MiMeDB: Showing metabocard for Ankaflavin (MMDBc0006274)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-05-14 23:33:44 UTC

Update Date

2025-10-07 16:04:15 UTC

Metabolite ID

MMDBc0006274

Metabolite Identification

Common Name

Ankaflavin

Description

Ankaflavin is a yellow pigment belonging to the chemical class of polyketides. Structurally, it features a complex arrangement of aromatic rings and hydroxyl groups, which contribute to its antioxidant properties. Ankaflavin is known to competitively inhibit xanthine oxidase (XOD), as confirmed by molecular docking studies, indicating its potential role in modulating purine metabolism (PMID:40870677 ). It is also involved in gut microbiota modulation and metabolic health, particularly when derived from Monascus pilosus SWM 008 fermented red mold rice (PMID:40002095 ). In concentrations of 10 μg/mL or higher, ankaflavin exhibits antioxidant activity alongside other Monascus pigments (PMID:39906945 ). Furthermore, it has been shown to lower serum levels of low-density lipoprotein cholesterol in rats on a high-fat diet, suggesting a lipid-lowering effect (PMID:39906945 ). Ankaflavin also demonstrates anti-glycation properties in bovine serum albumin models (PMID:39322168 ) and has been investigated for its ability to prevent fibrillogenesis in hen egg white lysozyme (PMID:39368112 ). Overall, ankaflavin's diverse biochemical interactions highlight its significance in various metabolic pathways.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652305152101332D          

 30 32  0  0  0  0            999 V2000
   -6.2116    2.9427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6986   -1.0459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2948    3.8877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4971    2.5302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4436   -0.2613    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7826    2.9427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0681    2.5302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3537    2.9427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6392    2.5302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6367   -0.0898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9247    2.9427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5747    0.8664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5128    1.8225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6788    2.0926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3198    1.6510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3817    0.6949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8718    2.2641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2579    2.6071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2103    2.5302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4958    2.9427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6169    3.0487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4095    3.7632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8099    3.2202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2103    1.7052    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1689    3.6618    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0226    4.3152    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9337    1.3079    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3974    3.9347    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9957    0.3518    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0846   -0.7029    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  4  1  1  0  0  0  0
  5  2  1  0  0  0  0
  6  4  1  0  0  0  0
  7  6  1  0  0  0  0
  8  7  1  0  0  0  0
  9  8  1  0  0  0  0
 10  5  2  0  0  0  0
 11  9  1  0  0  0  0
 15 12  1  0  0  0  0
 15 13  1  0  0  0  0
 16 10  1  0  0  0  0
 16 12  2  0  0  0  0
 17 14  1  0  0  0  0
 17 15  2  0  0  0  0
 18 13  1  0  0  0  0
 19 11  1  0  0  0  0
 20 18  1  0  0  0  0
 20 19  1  0  0  0  0
 21 17  1  0  0  0  0
 22 20  1  0  0  0  0
 23  3  1  0  0  0  0
 23 18  1  0  0  0  0
 23 21  1  0  0  0  0
 24 19  2  0  0  0  0
 25 21  2  0  0  0  0
 26 22  2  0  0  0  0
 27 14  1  0  0  0  0
 27 16  1  0  0  0  0
 28 22  1  0  0  0  0
 28 23  1  0  0  0  0
 29  5  1  0  0  0  0
 30 10  1  0  0  0  0
M  END


