MiMeDB: Showing metabocard for Herqueiazole (MMDBc0006803)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-05-15 00:12:14 UTC

Update Date

2025-10-07 16:05:14 UTC

Metabolite ID

MMDBc0006803

Metabolite Identification

Common Name

Herqueiazole

Description

Herqueiazole is a polyaromatic metabolite belonging to a novel skeletal class, isolated from the marine-derived fungus Penicillium sp. (PMID:23431962 ). This compound, alongside herqueioxazole and herqueidiketal, represents a unique group of metabolites that may possess distinct chemical properties and biological activities. The structural characteristics of herqueiazole suggest potential interactions with biological systems, although specific biological functions remain to be fully elucidated. Given the increasing interest in marine-derived natural products, herqueiazole could serve as a lead compound for further research into its pharmacological potential, particularly in the context of drug discovery and development. The exploration of such metabolites may uncover new therapeutic avenues, especially considering the diverse chemical repertoire of marine fungi. As research progresses, understanding the biosynthetic pathways and ecological roles of herqueiazole and its analogs will be crucial for appreciating their significance in both chemistry and biology.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652305152102122D          

 29 33  0  0  1  0            999 V2000
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5433   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5902   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9948   -3.0154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9448   -3.3566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -1.2680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3683   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7652   -1.9354    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2803   -2.6029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.8532   -2.6029    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5819   -3.1684    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2803   -1.2680    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1398   -2.6705    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  8  1  1  0  0  0  0
  8  6  2  0  0  0  0
  9  2  1  0  0  0  0
  9  7  2  0  0  0  0
 10  3  1  1  0  0  0
 11  7  1  0  0  0  0
 12  6  1  0  0  0  0
 13  8  1  0  0  0  0
 14 11  1  0  0  0  0
 14 12  2  0  0  0  0
 15 13  1  0  0  0  0
 15 14  1  0  0  0  0
 16 15  2  0  0  0  0
 17 11  2  0  0  0  0
 18 16  1  0  0  0  0
 18 17  1  0  0  0  0
 19 16  1  0  0  0  0
 20 13  2  0  0  0  0
 21  4  1  0  0  0  0
 21  5  1  0  0  0  0
 21 10  1  0  0  0  0
 22 19  1  0  0  0  0
 22 20  1  0  0  0  0
 22 21  1  0  0  0  0
 23  9  1  0  0  0  0
 23 17  1  0  0  0  0
 24 12  1  0  0  0  0
 25 18  2  0  0  0  0
 26 19  2  0  0  0  0
 22 27  1  6  0  0  0
 28 10  1  0  0  0  0
 28 20  1  0  0  0  0
 10 29  1  6  0  0  0
M  END


  Mrv1652305152102122D          

 29 33  0  0  1  0            999 V2000
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5433   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5902   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9948   -3.0154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9448   -3.3566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -1.2680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3683   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7652   -1.9354    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2803   -2.6029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.8532   -2.6029    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5819   -3.1684    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2803   -1.2680    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1398   -2.6705    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  8  1  1  0  0  0  0
  8  6  2  0  0  0  0
  9  2  1  0  0  0  0
  9  7  2  0  0  0  0
 10  3  1  1  0  0  0
 11  7  1  0  0  0  0
 12  6  1  0  0  0  0
 13  8  1  0  0  0  0
 14 11  1  0  0  0  0
 14 12  2  0  0  0  0
 15 13  1  0  0  0  0
 15 14  1  0  0  0  0
 16 15  2  0  0  0  0
 17 11  2  0  0  0  0
 18 16  1  0  0  0  0
 18 17  1  0  0  0  0
 19 16  1  0  0  0  0
 20 13  2  0  0  0  0
 21  4  1  0  0  0  0
 21  5  1  0  0  0  0
 21 10  1  0  0  0  0
 22 19  1  0  0  0  0
 22 20  1  0  0  0  0
 22 21  1  0  0  0  0
 23  9  1  0  0  0  0
 23 17  1  0  0  0  0
 24 12  1  0  0  0  0
 25 18  2  0  0  0  0
 26 19  2  0  0  0  0
 22 27  1  6  0  0  0
 28 10  1  0  0  0  0
 28 20  1  0  0  0  0
 10 29  1  6  0  0  0
M  END
> <DATABASE_ID>
MMDBc0006803

