MiMeDB: Showing metabocard for Avermitilol (MMDBc0019474)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-05-15 09:31:57 UTC

Update Date

2025-10-07 16:06:58 UTC

Metabolite ID

MMDBc0019474

Metabolite Identification

Common Name

Avermitilol

Description

Avermitilol is a sesquiterpene alcohol belonging to the class of terpenoids. Its biosynthesis involves complex pathways in the bacterium Streptomyces avermitilis, where the enzyme SAV_76 catalyzes the conversion of farnesyl diphosphate (FPP) into avermitilol. Quantum chemical calculations have identified several secondary carbocations as potential intermediates in this biosynthetic pathway (PMID:21322615 ). The structure of avermitilol was elucidated through a combination of NMR techniques, revealing its stereochemistry and confirming its identity as a new sesquiterpene alcohol (PMID:20536237 ). The synthesis proceeds through a cyclization mechanism that involves the formation of an intermediate bicyclogermacrene, which undergoes proton-initiated anti-Markovnikov cyclization and subsequent hydration to yield avermitilol (PMID:20536237 ). The recombinant expression of SAV_76 has also led to the production of avermitilone, a derived ketone, alongside minor amounts of other sesquiterpenes such as germacrene A, germacrene B, and viridiflorol (PMID:20536237 ). This intricate biosynthetic process highlights the chemical complexity and biological significance of avermitilol within the terpenoid family.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652305152111312D          

 21 23  0  0  1  0            999 V2000
    2.7991   -1.1016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4046    0.3200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6512   -0.6949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3073    1.8320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6517   -0.2499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3239    0.5071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9464    1.6427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1269    1.7374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4712   -0.3446    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.2743    0.8857    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.8156    1.1696    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.9630    0.3179    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.7825    0.2232    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.6021    0.1286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6351    1.0749    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4878    1.9266    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2908   -0.4392    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0313    1.2135    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9960    1.2642    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4547    0.9803    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1103   -0.5338    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  6  5  1  0  0  0  0
  8  7  1  0  0  0  0
  9  1  1  6  0  0  0
  9  5  1  0  0  0  0
 10  7  1  0  0  0  0
 11  6  1  0  0  0  0
 12  9  1  0  0  0  0
 13 10  1  0  0  0  0
 13 12  1  0  0  0  0
 14  2  1  0  0  0  0
 14  3  1  0  0  0  0
 14 10  1  0  0  0  0
 14 13  1  0  0  0  0
 15  4  1  6  0  0  0
 15  8  1  0  0  0  0
 15 11  1  0  0  0  0
 15 12  1  0  0  0  0
 11 16  1  6  0  0  0
  9 17  1  1  0  0  0
 10 18  1  6  0  0  0
 11 19  1  1  0  0  0
 12 20  1  1  0  0  0
 13 21  1  6  0  0  0
M  END
> <DATABASE_ID>
MMDBc0019474

> <DATABASE_NAME>
MIME

> <SMILES>
[H][C@@]12CC[C@]3(C)[C@@]([H])(O)CC[C@@]([H])(C)[C@@]3([H])[C@]1([H])C2(C)C

> <INCHI_IDENTIFIER>
InChI=1S/C15H26O/c1-9-5-6-11(16)15(4)8-7-10-13(12(9)15)14(10,2)3/h9-13,16H,5-8H2,1-4H3/t9-,10-,11+,12+,13-,15-/m1/s1

> <INCHI_KEY>
BLGPPSRDEKNCLT-CDWXYHGHSA-N

> <FORMULA>
C15H26O

> <MOLECULAR_WEIGHT>
222.372

> <EXACT_MASS>
222.198365457

> <JCHEM_ACCEPTOR_COUNT>
1

> <JCHEM_ATOM_COUNT>
42

> <JCHEM_AVERAGE_POLARIZABILITY>
27.374530797741677

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1aR,1bS,2R,5S,5aS,7aR)-1,1,2,5a-tetramethyl-decahydro-1H-cyclopropa[a]naphthalen-5-ol

> <ALOGPS_LOGP>
3.06

> <JCHEM_LOGP>
3.275926600666666

> <ALOGPS_LOGS>
-4.39

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
19.759304353466522

> <JCHEM_PKA_STRONGEST_BASIC>
-0.7170802757937426

> <JCHEM_POLAR_SURFACE_AREA>
20.23

> <JCHEM_REFRACTIVITY>
66.35990000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
9.03e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1aR,1bS,2R,5S,5aS,7aR)-1,1,2,5a-tetramethyl-octahydro-1aH-cyclopropa[a]naphthalen-5-ol

