0  0  0  0
  8  7  1  0  0  0  0
 10  9  2  0  0  0  0
 11  1  1  6  0  0  0
 11  5  1  0  0  0  0
 12  6  1  0  0  0  0
 13  7  1  0  0  0  0
 13 12  1  0  0  0  0
 14  8  1  0  0  0  0
 14 12  1  0  0  0  0
 15  9  1  0  0  0  0
 15 13  1  0  0  0  0
 16 10  1  0  0  0  0
 14 17  1  6  0  0  0
 15 18  1  1  0  0  0
 19 16  2  0  0  0  0
 20 11  1  0  0  0  0
 20 16  1  0  0  0  0
 21  4  1  0  0  0  0
 22  6  1  0  0  0  0
 23  9  1  0  0  0  0
 24 10  1  0  0  0  0
 11 25  1  1  0  0  0
 12 26  1  1  0  0  0
 13 27  1  6  0  0  0
 14 28  1  1  0  0  0
 15 29  1  6  0  0  0
M  END


  Mrv1652305142122362D          

 29 30  0  0  1  0            999 V2000
    9.0803   -0.6589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5709   -2.3521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2491   -1.7562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7787   -2.1218    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0737   -1.7304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -1.3206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7704   -0.2285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4586   -0.9923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9809    0.0516    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5765    0.6225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3040   -0.9382    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.7898   -1.0903    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.5932   -0.2891    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.0886   -1.5249    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.1887    0.2819    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    7.3687    0.3922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0280   -2.3477    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9921    1.0831    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9517    0.9759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6217   -0.4744    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1831   -2.6927    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.1776   -0.7497    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.7731   -0.1787    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.3798    1.4237    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.9053   -1.5031    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9017   -1.9077    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.3854   -0.5194    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3280   -1.8445    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7843    0.8528    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  3  2  1  0  0  0  0
  4  2  1  0  0  0  0
  5  3  1  0  0  0  0
  6  4  2  0  0  0  0
  8  7  1  0  0  0  0
 10  9  2  0  0  0  0
 11  1  1  6  0  0  0
 11  5  1  0  0  0  0
 12  6  1  0  0  0  0
 13  7  1  0  0  0  0
 13 12  1  0  0  0  0
 14  8  1  0  0  0  0
 14 12  1  0  0  0  0
 15  9  1  0  0  0  0
 15 13  1  0  0  0  0
 16 10  1  0  0  0  0
 14 17  1  6  0  0  0
 15 18  1  1  0  0  0
 19 16  2  0  0  0  0
 20 11  1  0  0  0  0
 20 16  1  0  0  0  0
 21  4  1  0  0  0  0
 22  6  1  0  0  0  0
 23  9  1  0  0  0  0
 24 10  1  0  0  0  0
 11 25  1  1  0  0  0
 12 26  1  1  0  0  0
 13 27  1  6  0  0  0
 14 28  1  1  0  0  0
 15 29  1  6  0  0  0
M  END
> <DATABASE_ID>
MMDBc0002041

> <DATABASE_NAME>
MIME

> <SMILES>
[H]\C1=C([H])/[C@]2([H])[C@]([H])(O)CC[C@@]2([H])[C@@]([H])(O)\C([H])=C([H])\C(=O)O[C@]([H])(C)CCC1

> <INCHI_IDENTIFIER>
InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-13(7-8-14(12)17)15(18)9-10-16(19)20-11/h4,6,9-15,17-18H,2-3,5,7-8H2,1H3/b6-4+,10-9+/t11-,12+,13-,14-,15+/m1/s1

> <INCHI_KEY>
DTUZEFPEIMVBAJ-NCCFWWCZSA-N

> <FORMULA>
C16H24O4

> <MOLECULAR_WEIGHT>
280.364

> <EXACT_MASS>
280.167459253

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
44

> <JCHEM_AVERAGE_POLARIZABILITY>
30.90026218444031

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1S,6R,11aS,12R,14aR)-1,12-dihydroxy-6-methyl-1H,4H,6H,7H,8H,9H,11aH,12H,13H,14H,14aH-cyclopenta[f]oxacyclotridecan-4-one

