MiMeDB: Showing metabocard for Pyranonigrin E (MMDBc0013982)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-05-15 05:08:52 UTC

Update Date

2025-10-07 16:06:13 UTC

Metabolite ID

MMDBc0013982

Metabolite Identification

Common Name

Pyranonigrin E

Description

Pyranonigrin E is a polyketide-nonribosomal peptide synthase (PKS-NRPS) hybrid metabolite derived from the fungus Aspergillus niger. It is part of a broader class of secondary metabolites produced by various Penicillium and Aspergillus species, which are known for their diverse biosynthetic gene clusters (BGCs). Genome mining has revealed that pyranonigrin E is encoded within conserved BGCs, indicating its significance in the metabolic pathways of these fungi (PMID:34947073 ). Studies have identified pyranonigrin E alongside other metabolites such as clavaric acid and dimethyl coprogen, suggesting a complex interplay of biosynthetic capabilities among fungal strains (PMID:37208988 ). The isolation of pyranonigrin E has prompted further biosynthetic investigations, particularly in relation to its structural analogs, which may exhibit various biological activities (PMID:24084681 ). Additionally, the identification of pyranonigrin E through genome mining highlights its potential relevance in the study of fungal metabolites and their applications in biotechnology and pharmacology (PMID:24106156 ). Overall, pyranonigrin E exemplifies the intricate chemistry of fungal secondary metabolites and their potential utility in various fields.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652305152107082D          

 27 28  0  0  0  0            999 V2000
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6119   -3.4979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6669   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -4.2826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -5.6174    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8419   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6119   -6.4021    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -3.3000    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  4  1  1  0  0  0  0
  5  4  1  0  0  0  0
  6  5  1  0  0  0  0
  7  6  1  0  0  0  0
  8  7  1  0  0  0  0
  9  8  2  0  0  0  0
 10  9  1  0  0  0  0
 11 10  2  0  0  0  0
 12  2  2  0  0  0  0
 13 11  1  0  0  0  0
 15 13  2  0  0  0  0
 16 14  1  0  0  0  0
 16 15  1  0  0  0  0
 17 12  1  0  0  0  0
 17 14  2  0  0  0  0
 18 14  1  0  0  0  0
 19  3  1  0  0  0  0
 19 12  1  0  0  0  0
 19 18  1  0  0  0  0
 20 15  1  0  0  0  0
 21 16  2  0  0  0  0
 22 18  2  0  0  0  0
 23 13  1  0  0  0  0
 23 17  1  0  0  0  0
 24  8  1  0  0  0  0
 25  9  1  0  0  0  0
 26 10  1  0  0  0  0
 27 11  1  0  0  0  0
M  END


  Mrv1652305152107082D          

 27 28  0  0  0  0            999 V2000
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6119   -3.4979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6669   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -4.2826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -5.6174    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8419   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6119   -6.4021    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -3.3000    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  4  1  1  0  0  0  0
  5  4  1  0  0  0  0
  6  5  1  0  0  0  0
  7  6  1  0  0  0  0
  8  7  1  0  0  0  0
  9  8  2  0  0  0  0
 10  9  1  0  0  0  0
 11 10  2  0  0  0  0
 12  2  2  0  0  0  0
 13 11  1  0  0  0  0
 15 13  2  0  0  0  0
 16 14  1  0  0  0  0
 16 15  1  0  0  0  0
 17 12  1  0  0  0  0
 17 14  2  0  0  0  0
 18 14  1  0  0  0  0
 19  3  1  0  0  0  0
 19 12  1  0  0  0  0
 19 18  1  0  0  0  0
 20 15  1  0  0  0  0
 21 16  2  0  0  0  0
 22 18  2  0  0  0  0
 23 13  1  0  0  0  0
 23 17  1  0  0  0  0
 24  8  1  0  0  0  0
 25  9  1  0  0  0  0
 26 10  1  0  0  0  0
 27 11  1  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0013982

> <DATABASE_NAME>
MIME

> <SMILES>
[H]\C(CCCCC)=C(\[H])/C(/[H])=C(\[H])C1=C(O)C(=O)C2=C(O1)C(=C)N(C)C2=O

> <INCHI_IDENTIFIER>
InChI=1S/C18H21NO4/c1-4-5-6-7-8-9-10-11-13-15(20)16(21)14-17(23-13)12(2)19(3)18(14)22/h8-11,20H,2,4-7H2,1,3H3/b9-8+,11-10+

> <INCHI_KEY>
ITJJIMKGOLMIJY-BNFZFUHLSA-N

> <FORMULA>
C18H21NO4

> <MOLECULAR_WEIGHT>
315.369

> <EXACT_MASS>
315.14705816

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
44

> <JCHEM_AVERAGE_POLARIZABILITY>
35.5696176277011

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
3-hydroxy-6-methyl-7-methylidene-2-[(1E,3E)-nona-1,3-dien-1-yl]-4H,5H,6H,7H-pyrano[2,3-c]pyrrole-4,5-dione

> <ALOGPS_LOGP>
3.40

> <JCHEM_LOGP>
2.7345933559999995

> <ALOGPS_LOGS>
-4.21

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
9.11624176735213

> <JCHEM_PKA_STRONGEST_BASIC>
-3.740815850960204

> <JCHEM_POLAR_SURFACE_AREA>
66.84

> <JCHEM_REFRACTIVITY>
94.08629999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.93e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
3-hydroxy-6-methyl-7-methylidene-2-[(1E,3E)-nona-1,3-dien-1-yl]pyrano[2,3-c]pyrrole-4,5-dione