> <DATABASE_NAME>
MIME

> <SMILES>
[H][C@@]1(C)OC2=C3C(C)=CC(O)=C4C5=C(NC(C)=C5)C(=O)C(C(=O)[C@]2(O)C1(C)C)=C34

> <INCHI_IDENTIFIER>
InChI=1S/C22H21NO5/c1-8-6-12(24)14-11-7-9(2)23-17(11)18(25)16-15(14)13(8)20-22(27,19(16)26)21(4,5)10(3)28-20/h6-7,10,23-24,27H,1-5H3/t10-,22+/m0/s1

> <INCHI_KEY>
IXKZXMJHICVGBA-MLMJSJRWSA-N

> <FORMULA>
C22H21NO5

> <MOLECULAR_WEIGHT>
379.412

> <EXACT_MASS>
379.14197278

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
49

> <JCHEM_AVERAGE_POLARIZABILITY>
40.33368527299946

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(15S,17S)-9,17-dihydroxy-5,11,15,16,16-pentamethyl-14-oxa-4-azapentacyclo[10.6.1.0^{3,7}.0^{8,19}.0^{13,17}]nonadeca-1(19),3(7),5,8,10,12-hexaene-2,18-dione

> <ALOGPS_LOGP>
2.25

> <JCHEM_LOGP>
1.0479475096666655

> <ALOGPS_LOGS>
-3.46

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
11.568608323849428

> <JCHEM_PKA_STRONGEST_ACIDIC>
8.787097601854256

> <JCHEM_PKA_STRONGEST_BASIC>
-4.377952793355061

> <JCHEM_POLAR_SURFACE_AREA>
99.62

> <JCHEM_REFRACTIVITY>
106.84589999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.31e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(15S,17S)-9,17-dihydroxy-5,11,15,16,16-pentamethyl-14-oxa-4-azapentacyclo[10.6.1.0^{3,7}.0^{8,19}.0^{13,17}]nonadeca-1(19),3(7),5,8,10,12-hexaene-2,18-dione

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 15-MAY-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-MAY-21         0                                  
HETATM    1  C   UNK     0      10.259   0.237   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       1.014  -3.613   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      14.168  -3.613   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      13.057  -5.629   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      11.097  -6.266   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       7.591   0.237   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       3.459  -2.367   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       8.925  -0.533   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       2.554  -3.613   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      12.628  -3.613   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       4.924  -2.843   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       6.258  -0.533   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       8.925  -2.073   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       6.258  -2.073   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       7.591  -2.843   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       7.591  -4.383   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       4.924  -4.383   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       6.258  -5.153   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       8.925  -5.153   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      10.259  -2.843   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      11.723  -4.859   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      10.259  -4.383   0.000  0.00  0.00           C+0
HETATM   23  N   UNK     0       3.459  -4.859   0.000  0.00  0.00           N+0
HETATM   24  O   UNK     0       4.924   0.237   0.000  0.00  0.00           O+0
HETATM   25  O   UNK     0       6.258  -6.693   0.000  0.00  0.00           O+0
HETATM   26  O   UNK     0       8.925  -6.693   0.000  0.00  0.00           O+0
HETATM   27  O   UNK     0      10.420  -5.914   0.000  0.00  0.00           O+0
HETATM   28  O   UNK     0      11.723  -2.367   0.000  0.00  0.00           O+0
HETATM   29  H   UNK     0      13.328  -4.985   0.000  0.00  0.00           H+0
CONECT    1    8                                                            
CONECT    2    9                                                            
CONECT    3   10                                                            
CONECT    4   21                                                            
CONECT    5   21                                                            
CONECT    6    8   12                                                       
CONECT    7    9   11                                                       
CONECT    8    1    6   13                                                  
CONECT    9    2    7   23                                                  
CONECT   10    3   21   28   29                                             
CONECT   11    7   14   17                                                  
CONECT   12    6   14   24                                                  
CONECT   13    8   15   20                                                  
CONECT   14   11   12   15                                                  
CONECT   15   13   14   16                                                  
CONECT   16   15   18   19                                                  
CONECT   17   11   18   23                                                  
CONECT   18   16   17   25                                                  
CONECT   19   16   22   26                                                  
CONECT   20   13   22   28                                                  
CONECT   21    4    5   10   22                                             
CONECT   22   19   20   21   27                                             
CONECT   23    9   17                                                       
CONECT   24   12                                                            
CONECT   25   18                                                            
CONECT   26   19                                                            
CONECT   27   22                                                            
CONECT   28   10   20                                                       
CONECT   29   10                                                            
MASTER        0    0    0    0    0    0    0    0   29    0   66    0
END

