MiMeDB: Showing metabocard for Burkholone (MMDBc0018511)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-05-15 08:41:20 UTC

Update Date

2025-10-07 16:06:50 UTC

Metabolite ID

MMDBc0018511

Metabolite Identification

Common Name

Burkholone

Description

Burkholone is a quinolone antibiotic, specifically classified as a cytotoxic metabolite derived from Burkholderia sp. Its chemical structure has been elucidated as (E)-3-methyl-2-(2-octenyl)-4-quinolone through a series of NMR analyses (PMID:18057702 ). This compound exhibits significant activity against IGF-I dependent cells, demonstrating an IC50 value of 160 nM in IGF-I containing medium, while showing no cytotoxic effects in IL-3 containing medium at concentrations up to 37 µM (PMID:18057702 ). The pathways in which burkholone is involved include the inhibition of IGF-I signaling, which is critical for cell survival and proliferation. The discovery of burkholone highlights its potential as a lead compound in the development of new therapeutic agents targeting IGF-I dependent pathways, particularly in cancer biology where IGF-I signaling plays a pivotal role in tumor growth and resistance to apoptosis (PMID:18057702 ).

Structure

MOL SDF PDB SMILES InChI


  Mrv1652305152110412D          

 22 23  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  3  1  1  0  0  0  0
  4  3  1  0  0  0  0
  5  4  1  0  0  0  0
  6  5  1  0  0  0  0
  7  6  1  0  0  0  0
  8  7  2  0  0  0  0
 10  9  2  0  0  0  0
 11  9  1  0  0  0  0
 12  8  1  0  0  0  0
 13 10  1  0  0  0  0
 14  2  1  0  0  0  0
 15 11  2  0  0  0  0
 16 12  1  0  0  0  0
 16 14  2  0  0  0  0
 17 13  2  0  0  0  0
 17 15  1  0  0  0  0
 18 14  1  0  0  0  0
 18 15  1  0  0  0  0
 19 16  1  0  0  0  0
 19 17  1  0  0  0  0
 20 18  2  0  0  0  0
 21  7  1  0  0  0  0
 22  8  1  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0018511

> <DATABASE_NAME>
MIME

> <SMILES>
[H]\C(CCCCC)=C(\[H])CC1=C(C)C(=O)C2=CC=CC=C2N1

> <INCHI_IDENTIFIER>
InChI=1S/C18H23NO/c1-3-4-5-6-7-8-12-16-14(2)18(20)15-11-9-10-13-17(15)19-16/h7-11,13H,3-6,12H2,1-2H3,(H,19,20)/b8-7+

> <INCHI_KEY>
HROARYQHAQCVQN-BQYQJAHWSA-N

> <FORMULA>
C18H23NO

> <MOLECULAR_WEIGHT>
269.388

> <EXACT_MASS>
269.177964365

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
43

> <JCHEM_AVERAGE_POLARIZABILITY>
32.682985427113195

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
3-methyl-2-[(2E)-oct-2-en-1-yl]-1,4-dihydroquinolin-4-one

> <ALOGPS_LOGP>
5.54

> <JCHEM_LOGP>
5.37556588

> <ALOGPS_LOGS>
-4.70

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
11.761788163300729

> <JCHEM_PKA_STRONGEST_BASIC>
1.6595275986651004

> <JCHEM_POLAR_SURFACE_AREA>
29.1

> <JCHEM_REFRACTIVITY>
88.4415

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
5.36e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
3-methyl-2-[(2E)-oct-2-en-1-yl]-1H-quinolin-4-one

