MiMeDB: Showing metabocard for Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu) (MMDBc0018561)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-05-15 08:44:51 UTC

Update Date

2025-10-07 16:06:50 UTC

Metabolite ID

MMDBc0018561

Metabolite Identification

Common Name

Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)

Description

Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L-Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu) is a class of cyclic dipeptides. There is limited literature available on these metabolites, indicating that further research is needed to fully understand their biological roles and potential applications.

Structure

MOL SDF PDB SMILES InChI


  Mrv0541 05031419592D          

 28 31  0  0  1  0            999 V2000
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4509   -2.8231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1538   -1.4253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2579   -2.6515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9608   -1.2538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919   -2.3815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8989   -2.2100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5128   -1.8669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -1.7684    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4358   -0.5422    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.7948   -0.9838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -1.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -1.9399    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -0.3707    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3198   -1.6954    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6018   -0.8123    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -1.4984    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3469   -1.5969    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6288   -0.7137    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  2  0  0  0  0
  3  1  1  0  0  0  0
  4  2  1  0  0  0  0
  7  5  1  0  0  0  0
  8  6  2  0  0  0  0
 12  5  2  0  0  0  0
 12  6  1  0  0  0  0
 12  9  1  0  0  0  0
 13 10  1  0  0  0  0
 13 11  2  0  0  0  0
 14  7  2  0  0  0  0
 14  8  1  0  0  0  0
 15  3  2  0  0  0  0
 15 13  1  0  0  0  0
 16  4  2  0  0  0  0
 16 15  1  0  0  0  0
 17  9  1  6  0  0  0
 18 10  1  6  0  0  0
 19 17  1  0  0  0  0
 20 18  1  0  0  0  0
 21 11  1  0  0  0  0
 21 16  1  0  0  0  0
 22 17  1  0  0  0  0
 22 20  2  0  0  0  0
 23 18  1  0  0  0  0
 23 19  2  0  0  0  0
 24 14  1  0  0  0  0
 25 19  1  0  0  0  0
 26 20  1  0  0  0  0
 17 27  1  1  0  0  0
 18 28  1  1  0  0  0
M  END


  Mrv0541 05031419592D          

 28 31  0  0  1  0            999 V2000
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4509   -2.8231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1538   -1.4253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2579   -2.6515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9608   -1.2538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919   -2.3815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8989   -2.2100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5128   -1.8669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -1.7684    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4358   -0.5422    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.7948   -0.9838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -1.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -1.9399    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -0.3707    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3198   -1.6954    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6018   -0.8123    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -1.4984    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3469   -1.5969    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6288   -0.7137    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  2  0  0  0  0
  3  1  1  0  0  0  0
  4  2  1  0  0  0  0
  7  5  1  0  0  0  0
  8  6  2  0  0  0  0
 12  5  2  0  0  0  0
 12  6  1  0  0  0  0
 12  9  1  0  0  0  0
 13 10  1  0  0  0  0
 13 11  2  0  0  0  0
 14  7  2  0  0  0  0
 14  8  1  0  0  0  0
 15  3  2  0  0  0  0
 15 13  1  0  0  0  0
 16  4  2  0  0  0  0
 16 15  1  0  0  0  0
 17  9  1  6  0  0  0
 18 10  1  6  0  0  0
 19 17  1  0  0  0  0
 20 18  1  0  0  0  0
 21 11  1  0  0  0  0
 21 16  1  0  0  0  0
 22 17  1  0  0  0  0
 22 20  2  0  0  0  0
 23 18  1  0  0  0  0
 23 19  2  0  0  0  0
 24 14  1  0  0  0  0
 25 19  1  0  0  0  0
 26 20  1  0  0  0  0
 17 27  1  1  0  0  0
 18 28  1  1  0  0  0
M  END
> <DATABASE_ID>
MMDBc0018561

> <DATABASE_NAME>
MIME

> <SMILES>
[H][C@@]1(CC2=CNC3=CC=CC=C23)N=C(O)[C@]([H])(CC2=CC=C(O)C=C2)N=C1O

> <INCHI_IDENTIFIER>
InChI=1S/C20H19N3O3/c24-14-7-5-12(6-8-14)9-17-19(25)23-18(20(26)22-17)10-13-11-21-16-4-2-1-3-15(13)16/h1-8,11,17-18,21,24H,9-10H2,(H,22,26)(H,23,25)/t17-,18-/m0/s1

