MiMeDB: Showing metabocard for Trisindoline (MMDBc0017260)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-05-15 07:41:36 UTC

Update Date

2025-10-07 16:06:39 UTC

Metabolite ID

MMDBc0017260

Metabolite Identification

Common Name

Trisindoline

Description

Trisindoline is a member of the indole chemical class, characterized by its unique structure that incorporates multiple indole units. This compound has garnered attention due to its antibacterial properties, particularly against methicillin-resistant Staphylococcus aureus (MRSA), as evidenced by studies demonstrating its efficacy in reducing bacterial load in systemic infection models (PMID:40993141 ). The structure-activity relationship (SAR) analysis highlights the significance of specific substitutions on the trisindoline core, which enhance its anti-staphylococcal activity (PMID:40993141 ). Additionally, trisindoline has been isolated from marine organisms, including sponges and bacteria, and exhibits interactions with the arylhydrocarbon receptor, leading to increased recruitment and activation of immune cells such as neutrophils and macrophages (PMID:40825123 ). Furthermore, it has shown potential anti-cancer effects through mechanisms involving apoptosis and cytotoxicity against resistant cell lines (PMID:36249936 ). Overall, trisindoline represents a promising candidate for therapeutic applications, particularly in combating resistant bacterial infections and exploring its anticancer properties.

Structure

MOL SDF PDB SMILES InChI


  Mrv1533004231520132D          

 28 33  0  0  0  0            999 V2000
    2.3527   -2.0884    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6339   -2.4934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5391   -3.3130    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7304   -3.4760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3104   -4.1861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5146   -4.1775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9196   -3.4588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4996   -2.7486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3254   -2.7573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1781   -1.7226    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1091   -0.9005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6941   -0.7121    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1215   -1.4178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9319   -1.5724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2032   -2.3515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6641   -2.9760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8537   -2.8214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5824   -2.0423    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  4  9  1  0  0  0  0
  9 10  1  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 11 19  1  0  0  0  0
 14 19  1  0  0  0  0
 10 20  1  0  0  0  0
 20 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 20 28  1  0  0  0  0
 23 28  1  0  0  0  0
M  END


  Mrv1533004231520132D          

 28 33  0  0  0  0            999 V2000
    2.3527   -2.0884    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6339   -2.4934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5391   -3.3130    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7304   -3.4760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3104   -4.1861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5146   -4.1775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9196   -3.4588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4996   -2.7486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3254   -2.7573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1781   -1.7226    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1091   -0.9005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6941   -0.7121    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1215   -1.4178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9319   -1.5724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2032   -2.3515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6641   -2.9760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8537   -2.8214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5824   -2.0423    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  4  9  1  0  0  0  0
  9 10  1  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 11 19  1  0  0  0  0
 14 19  1  0  0  0  0
 10 20  1  0  0  0  0
 20 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 20 28  1  0  0  0  0
 23 28  1  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0017260

> <DATABASE_NAME>
MIME

> <SMILES>
O=C1NC2=CC=CC=C2C1(C1=CNC2=CC=CC=C12)C1=CNC2=CC=CC=C12

> <INCHI_IDENTIFIER>
InChI=1S/C24H17N3O/c28-23-24(17-9-3-6-12-22(17)27-23,18-13-25-20-10-4-1-7-15(18)20)19-14-26-21-11-5-2-8-16(19)21/h1-14,25-26H,(H,27,28)

> <INCHI_KEY>
BSOAGODEMKWJIG-UHFFFAOYSA-N

> <FORMULA>
C24H17N3O

> <MOLECULAR_WEIGHT>
363.42

> <EXACT_MASS>
363.137162179

> <JCHEM_ACCEPTOR_COUNT>
1

> <JCHEM_ATOM_COUNT>
45

> <JCHEM_AVERAGE_POLARIZABILITY>
39.163327571283446

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
3,3-bis(1H-indol-3-yl)-2,3-dihydro-1H-indol-2-one

> <ALOGPS_LOGP>
5.15

> <JCHEM_LOGP>
4.6361826986666665

> <ALOGPS_LOGS>
-5.93

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
6

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
15.65547959607973

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.794145989932439

> <JCHEM_PKA_STRONGEST_BASIC>
-6.836591473866838

> <JCHEM_POLAR_SURFACE_AREA>
60.68

> <JCHEM_REFRACTIVITY>
111.90150000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
4.31e-04 g/l

