MiMeDB: Showing metabocard for 5-Methylaminomethyl-2-thiouridine (MMDBc0030124)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-11-17 23:54:50 UTC

Update Date

2022-08-31 17:39:53 UTC

Metabolite ID

MMDBc0030124

Metabolite Identification

Common Name

5-Methylaminomethyl-2-thiouridine

Description

5-methylaminomethyl-2-thiouridine is a member of the chemical class known as Pyrimidine Nucleosides and Analogues. These are compounds comprising a pyrimidine base attached to a sugar. 5-methylaminomethyl-2-thiouridine is invovled in Selenouridine biosynthesis (tRNA). The selenium-modified nucleoside is 5-methyl-aminomethyl-2-selenouridine (mnm5Se2U), which is the chemical analog of 5-methylaminomethyl-2-thiouridine, a previously identified minor base of E. coli. tRNA2Glu. (PMID 6227514 )

Structure

MOL SDF PDB SMILES InChI


  Mrv0541 10241208092D          

 24 25  0  0  0  0            999 V2000
   -5.6509   -0.7230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3455   -0.1418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0401    0.4394    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1298    2.0602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5251   -0.2280    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6548    1.8053    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.3222    2.2902    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.9897    1.8053    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.1895   -0.9817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7347    1.0206    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.8841   -0.4005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8305   -0.8092    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3690   -1.0679    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2197    0.3532    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3014    2.8672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222    3.1152    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7743    2.0602    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6744   -1.6491    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9097    1.0206    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0636   -0.4867    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8122    2.6151    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7596    2.8935    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1187    2.6201    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5496    1.1497    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  5  2  1  0  0  0  0
  5  3  2  0  0  0  0
  6  4  1  6  0  0  0
  7  6  1  0  0  0  0
  8  7  1  0  0  0  0
  9  5  1  0  0  0  0
 10  8  1  0  0  0  0
 12  1  1  0  0  0  0
 12  2  1  0  0  0  0
 13  9  2  0  0  0  0
 13 11  1  0  0  0  0
 14  3  1  0  0  0  0
 10 14  1  6  0  0  0
 14 11  1  0  0  0  0
 15  4  1  0  0  0  0
  7 16  1  1  0  0  0
  8 17  1  1  0  0  0
 18  9  1  0  0  0  0
 19  6  1  0  0  0  0
 19 10  1  0  0  0  0
 20 11  2  0  0  0  0
  6 21  1  1  0  0  0
  7 22  1  6  0  0  0
  8 23  1  6  0  0  0
 10 24  1  1  0  0  0
M  END
> <DATABASE_ID>
MMDBc0030124

> <DATABASE_NAME>
MIME

> <SMILES>
[H][C@@]1(CO)O[C@]([H])(N2C=C(CNC)C(O)=NC2=S)[C@@]([H])(O)[C@@]1([H])O

> <INCHI_IDENTIFIER>
InChI=1S/C11H17N3O5S/c1-12-2-5-3-14(11(20)13-9(5)18)10-8(17)7(16)6(4-15)19-10/h3,6-8,10,12,15-17H,2,4H2,1H3,(H,13,18,20)/t6-,7-,8-,10-/m0/s1

> <INCHI_KEY>
HXVKEKIORVUWDR-GHCJXIJMSA-N

> <FORMULA>
C11H17N3O5S

> <MOLECULAR_WEIGHT>
303.335

> <EXACT_MASS>
303.088891359

> <JCHEM_ACCEPTOR_COUNT>
7

> <JCHEM_AVERAGE_POLARIZABILITY>
29.608750541132473

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
5

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
1-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-5-[(methylamino)methyl]-1,2-dihydropyrimidine-2-thione

> <ALOGPS_LOGP>
-1.40

> <JCHEM_LOGP>
-3.303891551916258

> <ALOGPS_LOGS>
-2.07

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA>
12.55597576317983

> <JCHEM_PKA_STRONGEST_ACIDIC>
7.739826938854929

> <JCHEM_PKA_STRONGEST_BASIC>
9.220828717973758

> <JCHEM_POLAR_SURFACE_AREA>
117.78000000000002

> <JCHEM_REFRACTIVITY>
73.4421

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.60e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
1-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-5-[(methylamino)methyl]pyrimidine-2-thione

