MiMeDB: Showing metabocard for 5-hydroxyculmorin (MMDBc0009360)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-05-15 01:53:58 UTC

Update Date

2025-10-07 16:05:35 UTC

Metabolite ID

MMDBc0009360

Metabolite Identification

Common Name

5-hydroxyculmorin

Description

5-hydroxyculmorin is a fungal metabolite belonging to the class of phenolic compounds. It is derived from culmorin and exhibits significant presence in various fungal species, particularly those within the Fusarium genus. This compound has been quantified in studies assessing mycotoxin levels, where it was found at notable concentrations in contaminated samples, with an average of 21,219 µg/kg reported (PMID:32316403 ). Additionally, 5-hydroxyculmorin has been associated with the modulation of mycotoxin levels, as evidenced by its observed lowering effects alongside other compounds like 15Ac-DON and sambucinol (PMID:27690101 ). Furthermore, research indicates positive correlations between levels of 5-hydroxyculmorin and other mycotoxins in durum wheat cultivars, suggesting its potential role in the biochemical interactions of these metabolites (PMID:24844356 ). The biological implications of 5-hydroxyculmorin are still under investigation, but its presence in significant quantities highlights its relevance in food safety and mycotoxin research.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652305152103532D          

 23 25  0  0  1  0            999 V2000
    2.0248    1.0291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1972    1.6610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9087   -0.7702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5146    1.1981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1945   -0.6671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3502   -0.8044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4956    0.1158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8601   -0.4597    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.5798    0.0793    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.1172    0.2631    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.3722    0.9861    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.4091    1.3027    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.2226    0.8364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2924   -0.2217    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.9076    0.6394    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.5188   -0.9565    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4046    0.0645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6297    2.0977    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8749    0.3651    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0277    0.7721    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6180   -0.1112    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5999    1.7790    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2066    1.8518    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  6  5  1  0  0  0  0
  8  7  1  0  0  0  0
  9  5  1  0  0  0  0
 10  8  1  0  0  0  0
 11 10  1  0  0  0  0
 12 11  1  0  0  0  0
 13  1  1  0  0  0  0
 13  2  1  0  0  0  0
 13  9  1  0  0  0  0
 13 11  1  0  0  0  0
 14  3  1  1  0  0  0
 14  6  1  0  0  0  0
 14 10  1  0  0  0  0
 15  4  1  1  0  0  0
 15  7  1  0  0  0  0
 15 12  1  0  0  0  0
 15 14  1  0  0  0  0
  8 16  1  1  0  0  0
  9 17  1  6  0  0  0
 12 18  1  6  0  0  0
  8 19  1  1  0  0  0
  9 20  1  1  0  0  0
 10 21  1  6  0  0  0
 11 22  1  6  0  0  0
 12 23  1  1  0  0  0
M  END
> <DATABASE_ID>
MMDBc0009360

> <DATABASE_NAME>
MIME

> <SMILES>
[H][C@@]1(O)C[C@]2(C)[C@]([H])(O)[C@]3([H])[C@@]1([H])[C@]2(C)CC[C@@]([H])(O)C3(C)C

> <INCHI_IDENTIFIER>
InChI=1S/C15H26O3/c1-13(2)9(17)5-6-14(3)10-8(16)7-15(14,4)12(18)11(10)13/h8-12,16-18H,5-7H2,1-4H3/t8-,9-,10+,11+,12-,14+,15-/m1/s1

