MiMeDB: Showing metabocard for Herqueidiketal (MMDBc0006185)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-05-14 23:29:36 UTC

Update Date

2025-10-07 16:05:07 UTC

Metabolite ID

MMDBc0006185

Metabolite Identification

Common Name

Herqueidiketal

Description

Herqueidiketal is a polyaromatic metabolite belonging to the class of secondary metabolites produced by certain fungi. It has been identified in the context of various fungal species, including Penicillium herquei, a symbiotic fungus associated with the mushroom Pulveroboletus brunneopunctatus, where it was isolated alongside other compounds such as epi-peniciherqueinone (PMID:37580280 ). Additionally, herqueidiketal has been noted as part of a novel skeletal class of metabolites, along with herqueiazole and herqueioxazole, derived from marine-derived fungi (PMID:23431962 ). These compounds are of interest not only for their unique chemical structures but also for their potential biological activities, which are often explored in the context of natural product chemistry and pharmacology. The isolation of herqueidiketal and related metabolites highlights the diverse biochemical capabilities of fungi and their potential applications in biotechnology and medicine.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652305152101292D          

 28 31  0  0  1  0            999 V2000
    6.2026    1.3644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8753    0.8628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4903   -0.3087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9558   -1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8502   -3.2194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6663    0.0128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0442    0.5547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4373    0.2588    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    6.5079   -0.7969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7276   -1.0646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1056   -0.5227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3252   -0.7904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2639    0.2870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5693   -1.8743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1669   -1.6001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7889   -2.1420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2790   -0.5508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6041   -0.3896    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.0001   -0.9516    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    7.1300   -1.3388    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6418    0.8289    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1913   -2.4162    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2081    0.1724    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3961   -1.5136    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6306   -2.9517    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2563    0.3585    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3479   -1.6997    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6440    0.0323    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  7  1  1  0  0  0  0
  7  6  2  0  0  0  0
  8  2  1  1  0  0  0
  9  6  1  0  0  0  0
 10  9  1  0  0  0  0
 11 10  2  0  0  0  0
 12 11  1  0  0  0  0
 13  7  1  0  0  0  0
 13 11  1  0  0  0  0
 14 10  1  0  0  0  0
 15 12  2  0  0  0  0
 16 14  2  0  0  0  0
 16 15  1  0  0  0  0
 17  3  1  0  0  0  0
 17  4  1  0  0  0  0
 17  8  1  0  0  0  0
 18 12  1  0  0  0  0
 19 17  1  0  0  0  0
 19 18  1  0  0  0  0
 20  9  2  0  0  0  0
 21 13  2  0  0  0  0
 22 14  1  0  0  0  0
 18 23  1  1  0  0  0
 19 24  1  1  0  0  0
 25  5  1  0  0  0  0
 25 16  1  0  0  0  0
 26  8  1  0  0  0  0
 26 18  1  0  0  0  0
 27 15  1  0  0  0  0
 27 19  1  0  0  0  0
  8 28  1  6  0  0  0
M  END


  Mrv1652305152101292D          

 28 31  0  0  1  0            999 V2000
    6.2026    1.3644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8753    0.8628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4903   -0.3087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9558   -1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8502   -3.2194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6663    0.0128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0442    0.5547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4373    0.2588    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    6.5079   -0.7969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7276   -1.0646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1056   -0.5227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3252   -0.7904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2639    0.2870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5693   -1.8743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1669   -1.6001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7889   -2.1420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2790   -0.5508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6041   -0.3896    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.0001   -0.9516    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    7.1300   -1.3388    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6418    0.8289    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1913   -2.4162    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2081    0.1724    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3961   -1.5136    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6306   -2.9517    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2563    0.3585    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3479   -1.6997    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6440    0.0323    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  7  1  1  0  0  0  0
  7  6  2  0  0  0  0
  8  2  1  1  0  0  0
  9  6  1  0  0  0  0
 10  9  1  0  0  0  0
 11 10  2  0  0  0  0
 12 11  1  0  0  0  0
 13  7  1  0  0  0  0
 13 11  1  0  0  0  0
 14 10  1  0  0  0  0
 15 12  2  0  0  0  0
 16 14  2  0  0  0  0
 16 15  1  0  0  0  0
 17  3  1  0  0  0  0
 17  4  1  0  0  0  0
 17  8  1  0  0  0  0
 18 12  1  0  0  0  0
 19 17  1  0  0  0  0
 19 18  1  0  0  0  0
 20  9  2  0  0  0  0
 21 13  2  0  0  0  0
 22 14  1  0  0  0  0
 18 23  1  1  0  0  0
 19 24  1  1  0  0  0
 25  5  1  0  0  0  0
 25 16  1  0  0  0  0
 26  8  1  0  0  0  0
 26 18  1  0  0  0  0
 27 15  1  0  0  0  0
 27 19  1  0  0  0  0
  8 28  1  6  0  0  0
M  END
> <DATABASE_ID>
MMDBc0006185

