MiMeDB: Showing metabocard for Peniamidienone (MMDBc0008647)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-05-15 01:25:47 UTC

Update Date

2025-10-07 16:05:30 UTC

Metabolite ID

MMDBc0008647

Metabolite Identification

Common Name

Peniamidienone

Description

Peniamidienone is a secondary metabolite belonging to the class of plant growth regulators, specifically produced by the fungus Penicillium sp. It has been isolated from cultures of this fungus alongside another compound, penidilamine (PMID:10820786 ). Peniamidienone exhibits biological activity, as evidenced by its weak inhibitory effect on lettuce seedling growth (PMID:10820786 ). This suggests that it may play a role in the regulation of plant growth processes, although its precise mechanisms of action and potential applications in agriculture or biotechnology remain to be fully elucidated. The study of peniamidienone and its related compounds could provide insights into the interactions between fungal metabolites and plant development, contributing to our understanding of natural plant growth regulators and their potential uses in crop management. Further research is warranted to explore the broader implications of peniamidienone in both ecological and agricultural contexts.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652305152103252D          

 28 29  0  0  0  0            999 V2000
    7.0430   -3.1901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2225   -3.1038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8870   -2.3502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0665   -2.2639    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7309   -1.5102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9105   -1.4240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4490   -1.1653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5749   -0.6703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2695   -1.2515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1135   -0.4116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7982    3.0428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9038    0.8370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7544   -0.5841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4189    0.1696    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0531    2.2581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5984    0.2558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8781    2.2581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5682    1.5907    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2628    1.0095    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3631    1.5907    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1331    3.0428    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5816   -2.9314    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.2159   -0.8428    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4255   -2.0914    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0598   -0.0029    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7243    0.7508    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  3  1  1  0  0  0  0
  4  3  1  0  0  0  0
  5  4  1  0  0  0  0
  6  5  2  0  0  0  0
  7  6  1  0  0  0  0
  9  7  2  0  0  0  0
 10  8  1  0  0  0  0
 11  8  2  0  0  0  0
 14  2  1  0  0  0  0
 14 12  1  0  0  0  0
 15  9  1  0  0  0  0
 15 10  1  0  0  0  0
 16 13  2  0  0  0  0
 16 15  1  0  0  0  0
 17 12  2  0  0  0  0
 18 11  1  0  0  0  0
 18 16  1  0  0  0  0
 19 17  1  0  0  0  0
 20 13  1  0  0  0  0
 20 17  1  0  0  0  0
 21 18  2  0  0  0  0
 22 19  2  0  0  0  0
 23 14  1  0  0  0  0
 23 19  1  0  0  0  0
 24  5  1  0  0  0  0
 25  6  1  0  0  0  0
 26  7  1  0  0  0  0
 27  9  1  0  0  0  0
 28 13  1  0  0  0  0
M  END


  Mrv1652305152103252D          

 28 29  0  0  0  0            999 V2000
    7.0430   -3.1901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2225   -3.1038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8870   -2.3502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0665   -2.2639    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7309   -1.5102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9105   -1.4240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4490   -1.1653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5749   -0.6703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2695   -1.2515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1135   -0.4116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7982    3.0428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9038    0.8370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7544   -0.5841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4189    0.1696    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0531    2.2581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5984    0.2558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8781    2.2581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5682    1.5907    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2628    1.0095    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3631    1.5907    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1331    3.0428    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5816   -2.9314    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.2159   -0.8428    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4255   -2.0914    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0598   -0.0029    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7243    0.7508    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  3  1  1  0  0  0  0
  4  3  1  0  0  0  0
  5  4  1  0  0  0  0
  6  5  2  0  0  0  0
  7  6  1  0  0  0  0
  9  7  2  0  0  0  0
 10  8  1  0  0  0  0
 11  8  2  0  0  0  0
 14  2  1  0  0  0  0
 14 12  1  0  0  0  0
 15  9  1  0  0  0  0
 15 10  1  0  0  0  0
 16 13  2  0  0  0  0
 16 15  1  0  0  0  0
 17 12  2  0  0  0  0
 18 11  1  0  0  0  0
 18 16  1  0  0  0  0
 19 17  1  0  0  0  0
 20 13  1  0  0  0  0
 20 17  1  0  0  0  0
 21 18  2  0  0  0  0
 22 19  2  0  0  0  0
 23 14  1  0  0  0  0
 23 19  1  0  0  0  0
 24  5  1  0  0  0  0
 25  6  1  0  0  0  0
 26  7  1  0  0  0  0
 27  9  1  0  0  0  0
 28 13  1  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0008647

