MiMeDB: Showing metabocard for Phenopyrrozin (MMDBc0015746)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-05-15 06:31:22 UTC

Update Date

2025-10-07 16:06:27 UTC

Metabolite ID

MMDBc0015746

Metabolite Identification

Common Name

Phenopyrrozin

Description

Phenopyrrozin is a member of the pyrrolizine chemical class and is characterized as a metabolite with notable biological activity. It has been isolated from marine-derived fungi, specifically from the species Chromocleista sp. and Penicillium sp. The synthesis of phenopyrrozin can be achieved through a concise three-step process, highlighting its accessibility for research and potential applications (PMID:29206454 ). In a chemical investigation, phenopyrrozin was identified alongside other compounds, including p-hydroxyphenopyrrozin and diketopiperazines, demonstrating its occurrence in diverse fungal sources (PMID:16643030 ). The compound has been recognized for its radical scavenging properties, which are significant in mitigating oxidative stress, as evidenced by its ability to reduce chromosomal aberrations induced by paraquat and its IC50 value of 73 micrograms/ml against lipid peroxidation (PMID:8557596 ). The structure of phenopyrrozin has been elucidated as 5,6,7,7a-tetrahydro-2-hydroxy-1-phenyl-3H-pyrrolizin-3-one, further establishing its chemical identity and potential therapeutic relevance (PMID:8557596 ). Overall, phenopyrrozin represents a promising compound in the realm of natural products with antioxidant properties.

Structure

MOL SDF PDB SMILES InChI


  Mrv1533004171504322D          

 16 18  0  0  0  0            999 V2000
   -0.0404   -0.2549    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076    1.3686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473    2.1533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047    2.7664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  2  9  1  0  0  0  0
  9 10  2  0  0  0  0
  3 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 11 16  1  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0015746

> <DATABASE_NAME>
MIME

> <SMILES>
OC1=C(C2CCCN2C1=O)C1=CC=CC=C1

> <INCHI_IDENTIFIER>
InChI=1S/C13H13NO2/c15-12-11(9-5-2-1-3-6-9)10-7-4-8-14(10)13(12)16/h1-3,5-6,10,15H,4,7-8H2

> <INCHI_KEY>
APSZCQZJXWEGJS-UHFFFAOYSA-N

> <FORMULA>
C13H13NO2

> <MOLECULAR_WEIGHT>
215.252

> <EXACT_MASS>
215.094628663

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
29

> <JCHEM_AVERAGE_POLARIZABILITY>
22.972099638604078

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
6-hydroxy-7-phenyl-2,3,5,7a-tetrahydro-1H-pyrrolizin-5-one

> <ALOGPS_LOGP>
0.80

> <JCHEM_LOGP>
1.2606031500000001

> <ALOGPS_LOGS>
-1.39

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
16.76149421807618

> <JCHEM_PKA_STRONGEST_ACIDIC>
8.174309646132913

> <JCHEM_PKA_STRONGEST_BASIC>
-1.2712277785294988

> <JCHEM_POLAR_SURFACE_AREA>
40.54

> <JCHEM_REFRACTIVITY>
61.64950000000002

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
8.72e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
2-hydroxy-1-phenyl-5,6,7,7a-tetrahydropyrrolizin-3-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 17-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   17-APR-15         0                                  
HETATM    1  O   UNK     0      -0.075  -0.476   0.000  0.00  0.00           O+0
HETATM    2  C   UNK     0       1.465  -0.476   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       2.370   0.770   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       3.834   0.294   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       5.299   0.770   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       6.204  -0.476   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       5.299  -1.722   0.000  0.00  0.00           C+0
HETATM    8  N   UNK     0       3.834  -1.246   0.000  0.00  0.00           N+0
HETATM    9  C   UNK     0       2.370  -1.722   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       1.894  -3.186   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       1.894   2.235   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       0.388   2.555   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      -0.088   4.019   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       0.942   5.164   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       2.449   4.844   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       2.924   3.379   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    9                                                  
CONECT    3    2    4   11                                                  
CONECT    4    3    5    8                                                  
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    4    9                                                  
CONECT    9    8    2   10                                                  
CONECT   10    9                                                            
CONECT   11    3   12   16                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   11                                                       
MASTER        0    0    0    0    0    0    0    0   16    0   36    0
END

Synonyms

Value	Source
Phenopyrrozin	MeSH
5,6,7,7a-Tetrahydro-2-hydroxy-1-phenyl-3H-pyrrolizin-3-one	MeSH

Molecular Formula

C₁₃H₁₃NO₂

Average Mass

215.252

Monoisotopic Mass

215.094628663

IUPAC Name

6-hydroxy-7-phenyl-2,3,5,7a-tetrahydro-1H-pyrrolizin-5-one

Traditional Name

2-hydroxy-1-phenyl-5,6,7,7a-tetrahydropyrrolizin-3-one

CAS Registry Number

Not Available

SMILES

OC1=C(C2CCCN2C1=O)C1=CC=CC=C1

InChI Identifier

InChI=1S/C13H13NO2/c15-12-11(9-5-2-1-3-6-9)10-7-4-8-14(10)13(12)16/h1-3,5-6,10,15H,4,7-8H2

InChI Key

APSZCQZJXWEGJS-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as pyrrolizines. Pyrrolizines are compounds containing a pyrrolizine moiety, which consists of a pyrrole ring fused to a pyrrolidine ring.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Pyrrolizines

Sub Class

Not Available

Direct Parent

Pyrrolizines

Alternative Parents

Substituents

Pyrrolizine
Monocyclic benzene moiety
Benzenoid
Pyrrolidine
Pyrroline
Tertiary carboxylic acid amide
Lactam
Carboxamide group
Enol
Carboxylic acid derivative
Azacycle
Carbonyl group
Organic oxygen compound
Organic nitrogen compound
Organooxygen compound
Organonitrogen compound
Organic oxide
Hydrocarbon derivative
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	8.72 g/L	ALOGPS
logP	0.8	ALOGPS
logP	1.26	ChemAxon
logS	-1.4	ALOGPS
pKa (Strongest Acidic)	8.17	ChemAxon
pKa (Strongest Basic)	-1.3	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	40.54 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	61.65 m³·mol⁻¹	ChemAxon
Polarizability	22.97 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	2	Human sputum; Human ; Human feces	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

10220018

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Phenopyrrozin (MMDBc0015746)

MOL for #<Metabolite:0x00007f8db4939010>

3D MOL for #<Metabolite:0x00007f8db4939010>

3D SDF for #<Metabolite:0x00007f8db4939010>

3D-SDF for #<Metabolite:0x00007f8db4939010>

PDB for #<Metabolite:0x00007f8db4939010>

3D PDB for #<Metabolite:0x00007f8db4939010>

SMILES for #<Metabolite:0x00007f8db4939010>

INCHI for #<Metabolite:0x00007f8db4939010>

Structure for #<Metabolite:0x00007f8db4939010>

3D Structure for #<Metabolite:0x00007f8db4939010>