MiMeDB: Showing metabocard for Î³-L-glutamyl-L-leucine (MMDBc0004599)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-05-14 22:31:57 UTC

Update Date

2025-10-07 16:04:54 UTC

Metabolite ID

MMDBc0004599

Metabolite Identification

Common Name

Î³-L-glutamyl-L-leucine

Description

Î³-L-glutamyl-L-leucine is a dipeptide belonging to the class of amino acid derivatives. There is limited literature available on this metabolite, indicating that further research may be needed to fully understand its biological significance and potential applications.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652305152100312D          

 20 19  0  0  1  0            999 V2000
    0.5230   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3809    3.6020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6664    3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3809    4.4270    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.9520    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6664    2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954    4.8395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6664    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6664    4.8395    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    1.9520    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3809    1.9520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954    5.6645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8099    4.4270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3809    1.1270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6664   -0.1105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954    4.0145    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    0.3020    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  4  3  1  0  0  0  0
  6  1  1  0  0  0  0
  6  2  1  0  0  0  0
  6  5  1  0  0  0  0
  7  3  1  0  0  0  0
  8  5  1  0  0  0  0
  9  4  1  0  0  0  0
 10  7  1  0  0  0  0
 11  8  1  0  0  0  0
  7 12  1  1  0  0  0
 13  8  1  4  0  0  0
 13  9  2  0  0  0  0
 14  9  1  0  0  0  0
 15 10  2  0  0  0  0
 16 10  1  0  0  0  0
 17 11  2  0  0  0  0
 18 11  1  0  0  0  0
  7 19  1  1  0  0  0
 20  8  1  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0004599

> <DATABASE_NAME>
MIME

> <SMILES>
[H][C@](N)(CCC(O)=NC([H])(CC(C)C)C(O)=O)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C11H20N2O5/c1-6(2)5-8(11(17)18)13-9(14)4-3-7(12)10(15)16/h6-8H,3-5,12H2,1-2H3,(H,13,14)(H,15,16)(H,17,18)/t7-,8?/m0/s1

> <INCHI_KEY>
MYFMARDICOWMQP-JAMMHHFISA-N

> <FORMULA>
C11H20N2O5

> <MOLECULAR_WEIGHT>
260.29

> <EXACT_MASS>
260.137221752

> <JCHEM_ACCEPTOR_COUNT>
7

> <JCHEM_ATOM_COUNT>
38

> <JCHEM_AVERAGE_POLARIZABILITY>
26.406195117994272

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
2-{[(4S)-4-amino-4-carboxy-1-hydroxybutylidene]amino}-4-methylpentanoic acid

> <ALOGPS_LOGP>
-2.39

> <JCHEM_LOGP>
-1.7190551826660616

> <ALOGPS_LOGS>
-2.16

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
4.082599477376457

> <JCHEM_PKA_STRONGEST_ACIDIC>
1.8743862744716244

> <JCHEM_PKA_STRONGEST_BASIC>
9.536186536049717

> <JCHEM_POLAR_SURFACE_AREA>
133.21

> <JCHEM_REFRACTIVITY>
62.78040000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
8