Synonyms

Not Available

Molecular Formula

C₂₂H₂₁NO₅

Average Mass

379.412

Monoisotopic Mass

379.14197278

IUPAC Name

(15S,17S)-9,17-dihydroxy-5,11,15,16,16-pentamethyl-14-oxa-4-azapentacyclo[10.6.1.0^{3,7}.0^{8,19}.0^{13,17}]nonadeca-1(19),3(7),5,8,10,12-hexaene-2,18-dione

Traditional Name

(15S,17S)-9,17-dihydroxy-5,11,15,16,16-pentamethyl-14-oxa-4-azapentacyclo[10.6.1.0^{3,7}.0^{8,19}.0^{13,17}]nonadeca-1(19),3(7),5,8,10,12-hexaene-2,18-dione

CAS Registry Number

Not Available

SMILES

[H][C@@]1(C)OC2=C3C(C)=CC(O)=C4C5=C(NC(C)=C5)C(=O)C(C(=O)[C@]2(O)C1(C)C)=C34

InChI Identifier

InChI=1S/C22H21NO5/c1-8-6-12(24)14-11-7-9(2)23-17(11)18(25)16-15(14)13(8)20-22(27,19(16)26)21(4,5)10(3)28-20/h6-7,10,23-24,27H,1-5H3/t10-,22+/m0/s1

InChI Key

IXKZXMJHICVGBA-MLMJSJRWSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as naphthofurans. Naphthofurans are compounds containing a furan ring fused to a naphthalene moiety. Furan is a 5 membered- ring aromatic ring with four carbon and one oxygen atoms. Naphthalene is a polycyclic aromatic hydrocarbon made up of two fused benzene rings.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Naphthofurans

Sub Class

Not Available

Direct Parent

Naphthofurans

Alternative Parents

Substituents

Naphthofuran
Naphthalene
Indole or derivatives
Aryl ketone
1-hydroxy-2-unsubstituted benzenoid
Benzenoid
Substituted pyrrole
Heteroaromatic compound
Tetrahydrofuran
Tertiary alcohol
Pyrrole
Ketone
Oxacycle
Azacycle
Organic nitrogen compound
Organic oxygen compound
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Organonitrogen compound
Carbonyl group
Alcohol
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.13 g/L	ALOGPS
logP	2.25	ALOGPS
logP	1.05	ChemAxon
logS	-3.5	ALOGPS
pKa (Strongest Acidic)	8.79	ChemAxon
pKa (Strongest Basic)	-4.4	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	99.62 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	106.85 m³·mol⁻¹	ChemAxon
Polarizability	40.33 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

This table shows at most 5 pathways. For the full list of associated pathways:

See All Associated Bacterial Pathways

Name	SMPDB/PathBank	Species

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	1	Human feces	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

28945557

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

136218793

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

References

Synthesis Reference

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Herqueiazole (MMDBc0006803)

MOL for #<Metabolite:0x00007f2abae82bf0>

3D MOL for #<Metabolite:0x00007f2abae82bf0>

3D SDF for #<Metabolite:0x00007f2abae82bf0>

3D-SDF for #<Metabolite:0x00007f2abae82bf0>

PDB for #<Metabolite:0x00007f2abae82bf0>

3D PDB for #<Metabolite:0x00007f2abae82bf0>

SMILES for #<Metabolite:0x00007f2abae82bf0>

INCHI for #<Metabolite:0x00007f2abae82bf0>

Structure for #<Metabolite:0x00007f2abae82bf0>

3D Structure for #<Metabolite:0x00007f2abae82bf0>