MiMeDB: Showing metabocard for Marcfortine A (MMDBc0018331)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-05-15 08:32:07 UTC

Update Date

2025-10-07 16:06:49 UTC

Metabolite ID

MMDBc0018331

Metabolite Identification

Common Name

Marcfortine A

Description

Marcfortine A is a secondary metabolite belonging to the class of polyketides, specifically produced by the fungus Penicillium roqueforti. Its chemical structure features a complex arrangement of rings, including a six-membered ring G that is devoid of substituents, distinguishing it from its structural analog paraherquamide A, which contains additional functional groups. Marcfortine A is involved in various biochemical pathways, particularly those related to the synthesis of other mycotoxins and antifungal agents. It has been identified in complex mixtures alongside other toxic compounds such as mycophenolic acid and roquefortines, highlighting its prevalence in contaminated silage and fungal metabolites (PMID:35347677 , PMID:27707355 , PMID:20213172 ). Additionally, marcfortine A has demonstrated potent antiparasitic properties, making it a candidate for further pharmacological exploration (PMID:12945765 ). Its structural relationship to paraherquamide A suggests potential for development as an anthelmintic agent (PMID:12052190 ). Overall, marcfortine A represents a significant compound within the realm of fungal metabolites, contributing to both ecological interactions and potential therapeutic applications.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652305152110322D          

 36 42  0  0  1  0            999 V2000
    6.2059   -1.7753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5988   -2.6059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1610   -1.7878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3482   -2.4351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9448   -0.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4926   -0.4197    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5301   -1.2566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5178   -2.2488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3157   -2.4586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7803    0.0192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5312   -0.9987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6968   -1.6016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9901   -0.3759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2109   -0.6429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7385   -1.1931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5069   -1.6934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3006   -1.4530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8963   -1.8726    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2058   -0.7747    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8812   -0.8669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6791   -1.0767    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7458   -0.1645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2768    0.2237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3816   -1.8100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9809   -1.6964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9777   -0.2688    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.6479   -1.4992    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.5637   -1.0819    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.5032   -0.1336    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7117   -0.4558    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1476   -1.1209    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1029    0.3142    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1679    1.0415    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1658   -0.4106    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6540   -2.1989    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4010   -0.5931    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  7  6  1  0  0  0  0
  9  8  2  0  0  0  0
 10  6  1  0  0  0  0
 12  7  1  0  0  0  0
 13 11  2  0  0  0  0
 17  8  1  0  0  0  0
 18  9  1  0  0  0  0
 19 14  1  0  0  0  0
 20 17  2  0  0  0  0
 21 18  2  0  0  0  0
 21 20  1  0  0  0  0
 24  1  1  0  0  0  0
 24  2  1  0  0  0  0
 24 11  1  0  0  0  0
 25  3  1  0  0  0  0
 25  4  1  0  0  0  0
 25 19  1  0  0  0  0
 26 10  1  0  0  0  0
 26 14  1  0  0  0  0
 26 23  1  0  0  0  0
 27 15  1  1  0  0  0
 27 16  1  0  0  0  0
 27 19  1  0  0  0  0
 28 15  1  6  0  0  0
 28 17  1  0  0  0  0
 28 22  1  0  0  0  0
 28 25  1  0  0  0  0
 29 20  1  0  0  0  0
 29 22  2  0  0  0  0
 30  5  1  0  0  0  0
 30 23  1  0  0  0  0
 30 27  1  0  0  0  0
 31 12  1  0  0  0  0
 31 16  1  0  0  0  0
 26 31  1  1  0  0  0
 32 22  1  0  0  0  0
 33 23  2  0  0  0  0
 34 13  1  0  0  0  0
 34 21  1  0  0  0  0
 35 18  1  0  0  0  0
 35 24  1  0  0  0  0
 19 36  1  1  0  0  0
M  END