  Mrv1652305152101332D          

 30 32  0  0  0  0            999 V2000
   -6.2116    2.9427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6986   -1.0459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2948    3.8877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4971    2.5302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4436   -0.2613    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7826    2.9427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0681    2.5302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3537    2.9427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6392    2.5302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6367   -0.0898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9247    2.9427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5747    0.8664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5128    1.8225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6788    2.0926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3198    1.6510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3817    0.6949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8718    2.2641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2579    2.6071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2103    2.5302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4958    2.9427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6169    3.0487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4095    3.7632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8099    3.2202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2103    1.7052    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1689    3.6618    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0226    4.3152    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9337    1.3079    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3974    3.9347    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9957    0.3518    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0846   -0.7029    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  4  1  1  0  0  0  0
  5  2  1  0  0  0  0
  6  4  1  0  0  0  0
  7  6  1  0  0  0  0
  8  7  1  0  0  0  0
  9  8  1  0  0  0  0
 10  5  2  0  0  0  0
 11  9  1  0  0  0  0
 15 12  1  0  0  0  0
 15 13  1  0  0  0  0
 16 10  1  0  0  0  0
 16 12  2  0  0  0  0
 17 14  1  0  0  0  0
 17 15  2  0  0  0  0
 18 13  1  0  0  0  0
 19 11  1  0  0  0  0
 20 18  1  0  0  0  0
 20 19  1  0  0  0  0
 21 17  1  0  0  0  0
 22 20  1  0  0  0  0
 23  3  1  0  0  0  0
 23 18  1  0  0  0  0
 23 21  1  0  0  0  0
 24 19  2  0  0  0  0
 25 21  2  0  0  0  0
 26 22  2  0  0  0  0
 27 14  1  0  0  0  0
 27 16  1  0  0  0  0
 28 22  1  0  0  0  0
 28 23  1  0  0  0  0
 29  5  1  0  0  0  0
 30 10  1  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0006274

> <DATABASE_NAME>
MIME

> <SMILES>
[H]\C(C)=C(\[H])C1=CC2=C(CO1)C(=O)C1(C)OC(=O)C(C1C2)C(=O)CCCCCCC

> <INCHI_IDENTIFIER>
InChI=1S/C23H30O5/c1-4-6-7-8-9-11-19(24)20-18-13-15-12-16(10-5-2)27-14-17(15)21(25)23(18,3)28-22(20)26/h5,10,12,18,20H,4,6-9,11,13-14H2,1-3H3/b10-5+

> <INCHI_KEY>
AQTJNEHGKRUSLT-BJMVGYQFSA-N

> <FORMULA>
C23H30O5

> <MOLECULAR_WEIGHT>
386.488

> <EXACT_MASS>
386.209324066

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
58

> <JCHEM_AVERAGE_POLARIZABILITY>
43.951406806284055

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
9a-methyl-3-octanoyl-6-[(1E)-prop-1-en-1-yl]-2H,3H,3aH,4H,8H,9H,9aH-furo[3,2-g]isochromene-2,9-dione

> <ALOGPS_LOGP>
4.30

> <JCHEM_LOGP>
4.562301652666665

> <ALOGPS_LOGS>
-4.54

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
10.973419023577385

> <JCHEM_PKA_STRONGEST_BASIC>
-4.818593024133393

> <JCHEM_POLAR_SURFACE_AREA>
69.67

> <JCHEM_REFRACTIVITY>
109.69989999999997

> <JCHEM_ROTATABLE_BOND_COUNT>
8

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.11e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
9a-methyl-3-octanoyl-6-[(1E)-prop-1-en-1-yl]-3H,3aH,4H,8H-furo[3,2-g]isochromene-2,9-dione

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 15-MAY-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-MAY-21         0                                  
HETATM    1  C   UNK     0     -11.595   5.493   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       6.904  -1.952   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       2.417   7.257   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0     -10.261   4.723   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       6.428  -0.488   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -8.928   5.493   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -7.594   4.723   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -6.260   5.493   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -4.926   4.723   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       4.922  -0.168   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      -3.593   5.493   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       2.940   1.617   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       0.957   3.402   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       5.000   3.906   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       2.464   3.082   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       4.446   1.297   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       3.494   4.226   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       0.481   4.867   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      -2.259   4.723   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      -0.925   5.493   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       3.018   5.691   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      -0.764   7.025   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       1.512   6.011   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0      -2.259   3.183   0.000  0.00  0.00           O+0
HETATM   25  O   UNK     0       4.049   6.835   0.000  0.00  0.00           O+0
HETATM   26  O   UNK     0      -1.909   8.055   0.000  0.00  0.00           O+0
HETATM   27  O   UNK     0       5.476   2.442   0.000  0.00  0.00           O+0
HETATM   28  O   UNK     0       0.742   7.345   0.000  0.00  0.00           O+0
HETATM   29  H   UNK     0       7.459   0.657   0.000  0.00  0.00           H+0
HETATM   30  H   UNK     0       3.891  -1.312   0.000  0.00  0.00           H+0
CONECT    1    4                                                            
CONECT    2    5                                                            
CONECT    3   23                                                            
CONECT    4    1    6                                                       
CONECT    5    2   10   29                                                  
CONECT    6    4    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   11                                                       
CONECT   10    5   16   30                                                  
CONECT   11    9   19                                                       
CONECT   12   15   16                                                       
CONECT   13   15   18                                                       
CONECT   14   17   27                                                       
CONECT   15   12   13   17                                                  
CONECT   16   10   12   27                                                  
CONECT   17   14   15   21                                                  
CONECT   18   13   20   23                                                  
CONECT   19   11   20   24                                                  
CONECT   20   18   19   22                                                  
CONECT   21   17   23   25                                                  
CONECT   22   20   26   28                                                  
CONECT   23    3   18   21   28                                             
CONECT   24   19                                                            
CONECT   25   21                                                            
CONECT   26   22                                                            
CONECT   27   14   16                                                       
CONECT   28   22   23                                                       
CONECT   29    5                                                            
CONECT   30   10                                                            
MASTER        0    0    0    0    0    0    0    0   30    0   64    0
END

