MiMeDB: Showing metabocard for Trichodiene (MMDBc0012894)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-05-15 04:18:59 UTC

Update Date

2025-10-07 16:06:03 UTC

Metabolite ID

MMDBc0012894

Metabolite Identification

Common Name

Trichodiene

Description

Trichodiene is a tetracyclic sesquiterpene compound classified within the chemical class of terpenes. It serves as a significant metabolite in the biosynthesis of trichothecene mycotoxins, particularly in fungi such as Fusarium. The biosynthetic pathway begins with the cyclization of farnesyl pyrophosphate to form trichodiene, which is subsequently modified through oxygenation to produce isotrichotriol (PMID:38673874 ). The enzyme trichodiene synthase (Tri5) plays a crucial role in this process, and its expression can be influenced by various factors, including histone deacetylase activity (PMID:39737208 ). Recent studies have identified a unique family of trichodiene synthase-like sesquiterpene synthases (TDTSs) specific to fungi, highlighting the evolutionary significance of these enzymes in fungal metabolism (PMID:38786705 ). Furthermore, the presence of mycoviruses in certain fungal strains has been shown to suppress the synthesis of trichodiene and its related mycotoxins, indicating a complex interplay between viral infection and fungal secondary metabolism (PMID:4027 ...). Overall, trichodiene is a pivotal compound in the study of fungal biology and mycotoxin biosynthesis.

Structure

MOL SDF PDB SMILES InChI

 
  Mrv1533006081518272D          
 
 15 16  0  0  1  0            999 V2000
   14.0195   -9.1611    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   12.7037   -9.1611    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   14.5022   -9.8285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.5022   -8.4937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5972   -8.4447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.2964   -8.4447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.2927   -9.8814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1445   -9.9036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.2789   -9.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2494  -10.6502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.2827   -8.7577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4632   -8.4523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4707   -9.8851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0521   -9.1686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2713   -9.1762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  6  0  0  0
  2  6  1  0  0  0  0
  2  7  1  0  0  0  0
  2  8  1  1  0  0  0
  3  9  1  0  0  0  0
  3 10  2  0  0  0  0
  4 11  1  0  0  0  0
  6 12  1  0  0  0  0
  7 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
  9 11  1  0  0  0  0
 13 14  2  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0012894

> <DATABASE_NAME>
MIME

> <SMILES>
CC1=CC[C@](C)(CC1)[C@@]1(C)CCCC1=C

> <INCHI_IDENTIFIER>
InChI=1S/C15H24/c1-12-7-10-14(3,11-8-12)15(4)9-5-6-13(15)2/h7H,2,5-6,8-11H2,1,3-4H3/t14-,15+/m1/s1

> <INCHI_KEY>
YFLSTROSSKYYNK-CABCVRRESA-N

> <FORMULA>
C15H24

> <MOLECULAR_WEIGHT>
204.357

> <EXACT_MASS>
204.187800773

> <JCHEM_ACCEPTOR_COUNT>
0

> <JCHEM_ATOM_COUNT>
39

> <JCHEM_AVERAGE_POLARIZABILITY>
25.2720847458581

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(4S)-1,4-dimethyl-4-[(1S)-1-methyl-2-methylidenecyclopentyl]cyclohex-1-ene

> <ALOGPS_LOGP>
6.03

> <JCHEM_LOGP>
4.532337415333334

> <ALOGPS_LOGS>
-5.10

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_POLAR_SURFACE_AREA>
0.0

> <JCHEM_REFRACTIVITY>
67.37889999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.64e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
trichodiene