  Mrv1652305152110322D          

 36 42  0  0  1  0            999 V2000
    6.2059   -1.7753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5988   -2.6059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1610   -1.7878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3482   -2.4351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9448   -0.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4926   -0.4197    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5301   -1.2566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5178   -2.2488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3157   -2.4586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7803    0.0192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5312   -0.9987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6968   -1.6016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9901   -0.3759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2109   -0.6429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7385   -1.1931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5069   -1.6934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3006   -1.4530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8963   -1.8726    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2058   -0.7747    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8812   -0.8669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6791   -1.0767    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7458   -0.1645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2768    0.2237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3816   -1.8100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9809   -1.6964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9777   -0.2688    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.6479   -1.4992    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.5637   -1.0819    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.5032   -0.1336    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7117   -0.4558    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1476   -1.1209    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1029    0.3142    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1679    1.0415    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1658   -0.4106    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6540   -2.1989    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4010   -0.5931    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  7  6  1  0  0  0  0
  9  8  2  0  0  0  0
 10  6  1  0  0  0  0
 12  7  1  0  0  0  0
 13 11  2  0  0  0  0
 17  8  1  0  0  0  0
 18  9  1  0  0  0  0
 19 14  1  0  0  0  0
 20 17  2  0  0  0  0
 21 18  2  0  0  0  0
 21 20  1  0  0  0  0
 24  1  1  0  0  0  0
 24  2  1  0  0  0  0
 24 11  1  0  0  0  0
 25  3  1  0  0  0  0
 25  4  1  0  0  0  0
 25 19  1  0  0  0  0
 26 10  1  0  0  0  0
 26 14  1  0  0  0  0
 26 23  1  0  0  0  0
 27 15  1  1  0  0  0
 27 16  1  0  0  0  0
 27 19  1  0  0  0  0
 28 15  1  6  0  0  0
 28 17  1  0  0  0  0
 28 22  1  0  0  0  0
 28 25  1  0  0  0  0
 29 20  1  0  0  0  0
 29 22  2  0  0  0  0
 30  5  1  0  0  0  0
 30 23  1  0  0  0  0
 30 27  1  0  0  0  0
 31 12  1  0  0  0  0
 31 16  1  0  0  0  0
 26 31  1  1  0  0  0
 32 22  1  0  0  0  0
 33 23  2  0  0  0  0
 34 13  1  0  0  0  0
 34 21  1  0  0  0  0
 35 18  1  0  0  0  0
 35 24  1  0  0  0  0
 19 36  1  1  0  0  0
M  END
> <DATABASE_ID>
MMDBc0018331

> <DATABASE_NAME>
MIME

> <SMILES>
[H][C@@]12C[C@]34CCCCN3C[C@@]1(C[C@@]1(C(O)=NC3=C1C=CC1=C3OC=CC(C)(C)O1)C2(C)C)N(C)C4=O

> <INCHI_IDENTIFIER>
InChI=1S/C28H35N3O4/c1-24(2)11-13-34-21-18(35-24)9-8-17-20(21)29-22(32)28(17)15-27-16-31-12-7-6-10-26(31,23(33)30(27)5)14-19(27)25(28,3)4/h8-9,11,13,19H,6-7,10,12,14-16H2,1-5H3,(H,29,32)/t19-,26-,27+,28+/m0/s1

> <INCHI_KEY>
KYKUTNUWXQVSSU-ZALBMCOMSA-N

> <FORMULA>
C28H35N3O4

> <MOLECULAR_WEIGHT>
477.605

> <EXACT_MASS>
477.262756619

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
70

> <JCHEM_AVERAGE_POLARIZABILITY>
52.966238824404435

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(1'S,8R,8'S,10'S)-9-hydroxy-4,4,11',11',14'-pentamethyl-4H-3',14'-diazaspiro[[1,4]dioxepino[2,3-g]indole-8,12'-tetracyclo[6.5.2.0^{1,10}.0^{3,8}]pentadecane]-15'-one