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.82e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
2-{[(4S)-4-amino-4-carboxy-1-hydroxybutylidene]amino}-4-methylpentanoic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 15-MAY-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-MAY-21         0                                  
HETATM    1  C   UNK     0       0.976  -0.976   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       3.644  -0.976   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       6.311   6.724   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       4.977   5.954   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       2.310   1.334   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       2.310  -0.206   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       6.311   8.264   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       3.644   2.104   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       4.977   4.414   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       7.645   9.034   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       4.977   1.334   0.000  0.00  0.00           C+0
HETATM   12  N   UNK     0       4.977   9.034   0.000  0.00  0.00           N+0
HETATM   13  N   UNK     0       3.644   3.644   0.000  0.00  0.00           N+0
HETATM   14  O   UNK     0       6.311   3.644   0.000  0.00  0.00           O+0
HETATM   15  O   UNK     0       7.645  10.574   0.000  0.00  0.00           O+0
HETATM   16  O   UNK     0       8.978   8.264   0.000  0.00  0.00           O+0
HETATM   17  O   UNK     0       6.311   2.104   0.000  0.00  0.00           O+0
HETATM   18  O   UNK     0       4.977  -0.206   0.000  0.00  0.00           O+0
HETATM   19  H   UNK     0       7.645   7.494   0.000  0.00  0.00           H+0
HETATM   20  H   UNK     0       3.644   0.564   0.000  0.00  0.00           H+0
CONECT    1    6                                                            
CONECT    2    6                                                            
CONECT    3    4    7                                                       
CONECT    4    3    9                                                       
CONECT    5    6    8                                                       
CONECT    6    1    2    5                                                  
CONECT    7    3   10   12   19                                             
CONECT    8    5   11   13   20                                             
CONECT    9    4   13   14                                                  
CONECT   10    7   15   16                                                  
CONECT   11    8   17   18                                                  
CONECT   12    7                                                            
CONECT   13    8    9                                                       
CONECT   14    9                                                            
CONECT   15   10                                                            
CONECT   16   10                                                            
CONECT   17   11                                                            
CONECT   18   11                                                            
CONECT   19    7                                                            
CONECT   20    8                                                            
MASTER        0    0    0    0    0    0    0    0   20    0   38    0
END

Synonyms

Value	Source
g-L-Glutamyl-L-leucine	Generator
Γ-L-glutamyl-L-leucine	Generator

Molecular Formula

C₁₁H₂₀N₂O₅

Average Mass

260.29

Monoisotopic Mass

260.137221752

IUPAC Name

2-{[(4S)-4-amino-4-carboxy-1-hydroxybutylidene]amino}-4-methylpentanoic acid

Traditional Name

2-{[(4S)-4-amino-4-carboxy-1-hydroxybutylidene]amino}-4-methylpentanoic acid

CAS Registry Number

Not Available

SMILES

[H][C@](N)(CCC(O)=NC([H])(CC(C)C)C(O)=O)C(O)=O

InChI Identifier

InChI=1S/C11H20N2O5/c1-6(2)5-8(11(17)18)13-9(14)4-3-7(12)10(15)16/h6-8H,3-5,12H2,1-2H3,(H,13,14)(H,15,16)(H,17,18)/t7-,8?/m0/s1

InChI Key

MYFMARDICOWMQP-JAMMHHFISA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as leucine and derivatives. Leucine and derivatives are compounds containing leucine or a derivative thereof resulting from reaction of leucine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Leucine and derivatives

Alternative Parents

Substituents

Leucine or derivatives
N-acyl-alpha amino acid or derivatives
N-acyl-alpha-amino acid
L-alpha-amino acid
Alpha-amino acid
Methyl-branched fatty acid
Branched fatty acid
Fatty acyl
Fatty acid
Dicarboxylic acid or derivatives
Amino acid
Organic 1,3-dipolar compound
Propargyl-type 1,3-dipolar organic compound
Carboxylic acid
Carboximidic acid derivative
Carboximidic acid
Organic nitrogen compound
Organic oxygen compound
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Primary amine
Organooxygen compound
Organonitrogen compound
Primary aliphatic amine
Carbonyl group
Amine
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	1.82 g/L	ALOGPS
logP	-2.4	ALOGPS
logP	-1.7	ChemAxon
logS	-2.2	ALOGPS
pKa (Strongest Acidic)	1.87	ChemAxon
pKa (Strongest Basic)	9.54	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	7	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	133.21 Å²	ChemAxon
Rotatable Bond Count	8	ChemAxon
Refractivity	62.78 m³·mol⁻¹	ChemAxon
Polarizability	26.41 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Chromatographic Retention Times and Retention Indices