> <INCHI_KEY>
ZJDMXAAEAVGGSK-ROUUACIJSA-N

> <FORMULA>
C20H19N3O3

> <MOLECULAR_WEIGHT>
349.3832

> <EXACT_MASS>
349.142641489

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_AVERAGE_POLARIZABILITY>
36.561283365885316

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(3S,6S)-3-[(4-hydroxyphenyl)methyl]-6-(1H-indol-3-ylmethyl)-3,6-dihydropyrazine-2,5-diol

> <ALOGPS_LOGP>
2.63

> <JCHEM_LOGP>
3.2594083378619407

> <ALOGPS_LOGS>
-4.15

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
6.2551811746198736

> <JCHEM_PKA_STRONGEST_ACIDIC>
5.449224120965689

> <JCHEM_PKA_STRONGEST_BASIC>
3.7367561199729673

> <JCHEM_POLAR_SURFACE_AREA>
101.2

> <JCHEM_REFRACTIVITY>
97.94360000000002

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.50e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(3S,6S)-3-[(4-hydroxyphenyl)methyl]-6-(1H-indol-3-ylmethyl)-3,6-dihydropyrazine-2,5-diol

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 03-MAY-14   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   03-MAY-14         0                                  
HETATM    1  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM   21  N   UNK     0       0.000   0.000   0.000  0.00  0.00           N+0
HETATM   22  N   UNK     0       0.000   0.000   0.000  0.00  0.00           N+0
HETATM   23  N   UNK     0       0.000   0.000   0.000  0.00  0.00           N+0
HETATM   24  O   UNK     0       0.000   0.000   0.000  0.00  0.00           O+0
HETATM   25  O   UNK     0       0.000   0.000   0.000  0.00  0.00           O+0
HETATM   26  O   UNK     0       0.000   0.000   0.000  0.00  0.00           O+0
HETATM   27  H   UNK     0       0.000   0.000   0.000  0.00  0.00           H+0
HETATM   28  H   UNK     0       0.000   0.000   0.000  0.00  0.00           H+0
CONECT    1    2    3                                                       
CONECT    2    1    4                                                       
CONECT    3    1   15                                                       
CONECT    4    2   16                                                       
CONECT    5    7   12                                                       
CONECT    6    8   12                                                       
CONECT    7    5   14                                                       
CONECT    8    6   14                                                       
CONECT    9   12   17                                                       
CONECT   10   13   18                                                       
CONECT   11   13   21                                                       
CONECT   12    5    6    9                                                  
CONECT   13   10   11   15                                                  
CONECT   14    7    8   24                                                  
CONECT   15    3   13   16                                                  
CONECT   16    4   15   21                                                  
CONECT   17    9   19   22   27                                             
CONECT   18   10   20   23   28                                             
CONECT   19   17   23   25                                                  
CONECT   20   18   22   26                                                  
CONECT   21   11   16                                                       
CONECT   22   17   20                                                       
CONECT   23   18   19                                                       
CONECT   24   14                                                            
CONECT   25   19                                                            
CONECT   26   20                                                            
CONECT   27   17                                                            
CONECT   28   18                                                            
MASTER        0    0    0    0    0    0    0    0   28    0   62    0
END

Synonyms

Not Available

Molecular Formula

C₂₀H₁₉N₃O₃

Average Mass

349.3832

Monoisotopic Mass

349.142641489

IUPAC Name

(3S,6S)-3-[(4-hydroxyphenyl)methyl]-6-(1H-indol-3-ylmethyl)-3,6-dihydropyrazine-2,5-diol

Traditional Name

(3S,6S)-3-[(4-hydroxyphenyl)methyl]-6-(1H-indol-3-ylmethyl)-3,6-dihydropyrazine-2,5-diol

