MiMeDB: Showing metabocard for Citreoviripyrone A (MMDBc0015085)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-05-15 05:59:10 UTC

Update Date

2025-10-07 16:06:21 UTC

Metabolite ID

MMDBc0015085

Metabolite Identification

Common Name

Citreoviripyrone A

Description

Citreoviripyrone A is a novel polyketide metabolite isolated from the mycelium of an endophytic fungus. This compound, along with citreoviripyrone B, citreomontanin, and (-)-citreoviridin, represents a unique class of secondary metabolites characterized by their complex polycyclic structures. The isolation of citreoviripyrone A highlights the diverse chemical repertoire of endophytic fungi, which are known to produce a variety of bioactive compounds with potential pharmaceutical applications. The structural elucidation and biological activities of such polyketides are of significant interest in the fields of medicinal chemistry and natural product research, as they may exhibit antimicrobial, antifungal, or anticancer properties. The discovery of citreoviripyrone A contributes to the understanding of fungal metabolites and their ecological roles, as well as their potential utility in drug development (PMID:23405967 ).

Structure

MOL SDF PDB SMILES InChI


  Mrv1652305152107592D          

 33 35  0  0  1  0            999 V2000
    3.8339    2.2135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4049   -0.2615    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4576   -2.3679    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2821    2.3843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4769    2.5979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8274   -3.7481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5148    0.6061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0982    0.0228    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2821    0.3926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8846   -0.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1194    0.9760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6347   -2.5242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4049    2.2135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1194    1.8010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4049    0.5635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2545   -2.1544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8655    1.8010    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.8655    0.9760    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.4680   -1.3575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8378   -2.7377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8482   -1.7273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6905    0.9760    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.6905    1.8010    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -3.6451   -1.5138    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6243   -3.5346    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2649   -1.1439    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7283    1.4030    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8950    0.2363    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4956   -0.4043    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0877   -0.9876    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1033    1.4853    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1812    0.2138    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4049    1.3885    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  8  7  1  0  0  0  0
  9  7  2  0  0  0  0
 10  8  2  0  0  0  0
 14  1  1  0  0  0  0
 14 11  1  0  0  0  0
 14 13  2  0  0  0  0
 15  2  1  0  0  0  0
 15 11  2  0  0  0  0
 16  3  1  0  0  0  0
 17  4  1  6  0  0  0
 18  9  1  1  0  0  0
 18 17  1  0  0  0  0
 19 10  1  0  0  0  0
 19 16  2  0  0  0  0
 20 12  2  0  0  0  0
 20 16  1  0  0  0  0
 21 12  1  0  0  0  0
 22 15  1  0  0  0  0
 22 18  1  0  0  0  0
 23  5  1  1  0  0  0
 23 13  1  0  0  0  0
 23 17  1  0  0  0  0
 23 22  1  0  0  0  0
 24 21  2  0  0  0  0
 25  6  1  0  0  0  0
 25 20  1  0  0  0  0
 26 19  1  0  0  0  0
 26 21  1  0  0  0  0
 27  7  1  0  0  0  0
 28  8  1  0  0  0  0
 29  9  1  0  0  0  0
 30 10  1  0  0  0  0
 17 31  1  1  0  0  0
 18 32  1  6  0  0  0
 22 33  1  1  0  0  0
M  END


  Mrv1652305152107592D          

 33 35  0  0  1  0            999 V2000
    3.8339    2.2135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4049   -0.2615    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4576   -2.3679    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2821    2.3843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4769    2.5979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8274   -3.7481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5148    0.6061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0982    0.0228    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2821    0.3926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8846   -0.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1194    0.9760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6347   -2.5242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4049    2.2135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1194    1.8010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4049    0.5635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2545   -2.1544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8655    1.8010    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.8655    0.9760    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.4680   -1.3575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8378   -2.7377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8482   -1.7273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6905    0.9760    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.6905    1.8010    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -3.6451   -1.5138    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6243   -3.5346    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2649   -1.1439    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7283    1.4030    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8950    0.2363    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4956   -0.4043    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0877   -0.9876    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1033    1.4853    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1812    0.2138    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4049    1.3885    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  8  7  1  0  0  0  0
  9  7  2  0  0  0  0
 10  8  2  0  0  0  0
 14  1  1  0  0  0  0
 14 11  1  0  0  0  0
 14 13  2  0  0  0  0
 15  2  1  0  0  0  0
 15 11  2  0  0  0  0
 16  3  1  0  0  0  0
 17  4  1  6  0  0  0
 18  9  1  1  0  0  0
 18 17  1  0  0  0  0
 19 10  1  0  0  0  0
 19 16  2  0  0  0  0
 20 12  2  0  0  0  0
 20 16  1  0  0  0  0
 21 12  1  0  0  0  0
 22 15  1  0  0  0  0
 22 18  1  0  0  0  0
 23  5  1  1  0  0  0
 23 13  1  0  0  0  0
 23 17  1  0  0  0  0
 23 22  1  0  0  0  0
 24 21  2  0  0  0  0
 25  6  1  0  0  0  0
 25 20  1  0  0  0  0
 26 19  1  0  0  0  0
 26 21  1  0  0  0  0
 27  7  1  0  0  0  0
 28  8  1  0  0  0  0
 29  9  1  0  0  0  0
 30 10  1  0  0  0  0
 17 31  1  1  0  0  0
 18 32  1  6  0  0  0
 22 33  1  1  0  0  0
M  END
> <DATABASE_ID>
MMDBc0015085

