MiMeDB: Showing metabocard for Lavanduquinocin (MMDBc0014603)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-05-15 05:36:11 UTC

Update Date

2025-10-07 16:06:18 UTC

Metabolite ID

MMDBc0014603

Metabolite Identification

Common Name

Lavanduquinocin

Description

Lavanduquinocin is a potent neuroprotective carbazole alkaloid belonging to the chemical class of alkaloids, derived from Streptomyces species. This compound features a unique cyclic monoterpene/cyclolavandulyl moiety attached to its tricyclic carbazole nucleus, which contributes to its biological activity. The synthesis of lavanduquinocin has been achieved through various asymmetric synthetic routes, including the use of lipase-catalyzed reactions and transition metal complexes, highlighting its complex chemical structure (PMID:36608315 , PMID:17603201 , PMID:10824182 ). Notably, lavanduquinocin has demonstrated significant neuroprotective effects, as evidenced by its ability to protect neuronal hybridoma N18-RE-105 cells from L-glutamate toxicity, with an effective concentration (EC50) of 15.5 nM (PMID:7649853 ). This highlights its potential therapeutic applications in neurodegenerative conditions. The compound was first isolated from Streptomyces viridochromogenes, underscoring the importance of microbial sources in discovering novel neuroprotective agents (PMID:7649853 ). Overall, lavanduquinocin represents a promising candidate in the field of neuroprotection and synthetic organic chemistry.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652305152107362D          

 31 34  0  0  1  0            999 V2000
    2.6435    1.9817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8573   -2.1129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.0694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8017    4.7575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7930    4.4297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5546    3.0364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2996    3.8210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2046   -1.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9406    3.3795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1956    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6024   -1.3283    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0025    2.4233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4927    3.9926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1544   -0.7152    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896    1.6387    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2243    1.9817    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0503   -1.9414    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  7  6  2  0  0  0  0
  9  8  1  0  0  0  0
 14  1  1  0  0  0  0
 14 13  1  0  0  0  0
 15  2  1  0  0  0  0
 15 10  1  0  0  0  0
 16  3  1  0  0  0  0
 17  6  1  0  0  0  0
 17 11  1  0  0  0  0
 17 12  2  0  0  0  0
 18  8  1  0  0  0  0
 18 11  1  0  0  0  0
 18 14  2  0  0  0  0
 19 10  1  0  0  0  0
 19 16  2  0  0  0  0
 20 12  1  0  0  0  0
 21  7  1  0  0  0  0
 21 20  2  0  0  0  0
 22 20  1  0  0  0  0
 23 19  1  0  0  0  0
 23 22  2  0  0  0  0
 24 16  1  0  0  0  0
 25 22  1  0  0  0  0
 25 24  1  0  0  0  0
 26  4  1  0  0  0  0
 26  5  1  0  0  0  0
 26  9  1  0  0  0  0
 26 13  1  0  0  0  0
 27 21  1  0  0  0  0
 27 23  1  0  0  0  0
 15 28  1  6  0  0  0
 29 24  2  0  0  0  0
 30 25  2  0  0  0  0
 15 31  1  6  0  0  0
M  END


  Mrv1652305152107362D          

 31 34  0  0  1  0            999 V2000
    2.6435    1.9817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8573   -2.1129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.0694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8017    4.7575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7930    4.4297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5546    3.0364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2996    3.8210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2046   -1.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9406    3.3795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1956    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6024   -1.3283    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0025    2.4233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4927    3.9926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1544   -0.7152    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896    1.6387    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2243    1.9817    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0503   -1.9414    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  7  6  2  0  0  0  0
  9  8  1  0  0  0  0
 14  1  1  0  0  0  0
 14 13  1  0  0  0  0
 15  2  1  0  0  0  0
 15 10  1  0  0  0  0
 16  3  1  0  0  0  0
 17  6  1  0  0  0  0
 17 11  1  0  0  0  0
 17 12  2  0  0  0  0
 18  8  1  0  0  0  0
 18 11  1  0  0  0  0
 18 14  2  0  0  0  0
 19 10  1  0  0  0  0
 19 16  2  0  0  0  0
 20 12  1  0  0  0  0
 21  7  1  0  0  0  0
 21 20  2  0  0  0  0
 22 20  1  0  0  0  0
 23 19  1  0  0  0  0
 23 22  2  0  0  0  0
 24 16  1  0  0  0  0
 25 22  1  0  0  0  0
 25 24  1  0  0  0  0
 26  4  1  0  0  0  0
 26  5  1  0  0  0  0
 26  9  1  0  0  0  0
 26 13  1  0  0  0  0
 27 21  1  0  0  0  0
 27 23  1  0  0  0  0
 15 28  1  6  0  0  0
 29 24  2  0  0  0  0
 30 25  2  0  0  0  0
 15 31  1  6  0  0  0
M  END
> <DATABASE_ID>
MMDBc0014603