> <DATABASE_NAME>
MIME

> <SMILES>
[H]\C(CCC)=C(\[H])/C(/[H])=C(\[H])C1CC=CC(=O)\C1=C(\[H])NC1=CC(C)OC1=O

> <INCHI_IDENTIFIER>
InChI=1S/C19H23NO3/c1-3-4-5-6-7-9-15-10-8-11-18(21)16(15)13-20-17-12-14(2)23-19(17)22/h5-9,11-15,20H,3-4,10H2,1-2H3/b6-5+,9-7+,16-13-

> <INCHI_KEY>
AGEGFCGROUIHGU-TUFLQPMZSA-N

> <FORMULA>
C19H23NO3

> <MOLECULAR_WEIGHT>
313.397

> <EXACT_MASS>
313.167793605

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
46

> <JCHEM_AVERAGE_POLARIZABILITY>
34.90727561450764

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
3-({[(1Z)-6-[(1E,3E)-hepta-1,3-dien-1-yl]-2-oxocyclohex-3-en-1-ylidene]methyl}amino)-5-methyl-2,5-dihydrofuran-2-one

> <ALOGPS_LOGP>
3.86

> <JCHEM_LOGP>
3.7957110746666656

> <ALOGPS_LOGS>
-4.31

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
18.536643579721353

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.912418486093788

> <JCHEM_PKA_STRONGEST_BASIC>
-4.995996055161068

> <JCHEM_POLAR_SURFACE_AREA>
55.400000000000006

> <JCHEM_REFRACTIVITY>
95.88849999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.55e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
3-({[(1Z)-6-[(1E,3E)-hepta-1,3-dien-1-yl]-2-oxocyclohex-3-en-1-ylidene]methyl}amino)-5-methyl-5H-furan-2-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 15-MAY-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-MAY-21         0                                  
HETATM    1  C   UNK     0      13.147  -5.955   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       6.469   8.125   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      11.615  -5.794   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      10.989  -4.387   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       9.457  -4.226   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       8.831  -2.819   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       7.300  -2.658   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       2.705  -2.175   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       6.673  -1.251   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       4.236  -2.336   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       2.078  -0.768   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       5.223   5.680   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       5.420   1.562   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       6.469   6.585   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       5.142  -1.090   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       4.515   0.317   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       5.699   4.215   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       2.984   0.478   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       7.239   4.215   0.000  0.00  0.00           C+0
HETATM   20  N   UNK     0       4.794   2.969   0.000  0.00  0.00           N+0
HETATM   21  O   UNK     0       2.357   1.884   0.000  0.00  0.00           O+0
HETATM   22  O   UNK     0       8.144   2.969   0.000  0.00  0.00           O+0
HETATM   23  O   UNK     0       7.715   5.680   0.000  0.00  0.00           O+0
HETATM   24  H   UNK     0       8.552  -5.472   0.000  0.00  0.00           H+0
HETATM   25  H   UNK     0       9.736  -1.573   0.000  0.00  0.00           H+0
HETATM   26  H   UNK     0       6.394  -3.904   0.000  0.00  0.00           H+0
HETATM   27  H   UNK     0       7.578  -0.005   0.000  0.00  0.00           H+0
HETATM   28  H   UNK     0       6.952   1.401   0.000  0.00  0.00           H+0
CONECT    1    3                                                            
CONECT    2   14                                                            
CONECT    3    1    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6   24                                                  
CONECT    6    5    7   25                                                  
CONECT    7    6    9   26                                                  
CONECT    8   10   11                                                       
CONECT    9    7   15   27                                                  
CONECT   10    8   15                                                       
CONECT   11    8   18                                                       
CONECT   12   14   17                                                       
CONECT   13   16   20   28                                                  
CONECT   14    2   12   23                                                  
CONECT   15    9   10   16                                                  
CONECT   16   13   15   18                                                  
CONECT   17   12   19   20                                                  
CONECT   18   11   16   21                                                  
CONECT   19   17   22   23                                                  
CONECT   20   13   17                                                       
CONECT   21   18                                                            
CONECT   22   19                                                            
CONECT   23   14   19                                                       
CONECT   24    5                                                            
CONECT   25    6                                                            
CONECT   26    7                                                            
CONECT   27    9                                                            
CONECT   28   13                                                            
MASTER        0    0    0    0    0    0    0    0   28    0   58    0
END