> <INCHI_KEY>
XFKGEQRMYJCXFK-OFTJPINFSA-N

> <FORMULA>
C15H26O3

> <MOLECULAR_WEIGHT>
254.37

> <EXACT_MASS>
254.188194697

> <ALOGPS_LOGP>
1.06

> <ALOGPS_LOGS>
-1.67

> <ALOGPS_SOLUBILITY>
5.50e+00 g/l

$$$$

HEADER    PROTEIN                                 15-MAY-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-MAY-21         0                                  
HETATM    1  C   UNK     0       3.780   1.921   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       2.235   3.101   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -1.696  -1.438   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -2.827   2.236   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       2.230  -1.245   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       0.654  -1.502   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -2.792   0.216   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -1.606  -0.858   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       2.949   0.148   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      -0.219   0.491   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       0.695   1.841   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      -0.764   2.432   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       2.282   1.561   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      -0.546  -0.414   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      -1.694   1.194   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0      -2.835  -1.786   0.000  0.00  0.00           O+0
HETATM   17  O   UNK     0       4.489   0.120   0.000  0.00  0.00           O+0
HETATM   18  O   UNK     0      -1.175   3.916   0.000  0.00  0.00           O+0
HETATM   19  H   UNK     0      -1.633   0.682   0.000  0.00  0.00           H+0
HETATM   20  H   UNK     0       3.785   1.441   0.000  0.00  0.00           H+0
HETATM   21  H   UNK     0       1.154  -0.208   0.000  0.00  0.00           H+0
HETATM   22  H   UNK     0       1.120   3.321   0.000  0.00  0.00           H+0
HETATM   23  H   UNK     0       0.386   3.457   0.000  0.00  0.00           H+0
CONECT    1   13                                                            
CONECT    2   13                                                            
CONECT    3   14                                                            
CONECT    4   15                                                            
CONECT    5    6    9                                                       
CONECT    6    5   14                                                       
CONECT    7    8   15                                                       
CONECT    8    7   10   16   19                                             
CONECT    9    5   13   17   20                                             
CONECT   10    8   11   14   21                                             
CONECT   11   10   12   13   22                                             
CONECT   12   11   15   18   23                                             
CONECT   13    1    2    9   11                                             
CONECT   14    3    6   10   15                                             
CONECT   15    4    7   12   14                                             
CONECT   16    8                                                            
CONECT   17    9                                                            
CONECT   18   12                                                            
CONECT   19    8                                                            
CONECT   20    9                                                            
CONECT   21   10                                                            
CONECT   22   11                                                            
CONECT   23   12                                                            
MASTER        0    0    0    0    0    0    0    0   23    0   50    0
END

Synonyms

Not Available

Molecular Formula

C₁₅H₂₆O₃

Average Mass

254.37

Monoisotopic Mass

254.188194697

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

[H][C@@]1(O)C[C@]2(C)[C@]([H])(O)[C@]3([H])[C@@]1([H])[C@]2(C)CC[C@@]([H])(O)C3(C)C

InChI Identifier

InChI=1S/C15H26O3/c1-13(2)9(17)5-6-14(3)10-8(16)7-15(14,4)12(18)11(10)13/h8-12,16-18H,5-7H2,1-4H3/t8-,9-,10+,11+,12-,14+,15-/m1/s1

InChI Key

XFKGEQRMYJCXFK-OFTJPINFSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as bicyclic monoterpenoids. These are monoterpenoids containing exactly 2 rings, which are fused to each other.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Monoterpenoids

Direct Parent

Bicyclic monoterpenoids

Alternative Parents

Substituents

Bornane monoterpenoid
Cyclic alcohol
Secondary alcohol
Polyol
Organic oxygen compound
Hydrocarbon derivative
Organooxygen compound
Alcohol
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	5.5 g/L	ALOGPS
logP	1.06	ALOGPS
logS	-1.7	ALOGPS

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_3_1) - 70eV, Positive	Not Available	2022-08-08	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	Not Available	2022-08-09	View Spectrum
MS	Mass Spectrum (Electron Ionization)	Not Available	2022-08-06	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-22	View Spectrum

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

This table shows at most 5 pathways. For the full list of associated pathways:

See All Associated Bacterial Pathways

Name	SMPDB/PathBank	Species

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	1	Human feces	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

78442610

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

139585563

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

References

Synthesis Reference

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for 5-hydroxyculmorin (MMDBc0009360)

MOL for #<Metabolite:0x00007f2ad4161b50>

3D MOL for #<Metabolite:0x00007f2ad4161b50>

3D SDF for #<Metabolite:0x00007f2ad4161b50>

3D-SDF for #<Metabolite:0x00007f2ad4161b50>

PDB for #<Metabolite:0x00007f2ad4161b50>

3D PDB for #<Metabolite:0x00007f2ad4161b50>

SMILES for #<Metabolite:0x00007f2ad4161b50>

INCHI for #<Metabolite:0x00007f2ad4161b50>

Structure for #<Metabolite:0x00007f2ad4161b50>

3D Structure for #<Metabolite:0x00007f2ad4161b50>