MiMeDB: Showing metabocard for Penicillixanthone (MMDBc0008886)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-05-15 01:34:49 UTC

Update Date

2025-10-07 16:05:31 UTC

Metabolite ID

MMDBc0008886

Metabolite Identification

Common Name

Penicillixanthone

Description

Penicillixanthone is a xanthone derivative belonging to the chemical class of natural products. This metabolite has been isolated from various fungal species, particularly endophytic fungi such as Talaromyces sp. and marine-derived fungi like Aspergillus fumigatus. Penicillixanthone A, a notable variant, exhibits significant biological activity, including potent cytotoxic effects against cancer cell lines Hep G2 and A549, with IC50 values of 117 nM and 212 nM respectively, and demonstrates antitumor efficacy by inhibiting the PI3K-Akt-mTOR signaling pathway (PMID:38067576 ). Additionally, it has been identified as a dual-coreceptor antagonist with anti-HIV-1 properties, inhibiting both CCR5-tropic and CXCR4-tropic strains of HIV-1 (PMID:29258357 ). The compound has also been characterized in various studies, where it was found alongside other xanthone analogues and metabolites, indicating its relevance in the chemical diversity of fungal secondary metabolites (PMID:34235296 , PMID:32276418 ). Overall, penicillixanthone represents a promising candidate for further pharmacological exploration due to its diverse bioactive properties.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652305152103342D          

 24 26  0  0  0  0            999 V2000
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  5  1  1  0  0  0  0
  6  3  2  0  0  0  0
  6  4  1  0  0  0  0
  7  3  1  0  0  0  0
  8  4  2  0  0  0  0
  9  7  2  0  0  0  0
  9  8  1  0  0  0  0
 11  5  2  0  0  0  0
 12  5  1  0  0  0  0
 13  9  1  0  0  0  0
 13 10  1  0  0  0  0
 14 10  2  0  0  0  0
 14 11  1  0  0  0  0
 15 10  1  0  0  0  0
 15 12  2  0  0  0  0
 16  7  1  0  0  0  0
 17 11  1  0  0  0  0
 18 12  1  0  0  0  0
 19  6  1  0  0  0  0
 20 13  2  0  0  0  0
 21 14  1  0  0  0  0
 22 16  2  0  0  0  0
 23  2  1  0  0  0  0
 23 16  1  0  0  0  0
 24  8  1  0  0  0  0
 24 15  1  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0008886

> <DATABASE_NAME>
MIME

> <SMILES>
COC(=O)C1=C2C(OC3=C(Cl)C(C)=C(Cl)C(O)=C3C2=O)=CC(O)=C1

> <INCHI_IDENTIFIER>
InChI=1S/C16H10Cl2O6/c1-5-11(17)14(21)10-13(20)9-7(16(22)23-2)3-6(19)4-8(9)24-15(10)12(5)18/h3-4,19,21H,1-2H3

> <INCHI_KEY>
PQPCYOSNIFQULR-UHFFFAOYSA-N

> <FORMULA>
C16H10Cl2O6

> <MOLECULAR_WEIGHT>
369.15

> <EXACT_MASS>
367.9854434

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
34

> <JCHEM_AVERAGE_POLARIZABILITY>
34.39330658105866

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
methyl 5,7-dichloro-3,8-dihydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylate

