MiMeDB: Showing metabocard for Trichoderpyrone (MMDBc0022345)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-05-15 12:28:12 UTC

Update Date

2025-10-07 16:07:11 UTC

Metabolite ID

MMDBc0022345

Metabolite Identification

Common Name

Trichoderpyrone

Description

Trichoderpyrone is a unique polyketide hybrid with a cyclopentenone-pyrone skeleton, isolated from the plant endophytic fungus Trichoderma gamsii (PMID:28571311 ). Its chemical structure features a distinctive combination of a cyclopentenone and a pyrone, which contributes to its unique properties. Trichoderpyrone is synthesized through polyketide biosynthetic pathways, involving the assembly of acetyl-CoA and malonyl-CoA building blocks, followed by cyclization and modification steps typical of polyketide formation. In terms of biological activity, trichoderpyrone has been shown to exhibit weak cytotoxic effects against various cancer cell lines, including A549, HepG2, and HeLa (PMID:28571311 ). This suggests potential involvement in pathways related to cellular stress responses or apoptosis, although its precise mechanisms of action remain to be fully elucidated. The exploration of trichoderpyrone's chemical properties and biological interactions continues to be of interest in the field of natural product chemistry and pharmacology, highlighting the importance of fungal metabolites in the search for new therapeutic agents.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652305152114282D          

 22 23  0  0  1  0            999 V2000
    3.3957    3.9692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2161    1.9356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5986    0.8370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5887    4.1408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0600    1.0957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693    3.0428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3956    1.8494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9341    1.5907    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.6242    2.2581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2395    1.0095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492    2.2581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7546    1.6769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041    3.0428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0902    2.4306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    3.5277    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.1393    1.5907    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9040    0.2558    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4888    3.2977    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8352    3.2152    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4847    4.1408    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9106    2.5168    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1136    1.5045    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  4  1  2  0  0  0  0
  7  2  1  0  0  0  0
  7  5  2  0  0  0  0
  8  3  1  6  0  0  0
  9  6  1  0  0  0  0
 10  5  1  0  0  0  0
 11  8  1  0  0  0  0
 11  9  2  0  0  0  0
 12  8  1  0  0  0  0
 12 10  2  0  0  0  0
 13 11  1  0  0  0  0
 14 12  1  0  0  0  0
 15  4  1  1  0  0  0
 15  6  1  0  0  0  0
 15 13  1  0  0  0  0
 16  9  1  0  0  0  0
 17 10  1  0  0  0  0
 18 13  2  0  0  0  0
 19 14  2  0  0  0  0
 15 20  1  6  0  0  0
 21  7  1  0  0  0  0
 21 14  1  0  0  0  0
  8 22  1  1  0  0  0
M  END
> <DATABASE_ID>
MMDBc0022345

> <DATABASE_NAME>
MIME

> <SMILES>
[H][C@@](C)(C1=C(N)C[C@@](O)(C=C)C1=O)C1=C(O)C=C(C)OC1=O

> <INCHI_IDENTIFIER>
InChI=1S/C15H17NO5/c1-4-15(20)6-9(16)11(13(15)18)8(3)12-10(17)5-7(2)21-14(12)19/h4-5,8,17,20H,1,6,16H2,2-3H3/t8-,15+/m1/s1

> <INCHI_KEY>
IPFZSYWRCDUVTF-GLEZIHRCSA-N

> <FORMULA>
C15H17NO5

> <MOLECULAR_WEIGHT>
291.303

> <EXACT_MASS>
291.110672651

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
38

> <JCHEM_AVERAGE_POLARIZABILITY>
29.260168394280306

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
3-[(1R)-1-[(4R)-2-amino-4-ethenyl-4-hydroxy-5-oxocyclopent-1-en-1-yl]ethyl]-4-hydroxy-6-methyl-2H-pyran-2-one

