MiMeDB: Showing metabocard for Deoxyanserinone B (MMDBc0010904)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-05-15 02:56:21 UTC

Update Date

2025-10-07 16:05:48 UTC

Metabolite ID

MMDBc0010904

Metabolite Identification

Common Name

Deoxyanserinone B

Description

Deoxyanserinone B is a member of the anthraquinone chemical class, characterized by its structural features that include multiple methoxy groups. This compound has garnered attention in biomedical literature for its notable antimicrobial properties, demonstrated through studies revealing substantial efficacy against various microbial strains, including V. (PMID:38151632 ). Deoxyanserinone B, along with related compounds such as 1-hydroxy-2,6,8-trimethoxy-9,10-anthraquinone and khatmiamycin, exhibited antimicrobial activity comparable to standard antibiotics like amoxicillin, with effective concentrations ranging between 7 and 38 μg/mL (PMID:38151632 ). Additionally, deoxyanserinone B has been identified as a minor constituent in certain extracts, although it has not been completely purified in some studies (PMID:15043411 ). The potential of deoxyanserinone B in therapeutic applications, particularly in combating microbial infections, highlights its significance within the realm of natural product chemistry and pharmacology. Further research is warranted to fully elucidate its mechanisms of action and potential clinical applications.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652305152104562D          

 14 14  0  0  0  0            999 V2000
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  7  1  1  0  0  0  0
  7  4  1  0  0  0  0
  8  2  1  0  0  0  0
  9  4  1  0  0  0  0
  9  5  2  0  0  0  0
  9  8  1  0  0  0  0
 10  5  1  0  0  0  0
 10  6  2  0  0  0  0
 11  6  1  0  0  0  0
 11  8  2  0  0  0  0
 12  7  1  0  0  0  0
 13 11  1  0  0  0  0
 14  3  1  0  0  0  0
 14 10  1  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0010904

> <DATABASE_NAME>
MIME

> <SMILES>
COC1=CC(O)=C(C)C(CC(C)O)=C1

> <INCHI_IDENTIFIER>
InChI=1S/C11H16O3/c1-7(12)4-9-5-10(14-3)6-11(13)8(9)2/h5-7,12-13H,4H2,1-3H3

> <INCHI_KEY>
VOVNVNDGBNLJJB-UHFFFAOYSA-N

> <FORMULA>
C11H16O3

> <MOLECULAR_WEIGHT>
196.246

> <EXACT_MASS>
196.109944375

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
30

> <JCHEM_AVERAGE_POLARIZABILITY>
21.644674875819252

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
3-(2-hydroxypropyl)-5-methoxy-2-methylphenol

> <ALOGPS_LOGP>
1.50

> <JCHEM_LOGP>
1.9633170803333329

> <ALOGPS_LOGS>
-1.85

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
15.565491459735824

> <JCHEM_PKA_STRONGEST_ACIDIC>
9.835165670067083

> <JCHEM_PKA_STRONGEST_BASIC>
-2.565625314734837

> <JCHEM_POLAR_SURFACE_AREA>
49.69

> <JCHEM_REFRACTIVITY>
55.533

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.79e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
3-(2-hydroxypropyl)-5-methoxy-2-methylphenol

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 15-MAY-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-MAY-21         0                                  
HETATM    1  C   UNK     0       0.000   6.160   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -1.334   2.310   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       5.335  -0.000   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       1.334   3.850   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       2.667   1.540   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       0.000   4.620   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       0.000   1.540   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       1.334   2.310   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       2.667  -0.000   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM   12  O   UNK     0      -1.334   3.850   0.000  0.00  0.00           O+0
HETATM   13  O   UNK     0      -1.334  -0.770   0.000  0.00  0.00           O+0
HETATM   14  O   UNK     0       4.001  -0.770   0.000  0.00  0.00           O+0
CONECT    1    7                                                            
CONECT    2    8                                                            
CONECT    3   14                                                            
CONECT    4    7    9                                                       
CONECT    5    9   10                                                       
CONECT    6   10   11                                                       
CONECT    7    1    4   12                                                  
CONECT    8    2    9   11                                                  
CONECT    9    4    5    8                                                  
CONECT   10    5    6   14                                                  
CONECT   11    6    8   13                                                  
CONECT   12    7                                                            
CONECT   13   11                                                            
CONECT   14    3   10                                                       
MASTER        0    0    0    0    0    0    0    0   14    0   28    0
END

Synonyms

Not Available

Molecular Formula

C₁₁H₁₆O₃

Average Mass

196.246

Monoisotopic Mass

196.109944375

IUPAC Name

3-(2-hydroxypropyl)-5-methoxy-2-methylphenol

Traditional Name

3-(2-hydroxypropyl)-5-methoxy-2-methylphenol

CAS Registry Number

Not Available

SMILES

COC1=CC(O)=C(C)C(CC(C)O)=C1

InChI Identifier

InChI=1S/C11H16O3/c1-7(12)4-9-5-10(14-3)6-11(13)8(9)2/h5-7,12-13H,4H2,1-3H3

InChI Key

VOVNVNDGBNLJJB-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as methoxyphenols. Methoxyphenols are compounds containing a methoxy group attached to the benzene ring of a phenol moiety.

