MiMeDB: Showing metabocard for Chromoazepinone A (MMDBc0019955)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-05-15 09:57:34 UTC

Update Date

2025-10-07 16:07:02 UTC

Metabolite ID

MMDBc0019955

Metabolite Identification

Common Name

Chromoazepinone A

Description

Chromoazepinone A is a novel tryptophan-derived metabolite belonging to the chemical class of azepinones. Its chemical structure features a chromone moiety fused to a seven-membered azepinone ring, which contributes to its unique properties and potential biological activities. Chromoazepinone A, alongside its analogs, was isolated from a blocked mutant of Chromobacterium violaceum, highlighting its biosynthetic implications (PMID:20490411 ). This compound has been shown to inhibit Wnt signal transcriptional activity, a crucial pathway involved in cellular processes such as proliferation and differentiation, and is notably implicated in the development of various tumors when aberrantly activated (PMID:20490411 ). The discovery of chromoazepinone A, along with other metabolites like chromoazepinone B and C, underscores its potential relevance in the study of metabolic pathways and cancer biology (PMID:20490411 ).

Structure

MOL SDF PDB SMILES InChI


  Mrv1533004241509222D          

 27 31  0  0  0  0            999 V2000
    4.8134   -2.4527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0928   -2.8545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0805   -3.6794    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3846   -2.4314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6961   -2.8859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9115   -2.6309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6216   -1.8585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7974   -1.8955    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5779   -2.6908    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1599   -3.0598    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2093   -3.8834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4793   -4.3379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2171   -3.9688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -3.1453    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0447   -1.1503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5902   -0.4618    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8623   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4586   -1.6097    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1172   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6323    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1172    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9018    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6163    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3308    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3308   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6163   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9018    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
  6 14  1  0  0  0  0
  9 14  1  0  0  0  0
  7 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
  4 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 19 27  1  0  0  0  0
 22 27  1  0  0  0  0
M  END


  Mrv1533004241509222D          

 27 31  0  0  0  0            999 V2000
    4.8134   -2.4527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0928   -2.8545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0805   -3.6794    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3846   -2.4314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6961   -2.8859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9115   -2.6309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6216   -1.8585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7974   -1.8955    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5779   -2.6908    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1599   -3.0598    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2093   -3.8834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4793   -4.3379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2171   -3.9688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -3.1453    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0447   -1.1503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5902   -0.4618    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8623   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4586   -1.6097    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1172   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6323    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1172    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9018    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6163    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3308    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3308   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6163   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9018    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
  6 14  1  0  0  0  0
  9 14  1  0  0  0  0
  7 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
  4 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 19 27  1  0  0  0  0
 22 27  1  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0019955

> <DATABASE_NAME>
MIME

> <SMILES>
OC(=O)C1=CC2=C(NC3=CC=CC=C23)C(=O)C(N1)C1=CNC2=CC=CC=C12

> <INCHI_IDENTIFIER>
InChI=1S/C21H15N3O3/c25-20-18-13(11-5-2-4-8-16(11)23-18)9-17(21(26)27)24-19(20)14-10-22-15-7-3-1-6-12(14)15/h1-10,19,22-24H,(H,26,27)

> <INCHI_KEY>
WAYCTJIOHZZDEI-UHFFFAOYSA-N

> <FORMULA>
C21H15N3O3

> <MOLECULAR_WEIGHT>
357.369

> <EXACT_MASS>
357.111341355

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
42

> <JCHEM_AVERAGE_POLARIZABILITY>
37.21383116137608

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
4-(1H-indol-3-yl)-5-oxo-3H,4H,5H,6H-azepino[4,5-b]indole-2-carboxylic acid