> <ALOGPS_LOGP>
0.33

> <JCHEM_LOGP>
0.15976880433333338

> <ALOGPS_LOGS>
-2.04

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
12.542954134839682

> <JCHEM_PKA_STRONGEST_ACIDIC>
7.4804123756134455

> <JCHEM_PKA_STRONGEST_BASIC>
-3.87413585854467

> <JCHEM_POLAR_SURFACE_AREA>
109.85000000000001

> <JCHEM_REFRACTIVITY>
79.686

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.63e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
3-[(1R)-1-[(4R)-2-amino-4-ethenyl-4-hydroxy-5-oxocyclopent-1-en-1-yl]ethyl]-4-hydroxy-6-methylpyran-2-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 15-MAY-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-MAY-21         0                                  
HETATM    1  C   UNK     0       6.339   7.409   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      11.603   3.613   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       4.851   1.562   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       4.832   7.729   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       9.445   2.045   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       2.556   5.680   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      10.072   3.452   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       5.477   2.969   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       3.032   4.215   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       7.914   1.884   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       4.572   4.215   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       7.009   3.130   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       5.048   5.680   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       7.635   4.537   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       3.802   6.585   0.000  0.00  0.00           C+0
HETATM   16  N   UNK     0       2.127   2.969   0.000  0.00  0.00           N+0
HETATM   17  O   UNK     0       7.287   0.478   0.000  0.00  0.00           O+0
HETATM   18  O   UNK     0       6.512   6.156   0.000  0.00  0.00           O+0
HETATM   19  O   UNK     0       7.159   6.002   0.000  0.00  0.00           O+0
HETATM   20  O   UNK     0       2.771   7.729   0.000  0.00  0.00           O+0
HETATM   21  O   UNK     0       9.167   4.698   0.000  0.00  0.00           O+0
HETATM   22  H   UNK     0       3.945   2.808   0.000  0.00  0.00           H+0
CONECT    1    4                                                            
CONECT    2    7                                                            
CONECT    3    8                                                            
CONECT    4    1   15                                                       
CONECT    5    7   10                                                       
CONECT    6    9   15                                                       
CONECT    7    2    5   21                                                  
CONECT    8    3   11   12   22                                             
CONECT    9    6   11   16                                                  
CONECT   10    5   12   17                                                  
CONECT   11    8    9   13                                                  
CONECT   12    8   10   14                                                  
CONECT   13   11   15   18                                                  
CONECT   14   12   19   21                                                  
CONECT   15    4    6   13   20                                             
CONECT   16    9                                                            
CONECT   17   10                                                            
CONECT   18   13                                                            
CONECT   19   14                                                            
CONECT   20   15                                                            
CONECT   21    7   14                                                       
CONECT   22    8                                                            
MASTER        0    0    0    0    0    0    0    0   22    0   46    0
END

Synonyms

Not Available

Molecular Formula

C₁₅H₁₇NO₅

Average Mass

291.303

Monoisotopic Mass

291.110672651

IUPAC Name

3-[(1R)-1-[(4R)-2-amino-4-ethenyl-4-hydroxy-5-oxocyclopent-1-en-1-yl]ethyl]-4-hydroxy-6-methyl-2H-pyran-2-one

Traditional Name

3-[(1R)-1-[(4R)-2-amino-4-ethenyl-4-hydroxy-5-oxocyclopent-1-en-1-yl]ethyl]-4-hydroxy-6-methylpyran-2-one

CAS Registry Number

Not Available

SMILES

[H][C@@](C)(C1=C(N)C[C@@](O)(C=C)C1=O)C1=C(O)C=C(C)OC1=O

InChI Identifier

InChI=1S/C15H17NO5/c1-4-15(20)6-9(16)11(13(15)18)8(3)12-10(17)5-7(2)21-14(12)19/h4-5,8,17,20H,1,6,16H2,2-3H3/t8-,15+/m1/s1

InChI Key

IPFZSYWRCDUVTF-GLEZIHRCSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as terpene lactones. These are prenol lipids containing a lactone ring.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Terpene lactones

Direct Parent

Terpene lactones

Alternative Parents

Substituents

Terpene lactone
Monoterpenoid
Monocyclic monoterpenoid
Aromatic monoterpenoid
Pyranone
Pyran
Acyloin
Heteroaromatic compound
Vinylogous amide
Vinylogous acid
Tertiary alcohol
Cyclic ketone
Lactone
Ketone
Oxacycle
Organoheterocyclic compound
Enamine
Organic nitrogen compound
Organic oxygen compound
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Primary amine
Organooxygen compound
Organonitrogen compound
Primary aliphatic amine
Carbonyl group
Amine
Alcohol
Aromatic heteromonocyclic compound

Molecular Framework

Aromatic heteromonocyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	2.63 g/L	ALOGPS
logP	0.33	ALOGPS
logP	0.16	ChemAxon
logS	-2	ALOGPS
pKa (Strongest Acidic)	7.48	ChemAxon
pKa (Strongest Basic)	-3.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	109.85 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	79.69 m³·mol⁻¹	ChemAxon
Polarizability	29.26 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_1) - 70eV, Positive	Not Available	2022-08-08	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	Not Available	2022-08-10	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	Not Available	2022-08-10	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	Not Available	2022-08-10	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	Not Available	2022-08-10	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	Not Available	2022-08-10	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	Not Available	2022-08-10	View Spectrum
MS	Mass Spectrum (Electron Ionization)	Not Available	2022-08-06	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-18	View Spectrum

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	1	Human feces	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

59718195

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

139589739

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Trichoderpyrone (MMDBc0022345)

MOL for #<Metabolite:0x00007f8d93c5d9d8>

3D MOL for #<Metabolite:0x00007f8d93c5d9d8>

3D SDF for #<Metabolite:0x00007f8d93c5d9d8>

3D-SDF for #<Metabolite:0x00007f8d93c5d9d8>

PDB for #<Metabolite:0x00007f8d93c5d9d8>

3D PDB for #<Metabolite:0x00007f8d93c5d9d8>

SMILES for #<Metabolite:0x00007f8d93c5d9d8>

INCHI for #<Metabolite:0x00007f8d93c5d9d8>

Structure for #<Metabolite:0x00007f8d93c5d9d8>

3D Structure for #<Metabolite:0x00007f8d93c5d9d8>