CAS Registry Number

Not Available

SMILES

[H][C@@]1(CC2=CNC3=CC=CC=C23)N=C(O)[C@]([H])(CC2=CC=C(O)C=C2)N=C1O

InChI Identifier

InChI=1S/C20H19N3O3/c24-14-7-5-12(6-8-14)9-17-19(25)23-18(20(26)22-17)10-13-11-21-16-4-2-1-3-15(13)16/h1-8,11,17-18,21,24H,9-10H2,(H,22,26)(H,23,25)/t17-,18-/m0/s1

InChI Key

ZJDMXAAEAVGGSK-ROUUACIJSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Alpha amino acids and derivatives

Alternative Parents

Substituents

Alpha-amino acid or derivatives
3-alkylindole
Indole
Indole or derivatives
Dioxopiperazine
2,5-dioxopiperazine
1-hydroxy-2-unsubstituted benzenoid
Phenol
Monocyclic benzene moiety
1,4-diazinane
Benzenoid
Substituted pyrrole
Piperazine
Heteroaromatic compound
Pyrrole
Lactam
Carboxamide group
Secondary carboxylic acid amide
Organoheterocyclic compound
Azacycle
Organooxygen compound
Organonitrogen compound
Organic nitrogen compound
Hydrocarbon derivative
Organic oxide
Carbonyl group
Organic oxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Not Available

Predicted Properties

Property	Value	Source
Water Solubility	0.025 g/L	ALOGPS
logP	2.63	ALOGPS
logP	3.26	ChemAxon
logS	-4.2	ALOGPS
pKa (Strongest Acidic)	5.45	ChemAxon
pKa (Strongest Basic)	3.74	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	101.2 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	97.94 m³·mol⁻¹	ChemAxon
Polarizability	36.56 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Chromatographic Retention Times and Retention Indices

Retention Times

Chromatography Type	Technique	Column	Deposition Date	Retention Time (s)
Liquid Chromatography	HILIC	Waters Acquity UPLC-BEH Amide column (eluted)	2025-10-23	172.6
Liquid Chromatography	HILIC	Accucore 150 Amide HILIC (eluted)	2025-10-23	34.6
Liquid Chromatography	Reversed-phase	Hypersil Gold 1.9 µm C18 (eluted)	2025-10-23	450.9
Liquid Chromatography	Reversed-phase	Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) (eluted)	2025-10-23	359.5
Liquid Chromatography	Reversed-phase	XBridge C18 3.5u 2.1x50 mm (eluted)	2025-10-23	451.6
Liquid Chromatography	Reversed-phase	Ascentis Express C18 (eluted)	2025-10-23	230.1
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	1851.2
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (void)	2025-10-23	71.9
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC (eluted)	2025-10-23	280.9
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	202.5
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-23	132.0
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	164.4
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	156.8
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-23	26.7
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-23	270.7
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	249.4
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	302.6
Liquid Chromatography	Reversed-phase	Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex (eluted)	2025-10-23	1254.5
Liquid Chromatography	Reversed-phase	Waters Atlantis T3 (2.1 x 150 mm, 5 um) (eluted)	2025-10-23	927.0