> <DATABASE_NAME>
MIME

> <SMILES>
[H]\C(\C(\[H])=C(/[H])[C@@]1([H])[C@]([H])(C)[C@]2(C)C=C(C)C=C(C)[C@]12[H])=C(\[H])C1=C(C)C(OC)=CC(=O)O1

> <INCHI_IDENTIFIER>
InChI=1S/C23H28O3/c1-14-11-15(2)22-18(17(4)23(22,5)13-14)9-7-8-10-19-16(3)20(25-6)12-21(24)26-19/h7-13,17-18,22H,1-6H3/b9-7+,10-8+/t17-,18-,22+,23-/m0/s1

> <INCHI_KEY>
AFLXFQMVMOJBCC-PNWRMOOYSA-N

> <FORMULA>
C23H28O3

> <MOLECULAR_WEIGHT>
352.474

> <EXACT_MASS>
352.203844762

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
54

> <JCHEM_AVERAGE_POLARIZABILITY>
41.67175636562413

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
4-methoxy-5-methyl-6-[(1E,3E)-4-[(1R,6S,7S,8S)-1,3,5,8-tetramethylbicyclo[4.2.0]octa-2,4-dien-7-yl]buta-1,3-dien-1-yl]-2H-pyran-2-one

> <ALOGPS_LOGP>
5.24

> <JCHEM_LOGP>
4.255388437333333

> <ALOGPS_LOGS>
-5.06

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_BASIC>
-4.834576690752431

> <JCHEM_POLAR_SURFACE_AREA>
35.53

> <JCHEM_REFRACTIVITY>
111.51259999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
3.06e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
4-methoxy-5-methyl-6-[(1E,3E)-4-[(1R,6S,7S,8S)-1,3,5,8-tetramethylbicyclo[4.2.0]octa-2,4-dien-7-yl]buta-1,3-dien-1-yl]pyran-2-one