Synonyms

Value	Source
6-(N-(5-Methyl-2,5-dihydro-2-oxofuran-3-yl)aminomethylene)-5-((1E,3E)-1,3-heptadienyl)-2-cyclohexenone	MeSH

Molecular Formula

C₁₉H₂₃NO₃

Average Mass

313.397

Monoisotopic Mass

313.167793605

IUPAC Name

3-({[(1Z)-6-[(1E,3E)-hepta-1,3-dien-1-yl]-2-oxocyclohex-3-en-1-ylidene]methyl}amino)-5-methyl-2,5-dihydrofuran-2-one

Traditional Name

3-({[(1Z)-6-[(1E,3E)-hepta-1,3-dien-1-yl]-2-oxocyclohex-3-en-1-ylidene]methyl}amino)-5-methyl-5H-furan-2-one

CAS Registry Number

Not Available

SMILES

[H]\C(CCC)=C(\[H])/C(/[H])=C(\[H])C1CC=CC(=O)\C1=C(\[H])NC1=CC(C)OC1=O

InChI Identifier

InChI=1S/C19H23NO3/c1-3-4-5-6-7-9-15-10-8-11-18(21)16(15)13-20-17-12-14(2)23-19(17)22/h5-9,11-15,20H,3-4,10H2,1-2H3/b6-5+,9-7+,16-13-

InChI Key

AGEGFCGROUIHGU-TUFLQPMZSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Alpha amino acids and derivatives

Alternative Parents

Substituents

Alpha-amino acid or derivatives
O-quinomethane
Quinomethane
Cyclohexenone
2-furanone
Dihydrofuran
Vinylogous amide
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Carboxylic acid ester
Ketone
Lactone
Cyclic ketone
Secondary aliphatic amine
Allylamine
Enamine
Oxacycle
Monocarboxylic acid or derivatives
Organoheterocyclic compound
Secondary amine
Amine
Organic nitrogen compound
Hydrocarbon derivative
Organic oxygen compound
Carbonyl group
Organic oxide
Organonitrogen compound
Organooxygen compound
Aliphatic heteromonocyclic compound

Molecular Framework

Aliphatic heteromonocyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.016 g/L	ALOGPS
logP	3.86	ALOGPS
logP	3.8	ChemAxon
logS	-4.3	ALOGPS
pKa (Strongest Acidic)	13.91	ChemAxon
pKa (Strongest Basic)	-5	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	55.4 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	95.89 m³·mol⁻¹	ChemAxon
Polarizability	34.91 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

This table shows at most 5 pathways. For the full list of associated pathways:

See All Associated Bacterial Pathways

Name	SMPDB/PathBank	Species

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	1	Human feces	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

C00037608

Chemspider ID

8956792

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

10781479

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

References

Synthesis Reference

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Peniamidienone (MMDBc0008647)

MOL for #<Metabolite:0x00007f2ad6f9cf88>

3D MOL for #<Metabolite:0x00007f2ad6f9cf88>

3D SDF for #<Metabolite:0x00007f2ad6f9cf88>

3D-SDF for #<Metabolite:0x00007f2ad6f9cf88>

PDB for #<Metabolite:0x00007f2ad6f9cf88>

3D PDB for #<Metabolite:0x00007f2ad6f9cf88>

SMILES for #<Metabolite:0x00007f2ad6f9cf88>

INCHI for #<Metabolite:0x00007f2ad6f9cf88>

Structure for #<Metabolite:0x00007f2ad6f9cf88>

3D Structure for #<Metabolite:0x00007f2ad6f9cf88>