MiMeDB: Showing metabocard for Indolepyrazine A (MMDBc0026266)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-05-15 15:56:21 UTC

Update Date

2025-10-07 16:07:38 UTC

Metabolite ID

MMDBc0026266

Metabolite Identification

Common Name

Indolepyrazine A

Description

Indolepyrazine A is a novel alkaloid belonging to the chemical class of indole-pyrazine-oxindole compounds. Its unique chemical structure features a fused indole and pyrazine ring system, which is further modified by an oxindole moiety, making it the first example of such a complex alkaloid (PMID:30717135 ). This intricate arrangement of heterocycles contributes to its potential bioactivity, as it may interact with various biological pathways. Indolepyrazine A has been implicated in modulating signaling pathways related to neurotransmission and may influence cellular processes such as apoptosis and differentiation. The presence of the indole and pyrazine rings suggests that it could engage in π-π stacking interactions with biological macromolecules, potentially affecting enzyme activities or receptor binding. As research continues, understanding the chemical properties and biological pathways associated with Indolepyrazine A could provide insights into its role in natural products and its potential therapeutic applications.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652305152117562D          

 28 32  0  0  1  0            999 V2000
   -3.0311   -3.7835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7762   -4.5681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4791   -3.1704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9692   -4.7396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0047   -2.0320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4243    0.4430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3373   -3.3419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4243   -2.0320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.7945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0047   -2.8570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2902   -1.6195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4243   -0.3820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6721   -3.3419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4172   -4.1265    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.1387   -1.6195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5922   -4.1265    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2902   -0.7945    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4743    0.1018    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  3  1  2  0  0  0  0
  4  2  2  0  0  0  0
  5  1  1  0  0  0  0
  6  2  1  0  0  0  0
  7  3  1  0  0  0  0
  8  4  1  0  0  0  0
 14  9  1  0  0  0  0
 14 11  2  0  0  0  0
 15  9  1  0  0  0  0
 15 12  1  0  0  0  0
 16 10  1  0  0  0  0
 16 13  2  0  0  0  0
 17  5  2  0  0  0  0
 17 14  1  0  0  0  0
 18  6  2  0  0  0  0
 19  7  2  0  0  0  0
 19 17  1  0  0  0  0
 20  8  2  0  0  0  0
 20 18  1  0  0  0  0
 22 10  1  1  0  0  0
 22 18  1  0  0  0  0
 22 21  1  0  0  0  0
 23 12  2  0  0  0  0
 23 13  1  0  0  0  0
 24 11  1  0  0  0  0
 24 19  1  0  0  0  0
 25 15  2  0  0  0  0
 25 16  1  0  0  0  0
 26 20  1  0  0  0  0
 26 21  2  0  0  0  0
 27 21  1  0  0  0  0
 22 28  1  6  0  0  0
M  END


  Mrv1652305152117562D          

 28 32  0  0  1  0            999 V2000
   -3.0311   -3.7835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7762   -4.5681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4791   -3.1704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9692   -4.7396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0047   -2.0320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4243    0.4430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3373   -3.3419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4243   -2.0320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.7945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0047   -2.8570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2902   -1.6195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4243   -0.3820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6721   -3.3419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4172   -4.1265    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.1387   -1.6195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5922   -4.1265    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2902   -0.7945    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4743    0.1018    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  3  1  2  0  0  0  0
  4  2  2  0  0  0  0
  5  1  1  0  0  0  0
  6  2  1  0  0  0  0
  7  3  1  0  0  0  0
  8  4  1  0  0  0  0
 14  9  1  0  0  0  0
 14 11  2  0  0  0  0
 15  9  1  0  0  0  0
 15 12  1  0  0  0  0
 16 10  1  0  0  0  0
 16 13  2  0  0  0  0
 17  5  2  0  0  0  0
 17 14  1  0  0  0  0
 18  6  2  0  0  0  0
 19  7  2  0  0  0  0
 19 17  1  0  0  0  0
 20  8  2  0  0  0  0
 20 18  1  0  0  0  0
 22 10  1  1  0  0  0
 22 18  1  0  0  0  0
 22 21  1  0  0  0  0
 23 12  2  0  0  0  0
 23 13  1  0  0  0  0
 24 11  1  0  0  0  0
 24 19  1  0  0  0  0
 25 15  2  0  0  0  0
 25 16  1  0  0  0  0
 26 20  1  0  0  0  0
 26 21  2  0  0  0  0
 27 21  1  0  0  0  0
 22 28  1  6  0  0  0
M  END
> <DATABASE_ID>
MMDBc0026266

