MiMeDB: Showing metabocard for Feigrisolide B (MMDBc0004406)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-05-14 22:23:48 UTC

Update Date

2025-10-07 16:04:52 UTC

Metabolite ID

MMDBc0004406

Metabolite Identification

Common Name

Feigrisolide B

Description

Feigrisolide B is a secondary metabolite belonging to the class of natural products known as polyketides. It has been identified through mass spectrometry and NMR-spectra analysis alongside other compounds such as feigrisolide C and dinactin (PMID:32653809 ). In terms of biological activity, feigrisolide B has demonstrated strong antibacterial properties, as well as moderate cytotoxic and antiviral effects, indicating its potential as a lead compound for drug development (PMID:11099227 ). The diverse biological activities of feigrisolide B suggest that it may play a significant role in the ecological interactions of its producing organism and highlight its potential utility in therapeutic applications. Further studies are warranted to explore its mechanisms of action and to assess its efficacy in clinical settings.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652305152100232D          

 19 19  0  0  1  0            999 V2000
   -0.1435   -2.9975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1467    2.3518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4790   -2.2438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9803   -0.1553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2352    0.6294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3297   -0.8227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5678    1.9393    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.0059   -1.5764    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.1553   -0.1553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5678    1.1143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2822    2.3518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8264   -1.6626    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2822    3.1768    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9967    1.9393    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0997    0.6294    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1467    1.5268    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8146   -1.4901    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6596   -0.0262    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3028    1.4888    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  3  1  1  0  0  0  0
  5  4  1  0  0  0  0
  7  2  1  1  0  0  0
  8  3  1  0  0  0  0
  8  6  1  0  0  0  0
  9  4  1  0  0  0  0
  9  6  1  0  0  0  0
 10  5  1  0  0  0  0
 10  7  1  0  0  0  0
 11  7  1  0  0  0  0
  8 12  1  1  0  0  0
 13 11  2  0  0  0  0
 14 11  1  0  0  0  0
 15  9  1  0  0  0  0
 15 10  1  0  0  0  0
  7 16  1  6  0  0  0
  8 17  1  1  0  0  0
 18  9  1  0  0  0  0
 19 10  1  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0004406

> <DATABASE_NAME>
MIME

> <SMILES>
[H][C@@](O)(CC)CC1([H])CCC([H])(O1)[C@@]([H])(C)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C11H20O4/c1-3-8(12)6-9-4-5-10(15-9)7(2)11(13)14/h7-10,12H,3-6H2,1-2H3,(H,13,14)/t7-,8-,9?,10?/m1/s1

> <INCHI_KEY>
HTCUURQJNZBKIA-LGUIWLBCSA-N

> <FORMULA>
C11H20O4

> <MOLECULAR_WEIGHT>
216.277

> <EXACT_MASS>
216.136159124

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
35

> <JCHEM_AVERAGE_POLARIZABILITY>
23.87067209016154

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(2R)-2-{5-[(2R)-2-hydroxybutyl]oxolan-2-yl}propanoic acid