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 24-OCT-12   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-OCT-12         0                                  
HETATM    1  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM   12  N   UNK     0       0.000   0.000   0.000  0.00  0.00           N+0
HETATM   13  N   UNK     0       0.000   0.000   0.000  0.00  0.00           N+0
HETATM   14  N   UNK     0       0.000   0.000   0.000  0.00  0.00           N+0
HETATM   15  O   UNK     0       0.000   0.000   0.000  0.00  0.00           O+0
HETATM   16  O   UNK     0       0.000   0.000   0.000  0.00  0.00           O+0
HETATM   17  O   UNK     0       0.000   0.000   0.000  0.00  0.00           O+0
HETATM   18  O   UNK     0       0.000   0.000   0.000  0.00  0.00           O+0
HETATM   19  O   UNK     0       0.000   0.000   0.000  0.00  0.00           O+0
HETATM   20  S   UNK     0       0.000   0.000   0.000  0.00  0.00           S+0
HETATM   21  H   UNK     0       0.000   0.000   0.000  0.00  0.00           H+0
HETATM   22  H   UNK     0       0.000   0.000   0.000  0.00  0.00           H+0
HETATM   23  H   UNK     0       0.000   0.000   0.000  0.00  0.00           H+0
HETATM   24  H   UNK     0       0.000   0.000   0.000  0.00  0.00           H+0
CONECT    1   12                                                            
CONECT    2    5   12                                                       
CONECT    3    5   14                                                       
CONECT    4    6   15                                                       
CONECT    5    2    3    9                                                  
CONECT    6    4    7   19   21                                             
CONECT    7    6    8   16   22                                             
CONECT    8    7   10   17   23                                             
CONECT    9    5   13   18                                                  
CONECT   10    8   14   19   24                                             
CONECT   11   13   14   20                                                  
CONECT   12    1    2                                                       
CONECT   13    9   11                                                       
CONECT   14    3   10   11                                                  
CONECT   15    4                                                            
CONECT   16    7                                                            
CONECT   17    8                                                            
CONECT   18    9                                                            
CONECT   19    6   10                                                       
CONECT   20   11                                                            
CONECT   21    6                                                            
CONECT   22    7                                                            
CONECT   23    8                                                            
CONECT   24   10                                                            
MASTER        0    0    0    0    0    0    0    0   24    0   50    0
END

Synonyms

Not Available

Molecular Formula

C₁₁H₁₇N₃O₅S

Average Mass

303.335

Monoisotopic Mass

303.088891359

IUPAC Name

1-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-5-[(methylamino)methyl]-1,2-dihydropyrimidine-2-thione

Traditional Name

1-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-5-[(methylamino)methyl]pyrimidine-2-thione

CAS Registry Number

32860-54-1

SMILES

[H][C@@]1(CO)O[C@]([H])(N2C=C(CNC)C(O)=NC2=S)[C@@]([H])(O)[C@@]1([H])O

InChI Identifier

InChI=1S/C11H17N3O5S/c1-12-2-5-3-14(11(20)13-9(5)18)10-8(17)7(16)6(4-15)19-10/h3,6-8,10,12,15-17H,2,4H2,1H3,(H,13,18,20)/t6-,7-,8-,10-/m0/s1

InChI Key

HXVKEKIORVUWDR-GHCJXIJMSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as pyrimidine nucleosides. Pyrimidine nucleosides are compounds comprising a pyrimidine base attached to a ribosyl or deoxyribosyl moiety.