> <JCHEM_TRADITIONAL_IUPAC>
3,3-bis(1H-indol-3-yl)-1H-indol-2-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 23-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   23-APR-15         0                                  
HETATM    1  O   UNK     0       4.392  -3.898   0.000  0.00  0.00           O+0
HETATM    2  C   UNK     0       3.050  -4.654   0.000  0.00  0.00           C+0
HETATM    3  N   UNK     0       2.873  -6.184   0.000  0.00  0.00           N+0
HETATM    4  C   UNK     0       1.363  -6.489   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       0.579  -7.814   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -0.961  -7.798   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -1.717  -6.456   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -0.933  -5.131   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       0.607  -5.147   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       1.650  -4.013   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       0.332  -3.216   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       0.204  -1.681   0.000  0.00  0.00           C+0
HETATM   13  N   UNK     0      -1.296  -1.329   0.000  0.00  0.00           N+0
HETATM   14  C   UNK     0      -2.093  -2.647   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      -3.606  -2.935   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      -4.113  -4.389   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      -3.106  -5.555   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      -1.594  -5.267   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      -1.087  -3.812   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       2.126  -2.549   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       1.220  -1.303   0.000  0.00  0.00           C+0
HETATM   22  N   UNK     0       2.126  -0.057   0.000  0.00  0.00           N+0
HETATM   23  C   UNK     0       3.590  -0.533   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       4.924   0.237   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       6.258  -0.533   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       6.258  -2.073   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       4.924  -2.843   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       3.590  -2.073   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3   10                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5    9                                                  
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8    4   10                                                  
CONECT   10    9    2   11   20                                             
CONECT   11   10   12   19                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15   19                                                  
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   11   14                                                  
CONECT   20   10   21   28                                                  
CONECT   21   20   22                                                       
CONECT   22   21   23                                                       
CONECT   23   22   24   28                                                  
CONECT   24   23   25                                                       
CONECT   25   24   26                                                       
CONECT   26   25   27                                                       
CONECT   27   26   28                                                       
CONECT   28   27   20   23                                                  
MASTER        0    0    0    0    0    0    0    0   28    0   66    0
END

Synonyms

Not Available

Molecular Formula

C₂₄H₁₇N₃O

Average Mass

363.42

Monoisotopic Mass

363.137162179

IUPAC Name

3,3-bis(1H-indol-3-yl)-2,3-dihydro-1H-indol-2-one

Traditional Name

3,3-bis(1H-indol-3-yl)-1H-indol-2-one

CAS Registry Number

Not Available

SMILES

O=C1NC2=CC=CC=C2C1(C1=CNC2=CC=CC=C12)C1=CNC2=CC=CC=C12

InChI Identifier

InChI=1S/C24H17N3O/c28-23-24(17-9-3-6-12-22(17)27-23,18-13-25-20-10-4-1-7-15(18)20)19-14-26-21-11-5-2-8-16(19)21/h1-14,25-26H,(H,27,28)

InChI Key

BSOAGODEMKWJIG-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as 3-alkylindoles. 3-Alkylindoles are compounds containing an indole moiety that carries an alkyl chain at the 3-position.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Indoles and derivatives

Sub Class

Indoles

Direct Parent

3-alkylindoles

Alternative Parents

Substituents

3-alkylindole
Dihydroindole
Substituted pyrrole
Benzenoid
Pyrrole
Heteroaromatic compound
Carboxamide group
Lactam
Secondary carboxylic acid amide
Carboxylic acid derivative
Azacycle
Organopnictogen compound
Organic oxygen compound
Organooxygen compound
Organonitrogen compound
Carbonyl group
Organic nitrogen compound
Organic oxide
Hydrocarbon derivative
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.00043 g/L	ALOGPS
logP	5.15	ALOGPS
logP	4.64	ChemAxon
logS	-5.9	ALOGPS
pKa (Strongest Acidic)	12.79	ChemAxon
pKa (Strongest Basic)	-6.8	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	1	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	60.68 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	111.9 m³·mol⁻¹	ChemAxon
Polarizability	39.16 Å³	ChemAxon
Number of Rings	6	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Chromatographic Retention Times and Retention Indices

