MiMeDB: Showing metabocard for Gloeosporone (MMDBc0017946)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-05-15 08:14:18 UTC

Update Date

2025-10-07 16:06:46 UTC

Metabolite ID

MMDBc0017946

Metabolite Identification

Common Name

Gloeosporone

Description

Gloeosporone is a polyketide metabolite that belongs to the chemical class of fungal secondary metabolites. Its chemical structure features a complex arrangement of carbon atoms, including multiple rings and functional groups, which contribute to its biological activity. Gloeosporone is synthesized through various pathways, including enantioselective alkyne-aldehyde coupling and nickel-catalyzed macrocyclization, as evidenced by studies demonstrating its total synthesis (PMID:25905431 , PMID:19536804 ). This compound acts as an autoinhibitor of spore germination in fungi, playing a crucial role in regulating fungal life cycles and preventing premature germination (PMID:14584786 ). The synthesis of (-)-gloeosporone has been achieved using innovative methodologies, such as pi-allyltricarbonyliron lactone complexes, which facilitate the construction of its intricate 1,7-diol framework (PMID:14584786 ). Structural studies have further elucidated its role as a spore germination autoinhibitor, highlighting its significance in fungal biology (PMID:22148801 ). Overall, gloeosporone exemplifies the intricate relationship between chemical structure and biological function within fungal metabolites.

Structure

MOL SDF PDB SMILES InChI


  Mrv1533004191514092D          

 23 24  0  0  0  0            999 V2000
   -2.2949   -2.2154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5805   -1.8029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.2154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1515   -1.8029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5629   -2.2154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2774   -1.8029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1697   -0.9850    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6720   -0.3305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4899   -0.2228    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1444   -0.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2521   -1.5430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7499   -2.1975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1624   -2.9120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9874   -2.9120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3999   -2.1975    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3999   -3.6264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6462   -3.9620    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0673   -3.1415    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7347   -3.6264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4798   -4.4111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9647   -5.0785    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6548   -4.4111    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9319   -2.3052    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 16 22  1  0  0  0  0
 12 23  1  0  0  0  0
  6 23  1  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0017946

> <DATABASE_NAME>
MIME

> <SMILES>
CCCCCC1CCCCCC(CC(=O)C2(O)CCC(=O)O2)O1

> <INCHI_IDENTIFIER>
InChI=1S/C18H30O5/c1-2-3-5-8-14-9-6-4-7-10-15(22-14)13-16(19)18(21)12-11-17(20)23-18/h14-15,21H,2-13H2,1H3

> <INCHI_KEY>
XGFGONPCXDNIMO-UHFFFAOYSA-N

> <FORMULA>
C18H30O5

> <MOLECULAR_WEIGHT>
326.433

> <EXACT_MASS>
326.209324066

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
53

> <JCHEM_AVERAGE_POLARIZABILITY>
36.53461048085707

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
5-hydroxy-5-[2-(8-pentyloxocan-2-yl)acetyl]oxolan-2-one

> <ALOGPS_LOGP>
3.26

> <JCHEM_LOGP>
4.0378852746666665

> <ALOGPS_LOGS>
-4.21

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
15.648046791236464

> <JCHEM_PKA_STRONGEST_ACIDIC>
10.178725936997571

> <JCHEM_PKA_STRONGEST_BASIC>
-4.168885974613877

> <JCHEM_POLAR_SURFACE_AREA>
72.83

> <JCHEM_REFRACTIVITY>
86.25469999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
7

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.04e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
5-hydroxy-5-[2-(8-pentyloxocan-2-yl)acetyl]oxolan-2-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 19-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   19-APR-15         0                                  
HETATM    1  C   UNK     0      -4.284  -4.136   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -2.950  -3.366   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -1.617  -4.136   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -0.283  -3.366   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       1.051  -4.136   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       2.384  -3.366   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       2.183  -1.839   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       3.121  -0.617   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       4.648  -0.416   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       5.870  -1.353   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       6.071  -2.880   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       5.133  -4.102   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       5.903  -5.436   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       7.443  -5.436   0.000  0.00  0.00           C+0
HETATM   15  O   UNK     0       8.213  -4.102   0.000  0.00  0.00           O+0
HETATM   16  C   UNK     0       8.213  -6.769   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0       6.806  -7.396   0.000  0.00  0.00           O+0
HETATM   18  C   UNK     0       9.459  -5.864   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      10.705  -6.769   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      10.229  -8.234   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0      11.134  -9.480   0.000  0.00  0.00           O+0
HETATM   22  O   UNK     0       8.689  -8.234   0.000  0.00  0.00           O+0
HETATM   23  O   UNK     0       3.606  -4.303   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7   23                                                  
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13   23                                                  
CONECT   13   12   14                                                       
CONECT   14   13   15   16                                                  
CONECT   15   14                                                            
CONECT   16   14   17   18   22                                             
CONECT   17   16                                                            
CONECT   18   16   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19   21   22                                                  
CONECT   21   20                                                            
CONECT   22   20   16                                                       
CONECT   23   12    6                                                       
MASTER        0    0    0    0    0    0    0    0   23    0   48    0
END

Synonyms

Not Available

Molecular Formula

C₁₈H₃₀O₅

Average Mass

326.433

Monoisotopic Mass

326.209324066

IUPAC Name

5-hydroxy-5-[2-(8-pentyloxocan-2-yl)acetyl]oxolan-2-one

Traditional Name

5-hydroxy-5-[2-(8-pentyloxocan-2-yl)acetyl]oxolan-2-one

CAS Registry Number

Not Available

SMILES

CCCCCC1CCCCCC(CC(=O)C2(O)CCC(=O)O2)O1

InChI Identifier

InChI=1S/C18H30O5/c1-2-3-5-8-14-9-6-4-7-10-15(22-14)13-16(19)18(21)12-11-17(20)23-18/h14-15,21H,2-13H2,1H3

InChI Key

XGFGONPCXDNIMO-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as alpha-acyloxy ketones. These are ketones that have an acyloxy substituent alpha to the carbonyl group. They have the general structure R4C(=O)OC(R2)(R3)C(R1)=O (R1=organyl, R4=H or organyl; R2,R3 = any atom).

