MiMeDB: Showing metabocard for Aszonalenin (MMDBc0017908)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-05-15 08:11:33 UTC

Update Date

2025-10-07 16:06:45 UTC

Metabolite ID

MMDBc0017908

Metabolite Identification

Common Name

Aszonalenin

Description

Aszonalenin is a prenylated indole alkaloid belonging to the chemical class of alkaloids. It is derived from the secondary metabolites of the endophytic fungus Aspergillus terreus, which is associated with coral species such as Pavona. The chemical structure of aszonalenin features a complex arrangement that includes a prenyl group, contributing to its biological activities. Aszonalenin has been shown to influence various cellular pathways, including the modulation of inflammation, apoptosis, and angiogenesis in human umbilical vein endothelial cells (HUVEC) in response to oxidized low-density lipoprotein (ox-LDL) (PMID:35704971 ). Additionally, it has been identified as a potential inhibitor of NF-κB activity, which is implicated in cancer progression, particularly in ependymoma driven by the ZFTA-RELA fusion protein (PMID:35131506 ). The compound's anticancer properties have also been linked to its interaction with cannabinoid G-protein coupled receptors type 1 (CB1), suggesting a mechanism for its effects on prostate malignancies (PMID:36313355 ). Overall, aszonalenin represents a promising candidate for further research in cancer therapeutics and related biological applications.

Structure

MOL SDF PDB SMILES InChI


  Mrv1533004171511092D          

 28 32  0  0  0  0            999 V2000
    4.5704    3.7687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2364    3.2819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9025    2.7951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7232    3.9479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5435    3.8594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7496    2.6158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2666    3.2846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4812    3.0319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4789    2.2069    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2628    1.9497    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7459    1.2809    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5312    1.5337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2445    1.1192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9601    1.5296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9625    2.3546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2492    2.7691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5335    2.3587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8325    1.6943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0138    0.8895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0287    1.8802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5620    1.1998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7395    1.2638    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3836    2.0081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8503    2.6885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6728    2.6245    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329    3.3668    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8377    3.5481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0235    4.3519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  2  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
  6 17  1  0  0  0  0
 12 17  1  0  0  0  0
  9 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 20 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
  8 27  1  0  0  0  0
 27 28  2  0  0  0  0
M  END


  Mrv1533004171511092D          

 28 32  0  0  0  0            999 V2000
    4.5704    3.7687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2364    3.2819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9025    2.7951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7232    3.9479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5435    3.8594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7496    2.6158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2666    3.2846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4812    3.0319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4789    2.2069    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2628    1.9497    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7459    1.2809    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5312    1.5337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2445    1.1192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9601    1.5296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9625    2.3546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2492    2.7691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5335    2.3587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8325    1.6943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0138    0.8895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0287    1.8802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5620    1.1998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7395    1.2638    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3836    2.0081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8503    2.6885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6728    2.6245    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329    3.3668    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8377    3.5481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0235    4.3519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  2  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
  6 17  1  0  0  0  0
 12 17  1  0  0  0  0
  9 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 20 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
  8 27  1  0  0  0  0
 27 28  2  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0017908

> <DATABASE_NAME>
MIME

> <SMILES>
CC(C)(C=C)C12CC3N(C1NC1=CC=CC=C21)C(=O)C1=CC=CC=C1NC3=O

> <INCHI_IDENTIFIER>
InChI=1S/C23H23N3O2/c1-4-22(2,3)23-13-18-19(27)24-16-11-7-5-9-14(16)20(28)26(18)21(23)25-17-12-8-6-10-15(17)23/h4-12,18,21,25H,1,13H2,2-3H3,(H,24,27)

> <INCHI_KEY>
AVLMMDWEIUEKEK-UHFFFAOYSA-N

> <FORMULA>
C23H23N3O2

> <MOLECULAR_WEIGHT>
373.456

> <EXACT_MASS>
373.179026993

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
51

> <JCHEM_AVERAGE_POLARIZABILITY>
40.33954330824598

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
10-(2-methylbut-3-en-2-yl)-1,3,14-triazapentacyclo[10.9.0.0²,¹⁰.0⁴,⁹.0¹⁵,²⁰]henicosa-4,6,8,15,17,19-hexaene-13,21-dione

> <ALOGPS_LOGP>
3.33

> <JCHEM_LOGP>
4.154155849333333

> <ALOGPS_LOGS>
-4.26

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
15.14879544594487

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.012816521291647

> <JCHEM_PKA_STRONGEST_BASIC>
2.1748940024292067

> <JCHEM_POLAR_SURFACE_AREA>
61.440000000000005

> <JCHEM_REFRACTIVITY>
110.71689999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.06e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
10-(2-methylbut-3-en-2-yl)-1,3,14-triazapentacyclo[10.9.0.0²,¹⁰.0⁴,⁹.0¹⁵,²⁰]henicosa-4,6,8,15,17,19-hexaene-13,21-dione

