MiMeDB: Showing metabocard for Oxysporone (MMDBc0012713)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-05-15 04:10:54 UTC

Update Date

2025-10-07 16:06:02 UTC

Metabolite ID

MMDBc0012713

Metabolite Identification

Common Name

Oxysporone

Description

Oxysporone is a dihydrofuropyranone, a chemical class known for its diverse biological activities. This metabolite has been identified as a significant virulence factor in the pathogenic fungus N. (PMID:32603933 ). Notably, oxysporone exhibits high levels of phytotoxic activity, with lesion areas ranging from 21.5 to 84.3 mm² after 9 days of treatment, surpassing the phytotoxic effects of related compounds (PMID:32603933 ). Additionally, oxysporone has demonstrated anti-MRSA activity, highlighting its potential as an antimicrobial agent, particularly when derived from the endophytic fungus Pestalotia sp. (PMID:29193363 ). The structural elucidation of oxysporone and its derivatives has been achieved through spectroscopic techniques, confirming its unique chemical properties (PMID:29193363 ). Furthermore, studies involving optical rotatory dispersion (ORD), electronic circular dichroism (ECD), and vibrational circular dichroism (VCD) have provided insights into the absolute configuration of oxysporone and related metabolites (PMID:23427901 ). The discovery of new oxysporone derivatives from the fermentation broth of Pestalotiopsis karstenii further emphasizes its significance in the realm of natural products and potential therapeutic applications (PMID:22805506 ).

Structure

MOL SDF PDB SMILES InChI


  Mrv1652305152106102D          

 14 15  0  0  1  0            999 V2000
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.6378   -0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    1.5229    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    0.2854    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8371    2.7559    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  2  0  0  0  0
  4  3  1  0  0  0  0
  5  1  1  0  0  0  0
  5  4  1  0  0  0  0
  6  3  1  0  0  0  0
  7  4  1  0  0  0  0
  5  8  1  1  0  0  0
  9  6  2  0  0  0  0
 10  2  1  0  0  0  0
 10  7  1  0  0  0  0
 11  6  1  0  0  0  0
 11  7  1  0  0  0  0
  4 12  1  1  0  0  0
  5 13  1  6  0  0  0
  7 14  1  1  0  0  0
M  END
> <DATABASE_ID>
MMDBc0012713

> <DATABASE_NAME>
MIME

> <SMILES>
[H][C@]12OC(=O)C[C@@]1([H])[C@]([H])(O)C=CO2

> <INCHI_IDENTIFIER>
InChI=1S/C7H8O4/c8-5-1-2-10-7-4(5)3-6(9)11-7/h1-2,4-5,7-8H,3H2/t4-,5+,7-/m0/s1

> <INCHI_KEY>
RJIMODGWTUNSPV-BFHQHQDPSA-N

> <FORMULA>
C7H8O4

> <MOLECULAR_WEIGHT>
156.137

> <EXACT_MASS>
156.042258738

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
19

> <JCHEM_AVERAGE_POLARIZABILITY>
13.856848586123968

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(3aS,4R,7aS)-4-hydroxy-2H,3H,3aH,4H,7aH-furo[2,3-b]pyran-2-one