Retention Times

Chromatography Type	Technique	Column	Deposition Date	Retention Time (s)
Liquid Chromatography	HILIC	Waters Acquity UPLC-BEH Amide column (eluted)	2025-10-23	516.1
Liquid Chromatography	HILIC	Accucore 150 Amide HILIC (eluted)	2025-10-23	405.9
Liquid Chromatography	Reversed-phase	Hypersil Gold 1.9 µm C18 (void)	2025-10-23	116.3
Liquid Chromatography	Reversed-phase	Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) (eluted)	2025-10-23	267.8
Liquid Chromatography	Reversed-phase	XBridge C18 3.5u 2.1x50 mm (eluted)	2025-10-23	306.4
Liquid Chromatography	Reversed-phase	Ascentis Express C18 (eluted)	2025-10-23	225.4
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	547.7
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-23	644.3
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC (eluted)	2025-10-23	504.2
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	145.6
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-23	436.6
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	158.0
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	62.8
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-23	345.7
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-23	485.4
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	53.1
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	197.6
Liquid Chromatography	Reversed-phase	Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex (eluted)	2025-10-23	830.4
Liquid Chromatography	Reversed-phase	Waters Atlantis T3 (2.1 x 150 mm, 5 um) (eluted)	2025-10-23	609.6

Retention Indices

Chromatography Type	Peak Label	SMILES	Stationary Phase	Deposition Date	Retention Index
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_1	CC(C)CC(N=C(CC[C@H](N)C(=O)O)O[Si](C)(C)C)C(=O)O	standard non polar	2025-10-23	1928.78
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_2	CC(C)CC(N=C(O)CC[C@H](N)C(=O)O)C(=O)O[Si](C)(C)C	standard non polar	2025-10-23	1915.98
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_3	CC(C)CC(N=C(O)CC[C@H](N)C(=O)O[Si](C)(C)C)C(=O)O	standard non polar	2025-10-23	2270.17
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_4	CC(C)CC(N=C(O)CC[C@H](N[Si](C)(C)C)C(=O)O)C(=O)O	standard non polar	2025-10-23	2186.51
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_5	CC(C)CC(N=C(CC[C@H](N)C(=O)O[Si](C)(C)C)O[Si](C)(C)C)C(=O)O	standard non polar	2025-10-23	1741.96
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_6	CC(C)CC(N=C(CC[C@H](N)C(=O)O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-23	2062.87
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_7	CC(C)CC(N=C(CC[C@H](N[Si](C)(C)C)C(=O)O)O[Si](C)(C)C)C(=O)O	standard non polar	2025-10-23	1901.89
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_8	CC(C)CC(N=C(O)CC[C@H](N)C(=O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-23	1591.92
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_9	CC(C)CC(N=C(O)CC[C@H](N[Si](C)(C)C)C(=O)O)C(=O)O[Si](C)(C)C	standard non polar	2025-10-23	1919.41
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_10	CC(C)CC(N=C(O)CC[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)C(=O)O	standard non polar	2025-10-23	2102.16
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_11	CC(C)CC(N=C(O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)C(=O)O	standard non polar	2025-10-23	2582.33
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_12	CC(C)CC(N=C(CC[C@H](N)C(=O)O[Si](C)(C)C)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-23	1498.29
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_13	CC(C)CC(N=C(CC[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)O[Si](C)(C)C)C(=O)O	standard non polar	2025-10-23	2535.75
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_14	CC(C)CC(N=C(CC[C@H](N[Si](C)(C)C)C(=O)O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-23	1537.53
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_15	CC(C)CC(N=C(CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C)C(=O)O	standard non polar	2025-10-23	1605.25
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_16	CC(C)CC(N=C(O)CC[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-23	2995.27
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_17	CC(C)CC(N=C(O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-23	2352.35
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_18	CC(C)CC(N=C(O)CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)C(=O)O	standard non polar	2025-10-23	1933.14
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_19	CC(C)CC(N=C(CC[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-23	2104.33
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_20	CC(C)CC(N=C(CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C)C(=O)O	standard non polar	2025-10-23	2766.18