> <DATABASE_NAME>
MIME

> <SMILES>
[H][C@](C)(O)CC1=C(C)C(=O)C(=O)C2=C1NC1=C2C=C(CC2=C(C)CC(C)(C)CC2)C=C1

> <INCHI_IDENTIFIER>
InChI=1S/C26H31NO3/c1-14-13-26(4,5)9-8-18(14)11-17-6-7-21-20(12-17)22-23(27-21)19(10-15(2)28)16(3)24(29)25(22)30/h6-7,12,15,27-28H,8-11,13H2,1-5H3/t15-/m1/s1

> <INCHI_KEY>
OKMZLNWBACAZGV-OAHLLOKOSA-N

> <FORMULA>
C26H31NO3

> <MOLECULAR_WEIGHT>
405.538

> <EXACT_MASS>
405.230393862

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
61

> <JCHEM_AVERAGE_POLARIZABILITY>
46.88395217605759

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
1-[(2R)-2-hydroxypropyl]-2-methyl-6-[(2,4,4-trimethylcyclohex-1-en-1-yl)methyl]-4,9-dihydro-3H-carbazole-3,4-dione

> <ALOGPS_LOGP>
4.21

> <JCHEM_LOGP>
5.328878359333334

> <ALOGPS_LOGS>
-5.54

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
15.594081297796397

> <JCHEM_PKA_STRONGEST_ACIDIC>
11.420330213232461

> <JCHEM_PKA_STRONGEST_BASIC>
-2.541108080519672

> <JCHEM_POLAR_SURFACE_AREA>
70.16

> <JCHEM_REFRACTIVITY>
121.66489999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
1.16e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
1-[(2R)-2-hydroxypropyl]-2-methyl-6-[(2,4,4-trimethylcyclohex-1-en-1-yl)methyl]-9H-carbazole-3,4-dione

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 15-MAY-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-MAY-21         0                                  
HETATM    1  C   UNK     0       4.935   3.699   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -1.600  -3.944   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -1.679   0.130   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       7.097   8.881   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       5.214   8.269   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       7.393   0.450   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       6.362  -0.695   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       8.502   5.668   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       8.026   7.133   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       0.382  -2.159   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       7.947   3.059   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       5.410   2.235   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       5.489   6.308   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       5.965   4.844   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      -1.124  -2.479   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      -0.173   0.450   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       6.917   1.914   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       7.471   4.524   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       0.858  -0.695   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       4.380   1.090   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       4.856  -0.374   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       2.840   1.090   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       2.364  -0.374   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       0.303   1.914   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       1.810   2.235   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       6.520   7.453   0.000  0.00  0.00           C+0
HETATM   27  N   UNK     0       3.610  -1.280   0.000  0.00  0.00           N+0
HETATM   28  O   UNK     0      -2.155  -1.335   0.000  0.00  0.00           O+0
HETATM   29  O   UNK     0      -0.727   3.059   0.000  0.00  0.00           O+0
HETATM   30  O   UNK     0       2.285   3.699   0.000  0.00  0.00           O+0
HETATM   31  H   UNK     0      -0.094  -3.624   0.000  0.00  0.00           H+0
CONECT    1   14                                                            
CONECT    2   15                                                            
CONECT    3   16                                                            
CONECT    4   26                                                            
CONECT    5   26                                                            
CONECT    6    7   17                                                       
CONECT    7    6   21                                                       
CONECT    8    9   18                                                       
CONECT    9    8   26                                                       
CONECT   10   15   19                                                       
CONECT   11   17   18                                                       
CONECT   12   17   20                                                       
CONECT   13   14   26                                                       
CONECT   14    1   13   18                                                  
CONECT   15    2   10   28   31                                             
CONECT   16    3   19   24                                                  
CONECT   17    6   11   12                                                  
CONECT   18    8   11   14                                                  
CONECT   19   10   16   23                                                  
CONECT   20   12   21   22                                                  
CONECT   21    7   20   27                                                  
CONECT   22   20   23   25                                                  
CONECT   23   19   22   27                                                  
CONECT   24   16   25   29                                                  
CONECT   25   22   24   30                                                  
CONECT   26    4    5    9   13                                             
CONECT   27   21   23                                                       
CONECT   28   15                                                            
CONECT   29   24                                                            
CONECT   30   25                                                            
CONECT   31   15                                                            
MASTER        0    0    0    0    0    0    0    0   31    0   68    0
END