> <ALOGPS_LOGP>
3.70

> <JCHEM_LOGP>
1.5357674204757714

> <ALOGPS_LOGS>
-4.31

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
7

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.258701495095449

> <JCHEM_PKA_STRONGEST_BASIC>
6.574329110776188

> <JCHEM_POLAR_SURFACE_AREA>
74.60000000000001

> <JCHEM_REFRACTIVITY>
134.3106

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.36e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1'S,8R,8'S,10'S)-9-hydroxy-4,4,11',11',14'-pentamethyl-3',14'-diazaspiro[[1,4]dioxepino[2,3-g]indole-8,12'-tetracyclo[6.5.2.0^{1,10}.0^{3,8}]pentadecane]-15'-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 15-MAY-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-MAY-21         0                                  
HETATM    1  C   UNK     0      16.648   3.071   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      16.309   1.181   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       6.919  -2.100   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       9.257  -1.629   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       4.700  -2.920   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       0.980   2.770   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       1.797   4.106   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      10.846  -0.739   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      12.357  -0.439   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       1.896   1.508   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      14.881   3.823   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       3.364   3.927   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      13.464   4.425   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       4.990   0.814   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       6.916  -0.582   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       5.587   1.684   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       9.831   0.419   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      12.852   1.020   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       6.737   0.514   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      10.326   1.877   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      11.837   2.178   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       7.835   1.910   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       3.173  -0.525   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      15.293   2.339   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       7.895  -0.909   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       3.424   1.079   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       5.451  -0.149   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       8.291   0.439   0.000  0.00  0.00           C+0
HETATM   29  N   UNK     0       9.092   2.799   0.000  0.00  0.00           N+0
HETATM   30  N   UNK     0       4.464  -1.398   0.000  0.00  0.00           N+0
HETATM   31  N   UNK     0       4.169   2.526   0.000  0.00  0.00           N+0
HETATM   32  O   UNK     0       6.377   2.405   0.000  0.00  0.00           O+0
HETATM   33  O   UNK     0       1.761  -1.140   0.000  0.00  0.00           O+0
HETATM   34  O   UNK     0      12.109   3.693   0.000  0.00  0.00           O+0
HETATM   35  O   UNK     0      14.390   1.091   0.000  0.00  0.00           O+0
HETATM   36  H   UNK     0       6.652   2.051   0.000  0.00  0.00           H+0
CONECT    1   24                                                            
CONECT    2   24                                                            
CONECT    3   25                                                            
CONECT    4   25                                                            
CONECT    5   30                                                            
CONECT    6    7   10                                                       
CONECT    7    6   12                                                       
CONECT    8    9   17                                                       
CONECT    9    8   18                                                       
CONECT   10    6   26                                                       
CONECT   11   13   24                                                       
CONECT   12    7   31                                                       
CONECT   13   11   34                                                       
CONECT   14   19   26                                                       
CONECT   15   27   28                                                       
CONECT   16   27   31                                                       
CONECT   17    8   20   28                                                  
CONECT   18    9   21   35                                                  
CONECT   19   14   25   27   36                                             
CONECT   20   17   21   29                                                  
CONECT   21   18   20   34                                                  
CONECT   22   28   29   32                                                  
CONECT   23   26   30   33                                                  
CONECT   24    1    2   11   35                                             
CONECT   25    3    4   19   28                                             
CONECT   26   10   14   23   31                                             
CONECT   27   15   16   19   30                                             
CONECT   28   15   17   22   25                                             
CONECT   29   20   22                                                       
CONECT   30    5   23   27                                                  
CONECT   31   12   16   26                                                  
CONECT   32   22                                                            
CONECT   33   23                                                            
CONECT   34   13   21                                                       
CONECT   35   18   24                                                       
CONECT   36   19                                                            
MASTER        0    0    0    0    0    0    0    0   36    0   84    0
END