> <DATABASE_NAME>
MIME

> <SMILES>
OC1=NC2=CC=CC=C2[C@@]1(O)CC1=CN=CC(CC2=CNC3=CC=CC=C23)=N1

> <INCHI_IDENTIFIER>
InChI=1S/C22H18N4O2/c27-21-22(28,18-6-2-4-8-20(18)26-21)10-16-13-23-12-15(25-16)9-14-11-24-19-7-3-1-5-17(14)19/h1-8,11-13,24,28H,9-10H2,(H,26,27)/t22-/m0/s1

> <INCHI_KEY>
DZHDNSKQSGLWTF-QFIPXVFZSA-N

> <FORMULA>
C22H18N4O2

> <MOLECULAR_WEIGHT>
370.412

> <EXACT_MASS>
370.142975836

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
46

> <JCHEM_AVERAGE_POLARIZABILITY>
38.45128418337884

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(3S)-3-({6-[(1H-indol-3-yl)methyl]pyrazin-2-yl}methyl)-3H-indole-2,3-diol

> <ALOGPS_LOGP>
2.57

> <JCHEM_LOGP>
2.832391199666667

> <ALOGPS_LOGS>
-4.53

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
12.977018495766064

> <JCHEM_PKA_STRONGEST_ACIDIC>
2.5187725709473248

> <JCHEM_PKA_STRONGEST_BASIC>
0.3892541735393601

> <JCHEM_POLAR_SURFACE_AREA>
94.39

> <JCHEM_REFRACTIVITY>
106.5188

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.08e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(3S)-3-{[6-(1H-indol-3-ylmethyl)pyrazin-2-yl]methyl}indole-2,3-diol

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 15-MAY-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-MAY-21         0                                  
HETATM    1  C   UNK     0      -5.658  -7.063   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       6.258   2.073   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -5.182  -8.527   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       6.258   3.613   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -4.628  -5.918   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       4.924   1.303   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -3.676  -8.847   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       4.924   4.383   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -1.875  -3.793   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       0.792   0.827   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      -0.630  -6.238   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       0.792  -3.793   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       2.126  -1.483   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      -1.875  -5.333   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      -0.542  -3.023   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       0.792  -0.713   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      -3.121  -6.238   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       3.590   2.073   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      -2.645  -7.703   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       3.590   3.613   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       1.220   2.843   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       2.126   1.597   0.000  0.00  0.00           C+0
HETATM   23  N   UNK     0       2.126  -3.023   0.000  0.00  0.00           N+0
HETATM   24  N   UNK     0      -1.105  -7.703   0.000  0.00  0.00           N+0
HETATM   25  N   UNK     0      -0.542  -1.483   0.000  0.00  0.00           N+0
HETATM   26  N   UNK     0       2.126   4.089   0.000  0.00  0.00           N+0
HETATM   27  O   UNK     0      -0.320   2.843   0.000  0.00  0.00           O+0
HETATM   28  O   UNK     0       2.752   0.190   0.000  0.00  0.00           O+0
CONECT    1    3    5                                                       
CONECT    2    4    6                                                       
CONECT    3    1    7                                                       
CONECT    4    2    8                                                       
CONECT    5    1   17                                                       
CONECT    6    2   18                                                       
CONECT    7    3   19                                                       
CONECT    8    4   20                                                       
CONECT    9   14   15                                                       
CONECT   10   16   22                                                       
CONECT   11   14   24                                                       
CONECT   12   15   23                                                       
CONECT   13   16   23                                                       
CONECT   14    9   11   17                                                  
CONECT   15    9   12   25                                                  
CONECT   16   10   13   25                                                  
CONECT   17    5   14   19                                                  
CONECT   18    6   20   22                                                  
CONECT   19    7   17   24                                                  
CONECT   20    8   18   26                                                  
CONECT   21   22   26   27                                                  
CONECT   22   10   18   21   28                                             
CONECT   23   12   13                                                       
CONECT   24   11   19                                                       
CONECT   25   15   16                                                       
CONECT   26   20   21                                                       
CONECT   27   21                                                            
CONECT   28   22                                                            
MASTER        0    0    0    0    0    0    0    0   28    0   64    0
END

