MiMeDB: Showing metabocard for Pyranonigrin A (MMDBc0013140)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-05-15 04:30:25 UTC

Update Date

2025-10-07 16:06:05 UTC

Metabolite ID

MMDBc0013140

Metabolite Identification

Common Name

Pyranonigrin A

Description

Pyranonigrin A is a secondary metabolite belonging to the chemical class of alkaloids. This compound has garnered attention for its antioxidant properties and its role in the metabolic pathways of various fungal species, particularly in the genus Aspergillus. Research indicates that pyranonigrin A production can be influenced by environmental factors, such as temperature, with studies showing a decrease in its levels alongside other metabolites when temperatures rise (PMID:40354730 ). Notably, it has been isolated from the mangrove endophytic fungus Aspergillus fumigatus SAS10, alongside other alkaloids (PMID:37874626 ). Furthermore, its production was significantly induced in strains regrown in space conditions, highlighting its potential for biotechnological applications (PMID:35847112 ). Chemical investigations of fermented cultures have also confirmed its presence among other compounds (PMID:35744888 ). Recent studies have elucidated the biosynthetic pathways of pyranonigrin A, demonstrating its regulation by specific genetic elements (PMID:32670208 ). Overall, pyranonigrin A represents a fascinating subject of study due to its diverse biological activities and its significance in fungal metabolism.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652305152106302D          

 19 20  0  0  1  0            999 V2000
    4.7812   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.5396    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.1104    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7221    0.2721    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  3  2  2  0  0  0  0
  4  3  1  0  0  0  0
  6  4  2  0  0  0  0
  7  5  1  0  0  0  0
  7  6  1  0  0  0  0
  8  5  2  0  0  0  0
  9  5  1  0  0  0  0
 10  8  1  0  0  0  0
 11  9  2  0  0  0  0
 11 10  1  0  0  0  0
 12  6  1  0  0  0  0
 13  7  2  0  0  0  0
 14  9  1  0  0  0  0
 10 15  1  1  0  0  0
 16  4  1  0  0  0  0
 16  8  1  0  0  0  0
 17  2  1  0  0  0  0
 18  3  1  0  0  0  0
 10 19  1  6  0  0  0
M  END
> <DATABASE_ID>
MMDBc0013140

> <DATABASE_NAME>
MIME

> <SMILES>
[H]\C(C)=C(\[H])C1=C(O)C(=O)C2=C(O1)[C@@]([H])(O)N=C2O

> <INCHI_IDENTIFIER>
InChI=1S/C10H9NO5/c1-2-3-4-6(12)7(13)5-8(16-4)10(15)11-9(5)14/h2-3,10,12,15H,1H3,(H,11,14)/b3-2+/t10-/m1/s1

> <INCHI_KEY>
OALBJWDVDNROSF-VMZHVLLKSA-N

> <FORMULA>
C10H9NO5

> <MOLECULAR_WEIGHT>
223.184

> <EXACT_MASS>
223.048072394

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
25

> <JCHEM_AVERAGE_POLARIZABILITY>
21.04125982960709

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(7R)-3,5,7-trihydroxy-2-[(1E)-prop-1-en-1-yl]-4H,7H-pyrano[2,3-c]pyrrol-4-one