> <ALOGPS_LOGP>
4.16

> <JCHEM_LOGP>
4.727497283

> <ALOGPS_LOGS>
-4.54

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
7.371310683486653

> <JCHEM_PKA_STRONGEST_ACIDIC>
6.525454612027512

> <JCHEM_PKA_STRONGEST_BASIC>
-3.807785969335748

> <JCHEM_POLAR_SURFACE_AREA>
93.06

> <JCHEM_REFRACTIVITY>
87.45419999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.07e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
methyl 5,7-dichloro-3,8-dihydroxy-6-methyl-9-oxoxanthene-1-carboxylate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 15-MAY-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-MAY-21         0                                  
HETATM    1  C   UNK     0       0.000   1.540   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       9.336   8.470   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       9.336   3.850   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       8.002   1.540   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       1.334   2.310   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       9.336   2.310   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       8.002   4.620   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       6.668   2.310   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       6.668   3.850   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       4.001   3.850   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       1.334   3.850   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       2.667   1.540   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       5.335   4.620   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       2.667   4.620   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       4.001   2.310   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       8.002   6.160   0.000  0.00  0.00           C+0
HETATM   17 Cl   UNK     0      -0.000   4.620   0.000  0.00  0.00          Cl+0
HETATM   18 Cl   UNK     0       2.667  -0.000   0.000  0.00  0.00          Cl+0
HETATM   19  O   UNK     0      10.669   1.540   0.000  0.00  0.00           O+0
HETATM   20  O   UNK     0       5.335   6.160   0.000  0.00  0.00           O+0
HETATM   21  O   UNK     0       2.667   6.160   0.000  0.00  0.00           O+0
HETATM   22  O   UNK     0       6.668   6.930   0.000  0.00  0.00           O+0
HETATM   23  O   UNK     0       9.336   6.930   0.000  0.00  0.00           O+0
HETATM   24  O   UNK     0       5.335   1.540   0.000  0.00  0.00           O+0
CONECT    1    5                                                            
CONECT    2   23                                                            
CONECT    3    6    7                                                       
CONECT    4    6    8                                                       
CONECT    5    1   11   12                                                  
CONECT    6    3    4   19                                                  
CONECT    7    3    9   16                                                  
CONECT    8    4    9   24                                                  
CONECT    9    7    8   13                                                  
CONECT   10   13   14   15                                                  
CONECT   11    5   14   17                                                  
CONECT   12    5   15   18                                                  
CONECT   13    9   10   20                                                  
CONECT   14   10   11   21                                                  
CONECT   15   10   12   24                                                  
CONECT   16    7   22   23                                                  
CONECT   17   11                                                            
CONECT   18   12                                                            
CONECT   19    6                                                            
CONECT   20   13                                                            
CONECT   21   14                                                            
CONECT   22   16                                                            
CONECT   23    2   16                                                       
CONECT   24    8   15                                                       
MASTER        0    0    0    0    0    0    0    0   24    0   52    0
END

Synonyms

Not Available

Molecular Formula

C₁₆H₁₀Cl₂O₆

Average Mass

369.15

Monoisotopic Mass

367.9854434

IUPAC Name

methyl 5,7-dichloro-3,8-dihydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylate

Traditional Name

methyl 5,7-dichloro-3,8-dihydroxy-6-methyl-9-oxoxanthene-1-carboxylate

CAS Registry Number

Not Available

SMILES

COC(=O)C1=C2C(OC3=C(Cl)C(C)=C(Cl)C(O)=C3C2=O)=CC(O)=C1

InChI Identifier

InChI=1S/C16H10Cl2O6/c1-5-11(17)14(21)10-13(20)9-7(16(22)23-2)3-6(19)4-8(9)24-15(10)12(5)18/h3-4,19,21H,1-2H3

InChI Key

PQPCYOSNIFQULR-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as xanthones. These are polycyclic aromatic compounds containing a xanthene moiety conjugated to a ketone group at carbon 9. Xanthene is a tricyclic compound made up of two benzene rings linearly fused to each other through a pyran ring.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Benzopyrans

Sub Class

1-benzopyrans

Direct Parent

Xanthones

Alternative Parents

Substituents

Xanthone
Chromone
4-halophenol
2-halophenol
1-hydroxy-2-unsubstituted benzenoid
Phenol
Pyranone
Benzenoid
Pyran
Aryl halide
Aryl chloride
Methyl ester
Heteroaromatic compound
Vinylogous acid
Carboxylic acid ester
Carboxylic acid derivative
Oxacycle
Organohalogen compound
Organic oxide
Organic oxygen compound
Hydrocarbon derivative
Organooxygen compound
Organochloride
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.011 g/L	ALOGPS
logP	4.16	ALOGPS
logP	4.73	ChemAxon
logS	-4.5	ALOGPS
pKa (Strongest Acidic)	6.53	ChemAxon
pKa (Strongest Basic)	-3.8	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	93.06 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	87.45 m³·mol⁻¹	ChemAxon
Polarizability	34.39 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

This table shows at most 5 pathways. For the full list of associated pathways:

See All Associated Bacterial Pathways

Name	SMPDB/PathBank	Species

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	1	Human feces	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

78434815

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

101898991

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

References

Synthesis Reference

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Penicillixanthone (MMDBc0008886)

MOL for #<Metabolite:0x00007f2add0b4898>

3D MOL for #<Metabolite:0x00007f2add0b4898>

3D SDF for #<Metabolite:0x00007f2add0b4898>

3D-SDF for #<Metabolite:0x00007f2add0b4898>

PDB for #<Metabolite:0x00007f2add0b4898>

3D PDB for #<Metabolite:0x00007f2add0b4898>

SMILES for #<Metabolite:0x00007f2add0b4898>

INCHI for #<Metabolite:0x00007f2add0b4898>

Structure for #<Metabolite:0x00007f2add0b4898>

3D Structure for #<Metabolite:0x00007f2add0b4898>