Showing metabocard for Staurosporine (MMDBc0014848)
Microbial
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| Version | 1.0 | ||||||||||||
| Status | Detected and Quantified | ||||||||||||
| Creation Date | 2021-05-15 05:47:31 UTC | ||||||||||||
| Update Date | 2022-08-12 19:59:48 UTC | ||||||||||||
| Metabolite ID | MMDBc0014848 | ||||||||||||
| Metabolite Identification | |||||||||||||
| Common Name | Staurosporine | ||||||||||||
| Description | Staurosporine, also known as STS, belongs to the class of organic compounds known as indolocarbazoles. These are polycyclic aromatic compounds containing an indole fused to a carbazole. It belongs to the most frequently isolated group of indolocarbazoles: Indolo(2,3-a)carbazoles. Staurosporine is a very strong basic compound (based on its pKa). Glucose is transformed to NTP-L-ristoamine by StaA/B/E/J/I/K which is then added on to the staurosporine aglycone at 1 indole N by StaG. This is followed by a nucleophilic attack between the indole nitrogens resulting in cyclization and then decarboxylation assisted by StaC exclusively forming staurosporine aglycone or K252c. The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. | ||||||||||||
| Structure |  | ||||||||||||
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| Molecular Formula | C28H26N4O3 | ||||||||||||
| Average Mass | 466.531 | ||||||||||||
| Monoisotopic Mass | 466.200490718 | ||||||||||||
| IUPAC Name | Not Available | ||||||||||||
| Traditional Name | Not Available | ||||||||||||
| CAS Registry Number | Not Available | ||||||||||||
| SMILES | Not Available | ||||||||||||
| InChI Identifier | InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | ||||||||||||
| InChI Key | HKSZLNNOFSGOKW-FYTWVXJKSA-N | ||||||||||||
| Chemical Taxonomy | |||||||||||||
| Description | Belongs to the class of organic compounds known as indolocarbazoles. These are polycyclic aromatic compounds containing an indole fused to a carbazole. | ||||||||||||
| Kingdom | Organic compounds | ||||||||||||
| Super Class | Organoheterocyclic compounds | ||||||||||||
| Class | Indoles and derivatives | ||||||||||||
| Sub Class | Carbazoles | ||||||||||||
| Direct Parent | Indolocarbazoles | ||||||||||||
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| Molecular Framework | Aromatic heteropolycyclic compounds | ||||||||||||
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| Physical Properties | |||||||||||||
| State | Expected Solid | ||||||||||||
| Predicted Properties | Not Available | ||||||||||||
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| Cellular Locations | Not Available | ||||||||||||
| Biospecimen Locations | Not Available | ||||||||||||
| Tissue Locations | Not Available | ||||||||||||
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| Pathways | This table shows at most 5 pathways. For the full list of associated pathways: See All Associated Bacterial Pathways
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Reactions This table shows at most 20 reactions. For the full list of associated reactions: See All Associated Reactions
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| External Links | |||||||||||||
| HMDB ID | Not Available | ||||||||||||
| DrugBank ID | DB02010 | ||||||||||||
| Phenol Explorer Compound ID | Not Available | ||||||||||||
| FooDB ID | Not Available | ||||||||||||
| KNApSAcK ID | C00018127 | ||||||||||||
| Chemspider ID | Not Available | ||||||||||||
| KEGG Compound ID | Not Available | ||||||||||||
| BioCyc ID | Not Available | ||||||||||||
| BiGG ID | Not Available | ||||||||||||
| Wikipedia Link | Staurosporine | ||||||||||||
| METLIN ID | Not Available | ||||||||||||
| PubChem Compound | 44259 | ||||||||||||
| PDB ID | Not Available | ||||||||||||
| ChEBI ID | 15738 | ||||||||||||
| Food Biomarker Ontology | Not Available | ||||||||||||
| CMMC Knowledgebase | Not Available | ||||||||||||
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| Synthesis Reference | Not Available | ||||||||||||
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