MiMeDB: Showing metabocard for Sterigmatin (MMDBc0005493)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-05-14 23:04:41 UTC

Update Date

2025-10-07 16:05:01 UTC

Metabolite ID

MMDBc0005493

Metabolite Identification

Common Name

Sterigmatin

Description

Sterigmatin is a secondary metabolite belonging to the chemical class of xanthones. It is characterized by a unique structure that combines a dihydrobisfuran ring with a xanthone nucleus in a linear arrangement, which contributes to its biological activity. Research indicates that sterigmatin is involved in various biochemical processes, including its conversion from unstable precursors like HAMA (PMID:32887494 ). Notably, sterigmatin does not serve as a precursor for G-group aflatoxins, highlighting its distinct metabolic pathway compared to other aflatoxins (PMID:10473388 ). Furthermore, studies have demonstrated that sterigmatin exhibits significant toxicity to mitochondrial functions, surpassing that of its structural isomer, demethylsterigmatocystin (PMID:23604834 ). Additionally, sterigmatin and related compounds have shown a positive response for DNA repair, suggesting potential carcinogenic properties (PMID:3081801 ). Overall, sterigmatin's chemical structure and biological effects underscore its relevance in both chemical and biological research contexts.

Structure

MOL SDF PDB SMILES InChI


  Mrv1533004241510222D          

 23 27  0  0  0  0            999 V2000
    2.3592   -3.6983    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2513   -2.8804    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4890   -2.5649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3811   -1.7470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0355   -1.2446    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7978   -1.5601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4522   -1.0577    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2145   -1.3732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8688   -0.8708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6311   -1.1863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3757   -0.8309    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9437   -1.4292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7549   -1.5793    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8629   -2.3972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1183   -2.7526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5503   -2.1543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7390   -2.0042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0847   -2.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1926   -3.3245    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3224   -2.1911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6680   -2.6935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7759   -3.5114    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9057   -2.3780    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 10 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
  8 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
  2 23  1  0  0  0  0
  6 23  2  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0005493

> <DATABASE_NAME>
MIME

> <SMILES>
OC1=CC=CC2=C1C(=O)C1=C(O)C3=C(OC4OC=CC34)C=C1O2

> <INCHI_IDENTIFIER>
InChI=1S/C17H10O6/c18-8-2-1-3-9-13(8)16(20)14-11(22-9)6-10-12(15(14)19)7-4-5-21-17(7)23-10/h1-7,17-19H

> <INCHI_KEY>
CWYJYLXZMAUSNI-UHFFFAOYSA-N

> <FORMULA>
C17H10O6

> <MOLECULAR_WEIGHT>
310.261

> <EXACT_MASS>
310.047738042

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
33

> <JCHEM_AVERAGE_POLARIZABILITY>
29.833514201382233

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
2,18-dihydroxy-7,9,13-trioxapentacyclo[10.8.0.0³,¹⁰.0⁴,⁸.0¹⁴,¹⁹]icosa-1,3(10),5,11,14(19),15,17-heptaen-20-one

> <ALOGPS_LOGP>
2.75

> <JCHEM_LOGP>
3.602697635

> <ALOGPS_LOGS>
-2.88

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
8.57819242751673

> <JCHEM_PKA_STRONGEST_ACIDIC>
7.844341192316938

> <JCHEM_PKA_STRONGEST_BASIC>
-3.7226334610061866

> <JCHEM_POLAR_SURFACE_AREA>
85.22

> <JCHEM_REFRACTIVITY>
79.2203

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
4.10e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
2,18-dihydroxy-7,9,13-trioxapentacyclo[10.8.0.0³,¹⁰.0⁴,⁸.0¹⁴,¹⁹]icosa-1,3(10),5,11,14(19),15,17-heptaen-20-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 24-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-APR-15         0                                  
HETATM    1  O   UNK     0       4.404  -6.904   0.000  0.00  0.00           O+0
HETATM    2  C   UNK     0       4.202  -5.377   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       2.780  -4.788   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       2.578  -3.261   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       3.800  -2.323   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       5.223  -2.912   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0       6.444  -1.974   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0       7.867  -2.563   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       9.088  -1.625   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      10.511  -2.214   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0      11.901  -1.551   0.000  0.00  0.00           O+0
HETATM   12  C   UNK     0      12.962  -2.668   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0      14.476  -2.948   0.000  0.00  0.00           O+0
HETATM   14  C   UNK     0      14.677  -4.475   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      13.288  -5.138   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      12.227  -4.021   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      10.713  -3.741   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       9.491  -4.679   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0       9.693  -6.206   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0       8.068  -4.090   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       6.847  -5.028   0.000  0.00  0.00           C+0
HETATM   22  O   UNK     0       7.048  -6.555   0.000  0.00  0.00           O+0
HETATM   23  C   UNK     0       5.424  -4.439   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3   23                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7   23                                                  
CONECT    7    6    8                                                       
CONECT    8    7    9   20                                                  
CONECT    9    8   10                                                       
CONECT   10    9   11   17                                                  
CONECT   11   10   12                                                       
CONECT   12   11   13   16                                                  
CONECT   13   12   14                                                       
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   12   17                                                  
CONECT   17   16   10   18                                                  
CONECT   18   17   19   20                                                  
CONECT   19   18                                                            
CONECT   20   18    8   21                                                  
CONECT   21   20   22   23                                                  
CONECT   22   21                                                            
CONECT   23   21    2    6                                                  
MASTER        0    0    0    0    0    0    0    0   23    0   54    0
END