Kingdom

Super Class

Class

Sub Class

Direct Parent

Alternative Parents

Substituents

Methoxyphenol
Phenylpropane
Anisole
Phenoxy compound
O-cresol
Phenol ether
Methoxybenzene
1-hydroxy-4-unsubstituted benzenoid
Alkyl aryl ether
Toluene
1-hydroxy-2-unsubstituted benzenoid
Monocyclic benzene moiety
Secondary alcohol
Ether
Alcohol
Organooxygen compound
Hydrocarbon derivative
Organic oxygen compound
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	2.79 g/L	ALOGPS
logP	1.5	ALOGPS
logP	1.96	ChemAxon
logS	-1.8	ALOGPS
pKa (Strongest Acidic)	9.84	ChemAxon
pKa (Strongest Basic)	-2.6	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	49.69 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	55.53 m³·mol⁻¹	ChemAxon
Polarizability	21.64 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Chromatographic Retention Times and Retention Indices

Retention Times

Chromatography Type	Technique	Column	Deposition Date	Retention Time (s)
Liquid Chromatography	HILIC	Waters Acquity UPLC-BEH Amide column (eluted)	2025-10-23	303.0
Liquid Chromatography	HILIC	Accucore 150 Amide HILIC (eluted)	2025-10-23	26.0
Liquid Chromatography	Reversed-phase	Hypersil Gold 1.9 µm C18 (eluted)	2025-10-23	428.3
Liquid Chromatography	Reversed-phase	Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) (eluted)	2025-10-23	490.4
Liquid Chromatography	Reversed-phase	XBridge C18 3.5u 2.1x50 mm (eluted)	2025-10-23	501.0
Liquid Chromatography	Reversed-phase	Ascentis Express C18 (void)	2025-10-23	316.2
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	1660.8
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (void)	2025-10-23	83.6
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC (eluted)	2025-10-23	351.8
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	381.4
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-23	255.3
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	176.2
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	147.5
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (void)	2025-10-23	21.0
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-23	333.7
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	111.8
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	345.4
Liquid Chromatography	Reversed-phase	Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex (eluted)	2025-10-23	1181.4
Liquid Chromatography	Reversed-phase	Waters Atlantis T3 (2.1 x 150 mm, 5 um) (eluted)	2025-10-23	959.9

Retention Indices

Chromatography Type	Peak Label	SMILES	Stationary Phase	Deposition Date	Retention Index
Gas Chromatography	Deoxyanserinone B_TMS_1	COC1=CC(CC(C)O)=C(C)C(O[Si](C)(C)C)=C1	standard non polar	2025-10-23	2420.03
Gas Chromatography	Deoxyanserinone B_TMS_2	COC1=CC(O)=C(C)C(CC(C)O[Si](C)(C)C)=C1	standard non polar	2025-10-23	2249.04
Gas Chromatography	Deoxyanserinone B_TMS_3	COC1=CC(CC(C)O[Si](C)(C)C)=C(C)C(O[Si](C)(C)C)=C1	standard non polar	2025-10-23	1760.04
Gas Chromatography	Deoxyanserinone B_TMS_1	COC1=CC(CC(C)O)=C(C)C(O[Si](C)(C)C)=C1	standard polar	2025-10-23	1867.44
Gas Chromatography	Deoxyanserinone B_TMS_2	COC1=CC(O)=C(C)C(CC(C)O[Si](C)(C)C)=C1	standard polar	2025-10-23	1607.31
Gas Chromatography	Deoxyanserinone B_TMS_3	COC1=CC(CC(C)O[Si](C)(C)C)=C(C)C(O[Si](C)(C)C)=C1	standard polar	2025-10-23	1672.69

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	1	Human feces	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

10185958

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

21576222

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Deoxyanserinone B (MMDBc0010904)

MOL for #<Metabolite:0x00007f9ad30efa68>

3D MOL for #<Metabolite:0x00007f9ad30efa68>

3D SDF for #<Metabolite:0x00007f9ad30efa68>

3D-SDF for #<Metabolite:0x00007f9ad30efa68>

PDB for #<Metabolite:0x00007f9ad30efa68>

3D PDB for #<Metabolite:0x00007f9ad30efa68>

SMILES for #<Metabolite:0x00007f9ad30efa68>

INCHI for #<Metabolite:0x00007f9ad30efa68>

Structure for #<Metabolite:0x00007f9ad30efa68>

3D Structure for #<Metabolite:0x00007f9ad30efa68>