> <JCHEM_VEBER_RULE>
1

$$$$

HEADER    PROTEIN                                 15-MAY-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-MAY-21         0                                  
HETATM    1  C   UNK     0       7.157   4.132   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       4.489  -0.488   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -0.854  -4.420   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       0.527   4.451   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       2.757   4.849   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -1.545  -6.997   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -0.961   1.131   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -2.050   0.043   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       0.527   0.733   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      -1.651  -1.445   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       5.823   1.822   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      -4.918  -4.712   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       4.489   4.132   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       5.823   3.362   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       4.489   1.052   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      -2.342  -4.021   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       1.616   3.362   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       1.616   1.822   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      -2.740  -2.534   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      -3.431  -5.110   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      -5.317  -3.224   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       3.156   1.822   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       3.156   3.362   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0      -6.804  -2.826   0.000  0.00  0.00           O+0
HETATM   25  O   UNK     0      -3.032  -6.598   0.000  0.00  0.00           O+0
HETATM   26  O   UNK     0      -4.228  -2.135   0.000  0.00  0.00           O+0
HETATM   27  H   UNK     0      -1.360   2.619   0.000  0.00  0.00           H+0
HETATM   28  H   UNK     0      -3.537   0.441   0.000  0.00  0.00           H+0
HETATM   29  H   UNK     0       0.925  -0.755   0.000  0.00  0.00           H+0
HETATM   30  H   UNK     0      -0.164  -1.844   0.000  0.00  0.00           H+0
HETATM   31  H   UNK     0       0.193   2.773   0.000  0.00  0.00           H+0
HETATM   32  H   UNK     0       2.205   0.399   0.000  0.00  0.00           H+0
HETATM   33  H   UNK     0       4.489   2.592   0.000  0.00  0.00           H+0
CONECT    1   14                                                            
CONECT    2   15                                                            
CONECT    3   16                                                            
CONECT    4   17                                                            
CONECT    5   23                                                            
CONECT    6   25                                                            
CONECT    7    8    9   27                                                  
CONECT    8    7   10   28                                                  
CONECT    9    7   18   29                                                  
CONECT   10    8   19   30                                                  
CONECT   11   14   15                                                       
CONECT   12   20   21                                                       
CONECT   13   14   23                                                       
CONECT   14    1   11   13                                                  
CONECT   15    2   11   22                                                  
CONECT   16    3   19   20                                                  
CONECT   17    4   18   23   31                                             
CONECT   18    9   17   22   32                                             
CONECT   19   10   16   26                                                  
CONECT   20   12   16   25                                                  
CONECT   21   12   24   26                                                  
CONECT   22   15   18   23   33                                             
CONECT   23    5   13   17   22                                             
CONECT   24   21                                                            
CONECT   25    6   20                                                       
CONECT   26   19   21                                                       
CONECT   27    7                                                            
CONECT   28    8                                                            
CONECT   29    9                                                            
CONECT   30   10                                                            
CONECT   31   17                                                            
CONECT   32   18                                                            
CONECT   33   22                                                            
MASTER        0    0    0    0    0    0    0    0   33    0   70    0
END

Synonyms

Not Available

Molecular Formula

C₂₃H₂₈O₃

Average Mass

352.474

Monoisotopic Mass

352.203844762

IUPAC Name

4-methoxy-5-methyl-6-[(1E,3E)-4-[(1R,6S,7S,8S)-1,3,5,8-tetramethylbicyclo[4.2.0]octa-2,4-dien-7-yl]buta-1,3-dien-1-yl]-2H-pyran-2-one

Traditional Name

4-methoxy-5-methyl-6-[(1E,3E)-4-[(1R,6S,7S,8S)-1,3,5,8-tetramethylbicyclo[4.2.0]octa-2,4-dien-7-yl]buta-1,3-dien-1-yl]pyran-2-one

CAS Registry Number

Not Available

SMILES

[H]\C(\C(\[H])=C(/[H])[C@@]1([H])[C@]([H])(C)[C@]2(C)C=C(C)C=C(C)[C@]12[H])=C(\[H])C1=C(C)C(OC)=CC(=O)O1

InChI Identifier

InChI=1S/C23H28O3/c1-14-11-15(2)22-18(17(4)23(22,5)13-14)9-7-8-10-19-16(3)20(25-6)12-21(24)26-19/h7-13,17-18,22H,1-6H3/b9-7+,10-8+/t17-,18-,22+,23-/m0/s1

InChI Key

AFLXFQMVMOJBCC-PNWRMOOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as pyranones and derivatives. Pyranones and derivatives are compounds containing a pyran ring which bears a ketone.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Pyrans

Sub Class

Pyranones and derivatives

Direct Parent

Pyranones and derivatives

Alternative Parents

Substituents

Pyranone
Alkyl aryl ether
Heteroaromatic compound
Vinylogous ester
Lactone
Oxacycle
Ether
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.0031 g/L	ALOGPS
logP	5.24	ALOGPS
logP	4.26	ChemAxon
logS	-5.1	ALOGPS
pKa (Strongest Basic)	-4.8	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	35.53 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	111.51 m³·mol⁻¹	ChemAxon
Polarizability	41.67 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	1	Human feces	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

78438053

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

139587237

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Citreoviripyrone A (MMDBc0015085)

MOL for #<Metabolite:0x00007f8dc76e8910>

3D MOL for #<Metabolite:0x00007f8dc76e8910>

3D SDF for #<Metabolite:0x00007f8dc76e8910>

3D-SDF for #<Metabolite:0x00007f8dc76e8910>

PDB for #<Metabolite:0x00007f8dc76e8910>

3D PDB for #<Metabolite:0x00007f8dc76e8910>

SMILES for #<Metabolite:0x00007f8dc76e8910>

INCHI for #<Metabolite:0x00007f8dc76e8910>

Structure for #<Metabolite:0x00007f8dc76e8910>

3D Structure for #<Metabolite:0x00007f8dc76e8910>