> <ALOGPS_LOGP>
-0.39

> <JCHEM_LOGP>
0.4406013203333331

> <ALOGPS_LOGS>
-1.85

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
9.494549588077835

> <JCHEM_PKA_STRONGEST_ACIDIC>
3.203537330954827

> <JCHEM_PKA_STRONGEST_BASIC>
-2.94254194018805

> <JCHEM_POLAR_SURFACE_AREA>
99.35000000000001

> <JCHEM_REFRACTIVITY>
57.25590000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
3.12e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(7R)-3,5,7-trihydroxy-2-[(1E)-prop-1-en-1-yl]-7H-pyrano[2,3-c]pyrrol-4-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 15-MAY-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-MAY-21         0                                  
HETATM    1  C   UNK     0       8.925  -1.007   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       7.591  -0.237   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       7.591   1.303   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       6.258   2.073   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       3.590   3.613   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       6.258   3.613   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       4.924   4.383   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       3.590   2.073   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       2.126   4.089   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       2.126   1.597   0.000  0.00  0.00           C+0
HETATM   11  N   UNK     0       1.220   2.843   0.000  0.00  0.00           N+0
HETATM   12  O   UNK     0       7.591   4.383   0.000  0.00  0.00           O+0
HETATM   13  O   UNK     0       4.924   5.923   0.000  0.00  0.00           O+0
HETATM   14  O   UNK     0       1.650   5.553   0.000  0.00  0.00           O+0
HETATM   15  O   UNK     0       1.650   0.132   0.000  0.00  0.00           O+0
HETATM   16  O   UNK     0       4.924   1.303   0.000  0.00  0.00           O+0
HETATM   17  H   UNK     0       6.258  -1.007   0.000  0.00  0.00           H+0
HETATM   18  H   UNK     0       8.925   2.073   0.000  0.00  0.00           H+0
HETATM   19  H   UNK     0       3.215   0.508   0.000  0.00  0.00           H+0
CONECT    1    2                                                            
CONECT    2    1    3   17                                                  
CONECT    3    2    4   18                                                  
CONECT    4    3    6   16                                                  
CONECT    5    7    8    9                                                  
CONECT    6    4    7   12                                                  
CONECT    7    5    6   13                                                  
CONECT    8    5   10   16                                                  
CONECT    9    5   11   14                                                  
CONECT   10    8   11   15   19                                             
CONECT   11    9   10                                                       
CONECT   12    6                                                            
CONECT   13    7                                                            
CONECT   14    9                                                            
CONECT   15   10                                                            
CONECT   16    4    8                                                       
CONECT   17    2                                                            
CONECT   18    3                                                            
CONECT   19   10                                                            
MASTER        0    0    0    0    0    0    0    0   19    0   40    0
END

Synonyms

Value	Source
(7R)-3,7-Dihydroxy-2-((1E)-prop-1-enyl)-6,7-dihydropyrano(2,3-c)pyrrole-4,5-dione	MeSH

Molecular Formula

C₁₀H₉NO₅

Average Mass

223.184

Monoisotopic Mass

223.048072394

IUPAC Name

(7R)-3,5,7-trihydroxy-2-[(1E)-prop-1-en-1-yl]-4H,7H-pyrano[2,3-c]pyrrol-4-one

Traditional Name

(7R)-3,5,7-trihydroxy-2-[(1E)-prop-1-en-1-yl]-7H-pyrano[2,3-c]pyrrol-4-one

CAS Registry Number

Not Available

SMILES

[H]\C(C)=C(\[H])C1=C(O)C(=O)C2=C(O1)[C@@]([H])(O)N=C2O

InChI Identifier

InChI=1S/C10H9NO5/c1-2-3-4-6(12)7(13)5-8(16-4)10(15)11-9(5)14/h2-3,10,12,15H,1H3,(H,11,14)/b3-2+/t10-/m1/s1

InChI Key

OALBJWDVDNROSF-VMZHVLLKSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as pyranones and derivatives. Pyranones and derivatives are compounds containing a pyran ring which bears a ketone.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Pyrans

Sub Class

Pyranones and derivatives

Direct Parent

Pyranones and derivatives

Alternative Parents

Substituents

Pyranone
Heteroaromatic compound
Carboxamide group
Lactam
Secondary carboxylic acid amide
Oxacycle
Azacycle
Alkanolamine
Carboxylic acid derivative
Organic oxygen compound
Organic nitrogen compound
Organooxygen compound
Organonitrogen compound
Hydrocarbon derivative
Organic oxide
Organopnictogen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	3.12 g/L	ALOGPS
logP	-0.39	ALOGPS
logP	0.44	ChemAxon
logS	-1.8	ALOGPS
pKa (Strongest Acidic)	3.2	ChemAxon
pKa (Strongest Basic)	-2.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	99.35 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	57.26 m³·mol⁻¹	ChemAxon
Polarizability	21.04 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_3) - 70eV, Positive	Not Available	2022-08-08	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	Not Available	2022-08-10	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	Not Available	2022-08-10	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	Not Available	2022-08-10	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	Not Available	2022-08-10	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	Not Available	2022-08-10	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	Not Available	2022-08-10	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-20	View Spectrum

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

This table shows at most 5 pathways. For the full list of associated pathways:

See All Associated Bacterial Pathways

Name	SMPDB/PathBank	Species

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	2	Human sputum; Human feces; Human	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

C00040123

Chemspider ID

23076409

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

16756786

PDB ID

Not Available

ChEBI ID

133779

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

References

Synthesis Reference

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Pyranonigrin A (MMDBc0013140)

MOL for #<Metabolite:0x00007f6d613b6e08>

3D MOL for #<Metabolite:0x00007f6d613b6e08>

3D SDF for #<Metabolite:0x00007f6d613b6e08>

3D-SDF for #<Metabolite:0x00007f6d613b6e08>

PDB for #<Metabolite:0x00007f6d613b6e08>

3D PDB for #<Metabolite:0x00007f6d613b6e08>

SMILES for #<Metabolite:0x00007f6d613b6e08>

INCHI for #<Metabolite:0x00007f6d613b6e08>

Structure for #<Metabolite:0x00007f6d613b6e08>

3D Structure for #<Metabolite:0x00007f6d613b6e08>