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 17-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   17-APR-15         0                                  
HETATM    1  C   UNK     0       8.531   7.035   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       9.775   6.126   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      11.018   5.217   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      10.683   7.370   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      12.214   7.204   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       8.866   4.883   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       7.964   6.131   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       6.498   5.660   0.000  0.00  0.00           C+0
HETATM    9  N   UNK     0       6.494   4.120   0.000  0.00  0.00           N+0
HETATM   10  C   UNK     0       7.957   3.640   0.000  0.00  0.00           C+0
HETATM   11  N   UNK     0       8.859   2.391   0.000  0.00  0.00           N+0
HETATM   12  C   UNK     0      10.325   2.863   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      11.656   2.089   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      12.992   2.855   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      12.997   4.395   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      11.665   5.169   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      10.329   4.403   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       5.287   3.163   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0       5.626   1.660   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0       3.787   3.510   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       2.916   2.240   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       1.380   2.359   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       0.716   3.748   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       1.587   5.018   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       3.123   4.899   0.000  0.00  0.00           C+0
HETATM   26  N   UNK     0       3.795   6.285   0.000  0.00  0.00           N+0
HETATM   27  C   UNK     0       5.297   6.623   0.000  0.00  0.00           C+0
HETATM   28  O   UNK     0       5.644   8.124   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3    4    6                                             
CONECT    3    2                                                            
CONECT    4    2    5                                                       
CONECT    5    4                                                            
CONECT    6    2    7   10   17                                             
CONECT    7    6    8                                                       
CONECT    8    7    9   27                                                  
CONECT    9    8   10   18                                                  
CONECT   10    9    6   11                                                  
CONECT   11   10   12                                                       
CONECT   12   11   13   17                                                  
CONECT   13   12   14                                                       
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16    6   12                                                  
CONECT   18    9   19   20                                                  
CONECT   19   18                                                            
CONECT   20   18   21   25                                                  
CONECT   21   20   22                                                       
CONECT   22   21   23                                                       
CONECT   23   22   24                                                       
CONECT   24   23   25                                                       
CONECT   25   24   20   26                                                  
CONECT   26   25   27                                                       
CONECT   27   26    8   28                                                  
CONECT   28   27                                                            
MASTER        0    0    0    0    0    0    0    0   28    0   64    0
END

Synonyms

Not Available

Molecular Formula

C₂₃H₂₃N₃O₂

Average Mass

373.456

Monoisotopic Mass

373.179026993

IUPAC Name

10-(2-methylbut-3-en-2-yl)-1,3,14-triazapentacyclo[10.9.0.0²,¹⁰.0⁴,⁹.0¹⁵,²⁰]henicosa-4,6,8,15,17,19-hexaene-13,21-dione

Traditional Name

10-(2-methylbut-3-en-2-yl)-1,3,14-triazapentacyclo[10.9.0.0²,¹⁰.0⁴,⁹.0¹⁵,²⁰]henicosa-4,6,8,15,17,19-hexaene-13,21-dione

CAS Registry Number

Not Available

SMILES

CC(C)(C=C)C12CC3N(C1NC1=CC=CC=C21)C(=O)C1=CC=CC=C1NC3=O

InChI Identifier

InChI=1S/C23H23N3O2/c1-4-22(2,3)23-13-18-19(27)24-16-11-7-5-9-14(16)20(28)26(18)21(23)25-17-12-8-6-10-15(17)23/h4-12,18,21,25H,1,13H2,2-3H3,(H,24,27)

InChI Key

AVLMMDWEIUEKEK-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as pyrroloindoles. Pyrroloindoles are compounds containing a pyrroloindole moiety, which is a tricyclic heterocycle which consists of a pyrrole ring fused to an indole. Pyrrole is 5-membered ring consisting of four carbon atoms and one nitrogen atom. Indole is a bicyclic compound consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Indoles and derivatives

Sub Class

Pyrroloindoles

Direct Parent

Pyrroloindoles

Alternative Parents

Substituents

Pyrroloindole
Benzodiazepine
1,4-benzodiazepine
Alpha-amino acid or derivatives
Indole
Dihydroindole
Benzenoid
Pyrrole
Pyrrolidine
Tertiary carboxylic acid amide
Vinylogous amide
Lactam
Carboxamide group
Secondary carboxylic acid amide
Carboxylic acid derivative
Azacycle
Amine
Organic nitrogen compound
Organooxygen compound
Organonitrogen compound
Hydrocarbon derivative
Organic oxide
Carbonyl group
Organic oxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.021 g/L	ALOGPS
logP	3.33	ALOGPS
logP	4.15	ChemAxon
logS	-4.3	ALOGPS
pKa (Strongest Acidic)	12.01	ChemAxon
pKa (Strongest Basic)	2.17	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	61.44 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	110.72 m³·mol⁻¹	ChemAxon
Polarizability	40.34 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	2	Human feces	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

4037170

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Aszonalenin (MMDBc0017908)

MOL for #<Metabolite:0x00007f8dbce24c98>

3D MOL for #<Metabolite:0x00007f8dbce24c98>

3D SDF for #<Metabolite:0x00007f8dbce24c98>

3D-SDF for #<Metabolite:0x00007f8dbce24c98>

PDB for #<Metabolite:0x00007f8dbce24c98>

3D PDB for #<Metabolite:0x00007f8dbce24c98>

SMILES for #<Metabolite:0x00007f8dbce24c98>

INCHI for #<Metabolite:0x00007f8dbce24c98>

Structure for #<Metabolite:0x00007f8dbce24c98>

3D Structure for #<Metabolite:0x00007f8dbce24c98>