Kingdom

Organic compounds

Super Class

Nucleosides, nucleotides, and analogues

Class

Pyrimidine nucleosides

Sub Class

Not Available

Direct Parent

Pyrimidine nucleosides

Alternative Parents

Substituents

Pyrimidine nucleoside
N-glycosyl compound
Glycosyl compound
Pentose monosaccharide
2-thiopyrimidine
Thiopyrimidine
Aralkylamine
Pyrimidone
Pyrimidinethione
Pyrimidine
Monosaccharide
Hydropyrimidine
Heteroaromatic compound
Vinylogous amide
Tetrahydrofuran
Thiourea
Secondary alcohol
Lactam
Oxacycle
Azacycle
Organoheterocyclic compound
Secondary amine
Secondary aliphatic amine
Organic nitrogen compound
Organic oxygen compound
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Primary alcohol
Organosulfur compound
Organooxygen compound
Organonitrogen compound
Amine
Alcohol
Aromatic heteromonocyclic compound

Molecular Framework

Aromatic heteromonocyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	2.6 g/L	ALOGPS
logP	-1.4	ALOGPS
logP	-3.3	ChemAxon
logS	-2.1	ALOGPS
pKa (Strongest Acidic)	7.74	ChemAxon
pKa (Strongest Basic)	9.22	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	7	ChemAxon
Hydrogen Donor Count	5	ChemAxon
Polar Surface Area	117.78 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	73.44 m³·mol⁻¹	ChemAxon
Polarizability	29.61 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_3_4) - 70eV, Positive	Not Available	2022-08-08	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-00di-0921000000-7dd67f46acaf758a4821	2015-09-15	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-00dl-1900000000-95cde416935abdfdce8d	2015-09-15	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-022c-5900000000-fe55b83c3ea1b2882b74	2015-09-15	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0udi-3469000000-97caf3bb7e171c289664	2015-09-15	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-00ec-2910000000-9ffb3a6eec7ebbede784	2015-09-15	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0a4i-9500000000-1b3a2eb33e858d83ceed	2015-09-15	View Spectrum
MS	Mass Spectrum (Electron Ionization)	Not Available	2022-08-06	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-22	View Spectrum

Chromatographic Retention Times and Retention Indices

Retention Times

Chromatography Type	Technique	Column	Deposition Date	Retention Time (s)
Liquid Chromatography	HILIC	Waters Acquity UPLC-BEH Amide column (eluted)	2025-10-23	492.8
Liquid Chromatography	HILIC	Accucore 150 Amide HILIC (eluted)	2025-10-23	387.4
Liquid Chromatography	Reversed-phase	Hypersil Gold 1.9 µm C18 (void)	2025-10-23	47.2
Liquid Chromatography	Reversed-phase	Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) (eluted)	2025-10-23	237.2
Liquid Chromatography	Reversed-phase	XBridge C18 3.5u 2.1x50 mm (eluted)	2025-10-23	328.8
Liquid Chromatography	Reversed-phase	Ascentis Express C18 (void)	2025-10-23	238.7
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	409.6
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-23	866.9
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC (eluted)	2025-10-23	475.0
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	150.3
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-23	704.6
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	165.6
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	46.8
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-23	351.7
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-23	838.4
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	62.0
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	251.1
Liquid Chromatography	Reversed-phase	Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex (eluted)	2025-10-23	595.1
Liquid Chromatography	Reversed-phase	Waters Atlantis T3 (2.1 x 150 mm, 5 um) (eluted)	2025-10-23	535.4