> <ALOGPS_LOGP>
1.75

> <JCHEM_LOGP>
2.085169637666666

> <ALOGPS_LOGS>
-2.51

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
15.036928684195143

> <JCHEM_PKA_STRONGEST_ACIDIC>
14.34414564924391

> <JCHEM_PKA_STRONGEST_BASIC>
-2.850428435212816

> <JCHEM_POLAR_SURFACE_AREA>
66.76

> <JCHEM_REFRACTIVITY>
78.67179999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
8.66e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1S,6R,11aS,12R,14aR)-1,12-dihydroxy-6-methyl-1H,6H,7H,8H,9H,11aH,12H,13H,14H,14aH-cyclopenta[f]oxacyclotridecan-4-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 14-MAY-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   14-MAY-21         0                                  
HETATM    1  C   UNK     0      16.950  -1.230   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      12.266  -4.391   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      13.532  -3.278   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      10.787  -3.961   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      15.071  -3.230   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      10.420  -2.465   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       7.038  -0.427   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       6.456  -1.852   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      11.164   0.096   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      12.276   1.162   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      15.501  -1.751   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       8.941  -2.035   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       8.574  -0.540   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       7.632  -2.846   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       9.686   0.526   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      13.755   0.732   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0       7.519  -4.382   0.000  0.00  0.00           O+0
HETATM   18  O   UNK     0       9.319   2.022   0.000  0.00  0.00           O+0
HETATM   19  O   UNK     0      14.843   1.822   0.000  0.00  0.00           O+0
HETATM   20  O   UNK     0      14.227  -0.886   0.000  0.00  0.00           O+0
HETATM   21  H   UNK     0       9.675  -5.026   0.000  0.00  0.00           H+0
HETATM   22  H   UNK     0      11.531  -1.399   0.000  0.00  0.00           H+0
HETATM   23  H   UNK     0      12.643  -0.334   0.000  0.00  0.00           H+0
HETATM   24  H   UNK     0      11.909   2.658   0.000  0.00  0.00           H+0
HETATM   25  H   UNK     0      16.623  -2.806   0.000  0.00  0.00           H+0
HETATM   26  H   UNK     0       9.150  -3.561   0.000  0.00  0.00           H+0
HETATM   27  H   UNK     0      10.053  -0.969   0.000  0.00  0.00           H+0
HETATM   28  H   UNK     0       6.212  -3.443   0.000  0.00  0.00           H+0
HETATM   29  H   UNK     0      10.797   1.592   0.000  0.00  0.00           H+0
CONECT    1   11                                                            
CONECT    2    3    4                                                       
CONECT    3    2    5                                                       
CONECT    4    2    6   21                                                  
CONECT    5    3   11                                                       
CONECT    6    4   12   22                                                  
CONECT    7    8   13                                                       
CONECT    8    7   14                                                       
CONECT    9   10   15   23                                                  
CONECT   10    9   16   24                                                  
CONECT   11    1    5   20   25                                             
CONECT   12    6   13   14   26                                             
CONECT   13    7   12   15   27                                             
CONECT   14    8   12   17   28                                             
CONECT   15    9   13   18   29                                             
CONECT   16   10   19   20                                                  
CONECT   17   14                                                            
CONECT   18   15                                                            
CONECT   19   16                                                            
CONECT   20   11   16                                                       
CONECT   21    4                                                            
CONECT   22    6                                                            
CONECT   23    9                                                            
CONECT   24   10                                                            
CONECT   25   11                                                            
CONECT   26   12                                                            
CONECT   27   13                                                            
CONECT   28   14                                                            
CONECT   29   15                                                            
MASTER        0    0    0    0    0    0    0    0   29    0   60    0
END

Synonyms

Value	Source
4-Epi-8a-hydroxy-15-epi-brefeldin C	Generator
4-Epi-8α-hydroxy-15-epi-brefeldin C	Generator

Molecular Formula

C₁₆H₂₄O₄

Average Mass

280.364

Monoisotopic Mass

280.167459253

IUPAC Name

(1S,6R,11aS,12R,14aR)-1,12-dihydroxy-6-methyl-1H,4H,6H,7H,8H,9H,11aH,12H,13H,14H,14aH-cyclopenta[f]oxacyclotridecan-4-one

Traditional Name

(1S,6R,11aS,12R,14aR)-1,12-dihydroxy-6-methyl-1H,6H,7H,8H,9H,11aH,12H,13H,14H,14aH-cyclopenta[f]oxacyclotridecan-4-one

CAS Registry Number

Not Available

SMILES

[H]\C1=C([H])/[C@]2([H])[C@]([H])(O)CC[C@@]2([H])[C@@]([H])(O)\C([H])=C([H])\C(=O)O[C@]([H])(C)CCC1

InChI Identifier

InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-13(7-8-14(12)17)15(18)9-10-16(19)20-11/h4,6,9-15,17-18H,2-3,5,7-8H2,1H3/b6-4+,10-9+/t11-,12+,13-,14-,15+/m1/s1

InChI Key

DTUZEFPEIMVBAJ-NCCFWWCZSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as macrolides and analogues. These are organic compounds containing a lactone ring of at least twelve members.

Kingdom

Organic compounds

Super Class

Phenylpropanoids and polyketides

Class

Macrolides and analogues

Sub Class

Not Available

Direct Parent

Macrolides and analogues

Alternative Parents

Substituents

Macrolide
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Cyclic alcohol
Secondary alcohol
Lactone
Carboxylic acid ester
Oxacycle
Organoheterocyclic compound
Monocarboxylic acid or derivatives
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Alcohol
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.87 g/L	ALOGPS
logP	1.75	ALOGPS
logP	2.09	ChemAxon
logS	-2.5	ALOGPS
pKa (Strongest Acidic)	14.34	ChemAxon
pKa (Strongest Basic)	-2.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	66.76 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	78.67 m³·mol⁻¹	ChemAxon
Polarizability	30.9 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

This table shows at most 5 pathways. For the full list of associated pathways:

See All Associated Bacterial Pathways

Name	SMPDB/PathBank	Species

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	1	Human feces	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

58197211

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

139583433

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

References

Synthesis Reference

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for 4-epi-8Î±-hydroxy-15-epi-brefeldin C (MMDBc0002041)

MOL for #<Metabolite:0x00007fb4cc60de60>

3D MOL for #<Metabolite:0x00007fb4cc60de60>

3D SDF for #<Metabolite:0x00007fb4cc60de60>

3D-SDF for #<Metabolite:0x00007fb4cc60de60>

PDB for #<Metabolite:0x00007fb4cc60de60>

3D PDB for #<Metabolite:0x00007fb4cc60de60>

SMILES for #<Metabolite:0x00007fb4cc60de60>

INCHI for #<Metabolite:0x00007fb4cc60de60>

Structure for #<Metabolite:0x00007fb4cc60de60>

3D Structure for #<Metabolite:0x00007fb4cc60de60>