> <JCHEM_VEBER_RULE>
1

$$$$

HEADER    PROTEIN                                 08-JUN-15   NONE
TITLE     NULL                                                        
COMPND    MOLECULE:                                                   
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   08-JUN-15         0                                  
HETATM    1  C   UNK     0      26.170 -17.101   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      23.714 -17.101   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      27.071 -18.347   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      27.071 -15.855   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      25.381 -15.763   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      22.953 -15.763   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      22.946 -18.445   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      24.536 -18.487   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      28.521 -17.861   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      26.599 -19.880   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      28.528 -16.348   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      21.398 -15.778   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      21.412 -18.452   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      20.631 -17.115   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      19.173 -17.129   0.000  0.00  0.00           C+0
CONECT    1    2    3    4    5                                             
CONECT    2    1    6    7    8                                             
CONECT    3    1    9   10                                                  
CONECT    4    1   11                                                       
CONECT    5    1                                                            
CONECT    6    2   12                                                       
CONECT    7    2   13                                                       
CONECT    8    2                                                            
CONECT    9    3   11                                                       
CONECT   10    3                                                            
CONECT   11    4    9                                                       
CONECT   12    6   14                                                       
CONECT   13    7   14                                                       
CONECT   14   12   15   13                                                  
CONECT   15   14                                                            
MASTER        0    0    0    0    0    0    0    0   15    0   32    0
END

Synonyms

Value	Source
1,4-Dimethyl-4-(1-methyl-2-methylenecyclopentyl)cyclohexene	ChEBI

Molecular Formula

C₁₅H₂₄

Average Mass

204.357

Monoisotopic Mass

204.187800773

IUPAC Name

(4S)-1,4-dimethyl-4-[(1S)-1-methyl-2-methylidenecyclopentyl]cyclohex-1-ene

Traditional Name

trichodiene

CAS Registry Number

Not Available

SMILES

CC1=CC[C@](C)(CC1)[C@@]1(C)CCCC1=C

InChI Identifier

InChI=1S/C15H24/c1-12-7-10-14(3,11-8-12)15(4)9-5-6-13(15)2/h7H,2,5-6,8-11H2,1,3-4H3/t14-,15+/m1/s1

InChI Key

YFLSTROSSKYYNK-CABCVRRESA-N

Chemical Taxonomy

Description

This compound belongs to the class of organic compounds known as cycloalkenes. These are unsaturated monocyclic hydrocarbons having one endocyclic double bond.

Kingdom

Organic compounds

Super Class

Hydrocarbons

Class

Unsaturated hydrocarbons

Sub Class

Olefins

Direct Parent

Cycloalkenes

Alternative Parents

Unsaturated aliphatic hydrocarbons

Substituents

Cycloalkene
Unsaturated aliphatic hydrocarbon
Aliphatic homomonocyclic compound

Molecular Framework

Aliphatic homomonocyclic compounds

External Descriptors

sesquiterpene (CHEBI:15861 )
Trichothecane sesquiterpenoids (C01860 )
Bisabolanes (C01860 )
Trichothecane sesquiterpenoids (LMPR0103180001 )

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.0016 g/L	ALOGPS
logP	6.03	ALOGPS
logP	4.53	ChemAxon
logS	-5.1	ALOGPS
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	0	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	0 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	67.38 m³·mol⁻¹	ChemAxon
Polarizability	25.27 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

This table shows at most 5 pathways. For the full list of associated pathways:

See All Associated Bacterial Pathways

Name	SMPDB/PathBank	Species

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	19	Human feces	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

102815

KEGG Compound ID

C01860

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

114857

PDB ID

Not Available

ChEBI ID

15861

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

References

Synthesis Reference

Not Available

General References

Bansal P, Morgat A, Axelsen KB, Muthukrishnan V, Coudert E, Aimo L, Hyka-Nouspikel N, Gasteiger E, Kerhornou A, Neto TB, Pozzato M, Blatter MC, Ignatchenko A, Redaschi N, Bridge A: Rhea, the reaction knowledgebase in 2022. Nucleic Acids Res. 2022 Jan 7;50(D1):D693-D700. doi: 10.1093/nar/gkab1016. [PubMed:34755880 ]

Showing metabocard for Trichodiene (MMDBc0012894)

MOL for #<Metabolite:0x00007f2a9a088a60>

3D MOL for #<Metabolite:0x00007f2a9a088a60>

3D SDF for #<Metabolite:0x00007f2a9a088a60>

3D-SDF for #<Metabolite:0x00007f2a9a088a60>

PDB for #<Metabolite:0x00007f2a9a088a60>

3D PDB for #<Metabolite:0x00007f2a9a088a60>

SMILES for #<Metabolite:0x00007f2a9a088a60>

INCHI for #<Metabolite:0x00007f2a9a088a60>

Structure for #<Metabolite:0x00007f2a9a088a60>

3D Structure for #<Metabolite:0x00007f2a9a088a60>