Retention Indices

Chromatography Type	Peak Label	SMILES	Stationary Phase	Deposition Date	Retention Index
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_1	C[Si](C)(C)OC1=N[C@@H](CC2=C[NH]C3=CC=CC=C23)C(O)=N[C@H]1CC1=CC=C(O)C=C1	standard non polar	2025-10-23	1410.12
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_2	C[Si](C)(C)OC1=CC=C(C[C@@H]2N=C(O)[C@H](CC3=C[NH]C4=CC=CC=C34)N=C2O)C=C1	standard non polar	2025-10-23	1855.95
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_3	C[Si](C)(C)OC1=N[C@@H](CC2=CC=C(O)C=C2)C(O)=N[C@H]1CC1=C[NH]C2=CC=CC=C12	standard non polar	2025-10-23	2049.66
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_4	C[Si](C)(C)N1C=C(C[C@@H]2N=C(O)[C@H](CC3=CC=C(O)C=C3)N=C2O)C2=CC=CC=C21	standard non polar	2025-10-23	1810.8
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_5	C[Si](C)(C)OC1=N[C@@H](CC2=C[NH]C3=CC=CC=C23)C(O[Si](C)(C)C)=N[C@H]1CC1=CC=C(O)C=C1	standard non polar	2025-10-23	2544.52
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_6	C[Si](C)(C)OC1=N[C@@H](CC2=C[NH]C3=CC=CC=C23)C(O)=N[C@H]1CC1=CC=C(O[Si](C)(C)C)C=C1	standard non polar	2025-10-23	1981.26
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_7	C[Si](C)(C)OC1=N[C@@H](CC2=CN([Si](C)(C)C)C3=CC=CC=C23)C(O)=N[C@H]1CC1=CC=C(O)C=C1	standard non polar	2025-10-23	1732.06
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_8	C[Si](C)(C)OC1=N[C@@H](CC2=CC=C(O[Si](C)(C)C)C=C2)C(O)=N[C@H]1CC1=C[NH]C2=CC=CC=C12	standard non polar	2025-10-23	1578.25
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_9	C[Si](C)(C)OC1=CC=C(C[C@@H]2N=C(O)[C@H](CC3=CN([Si](C)(C)C)C4=CC=CC=C34)N=C2O)C=C1	standard non polar	2025-10-23	1566.07
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_10	C[Si](C)(C)OC1=N[C@@H](CC2=CC=C(O)C=C2)C(O)=N[C@H]1CC1=CN([Si](C)(C)C)C2=CC=CC=C12	standard non polar	2025-10-23	769.805
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_11	C[Si](C)(C)OC1=N[C@@H](CC2=C[NH]C3=CC=CC=C23)C(O[Si](C)(C)C)=N[C@H]1CC1=CC=C(O[Si](C)(C)C)C=C1	standard non polar	2025-10-23	2062.04
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_12	C[Si](C)(C)OC1=N[C@@H](CC2=CN([Si](C)(C)C)C3=CC=CC=C23)C(O[Si](C)(C)C)=N[C@H]1CC1=CC=C(O)C=C1	standard non polar	2025-10-23	1276.64
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_13	C[Si](C)(C)OC1=N[C@@H](CC2=CN([Si](C)(C)C)C3=CC=CC=C23)C(O)=N[C@H]1CC1=CC=C(O[Si](C)(C)C)C=C1	standard non polar	2025-10-23	1849.37
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_14	C[Si](C)(C)OC1=N[C@@H](CC2=CC=C(O[Si](C)(C)C)C=C2)C(O)=N[C@H]1CC1=CN([Si](C)(C)C)C2=CC=CC=C12	standard non polar	2025-10-23	1605.89
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_15	C[Si](C)(C)OC1=N[C@@H](CC2=CN([Si](C)(C)C)C3=CC=CC=C23)C(O[Si](C)(C)C)=N[C@H]1CC1=CC=C(O[Si](C)(C)C)C=C1	standard non polar	2025-10-23	1661.82
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_1	C[Si](C)(C)OC1=N[C@@H](CC2=C[NH]C3=CC=CC=C23)C(O)=N[C@H]1CC1=CC=C(O)C=C1	standard polar	2025-10-23	2591.53
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_2	C[Si](C)(C)OC1=CC=C(C[C@@H]2N=C(O)[C@H](CC3=C[NH]C4=CC=CC=C34)N=C2O)C=C1	standard polar	2025-10-23	3116.2
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_3	C[Si](C)(C)OC1=N[C@@H](CC2=CC=C(O)C=C2)C(O)=N[C@H]1CC1=C[NH]C2=CC=CC=C12	standard polar	2025-10-23	982.191
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_4	C[Si](C)(C)N1C=C(C[C@@H]2N=C(O)[C@H](CC3=CC=C(O)C=C3)N=C2O)C2=CC=CC=C21	standard polar	2025-10-23	1863.61
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_5	C[Si](C)(C)OC1=N[C@@H](CC2=C[NH]C3=CC=CC=C23)C(O[Si](C)(C)C)=N[C@H]1CC1=CC=C(O)C=C1	standard polar	2025-10-23	3063.75
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_6	C[Si](C)(C)OC1=N[C@@H](CC2=C[NH]C3=CC=CC=C23)C(O)=N[C@H]1CC1=CC=C(O[Si](C)(C)C)C=C1	standard polar	2025-10-23	1497.23
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_7	C[Si](C)(C)OC1=N[C@@H](CC2=CN([Si](C)(C)C)C3=CC=CC=C23)C(O)=N[C@H]1CC1=CC=C(O)C=C1	standard polar	2025-10-23	2563.23
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_8	C[Si](C)(C)OC1=N[C@@H](CC2=CC=C(O[Si](C)(C)C)C=C2)C(O)=N[C@H]1CC1=C[NH]C2=CC=CC=C12	standard polar	2025-10-23	2297.76
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_9	C[Si](C)(C)OC1=CC=C(C[C@@H]2N=C(O)[C@H](CC3=CN([Si](C)(C)C)C4=CC=CC=C34)N=C2O)C=C1	standard polar	2025-10-23	2771.61
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_10	C[Si](C)(C)OC1=N[C@@H](CC2=CC=C(O)C=C2)C(O)=N[C@H]1CC1=CN([Si](C)(C)C)C2=CC=CC=C12	standard polar	2025-10-23	2000.01
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_11	C[Si](C)(C)OC1=N[C@@H](CC2=C[NH]C3=CC=CC=C23)C(O[Si](C)(C)C)=N[C@H]1CC1=CC=C(O[Si](C)(C)C)C=C1	standard polar	2025-10-23	1925.72
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_12	C[Si](C)(C)OC1=N[C@@H](CC2=CN([Si](C)(C)C)C3=CC=CC=C23)C(O[Si](C)(C)C)=N[C@H]1CC1=CC=C(O)C=C1	standard polar	2025-10-23	2711.4
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_13	C[Si](C)(C)OC1=N[C@@H](CC2=CN([Si](C)(C)C)C3=CC=CC=C23)C(O)=N[C@H]1CC1=CC=C(O[Si](C)(C)C)C=C1	standard polar	2025-10-23	1779.96
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_14	C[Si](C)(C)OC1=N[C@@H](CC2=CC=C(O[Si](C)(C)C)C=C2)C(O)=N[C@H]1CC1=CN([Si](C)(C)C)C2=CC=CC=C12	standard polar	2025-10-23	2728.06
Gas Chromatography	Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu)_TMS_15	C[Si](C)(C)OC1=N[C@@H](CC2=CN([Si](C)(C)C)C3=CC=CC=C23)C(O[Si](C)(C)C)=N[C@H]1CC1=CC=C(O[Si](C)(C)C)C=C1	standard polar	2025-10-23	1793.42