> <ALOGPS_LOGP>
1.32

> <JCHEM_LOGP>
1.2168185113333327

> <ALOGPS_LOGS>
-1.14

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
15.186760389663622

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.5768203135221155

> <JCHEM_PKA_STRONGEST_BASIC>
-2.717111385710938

> <JCHEM_POLAR_SURFACE_AREA>
66.76

> <JCHEM_REFRACTIVITY>
55.352900000000005

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.56e+01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(2R)-2-{5-[(2R)-2-hydroxybutyl]oxolan-2-yl}propanoic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 15-MAY-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-MAY-21         0                                  
HETATM    1  C   UNK     0      -0.268  -5.595   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -0.274   4.390   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -0.894  -4.188   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       1.830  -0.290   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       2.306   1.175   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -0.615  -1.536   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       1.060   3.620   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       0.011  -2.943   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       0.290  -0.290   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       1.060   2.080   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       2.393   4.390   0.000  0.00  0.00           C+0
HETATM   12  O   UNK     0       1.543  -3.104   0.000  0.00  0.00           O+0
HETATM   13  O   UNK     0       2.393   5.930   0.000  0.00  0.00           O+0
HETATM   14  O   UNK     0       3.727   3.620   0.000  0.00  0.00           O+0
HETATM   15  O   UNK     0      -0.186   1.175   0.000  0.00  0.00           O+0
HETATM   16  H   UNK     0      -0.274   2.850   0.000  0.00  0.00           H+0
HETATM   17  H   UNK     0      -1.521  -2.782   0.000  0.00  0.00           H+0
HETATM   18  H   UNK     0      -1.231  -0.049   0.000  0.00  0.00           H+0
HETATM   19  H   UNK     0       2.432   2.779   0.000  0.00  0.00           H+0
CONECT    1    3                                                            
CONECT    2    7                                                            
CONECT    3    1    8                                                       
CONECT    4    5    9                                                       
CONECT    5    4   10                                                       
CONECT    6    8    9                                                       
CONECT    7    2   10   11   16                                             
CONECT    8    3    6   12   17                                             
CONECT    9    4    6   15   18                                             
CONECT   10    5    7   15   19                                             
CONECT   11    7   13   14                                                  
CONECT   12    8                                                            
CONECT   13   11                                                            
CONECT   14   11                                                            
CONECT   15    9   10                                                       
CONECT   16    7                                                            
CONECT   17    8                                                            
CONECT   18    9                                                            
CONECT   19   10                                                            
MASTER        0    0    0    0    0    0    0    0   19    0   38    0
END

Synonyms

Value	Source
(2R)-2-{5-[(2R)-2-hydroxybutyl]oxolan-2-yl}propanoate	Generator

Molecular Formula

C₁₁H₂₀O₄

Average Mass

216.277

Monoisotopic Mass

216.136159124

IUPAC Name

(2R)-2-{5-[(2R)-2-hydroxybutyl]oxolan-2-yl}propanoic acid

Traditional Name

(2R)-2-{5-[(2R)-2-hydroxybutyl]oxolan-2-yl}propanoic acid

CAS Registry Number

Not Available

SMILES

[H][C@@](O)(CC)CC1([H])CCC([H])(O1)[C@@]([H])(C)C(O)=O

InChI Identifier

InChI=1S/C11H20O4/c1-3-8(12)6-9-4-5-10(15-9)7(2)11(13)14/h7-10,12H,3-6H2,1-2H3,(H,13,14)/t7-,8-,9?,10?/m1/s1

InChI Key

HTCUURQJNZBKIA-LGUIWLBCSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as tetrahydrofurans. These are heterocyclic compounds containing a saturated, aliphatic, five-membered ring where a carbon is replaced by an oxygen.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Tetrahydrofurans

Sub Class

Not Available

Direct Parent

Tetrahydrofurans

Alternative Parents

Substituents

Tetrahydrofuran
Secondary alcohol
Oxacycle
Monocarboxylic acid or derivatives
Ether
Dialkyl ether
Carboxylic acid
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Alcohol
Aliphatic heteromonocyclic compound

Molecular Framework

Aliphatic heteromonocyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	15.6 g/L	ALOGPS
logP	1.32	ALOGPS
logP	1.22	ChemAxon
logS	-1.1	ALOGPS
pKa (Strongest Acidic)	4.58	ChemAxon
pKa (Strongest Basic)	-2.7	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	66.76 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	55.35 m³·mol⁻¹	ChemAxon
Polarizability	23.87 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

This table shows at most 5 pathways. For the full list of associated pathways:

See All Associated Bacterial Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria/Eubacteria	Actinobacteria	1		Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

78439923

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

139584113

PDB ID

Not Available

ChEBI ID

Not Available

CMMC Knowledgebase

Not Available

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Feigrisolide B (MMDBc0004406)

MOL for #<Metabolite:0x00007fd409055728>

3D MOL for #<Metabolite:0x00007fd409055728>

3D SDF for #<Metabolite:0x00007fd409055728>

3D-SDF for #<Metabolite:0x00007fd409055728>

PDB for #<Metabolite:0x00007fd409055728>

3D PDB for #<Metabolite:0x00007fd409055728>

SMILES for #<Metabolite:0x00007fd409055728>

INCHI for #<Metabolite:0x00007fd409055728>

Structure for #<Metabolite:0x00007fd409055728>

3D Structure for #<Metabolite:0x00007fd409055728>