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 15-MAY-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-MAY-21         0                                  
HETATM    1  C   UNK     0      -8.002  -7.700   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       8.609  -6.529   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      10.578  -9.240   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -6.668  -8.470   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -5.335  -7.700   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -4.001  -8.470   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -2.667  -7.700   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -1.334  -8.470   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -0.000  -7.700   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       1.334  -8.470   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       2.667  -7.700   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       8.133  -7.994   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       4.001  -8.470   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       6.668 -10.010   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       4.001 -10.010   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       5.335 -10.780   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       6.668  -8.470   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       8.133 -10.486   0.000  0.00  0.00           C+0
HETATM   19  N   UNK     0       9.038  -9.240   0.000  0.00  0.00           N+0
HETATM   20  O   UNK     0       2.667 -10.780   0.000  0.00  0.00           O+0
HETATM   21  O   UNK     0       5.335 -12.320   0.000  0.00  0.00           O+0
HETATM   22  O   UNK     0       8.609 -11.951   0.000  0.00  0.00           O+0
HETATM   23  O   UNK     0       5.335  -7.700   0.000  0.00  0.00           O+0
HETATM   24  H   UNK     0      -1.334 -10.010   0.000  0.00  0.00           H+0
HETATM   25  H   UNK     0      -0.000  -6.160   0.000  0.00  0.00           H+0
HETATM   26  H   UNK     0       1.334 -10.010   0.000  0.00  0.00           H+0
HETATM   27  H   UNK     0       2.667  -6.160   0.000  0.00  0.00           H+0
CONECT    1    4                                                            
CONECT    2   12                                                            
CONECT    3   19                                                            
CONECT    4    1    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9   24                                                  
CONECT    9    8   10   25                                                  
CONECT   10    9   11   26                                                  
CONECT   11   10   13   27                                                  
CONECT   12    2   17   19                                                  
CONECT   13   11   15   23                                                  
CONECT   14   16   17   18                                                  
CONECT   15   13   16   20                                                  
CONECT   16   14   15   21                                                  
CONECT   17   12   14   23                                                  
CONECT   18   14   19   22                                                  
CONECT   19    3   12   18                                                  
CONECT   20   15                                                            
CONECT   21   16                                                            
CONECT   22   18                                                            
CONECT   23   13   17                                                       
CONECT   24    8                                                            
CONECT   25    9                                                            
CONECT   26   10                                                            
CONECT   27   11                                                            
MASTER        0    0    0    0    0    0    0    0   27    0   56    0
END

Synonyms

Not Available

Molecular Formula

C₁₈H₂₁NO₄

Average Mass

315.369

Monoisotopic Mass

315.14705816

IUPAC Name

3-hydroxy-6-methyl-7-methylidene-2-[(1E,3E)-nona-1,3-dien-1-yl]-4H,5H,6H,7H-pyrano[2,3-c]pyrrole-4,5-dione

Traditional Name

3-hydroxy-6-methyl-7-methylidene-2-[(1E,3E)-nona-1,3-dien-1-yl]pyrano[2,3-c]pyrrole-4,5-dione

CAS Registry Number

Not Available

SMILES

[H]\C(CCCCC)=C(\[H])/C(/[H])=C(\[H])C1=C(O)C(=O)C2=C(O1)C(=C)N(C)C2=O

InChI Identifier

InChI=1S/C18H21NO4/c1-4-5-6-7-8-9-10-11-13-15(20)16(21)14-17(23-13)12(2)19(3)18(14)22/h8-11,20H,2,4-7H2,1,3H3/b9-8+,11-10+

InChI Key

ITJJIMKGOLMIJY-BNFZFUHLSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as pyranones and derivatives. Pyranones and derivatives are compounds containing a pyran ring which bears a ketone.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Pyrans

Sub Class

Pyranones and derivatives

Direct Parent

Pyranones and derivatives

Alternative Parents

Substituents

Pyranone
Heteroaromatic compound
Tertiary carboxylic acid amide
Lactam
Carboxamide group
Oxacycle
Azacycle
Carboxylic acid derivative
Organic nitrogen compound
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Organonitrogen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.019 g/L	ALOGPS
logP	3.4	ALOGPS
logP	2.73	ChemAxon
logS	-4.2	ALOGPS
pKa (Strongest Acidic)	9.12	ChemAxon
pKa (Strongest Basic)	-3.7	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	66.84 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	94.09 m³·mol⁻¹	ChemAxon
Polarizability	35.57 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	1		Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

58827644

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

102128928

PDB ID

Not Available

ChEBI ID

133787

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Pyranonigrin E (MMDBc0013982)

MOL for #<Metabolite:0x00007f8dd0431a38>

3D MOL for #<Metabolite:0x00007f8dd0431a38>

3D SDF for #<Metabolite:0x00007f8dd0431a38>

3D-SDF for #<Metabolite:0x00007f8dd0431a38>

PDB for #<Metabolite:0x00007f8dd0431a38>

3D PDB for #<Metabolite:0x00007f8dd0431a38>

SMILES for #<Metabolite:0x00007f8dd0431a38>

INCHI for #<Metabolite:0x00007f8dd0431a38>

Structure for #<Metabolite:0x00007f8dd0431a38>

3D Structure for #<Metabolite:0x00007f8dd0431a38>