Retention Indices

Chromatography Type	Peak Label	SMILES	Stationary Phase	Deposition Date	Retention Index
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_1	CNCC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O)[C@@H]2O)C(=S)N=C1O	standard non polar	2025-10-24	2070.86
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_2	CNCC1=CN([C@H]2O[C@@H](CO)[C@H](O)[C@@H]2O)C(=S)N=C1O[Si](C)(C)C	standard non polar	2025-10-24	2434.89
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_3	CNCC1=CN([C@H]2O[C@@H](CO)[C@H](O)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O	standard non polar	2025-10-24	2250.23
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_4	CNCC1=CN([C@H]2O[C@@H](CO)[C@H](O[Si](C)(C)C)[C@@H]2O)C(=S)N=C1O	standard non polar	2025-10-24	2159.19
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_5	CN(CC1=CN([C@H]2O[C@@H](CO)[C@H](O)[C@@H]2O)C(=S)N=C1O)[Si](C)(C)C	standard non polar	2025-10-24	2148.71
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_6	CNCC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]2O)C(=S)N=C1O	standard non polar	2025-10-24	1908.51
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_7	CNCC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O	standard non polar	2025-10-24	2410.56
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_8	CNCC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O)[C@@H]2O)C(=S)N=C1O[Si](C)(C)C	standard non polar	2025-10-24	1777.21
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_9	CN(CC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O)[C@@H]2O)C(=S)N=C1O)[Si](C)(C)C	standard non polar	2025-10-24	1985.3
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_10	CNCC1=CN([C@H]2O[C@@H](CO)[C@H](O[Si](C)(C)C)[C@@H]2O)C(=S)N=C1O[Si](C)(C)C	standard non polar	2025-10-24	2248.26
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_11	CNCC1=CN([C@H]2O[C@@H](CO)[C@H](O)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O[Si](C)(C)C	standard non polar	2025-10-24	1932.33
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_12	CN(CC1=CN([C@H]2O[C@@H](CO)[C@H](O)[C@@H]2O)C(=S)N=C1O[Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1836.64
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_13	CNCC1=CN([C@H]2O[C@@H](CO)[C@H](O[Si](C)(C)C)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O	standard non polar	2025-10-24	1811.51
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_14	CN(CC1=CN([C@H]2O[C@@H](CO)[C@H](O)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O)[Si](C)(C)C	standard non polar	2025-10-24	2081.99
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_15	CN(CC1=CN([C@H]2O[C@@H](CO)[C@H](O[Si](C)(C)C)[C@@H]2O)C(=S)N=C1O)[Si](C)(C)C	standard non polar	2025-10-24	2108.48
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_16	CNCC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O	standard non polar	2025-10-24	2453.17
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_17	CNCC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]2O)C(=S)N=C1O[Si](C)(C)C	standard non polar	2025-10-24	1683.77
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_18	CN(CC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]2O)C(=S)N=C1O)[Si](C)(C)C	standard non polar	2025-10-24	2236.19
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_19	CNCC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O[Si](C)(C)C	standard non polar	2025-10-24	2255.23
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_20	CN(CC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O)[Si](C)(C)C	standard non polar	2025-10-24	1484.39
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_21	CN(CC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O)[C@@H]2O)C(=S)N=C1O[Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1677.15
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_22	CNCC1=CN([C@H]2O[C@@H](CO)[C@H](O[Si](C)(C)C)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O[Si](C)(C)C	standard non polar	2025-10-24	791.101
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_23	CN(CC1=CN([C@H]2O[C@@H](CO)[C@H](O[Si](C)(C)C)[C@@H]2O)C(=S)N=C1O[Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1707.01
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_24	CN(CC1=CN([C@H]2O[C@@H](CO)[C@H](O)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O[Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1762.2
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_25	CN(CC1=CN([C@H]2O[C@@H](CO)[C@H](O[Si](C)(C)C)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O)[Si](C)(C)C	standard non polar	2025-10-24	3458.71
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_26	CNCC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O[Si](C)(C)C	standard non polar	2025-10-24	1857.49
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_27	CN(CC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O)[Si](C)(C)C	standard non polar	2025-10-24	2492.67
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_28	CN(CC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]2O)C(=S)N=C1O[Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1706.32
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_29	CN(CC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O[Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1834.19
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_30	CN(CC1=CN([C@H]2O[C@@H](CO)[C@H](O[Si](C)(C)C)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O[Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	675.26
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_31	CN(CC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O[Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1984.81
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_1	CNCC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O)[C@@H]2O)C(=S)N=C1O	standard polar	2025-10-24	1862.18