> <ALOGPS_LOGP>
2.75

> <JCHEM_LOGP>
2.7257591173333324

> <ALOGPS_LOGS>
-4.60

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
12.35771212124807

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.031294770972561

> <JCHEM_PKA_STRONGEST_BASIC>
-2.1872372325109004

> <JCHEM_POLAR_SURFACE_AREA>
97.97999999999999

> <JCHEM_REFRACTIVITY>
101.71150000000003

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
9.08e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
4-(1H-indol-3-yl)-5-oxo-3H,4H,6H-azepino[4,5-b]indole-2-carboxylic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 24-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-APR-15         0                                  
HETATM    1  O   UNK     0       8.985  -4.578   0.000  0.00  0.00           O+0
HETATM    2  C   UNK     0       7.640  -5.328   0.000  0.00  0.00           C+0
HETATM    3  O   UNK     0       7.617  -6.868   0.000  0.00  0.00           O+0
HETATM    4  C   UNK     0       6.318  -4.539   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       5.033  -5.387   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       3.568  -4.911   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       3.027  -3.469   0.000  0.00  0.00           C+0
HETATM    8  N   UNK     0       1.489  -3.538   0.000  0.00  0.00           N+0
HETATM    9  C   UNK     0       1.079  -5.023   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      -0.299  -5.712   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      -0.391  -7.249   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       0.895  -8.097   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       2.272  -7.408   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       2.364  -5.871   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       3.817  -2.147   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0       2.968  -0.862   0.000  0.00  0.00           O+0
HETATM   17  C   UNK     0       5.343  -1.941   0.000  0.00  0.00           C+0
HETATM   18  N   UNK     0       6.456  -3.005   0.000  0.00  0.00           N+0
HETATM   19  C   UNK     0       5.819  -0.476   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       4.914   0.770   0.000  0.00  0.00           C+0
HETATM   21  N   UNK     0       5.819   2.016   0.000  0.00  0.00           N+0
HETATM   22  C   UNK     0       7.283   1.540   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       8.617   2.310   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       9.951   1.540   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       9.951  -0.000   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       8.617  -0.770   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       7.283   0.000   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    4                                                  
CONECT    3    2                                                            
CONECT    4    2    5   18                                                  
CONECT    5    4    6                                                       
CONECT    6    5    7   14                                                  
CONECT    7    6    8   15                                                  
CONECT    8    7    9                                                       
CONECT    9    8   10   14                                                  
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13    6    9                                                  
CONECT   15    7   16   17                                                  
CONECT   16   15                                                            
CONECT   17   15   18   19                                                  
CONECT   18   17    4                                                       
CONECT   19   17   20   27                                                  
CONECT   20   19   21                                                       
CONECT   21   20   22                                                       
CONECT   22   21   23   27                                                  
CONECT   23   22   24                                                       
CONECT   24   23   25                                                       
CONECT   25   24   26                                                       
CONECT   26   25   27                                                       
CONECT   27   26   19   22                                                  
MASTER        0    0    0    0    0    0    0    0   27    0   62    0
END

Synonyms

Value	Source
4-(1H-indol-3-yl)-5-oxo-3H,4H,5H,6H-Azepino[4,5-b]indole-2-carboxylate	Generator

Molecular Formula

C₂₁H₁₅N₃O₃

Average Mass

357.369

Monoisotopic Mass

357.111341355

IUPAC Name

4-(1H-indol-3-yl)-5-oxo-3H,4H,5H,6H-azepino[4,5-b]indole-2-carboxylic acid

Traditional Name

4-(1H-indol-3-yl)-5-oxo-3H,4H,6H-azepino[4,5-b]indole-2-carboxylic acid

CAS Registry Number

Not Available

SMILES

OC(=O)C1=CC2=C(NC3=CC=CC=C23)C(=O)C(N1)C1=CNC2=CC=CC=C12

InChI Identifier

InChI=1S/C21H15N3O3/c25-20-18-13(11-5-2-4-8-16(11)23-18)9-17(21(26)27)24-19(20)14-10-22-15-7-3-1-6-12(14)15/h1-10,19,22-24H,(H,26,27)

InChI Key

WAYCTJIOHZZDEI-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon).

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Alpha amino acids

Alternative Parents

Substituents

Alpha-amino acid
3-alkylindole
Indole
Indole or derivatives
Aryl alkyl ketone
Aryl ketone
Azepine
Aralkylamine
Substituted pyrrole
Benzenoid
Pyrrole
Heteroaromatic compound
Ketone
Monocarboxylic acid or derivatives
Enamine
Secondary aliphatic amine
Carboxylic acid
Azacycle
Organoheterocyclic compound
Amine
Organic nitrogen compound
Organooxygen compound
Organonitrogen compound
Hydrocarbon derivative
Organic oxide
Carbonyl group
Organic oxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.0091 g/L	ALOGPS
logP	2.75	ALOGPS
logP	2.73	ChemAxon
logS	-4.6	ALOGPS
pKa (Strongest Acidic)	4.03	ChemAxon
pKa (Strongest Basic)	-2.2	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	97.98 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	101.71 m³·mol⁻¹	ChemAxon
Polarizability	37.21 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

This table shows at most 5 pathways. For the full list of associated pathways:

See All Associated Bacterial Pathways

Name	SMPDB/PathBank	Species

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria/Eubacteria	Proteobacteria	1		Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

46861730

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

References

Synthesis Reference

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Chromoazepinone A (MMDBc0019955)

MOL for #<Metabolite:0x00007fb49dc947e0>

3D MOL for #<Metabolite:0x00007fb49dc947e0>

3D SDF for #<Metabolite:0x00007fb49dc947e0>

3D-SDF for #<Metabolite:0x00007fb49dc947e0>

PDB for #<Metabolite:0x00007fb49dc947e0>

3D PDB for #<Metabolite:0x00007fb49dc947e0>

SMILES for #<Metabolite:0x00007fb49dc947e0>

INCHI for #<Metabolite:0x00007fb49dc947e0>

Structure for #<Metabolite:0x00007fb49dc947e0>

3D Structure for #<Metabolite:0x00007fb49dc947e0>