Retention Times

Chromatography Type	Technique	Column	Deposition Date	Retention Time (s)
Liquid Chromatography	HILIC	Waters Acquity UPLC-BEH Amide column (void)	2025-10-23	286.3
Liquid Chromatography	HILIC	Accucore 150 Amide HILIC (void)	2025-10-23	27.9
Liquid Chromatography	Reversed-phase	Hypersil Gold 1.9 µm C18 (eluted)	2025-10-23	517.4
Liquid Chromatography	Reversed-phase	Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) (eluted)	2025-10-23	578.1
Liquid Chromatography	Reversed-phase	XBridge C18 3.5u 2.1x50 mm (eluted)	2025-10-23	569.1
Liquid Chromatography	Reversed-phase	Ascentis Express C18 (eluted)	2025-10-23	390.8
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	2849.7
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (void)	2025-10-23	84.9
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC (eluted)	2025-10-23	328.7
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	316.8
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-23	191.8
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	201.0
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	191.3
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (void)	2025-10-23	23.4
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-23	291.4
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	450.7
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	393.5
Liquid Chromatography	Reversed-phase	Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex (eluted)	2025-10-23	1577.1
Liquid Chromatography	Reversed-phase	Waters Atlantis T3 (2.1 x 150 mm, 5 um) (eluted)	2025-10-23	1346.6

Retention Indices

Chromatography Type	Peak Label	SMILES	Stationary Phase	Deposition Date	Retention Index
Gas Chromatography	Trisindoline_TMS_1	C[Si](C)(C)N1C(=O)C(C2=C[NH]C3=CC=CC=C23)(C2=C[NH]C3=CC=CC=C23)C2=CC=CC=C21	standard non polar	2025-10-23	1849.37
Gas Chromatography	Trisindoline_TMS_2	C[Si](C)(C)N1C=C(C2(C3=C[NH]C4=CC=CC=C34)C(=O)NC3=CC=CC=C32)C2=CC=CC=C21	standard non polar	2025-10-23	1399.87
Gas Chromatography	Trisindoline_TMS_3	C[Si](C)(C)N1C(=O)C(C2=C[NH]C3=CC=CC=C23)(C2=CN([Si](C)(C)C)C3=CC=CC=C23)C2=CC=CC=C21	standard non polar	2025-10-23	1975.01
Gas Chromatography	Trisindoline_TMS_4	C[Si](C)(C)N1C=C(C2(C3=CN([Si](C)(C)C)C4=CC=CC=C34)C(=O)NC3=CC=CC=C32)C2=CC=CC=C21	standard non polar	2025-10-23	798.966
Gas Chromatography	Trisindoline_TMS_5	C[Si](C)(C)N1C(=O)C(C2=CN([Si](C)(C)C)C3=CC=CC=C23)(C2=CN([Si](C)(C)C)C3=CC=CC=C23)C2=CC=CC=C21	standard non polar	2025-10-23	2779.1
Gas Chromatography	Trisindoline_TMS_1	C[Si](C)(C)N1C(=O)C(C2=C[NH]C3=CC=CC=C23)(C2=C[NH]C3=CC=CC=C23)C2=CC=CC=C21	standard polar	2025-10-23	1171.5
Gas Chromatography	Trisindoline_TMS_2	C[Si](C)(C)N1C=C(C2(C3=C[NH]C4=CC=CC=C34)C(=O)NC3=CC=CC=C32)C2=CC=CC=C21	standard polar	2025-10-23	2111.03
Gas Chromatography	Trisindoline_TMS_3	C[Si](C)(C)N1C(=O)C(C2=C[NH]C3=CC=CC=C23)(C2=CN([Si](C)(C)C)C3=CC=CC=C23)C2=CC=CC=C21	standard polar	2025-10-23	1989.75
Gas Chromatography	Trisindoline_TMS_4	C[Si](C)(C)N1C=C(C2(C3=CN([Si](C)(C)C)C4=CC=CC=C34)C(=O)NC3=CC=CC=C32)C2=CC=CC=C21	standard polar	2025-10-23	2283.31
Gas Chromatography	Trisindoline_TMS_5	C[Si](C)(C)N1C(=O)C(C2=CN([Si](C)(C)C)C3=CC=CC=C23)(C2=CN([Si](C)(C)C)C3=CC=CC=C23)C2=CC=CC=C21	standard polar	2025-10-23	2355.69

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria	Proteobacteria	1		Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

2883607

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Trisindoline (MMDBc0017260)

MOL for #<Metabolite:0x00007f9ac0656370>

3D MOL for #<Metabolite:0x00007f9ac0656370>

3D SDF for #<Metabolite:0x00007f9ac0656370>

3D-SDF for #<Metabolite:0x00007f9ac0656370>

PDB for #<Metabolite:0x00007f9ac0656370>

3D PDB for #<Metabolite:0x00007f9ac0656370>

SMILES for #<Metabolite:0x00007f9ac0656370>

INCHI for #<Metabolite:0x00007f9ac0656370>

Structure for #<Metabolite:0x00007f9ac0656370>

3D Structure for #<Metabolite:0x00007f9ac0656370>