> <ALOGPS_LOGP>
-0.46

> <JCHEM_LOGP>
-0.30764112800000026

> <ALOGPS_LOGS>
0.36

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
14.301030726371483

> <JCHEM_PKA_STRONGEST_BASIC>
-3.1045291602851135

> <JCHEM_POLAR_SURFACE_AREA>
55.760000000000005

> <JCHEM_REFRACTIVITY>
34.733200000000004

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
3.54e+02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(3aS,4R,7aS)-4-hydroxy-3H,3aH,4H,7aH-furo[2,3-b]pyran-2-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 15-MAY-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-MAY-21         0                                  
HETATM    1  C   UNK     0       6.258   2.073   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       6.258   3.613   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       2.126   1.597   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       3.590   2.073   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       4.924   1.303   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       1.220   2.843   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       3.590   3.613   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0       4.924  -0.237   0.000  0.00  0.00           O+0
HETATM    9  O   UNK     0      -0.320   2.843   0.000  0.00  0.00           O+0
HETATM   10  O   UNK     0       4.924   4.383   0.000  0.00  0.00           O+0
HETATM   11  O   UNK     0       2.126   4.089   0.000  0.00  0.00           O+0
HETATM   12  H   UNK     0       4.924   2.843   0.000  0.00  0.00           H+0
HETATM   13  H   UNK     0       3.590   0.533   0.000  0.00  0.00           H+0
HETATM   14  H   UNK     0       3.429   5.144   0.000  0.00  0.00           H+0
CONECT    1    2    5                                                       
CONECT    2    1   10                                                       
CONECT    3    4    6                                                       
CONECT    4    3    5    7   12                                             
CONECT    5    1    4    8   13                                             
CONECT    6    3    9   11                                                  
CONECT    7    4   10   11   14                                             
CONECT    8    5                                                            
CONECT    9    6                                                            
CONECT   10    2    7                                                       
CONECT   11    6    7                                                       
CONECT   12    4                                                            
CONECT   13    5                                                            
CONECT   14    7                                                            
MASTER        0    0    0    0    0    0    0    0   14    0   30    0
END

Synonyms

Not Available

Molecular Formula

C₇H₈O₄

Average Mass

156.137

Monoisotopic Mass

156.042258738

IUPAC Name

(3aS,4R,7aS)-4-hydroxy-2H,3H,3aH,4H,7aH-furo[2,3-b]pyran-2-one

Traditional Name

(3aS,4R,7aS)-4-hydroxy-3H,3aH,4H,7aH-furo[2,3-b]pyran-2-one

CAS Registry Number

Not Available

SMILES

[H][C@]12OC(=O)C[C@@]1([H])[C@]([H])(O)C=CO2

InChI Identifier

InChI=1S/C7H8O4/c8-5-1-2-10-7-4(5)3-6(9)11-7/h1-2,4-5,7-8H,3H2/t4-,5+,7-/m0/s1

InChI Key

RJIMODGWTUNSPV-BFHQHQDPSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as furopyrans. These are organic polycyclic compounds containing a furan ring fused to a pyran ring. Furan is a five-membered aromatic ring with four carbon atoms and one oxygen atom. Pyran a six-membered heterocyclic, non-aromatic ring, made up of five carbon atoms and one oxygen atom and containing two double bonds.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Furopyrans

Sub Class

Not Available

Direct Parent

Furopyrans

Alternative Parents

Substituents

Furopyran
Gamma butyrolactone
Pyran
Furan
Tetrahydrofuran
Carboxylic acid ester
Lactone
Secondary alcohol
Monocarboxylic acid or derivatives
Acetal
Carboxylic acid derivative
Oxacycle
Alcohol
Hydrocarbon derivative
Organic oxide
Organic oxygen compound
Carbonyl group
Organooxygen compound
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	354 g/L	ALOGPS
logP	-0.46	ALOGPS
logP	-0.31	ChemAxon
logS	0.36	ALOGPS
pKa (Strongest Acidic)	14.3	ChemAxon
pKa (Strongest Basic)	-3.1	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	55.76 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	34.73 m³·mol⁻¹	ChemAxon
Polarizability	13.86 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

This table shows at most 5 pathways. For the full list of associated pathways:

See All Associated Bacterial Pathways

Name	SMPDB/PathBank	Species

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	2	Human feces	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

C00023991

Chemspider ID

61604698

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

14841096

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

References

Synthesis Reference

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Oxysporone (MMDBc0012713)

MOL for #<Metabolite:0x0000564fa03803b0>

3D MOL for #<Metabolite:0x0000564fa03803b0>

3D SDF for #<Metabolite:0x0000564fa03803b0>

3D-SDF for #<Metabolite:0x0000564fa03803b0>

PDB for #<Metabolite:0x0000564fa03803b0>

3D PDB for #<Metabolite:0x0000564fa03803b0>

SMILES for #<Metabolite:0x0000564fa03803b0>

INCHI for #<Metabolite:0x0000564fa03803b0>

Structure for #<Metabolite:0x0000564fa03803b0>

3D Structure for #<Metabolite:0x0000564fa03803b0>