> <JCHEM_VEBER_RULE>
1

$$$$

HEADER    PROTEIN                                 15-MAY-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-MAY-21         0                                  
HETATM    1  C   UNK     0       5.225  -2.056   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      10.089   0.597   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       8.682  -1.297   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       4.307   3.420   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       3.083  -0.467   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       2.471   0.947   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       7.367   3.066   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       5.837   3.243   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       4.613  -0.643   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       7.979   1.653   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       3.389   2.183   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       5.531   0.593   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       7.061   0.417   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       8.591   0.240   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       4.919   2.007   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0       2.777   3.596   0.000  0.00  0.00           O+0
HETATM   17  H   UNK     0       6.143  -0.820   0.000  0.00  0.00           H+0
HETATM   18  H   UNK     0       9.392   2.265   0.000  0.00  0.00           H+0
HETATM   19  H   UNK     0       1.859   2.360   0.000  0.00  0.00           H+0
HETATM   20  H   UNK     0       6.449   1.830   0.000  0.00  0.00           H+0
HETATM   21  H   UNK     0       7.673  -0.997   0.000  0.00  0.00           H+0
CONECT    1    9                                                            
CONECT    2   14                                                            
CONECT    3   14                                                            
CONECT    4   15                                                            
CONECT    5    6    9                                                       
CONECT    6    5   11                                                       
CONECT    7    8   10                                                       
CONECT    8    7   15                                                       
CONECT    9    1    5   12   17                                             
CONECT   10    7   13   14   18                                             
CONECT   11    6   15   16   19                                             
CONECT   12    9   13   15   20                                             
CONECT   13   10   12   14   21                                             
CONECT   14    2    3   10   13                                             
CONECT   15    4    8   11   12                                             
CONECT   16   11                                                            
CONECT   17    9                                                            
CONECT   18   10                                                            
CONECT   19   11                                                            
CONECT   20   12                                                            
CONECT   21   13                                                            
MASTER        0    0    0    0    0    0    0    0   21    0   46    0
END

Synonyms

Not Available

Molecular Formula

C₁₅H₂₆O

Average Mass

222.372

Monoisotopic Mass

222.198365457

IUPAC Name

(1aR,1bS,2R,5S,5aS,7aR)-1,1,2,5a-tetramethyl-decahydro-1H-cyclopropa[a]naphthalen-5-ol

Traditional Name

(1aR,1bS,2R,5S,5aS,7aR)-1,1,2,5a-tetramethyl-octahydro-1aH-cyclopropa[a]naphthalen-5-ol

CAS Registry Number

Not Available

SMILES

[H][C@@]12CC[C@]3(C)[C@@]([H])(O)CC[C@@]([H])(C)[C@@]3([H])[C@]1([H])C2(C)C

InChI Identifier

InChI=1S/C15H26O/c1-9-5-6-11(16)15(4)8-7-10-13(12(9)15)14(10,2)3/h9-13,16H,5-8H2,1-4H3/t9-,10-,11+,12+,13-,15-/m1/s1

InChI Key

BLGPPSRDEKNCLT-CDWXYHGHSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as eudesmane, isoeudesmane or cycloeudesmane sesquiterpenoids. These are sesquiterpenoids with a structure based on the eudesmane skeleton.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Sesquiterpenoids

Direct Parent

Eudesmane, isoeudesmane or cycloeudesmane sesquiterpenoids

Alternative Parents

Substituents

Eudesmane, isoeudesmane or cycloeudesmane sesquiterpenoid
Cyclic alcohol
Secondary alcohol
Organic oxygen compound
Hydrocarbon derivative
Organooxygen compound
Alcohol
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

secondary alcohol (CHEBI:63702 )
sesquiterpenoid (CHEBI:63702 )
carbotricyclic compound (CHEBI:63702 )

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.009 g/L	ALOGPS
logP	3.06	ALOGPS
logP	3.28	ChemAxon
logS	-4.4	ALOGPS
pKa (Strongest Acidic)	19.76	ChemAxon
pKa (Strongest Basic)	-0.72	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	1	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	20.23 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	66.36 m³·mol⁻¹	ChemAxon
Polarizability	27.37 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_1) - 70eV, Positive	Not Available	2022-08-08	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	Not Available	2022-08-09	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	Not Available	2022-08-09	View Spectrum
MS	Mass Spectrum (Electron Ionization)	Not Available	2022-08-06	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-17	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-17	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-17	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-17	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-17	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-17	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-17	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-17	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-17	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-17	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-17	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-17	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-17	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-17	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-17	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-17	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-17	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-17	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-17	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-17	View Spectrum

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria/Eubacteria	Actinobacteria	2		Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

26606387

KEGG Compound ID

C20181

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

56927933

PDB ID

Not Available

ChEBI ID

63702

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

Bansal P, Morgat A, Axelsen KB, Muthukrishnan V, Coudert E, Aimo L, Hyka-Nouspikel N, Gasteiger E, Kerhornou A, Neto TB, Pozzato M, Blatter MC, Ignatchenko A, Redaschi N, Bridge A: Rhea, the reaction knowledgebase in 2022. Nucleic Acids Res. 2022 Jan 7;50(D1):D693-D700. doi: 10.1093/nar/gkab1016. [PubMed:34755880 ]

Showing metabocard for Avermitilol (MMDBc0019474)

MOL for #<Metabolite:0x00007f8dbfbcf6e8>

3D MOL for #<Metabolite:0x00007f8dbfbcf6e8>

3D SDF for #<Metabolite:0x00007f8dbfbcf6e8>

3D-SDF for #<Metabolite:0x00007f8dbfbcf6e8>

PDB for #<Metabolite:0x00007f8dbfbcf6e8>

3D PDB for #<Metabolite:0x00007f8dbfbcf6e8>

SMILES for #<Metabolite:0x00007f8dbfbcf6e8>

INCHI for #<Metabolite:0x00007f8dbfbcf6e8>

Structure for #<Metabolite:0x00007f8dbfbcf6e8>

3D Structure for #<Metabolite:0x00007f8dbfbcf6e8>