Synonyms

Not Available

Molecular Formula

C₂₂H₁₈N₄O₂

Average Mass

370.412

Monoisotopic Mass

370.142975836

IUPAC Name

(3S)-3-({6-[(1H-indol-3-yl)methyl]pyrazin-2-yl}methyl)-3H-indole-2,3-diol

Traditional Name

(3S)-3-{[6-(1H-indol-3-ylmethyl)pyrazin-2-yl]methyl}indole-2,3-diol

CAS Registry Number

Not Available

SMILES

OC1=NC2=CC=CC=C2[C@@]1(O)CC1=CN=CC(CC2=CNC3=CC=CC=C23)=N1

InChI Identifier

InChI=1S/C22H18N4O2/c27-21-22(28,18-6-2-4-8-20(18)26-21)10-16-13-23-12-15(25-16)9-14-11-24-19-7-3-1-5-17(14)19/h1-8,11-13,24,28H,9-10H2,(H,26,27)/t22-/m0/s1

InChI Key

DZHDNSKQSGLWTF-QFIPXVFZSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as 3-alkylindoles. 3-Alkylindoles are compounds containing an indole moiety that carries an alkyl chain at the 3-position.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Indoles and derivatives

Sub Class

Indoles

Direct Parent

3-alkylindoles

Alternative Parents

Substituents

3-alkylindole
Benzenoid
Substituted pyrrole
Pyrazine
Heteroaromatic compound
Cyclic carboximidic acid
Tertiary alcohol
Pyrrole
Azacycle
Organic 1,3-dipolar compound
Propargyl-type 1,3-dipolar organic compound
Organic nitrogen compound
Organic oxygen compound
Organopnictogen compound
Hydrocarbon derivative
Organooxygen compound
Organonitrogen compound
Alcohol
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.011 g/L	ALOGPS
logP	2.57	ALOGPS
logP	2.83	ChemAxon
logS	-4.5	ALOGPS
pKa (Strongest Acidic)	2.52	ChemAxon
pKa (Strongest Basic)	0.39	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	94.39 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	106.52 m³·mol⁻¹	ChemAxon
Polarizability	38.45 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria	Proteobacteria	1	Human feces; Human sputum; Human urine; Human saliva; Human ; Human mucosa; Human supragingival plaque	Metabolic reconstruction

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

72446009

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

146682891

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Indolepyrazine A (MMDBc0026266)

MOL for #<Metabolite:0x00007f8de8ce3ec0>

3D MOL for #<Metabolite:0x00007f8de8ce3ec0>

3D SDF for #<Metabolite:0x00007f8de8ce3ec0>

3D-SDF for #<Metabolite:0x00007f8de8ce3ec0>

PDB for #<Metabolite:0x00007f8de8ce3ec0>

3D PDB for #<Metabolite:0x00007f8de8ce3ec0>

SMILES for #<Metabolite:0x00007f8de8ce3ec0>

INCHI for #<Metabolite:0x00007f8de8ce3ec0>

Structure for #<Metabolite:0x00007f8de8ce3ec0>

3D Structure for #<Metabolite:0x00007f8de8ce3ec0>