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_21	CC(C)CC(N=C(CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-23	2898.71
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_22	CC(C)CC(N=C(O)CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-23	1600.54
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_23	CC(C)CC(N=C(CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-23	2574.76
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_1	CC(C)CC(N=C(CC[C@H](N)C(=O)O)O[Si](C)(C)C)C(=O)O	standard polar	2025-10-23	1891.99
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_2	CC(C)CC(N=C(O)CC[C@H](N)C(=O)O)C(=O)O[Si](C)(C)C	standard polar	2025-10-23	1970.05
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_3	CC(C)CC(N=C(O)CC[C@H](N)C(=O)O[Si](C)(C)C)C(=O)O	standard polar	2025-10-23	2926.62
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_4	CC(C)CC(N=C(O)CC[C@H](N[Si](C)(C)C)C(=O)O)C(=O)O	standard polar	2025-10-23	2045.6
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_5	CC(C)CC(N=C(CC[C@H](N)C(=O)O[Si](C)(C)C)O[Si](C)(C)C)C(=O)O	standard polar	2025-10-23	1866.01
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_6	CC(C)CC(N=C(CC[C@H](N)C(=O)O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-23	2161.7
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_7	CC(C)CC(N=C(CC[C@H](N[Si](C)(C)C)C(=O)O)O[Si](C)(C)C)C(=O)O	standard polar	2025-10-23	1876.06
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_8	CC(C)CC(N=C(O)CC[C@H](N)C(=O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-23	2273.56
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_9	CC(C)CC(N=C(O)CC[C@H](N[Si](C)(C)C)C(=O)O)C(=O)O[Si](C)(C)C	standard polar	2025-10-23	2038.2
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_10	CC(C)CC(N=C(O)CC[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)C(=O)O	standard polar	2025-10-23	2078.94
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_11	CC(C)CC(N=C(O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)C(=O)O	standard polar	2025-10-23	1791.86
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_12	CC(C)CC(N=C(CC[C@H](N)C(=O)O[Si](C)(C)C)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-23	2144.72
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_13	CC(C)CC(N=C(CC[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)O[Si](C)(C)C)C(=O)O	standard polar	2025-10-23	2363.45
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_14	CC(C)CC(N=C(CC[C@H](N[Si](C)(C)C)C(=O)O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-23	1670.61
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_15	CC(C)CC(N=C(CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C)C(=O)O	standard polar	2025-10-23	1827.52
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_16	CC(C)CC(N=C(O)CC[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-23	2313.04
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_17	CC(C)CC(N=C(O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-23	2866.46
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_18	CC(C)CC(N=C(O)CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)C(=O)O	standard polar	2025-10-23	1732.53
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_19	CC(C)CC(N=C(CC[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-23	2159.68
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_20	CC(C)CC(N=C(CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C)C(=O)O	standard polar	2025-10-23	2526.03
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_21	CC(C)CC(N=C(CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-23	2495.95
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_22	CC(C)CC(N=C(O)CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-23	2211.44
Gas Chromatography	Î³-L-glutamyl-L-leucine_TMS_23	CC(C)CC(N=C(CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-23	2502.79

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria/Eubacteria	Actinobacteria	1	Human urine; Human feces	Metabolic reconstruction
Bacteria	Actinobacteria	1	Human urine; Human feces	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

71044262

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

139584172

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Î³-L-glutamyl-L-leucine (MMDBc0004599)

MOL for #<Metabolite:0x00007f9ad391b1b0>

3D MOL for #<Metabolite:0x00007f9ad391b1b0>

3D SDF for #<Metabolite:0x00007f9ad391b1b0>

3D-SDF for #<Metabolite:0x00007f9ad391b1b0>

PDB for #<Metabolite:0x00007f9ad391b1b0>

3D PDB for #<Metabolite:0x00007f9ad391b1b0>

SMILES for #<Metabolite:0x00007f9ad391b1b0>

INCHI for #<Metabolite:0x00007f9ad391b1b0>

Structure for #<Metabolite:0x00007f9ad391b1b0>

3D Structure for #<Metabolite:0x00007f9ad391b1b0>