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Carbonyl compounds

Direct Parent

Alpha-acyloxy ketones

Alternative Parents

Substituents

Alpha-acyloxy ketone
Gamma butyrolactone
Alpha-hydroxy ketone
Oxolane
Carboxylic acid ester
Hemiacetal
Ketone
Lactone
Carboxylic acid derivative
Ether
Dialkyl ether
Monocarboxylic acid or derivatives
Oxacycle
Organoheterocyclic compound
Organic oxide
Hydrocarbon derivative
Aliphatic heteromonocyclic compound

Molecular Framework

Aliphatic heteromonocyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.02 g/L	ALOGPS
logP	3.26	ALOGPS
logP	4.04	ChemAxon
logS	-4.2	ALOGPS
pKa (Strongest Acidic)	10.18	ChemAxon
pKa (Strongest Basic)	-4.2	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	72.83 Å²	ChemAxon
Rotatable Bond Count	7	ChemAxon
Refractivity	86.25 m³·mol⁻¹	ChemAxon
Polarizability	36.53 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_1) - 70eV, Positive	Not Available	2022-08-08	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	Not Available	2022-08-09	View Spectrum
MS	Mass Spectrum (Electron Ionization)	Not Available	2022-08-06	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-20	View Spectrum

Chromatographic Retention Times and Retention Indices

Retention Times

Chromatography Type	Technique	Column	Deposition Date	Retention Time (s)
Liquid Chromatography	HILIC	Waters Acquity UPLC-BEH Amide column (eluted)	2025-10-23	162.5
Liquid Chromatography	HILIC	Accucore 150 Amide HILIC (void)	2025-10-23	32.0
Liquid Chromatography	Reversed-phase	Hypersil Gold 1.9 µm C18 (eluted)	2025-10-23	555.1
Liquid Chromatography	Reversed-phase	Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) (eluted)	2025-10-23	824.5
Liquid Chromatography	Reversed-phase	XBridge C18 3.5u 2.1x50 mm (eluted)	2025-10-23	906.6
Liquid Chromatography	Reversed-phase	Ascentis Express C18 (eluted)	2025-10-23	479.6
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	3065.8
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (void)	2025-10-23	83.9
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC (eluted)	2025-10-23	345.8
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	666.0
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (void)	2025-10-23	439.2
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	230.9
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	221.8
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (void)	2025-10-23	12.3
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-23	491.1
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	538.3
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	439.9
Liquid Chromatography	Reversed-phase	Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex (eluted)	2025-10-23	1774.6
Liquid Chromatography	Reversed-phase	Waters Atlantis T3 (2.1 x 150 mm, 5 um) (eluted)	2025-10-23	1784.8

Retention Indices

Chromatography Type	Peak Label	SMILES	Stationary Phase	Deposition Date	Retention Index
Gas Chromatography	Gloeosporone_TMS_1	CCCCCC1CCCCCC(CC(=O)C2(O[Si](C)(C)C)CCC(=O)O2)O1	standard non polar	2025-10-23	1788.08
Gas Chromatography	Gloeosporone_TMS_2	CCCCCC1CCCCCC(C=C(O[Si](C)(C)C)C2(O)CCC(=O)O2)O1	standard non polar	2025-10-23	1492.88
Gas Chromatography	Gloeosporone_TMS_3	CCCCCC1CCCCCC(C=C(O[Si](C)(C)C)C2(O[Si](C)(C)C)CCC(=O)O2)O1	standard non polar	2025-10-23	1730.84
Gas Chromatography	Gloeosporone_TMS_1	CCCCCC1CCCCCC(CC(=O)C2(O[Si](C)(C)C)CCC(=O)O2)O1	standard polar	2025-10-23	1612.72
Gas Chromatography	Gloeosporone_TMS_2	CCCCCC1CCCCCC(C=C(O[Si](C)(C)C)C2(O)CCC(=O)O2)O1	standard polar	2025-10-23	2056.77
Gas Chromatography	Gloeosporone_TMS_3	CCCCCC1CCCCCC(C=C(O[Si](C)(C)C)C2(O[Si](C)(C)C)CCC(=O)O2)O1	standard polar	2025-10-23	2106.66

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	1	Human feces	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

14160703

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Gloeosporone (MMDBc0017946)

MOL for #<Metabolite:0x00007f9af0ec0a80>

3D MOL for #<Metabolite:0x00007f9af0ec0a80>

3D SDF for #<Metabolite:0x00007f9af0ec0a80>

3D-SDF for #<Metabolite:0x00007f9af0ec0a80>

PDB for #<Metabolite:0x00007f9af0ec0a80>

3D PDB for #<Metabolite:0x00007f9af0ec0a80>

SMILES for #<Metabolite:0x00007f9af0ec0a80>

INCHI for #<Metabolite:0x00007f9af0ec0a80>

Structure for #<Metabolite:0x00007f9af0ec0a80>

3D Structure for #<Metabolite:0x00007f9af0ec0a80>