> <DATABASE_NAME>
MIME

> <SMILES>
[H][C@]1(C)O[C@]2(O)C3=C(O[C@]2(O)C1(C)C)C(OC)=C(O)C1=C3C(=O)C(C)=CC1=O

> <INCHI_IDENTIFIER>
InChI=1S/C19H20O8/c1-7-6-9(20)10-11(13(7)21)12-15(16(25-5)14(10)22)27-19(24)17(3,4)8(2)26-18(12,19)23/h6,8,22-24H,1-5H3/t8-,18-,19-/m1/s1

> <INCHI_KEY>
RFLUIIWXOBEDGV-QNTVGQKLSA-N

> <FORMULA>
C19H20O8

> <MOLECULAR_WEIGHT>
376.361

> <EXACT_MASS>
376.115817604

> <JCHEM_ACCEPTOR_COUNT>
8

> <JCHEM_ATOM_COUNT>
47

> <JCHEM_AVERAGE_POLARIZABILITY>
37.04027197693372

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(12R,14R,16R)-8,12,16-trihydroxy-9-methoxy-4,13,13,14-tetramethyl-11,15-dioxatetracyclo[8.6.0.0^{2,7}.0^{12,16}]hexadeca-1(10),2(7),4,8-tetraene-3,6-dione

> <ALOGPS_LOGP>
1.72

> <JCHEM_LOGP>
2.642063399333332

> <ALOGPS_LOGS>
-2.44

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
9.190837187307581

> <JCHEM_PKA_STRONGEST_ACIDIC>
8.479068841475096

> <JCHEM_PKA_STRONGEST_BASIC>
-4.254955604850259

> <JCHEM_POLAR_SURFACE_AREA>
122.52000000000002

> <JCHEM_REFRACTIVITY>
93.3952

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.38e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(12R,14R,16R)-8,12,16-trihydroxy-9-methoxy-4,13,13,14-tetramethyl-11,15-dioxatetracyclo[8.6.0.0^{2,7}.0^{12,16}]hexadeca-1(10),2(7),4,8-tetraene-3,6-dione

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 15-MAY-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-MAY-21         0                                  
HETATM    1  C   UNK     0      11.578   2.547   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       3.501   1.611   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       2.782  -0.576   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       3.651  -2.445   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       7.187  -6.010   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      12.444   0.024   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      11.283   1.035   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       4.550   0.483   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      12.148  -1.488   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      10.692  -1.987   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       9.530  -0.976   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       8.074  -1.475   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       9.826   0.536   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      10.396  -3.499   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       7.778  -2.987   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       8.939  -3.998   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       4.254  -1.028   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       6.728  -0.727   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       5.600  -1.776   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0      13.309  -2.499   0.000  0.00  0.00           O+0
HETATM   21  O   UNK     0       8.665   1.547   0.000  0.00  0.00           O+0
HETATM   22  O   UNK     0      11.557  -4.510   0.000  0.00  0.00           O+0
HETATM   23  O   UNK     0       7.855   0.322   0.000  0.00  0.00           O+0
HETATM   24  O   UNK     0       4.473  -2.825   0.000  0.00  0.00           O+0
HETATM   25  O   UNK     0       8.644  -5.510   0.000  0.00  0.00           O+0
HETATM   26  O   UNK     0       6.078   0.669   0.000  0.00  0.00           O+0
HETATM   27  O   UNK     0       6.249  -3.173   0.000  0.00  0.00           O+0
HETATM   28  H   UNK     0       3.069   0.060   0.000  0.00  0.00           H+0
CONECT    1    7                                                            
CONECT    2    8                                                            
CONECT    3   17                                                            
CONECT    4   17                                                            
CONECT    5   25                                                            
CONECT    6    7    9                                                       
CONECT    7    1    6   13                                                  
CONECT    8    2   17   26   28                                             
CONECT    9    6   10   20                                                  
CONECT   10    9   11   14                                                  
CONECT   11   10   12   13                                                  
CONECT   12   11   15   18                                                  
CONECT   13    7   11   21                                                  
CONECT   14   10   16   22                                                  
CONECT   15   12   16   27                                                  
CONECT   16   14   15   25                                                  
CONECT   17    3    4    8   19                                             
CONECT   18   12   19   23   26                                             
CONECT   19   17   18   24   27                                             
CONECT   20    9                                                            
CONECT   21   13                                                            
CONECT   22   14                                                            
CONECT   23   18                                                            
CONECT   24   19                                                            
CONECT   25    5   16                                                       
CONECT   26    8   18                                                       
CONECT   27   15   19                                                       
CONECT   28    8                                                            
MASTER        0    0    0    0    0    0    0    0   28    0   62    0
END