> <JCHEM_VEBER_RULE>
1

$$$$

HEADER    PROTEIN                                 15-MAY-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-MAY-21         0                                  
HETATM    1  C   UNK     0       2.667  -7.700   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      14.670  -5.390   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       4.001  -6.930   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       5.335  -7.700   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       6.668  -6.930   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       8.002  -7.700   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       9.336  -6.930   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      10.669  -7.700   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      17.338 -11.550   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      16.004 -12.320   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      17.338 -10.010   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      12.003  -6.930   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      14.670 -11.550   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      14.670  -6.930   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      16.004  -9.240   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      13.337  -7.700   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      14.670 -10.010   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      16.004  -7.700   0.000  0.00  0.00           C+0
HETATM   19  N   UNK     0      13.337  -9.240   0.000  0.00  0.00           N+0
HETATM   20  O   UNK     0      17.338  -6.930   0.000  0.00  0.00           O+0
HETATM   21  H   UNK     0       9.336  -5.390   0.000  0.00  0.00           H+0
HETATM   22  H   UNK     0      10.669  -9.240   0.000  0.00  0.00           H+0
CONECT    1    3                                                            
CONECT    2   14                                                            
CONECT    3    1    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8   21                                                  
CONECT    8    7   12   22                                                  
CONECT    9   10   11                                                       
CONECT   10    9   13                                                       
CONECT   11    9   15                                                       
CONECT   12    8   16                                                       
CONECT   13   10   17                                                       
CONECT   14    2   16   18                                                  
CONECT   15   11   17   18                                                  
CONECT   16   12   14   19                                                  
CONECT   17   13   15   19                                                  
CONECT   18   14   15   20                                                  
CONECT   19   16   17                                                       
CONECT   20   18                                                            
CONECT   21    7                                                            
CONECT   22    8                                                            
MASTER        0    0    0    0    0    0    0    0   22    0   46    0
END

Synonyms

Value	Source
3-Methyl-2-(2-octenyl)-4-quinolone	MeSH

Molecular Formula

C₁₈H₂₃NO

Average Mass

269.388

Monoisotopic Mass

269.177964365

IUPAC Name

3-methyl-2-[(2E)-oct-2-en-1-yl]-1,4-dihydroquinolin-4-one

Traditional Name

3-methyl-2-[(2E)-oct-2-en-1-yl]-1H-quinolin-4-one

CAS Registry Number

Not Available

SMILES

[H]\C(CCCCC)=C(\[H])CC1=C(C)C(=O)C2=CC=CC=C2N1

InChI Identifier

InChI=1S/C18H23NO/c1-3-4-5-6-7-8-12-16-14(2)18(20)15-11-9-10-13-17(15)19-16/h7-11,13H,3-6,12H2,1-2H3,(H,19,20)/b8-7+

InChI Key

HROARYQHAQCVQN-BQYQJAHWSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as hydroquinolones. Hydroquinolones are compounds containing a hydrogenated quinoline bearing a ketone group.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Quinolines and derivatives

Sub Class

Quinolones and derivatives

Direct Parent

Hydroquinolones

Alternative Parents

Substituents

Dihydroquinolone
Dihydroquinoline
Methylpyridine
Benzenoid
Pyridine
Heteroaromatic compound
Vinylogous amide
Azacycle
Organic nitrogen compound
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Organonitrogen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.0054 g/L	ALOGPS
logP	5.54	ALOGPS
logP	5.38	ChemAxon
logS	-4.7	ALOGPS
pKa (Strongest Acidic)	11.76	ChemAxon
pKa (Strongest Basic)	1.66	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	29.1 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	88.44 m³·mol⁻¹	ChemAxon
Polarizability	32.68 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria	Proteobacteria	1	Human	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

21378265

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

24740400

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Burkholone (MMDBc0018511)

MOL for #<Metabolite:0x00005560ad43c318>

3D MOL for #<Metabolite:0x00005560ad43c318>

3D SDF for #<Metabolite:0x00005560ad43c318>

3D-SDF for #<Metabolite:0x00005560ad43c318>

PDB for #<Metabolite:0x00005560ad43c318>

3D PDB for #<Metabolite:0x00005560ad43c318>

SMILES for #<Metabolite:0x00005560ad43c318>

INCHI for #<Metabolite:0x00005560ad43c318>

Structure for #<Metabolite:0x00005560ad43c318>

3D Structure for #<Metabolite:0x00005560ad43c318>