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria/Eubacteria	Proteobacteria	1	Human ; Human supragingival plaque	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

7408259

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

Simon-Manso Y, Marupaka R, Yan X, Liang Y, Telu KH, Mirokhin Y, Stein SE: Mass Spectrometry Fingerprints of Small-Molecule Metabolites in Biofluids: Building a Spectral Library of Recurrent Spectra for Urine Analysis. Anal Chem. 2019 Sep 17;91(18):12021-12029. doi: 10.1021/acs.analchem.9b02977. Epub 2019 Aug 30. [PubMed:31424920 ]

Showing metabocard for Cyclo-(L-Trp-L-Tyr), (C) Cyclo-(L- Trp-L-Ile), (D) Cyclo-(L-Trp-L-Leu) (MMDBc0018561)

MOL for #<Metabolite:0x00007fc94d913188>

3D MOL for #<Metabolite:0x00007fc94d913188>

3D SDF for #<Metabolite:0x00007fc94d913188>

3D-SDF for #<Metabolite:0x00007fc94d913188>

PDB for #<Metabolite:0x00007fc94d913188>

3D PDB for #<Metabolite:0x00007fc94d913188>

SMILES for #<Metabolite:0x00007fc94d913188>

INCHI for #<Metabolite:0x00007fc94d913188>

Structure for #<Metabolite:0x00007fc94d913188>

3D Structure for #<Metabolite:0x00007fc94d913188>