Synonyms

Not Available

Molecular Formula

C₁₉H₂₀O₈

Average Mass

376.361

Monoisotopic Mass

376.115817604

IUPAC Name

(12R,14R,16R)-8,12,16-trihydroxy-9-methoxy-4,13,13,14-tetramethyl-11,15-dioxatetracyclo[8.6.0.0^{2,7}.0^{12,16}]hexadeca-1(10),2(7),4,8-tetraene-3,6-dione

Traditional Name

(12R,14R,16R)-8,12,16-trihydroxy-9-methoxy-4,13,13,14-tetramethyl-11,15-dioxatetracyclo[8.6.0.0^{2,7}.0^{12,16}]hexadeca-1(10),2(7),4,8-tetraene-3,6-dione

CAS Registry Number

Not Available

SMILES

[H][C@]1(C)O[C@]2(O)C3=C(O[C@]2(O)C1(C)C)C(OC)=C(O)C1=C3C(=O)C(C)=CC1=O

InChI Identifier

InChI=1S/C19H20O8/c1-7-6-9(20)10-11(13(7)21)12-15(16(25-5)14(10)22)27-19(24)17(3,4)8(2)26-18(12,19)23/h6,8,22-24H,1-5H3/t8-,18-,19-/m1/s1

InChI Key

RFLUIIWXOBEDGV-QNTVGQKLSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as naphthofurans. Naphthofurans are compounds containing a furan ring fused to a naphthalene moiety. Furan is a 5 membered- ring aromatic ring with four carbon and one oxygen atoms. Naphthalene is a polycyclic aromatic hydrocarbon made up of two fused benzene rings.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Naphthofurans

Sub Class

Not Available

Direct Parent

Naphthofurans

Alternative Parents

Substituents

Naphthofuran
Naphthoquinone
Naphthalene
Coumaran
Aryl ketone
Quinone
Anisole
Alkyl aryl ether
Benzenoid
Vinylogous acid
Tetrahydrofuran
Ketone
Hemiacetal
Oxacycle
Polyol
Ether
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	1.38 g/L	ALOGPS
logP	1.72	ALOGPS
logP	2.64	ChemAxon
logS	-2.4	ALOGPS
pKa (Strongest Acidic)	8.48	ChemAxon
pKa (Strongest Basic)	-4.3	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	8	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	122.52 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	93.4 m³·mol⁻¹	ChemAxon
Polarizability	37.04 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

This table shows at most 5 pathways. For the full list of associated pathways:

See All Associated Bacterial Pathways

Name	SMPDB/PathBank	Species

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	1	Human feces	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

78436907

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

139584642

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

References

Synthesis Reference

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Herqueidiketal (MMDBc0006185)

MOL for #<Metabolite:0x00007fb49de6ac18>

3D MOL for #<Metabolite:0x00007fb49de6ac18>

3D SDF for #<Metabolite:0x00007fb49de6ac18>

3D-SDF for #<Metabolite:0x00007fb49de6ac18>

PDB for #<Metabolite:0x00007fb49de6ac18>

3D PDB for #<Metabolite:0x00007fb49de6ac18>

SMILES for #<Metabolite:0x00007fb49de6ac18>

INCHI for #<Metabolite:0x00007fb49de6ac18>

Structure for #<Metabolite:0x00007fb49de6ac18>

3D Structure for #<Metabolite:0x00007fb49de6ac18>