Synonyms

Not Available

Molecular Formula

C₂₆H₃₁NO₃

Average Mass

405.538

Monoisotopic Mass

405.230393862

IUPAC Name

1-[(2R)-2-hydroxypropyl]-2-methyl-6-[(2,4,4-trimethylcyclohex-1-en-1-yl)methyl]-4,9-dihydro-3H-carbazole-3,4-dione

Traditional Name

1-[(2R)-2-hydroxypropyl]-2-methyl-6-[(2,4,4-trimethylcyclohex-1-en-1-yl)methyl]-9H-carbazole-3,4-dione

CAS Registry Number

Not Available

SMILES

[H][C@](C)(O)CC1=C(C)C(=O)C(=O)C2=C1NC1=C2C=C(CC2=C(C)CC(C)(C)CC2)C=C1

InChI Identifier

InChI=1S/C26H31NO3/c1-14-13-26(4,5)9-8-18(14)11-17-6-7-21-20(12-17)22-23(27-21)19(10-15(2)28)16(3)24(29)25(22)30/h6-7,12,15,27-28H,8-11,13H2,1-5H3/t15-/m1/s1

InChI Key

OKMZLNWBACAZGV-OAHLLOKOSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as carbazoles. Carbazoles are compounds containing a three ring system containing a pyrrole ring fused on either side to a benzene ring.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Indoles and derivatives

Sub Class

Carbazoles

Direct Parent

Carbazoles

Alternative Parents

Substituents

Carbazole
Indole
Aryl ketone
Benzenoid
Pyrrole
Heteroaromatic compound
Vinylogous amide
Ketone
Secondary alcohol
Cyclic ketone
Azacycle
Organic oxide
Organooxygen compound
Organonitrogen compound
Alcohol
Organic oxygen compound
Carbonyl group
Organic nitrogen compound
Hydrocarbon derivative
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.0012 g/L	ALOGPS
logP	4.21	ALOGPS
logP	5.33	ChemAxon
logS	-5.5	ALOGPS
pKa (Strongest Acidic)	11.42	ChemAxon
pKa (Strongest Basic)	-2.5	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	70.16 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	121.66 m³·mol⁻¹	ChemAxon
Polarizability	46.88 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria	Actinobacteria	1		Metabolic reconstruction
Bacteria/Eubacteria	Actinobacteria	1		Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

C00016542

Chemspider ID

8562028

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

10386586

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Lavanduquinocin (MMDBc0014603)

MOL for #<Metabolite:0x00005560b0591cd8>

3D MOL for #<Metabolite:0x00005560b0591cd8>

3D SDF for #<Metabolite:0x00005560b0591cd8>

3D-SDF for #<Metabolite:0x00005560b0591cd8>

PDB for #<Metabolite:0x00005560b0591cd8>

3D PDB for #<Metabolite:0x00005560b0591cd8>

SMILES for #<Metabolite:0x00005560b0591cd8>

INCHI for #<Metabolite:0x00005560b0591cd8>

Structure for #<Metabolite:0x00005560b0591cd8>

3D Structure for #<Metabolite:0x00005560b0591cd8>