Synonyms

Not Available

Molecular Formula

C₁₇H₁₀O₆

Average Mass

310.261

Monoisotopic Mass

310.047738042

IUPAC Name

2,18-dihydroxy-7,9,13-trioxapentacyclo[10.8.0.0³,¹⁰.0⁴,⁸.0¹⁴,¹⁹]icosa-1,3(10),5,11,14(19),15,17-heptaen-20-one

Traditional Name

2,18-dihydroxy-7,9,13-trioxapentacyclo[10.8.0.0³,¹⁰.0⁴,⁸.0¹⁴,¹⁹]icosa-1,3(10),5,11,14(19),15,17-heptaen-20-one

CAS Registry Number

Not Available

SMILES

OC1=CC=CC2=C1C(=O)C1=C(O)C3=C(OC4OC=CC34)C=C1O2

InChI Identifier

InChI=1S/C17H10O6/c18-8-2-1-3-9-13(8)16(20)14-11(22-9)6-10-12(15(14)19)7-4-5-21-17(7)23-10/h1-7,17-19H

InChI Key

CWYJYLXZMAUSNI-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as xanthones. These are polycyclic aromatic compounds containing a xanthene moiety conjugated to a ketone group at carbon 9. Xanthene is a tricyclic compound made up of two benzene rings linearly fused to each other through a pyran ring.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Benzopyrans

Sub Class

1-benzopyrans

Direct Parent

Xanthones

Alternative Parents

Substituents

Xanthone
Furanochromone
Chromone
Coumaran
1-hydroxy-4-unsubstituted benzenoid
1-hydroxy-2-unsubstituted benzenoid
Pyranone
Pyran
Benzenoid
Heteroaromatic compound
Dihydrofuran
Vinylogous acid
Acetal
Oxacycle
Hydrocarbon derivative
Organooxygen compound
Organic oxide
Organic oxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

a small molecule (CPD-4590 )

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.41 g/L	ALOGPS
logP	2.75	ALOGPS
logP	3.6	ChemAxon
logS	-2.9	ALOGPS
pKa (Strongest Acidic)	7.84	ChemAxon
pKa (Strongest Basic)	-3.7	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	85.22 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	79.22 m³·mol⁻¹	ChemAxon
Polarizability	29.83 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_2) - 70eV, Positive	Not Available	2022-08-08	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	Not Available	2022-08-10	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	Not Available	2022-08-10	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	Not Available	2022-08-10	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	Not Available	2022-08-10	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	Not Available	2022-08-10	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	Not Available	2022-08-10	View Spectrum
MS	Mass Spectrum (Electron Ionization)	Not Available	2022-08-06	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-20	View Spectrum

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

This table shows at most 5 pathways. For the full list of associated pathways:

See All Associated Bacterial Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	1	Human feces	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

5486205

PDB ID

Not Available

ChEBI ID

Not Available

CMMC Knowledgebase

Not Available

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Sterigmatin (MMDBc0005493)

MOL for #<Metabolite:0x00005654a7e8b708>

3D MOL for #<Metabolite:0x00005654a7e8b708>

3D SDF for #<Metabolite:0x00005654a7e8b708>

3D-SDF for #<Metabolite:0x00005654a7e8b708>

PDB for #<Metabolite:0x00005654a7e8b708>

3D PDB for #<Metabolite:0x00005654a7e8b708>

SMILES for #<Metabolite:0x00005654a7e8b708>

INCHI for #<Metabolite:0x00005654a7e8b708>

Structure for #<Metabolite:0x00005654a7e8b708>

3D Structure for #<Metabolite:0x00005654a7e8b708>