Synonyms

Not Available

Molecular Formula

C₂₈H₃₅N₃O₄

Average Mass

477.605

Monoisotopic Mass

477.262756619

IUPAC Name

(1'S,8R,8'S,10'S)-9-hydroxy-4,4,11',11',14'-pentamethyl-4H-3',14'-diazaspiro[[1,4]dioxepino[2,3-g]indole-8,12'-tetracyclo[6.5.2.0^{1,10}.0^{3,8}]pentadecane]-15'-one

Traditional Name

(1'S,8R,8'S,10'S)-9-hydroxy-4,4,11',11',14'-pentamethyl-3',14'-diazaspiro[[1,4]dioxepino[2,3-g]indole-8,12'-tetracyclo[6.5.2.0^{1,10}.0^{3,8}]pentadecane]-15'-one

CAS Registry Number

Not Available

SMILES

[H][C@@]12C[C@]34CCCCN3C[C@@]1(C[C@@]1(C(O)=NC3=C1C=CC1=C3OC=CC(C)(C)O1)C2(C)C)N(C)C4=O

InChI Identifier

InChI=1S/C28H35N3O4/c1-24(2)11-13-34-21-18(35-24)9-8-17-20(21)29-22(32)28(17)15-27-16-31-12-7-6-10-26(31,23(33)30(27)5)14-19(27)25(28,3)4/h8-9,11,13,19H,6-7,10,12,14-16H2,1-5H3,(H,29,32)/t19-,26-,27+,28+/m0/s1

InChI Key

KYKUTNUWXQVSSU-ZALBMCOMSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as piperazinopiperidines. These are organic aromatic compounds containing a piperazine ring fused to a piperidine.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Piperazinopiperidines

Sub Class

Not Available

Direct Parent

Piperazinopiperidines

Alternative Parents

Substituents

Alpha-amino acid or derivatives
Azaspirodecane
Piperazino-1,2-a-piperidine
Quinolizidine
Indole or derivatives
Dihydroindole
1,4-dioxepine
Alkyl aryl ether
Delta-lactam
Dioxepine
Aralkylamine
N-alkylpiperazine
N-methylpiperazine
Piperidinone
1,4-diazinane
Benzenoid
Piperazine
Piperidine
Tertiary carboxylic acid amide
Secondary carboxylic acid amide
Tertiary amine
Lactam
Tertiary aliphatic amine
Amino acid or derivatives
Carboxamide group
Ether
Carboxylic acid derivative
Oxacycle
Azacycle
Organic oxide
Carbonyl group
Hydrocarbon derivative
Organic oxygen compound
Organooxygen compound
Amine
Organic nitrogen compound
Organonitrogen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.024 g/L	ALOGPS
logP	3.7	ALOGPS
logP	1.54	ChemAxon
logS	-4.3	ALOGPS
pKa (Strongest Acidic)	4.26	ChemAxon
pKa (Strongest Basic)	6.57	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	74.6 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	134.31 m³·mol⁻¹	ChemAxon
Polarizability	52.97 Å³	ChemAxon
Number of Rings	7	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_1) - 70eV, Positive	Not Available	2022-08-08	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	Not Available	2022-08-09	View Spectrum
MS	Mass Spectrum (Electron Ionization)	Not Available	2022-08-06	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-22	View Spectrum

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	1	Human feces	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

C00023600

Chemspider ID

9158840

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

10983639

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Marcfortine A (MMDBc0018331)

MOL for #<Metabolite:0x00007f8dbfb03e30>

3D MOL for #<Metabolite:0x00007f8dbfb03e30>

3D SDF for #<Metabolite:0x00007f8dbfb03e30>

3D-SDF for #<Metabolite:0x00007f8dbfb03e30>

PDB for #<Metabolite:0x00007f8dbfb03e30>

3D PDB for #<Metabolite:0x00007f8dbfb03e30>

SMILES for #<Metabolite:0x00007f8dbfb03e30>

INCHI for #<Metabolite:0x00007f8dbfb03e30>

Structure for #<Metabolite:0x00007f8dbfb03e30>

3D Structure for #<Metabolite:0x00007f8dbfb03e30>