Synonyms

Not Available

Molecular Formula

C₂₃H₃₀O₅

Average Mass

386.488

Monoisotopic Mass

386.209324066

IUPAC Name

9a-methyl-3-octanoyl-6-[(1E)-prop-1-en-1-yl]-2H,3H,3aH,4H,8H,9H,9aH-furo[3,2-g]isochromene-2,9-dione

Traditional Name

9a-methyl-3-octanoyl-6-[(1E)-prop-1-en-1-yl]-3H,3aH,4H,8H-furo[3,2-g]isochromene-2,9-dione

CAS Registry Number

Not Available

SMILES

[H]\C(C)=C(\[H])C1=CC2=C(CO1)C(=O)C1(C)OC(=O)C(C1C2)C(=O)CCCCCCC

InChI Identifier

InChI=1S/C23H30O5/c1-4-6-7-8-9-11-19(24)20-18-13-15-12-16(10-5-2)27-14-17(15)21(25)23(18,3)28-22(20)26/h5,10,12,18,20H,4,6-9,11,13-14H2,1-3H3/b10-5+

InChI Key

AQTJNEHGKRUSLT-BJMVGYQFSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as cyclohexenones. Cyclohexenones are compounds containing a cylohexenone moiety, which is a six-membered aliphatic ring that carries a ketone and has one endocyclic double bond.

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Carbonyl compounds

Direct Parent

Cyclohexenones

Alternative Parents

Substituents

Cyclohexenone
Alpha-acyloxy ketone
1,3-dicarbonyl compound
Pyran
Gamma butyrolactone
Oxolane
Lactone
Carboxylic acid ester
Oxacycle
Organoheterocyclic compound
Monocarboxylic acid or derivatives
Carboxylic acid derivative
Organic oxide
Hydrocarbon derivative
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.011 g/L	ALOGPS
logP	4.3	ALOGPS
logP	4.56	ChemAxon
logS	-4.5	ALOGPS
pKa (Strongest Acidic)	10.97	ChemAxon
pKa (Strongest Basic)	-4.8	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	69.67 Å²	ChemAxon
Rotatable Bond Count	8	ChemAxon
Refractivity	109.7 m³·mol⁻¹	ChemAxon
Polarizability	43.95 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

This table shows at most 5 pathways. For the full list of associated pathways:

See All Associated Bacterial Pathways

Name	SMPDB/PathBank	Species

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	3	Human feces	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

78444976

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

49834044

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

References

Synthesis Reference

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Ankaflavin (MMDBc0006274)

MOL for #<Metabolite:0x00007fb4856bbde0>

3D MOL for #<Metabolite:0x00007fb4856bbde0>

3D SDF for #<Metabolite:0x00007fb4856bbde0>

3D-SDF for #<Metabolite:0x00007fb4856bbde0>

PDB for #<Metabolite:0x00007fb4856bbde0>

3D PDB for #<Metabolite:0x00007fb4856bbde0>

SMILES for #<Metabolite:0x00007fb4856bbde0>

INCHI for #<Metabolite:0x00007fb4856bbde0>

Structure for #<Metabolite:0x00007fb4856bbde0>

3D Structure for #<Metabolite:0x00007fb4856bbde0>