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_2	CNCC1=CN([C@H]2O[C@@H](CO)[C@H](O)[C@@H]2O)C(=S)N=C1O[Si](C)(C)C	standard polar	2025-10-24	2504.38
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_3	CNCC1=CN([C@H]2O[C@@H](CO)[C@H](O)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O	standard polar	2025-10-24	2344.18
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_4	CNCC1=CN([C@H]2O[C@@H](CO)[C@H](O[Si](C)(C)C)[C@@H]2O)C(=S)N=C1O	standard polar	2025-10-24	1505.1
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_5	CN(CC1=CN([C@H]2O[C@@H](CO)[C@H](O)[C@@H]2O)C(=S)N=C1O)[Si](C)(C)C	standard polar	2025-10-24	2039.27
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_6	CNCC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]2O)C(=S)N=C1O	standard polar	2025-10-24	2516.3
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_7	CNCC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O	standard polar	2025-10-24	1158.37
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_8	CNCC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O)[C@@H]2O)C(=S)N=C1O[Si](C)(C)C	standard polar	2025-10-24	1694.97
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_9	CN(CC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O)[C@@H]2O)C(=S)N=C1O)[Si](C)(C)C	standard polar	2025-10-24	2539.77
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_10	CNCC1=CN([C@H]2O[C@@H](CO)[C@H](O[Si](C)(C)C)[C@@H]2O)C(=S)N=C1O[Si](C)(C)C	standard polar	2025-10-24	1953.64
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_11	CNCC1=CN([C@H]2O[C@@H](CO)[C@H](O)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O[Si](C)(C)C	standard polar	2025-10-24	1851.24
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_12	CN(CC1=CN([C@H]2O[C@@H](CO)[C@H](O)[C@@H]2O)C(=S)N=C1O[Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2630.77
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_13	CNCC1=CN([C@H]2O[C@@H](CO)[C@H](O[Si](C)(C)C)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O	standard polar	2025-10-24	2306.93
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_14	CN(CC1=CN([C@H]2O[C@@H](CO)[C@H](O)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O)[Si](C)(C)C	standard polar	2025-10-24	1952.39
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_15	CN(CC1=CN([C@H]2O[C@@H](CO)[C@H](O[Si](C)(C)C)[C@@H]2O)C(=S)N=C1O)[Si](C)(C)C	standard polar	2025-10-24	1998.73
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_16	CNCC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O	standard polar	2025-10-24	1657.98
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_17	CNCC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]2O)C(=S)N=C1O[Si](C)(C)C	standard polar	2025-10-24	2394.88
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_18	CN(CC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]2O)C(=S)N=C1O)[Si](C)(C)C	standard polar	2025-10-24	2151.38
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_19	CNCC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O[Si](C)(C)C	standard polar	2025-10-24	1520.38
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_20	CN(CC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O)[Si](C)(C)C	standard polar	2025-10-24	2370.71
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_21	CN(CC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O)[C@@H]2O)C(=S)N=C1O[Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2093.86
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_22	CNCC1=CN([C@H]2O[C@@H](CO)[C@H](O[Si](C)(C)C)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O[Si](C)(C)C	standard polar	2025-10-24	2390.43
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_23	CN(CC1=CN([C@H]2O[C@@H](CO)[C@H](O[Si](C)(C)C)[C@@H]2O)C(=S)N=C1O[Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	1107.81
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_24	CN(CC1=CN([C@H]2O[C@@H](CO)[C@H](O)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O[Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2243.76
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_25	CN(CC1=CN([C@H]2O[C@@H](CO)[C@H](O[Si](C)(C)C)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O)[Si](C)(C)C	standard polar	2025-10-24	2180.88
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_26	CNCC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O[Si](C)(C)C	standard polar	2025-10-24	1423.96
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_27	CN(CC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O)[Si](C)(C)C	standard polar	2025-10-24	1421.44
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_28	CN(CC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]2O)C(=S)N=C1O[Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	1280.5
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_29	CN(CC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O[Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2783.23
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_30	CN(CC1=CN([C@H]2O[C@@H](CO)[C@H](O[Si](C)(C)C)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O[Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	3187.29
Gas Chromatography	5-Methylaminomethyl-2-thiouridine_TMS_31	CN(CC1=CN([C@H]2O[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H]2O[Si](C)(C)C)C(=S)N=C1O[Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2082.21

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria/Eubacteria	Proteobacteria	1	Human ; Human feces; Human feces; pleural fluid plaque; bal; Human stool	Unknown

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

Stadtman TC: New biologic functions--selenium-dependent nucleic acids and proteins. Fundam Appl Toxicol. 1983 Sep-Oct;3(5):420-3. doi: 10.1016/s0272-0590(83)80015-3. [PubMed:6227514 ]
van der Werf MJ, Overkamp KM, Muilwijk B, Coulier L, Hankemeier T: Microbial metabolomics: toward a platform with full metabolome coverage. Anal Biochem. 2007 Nov 1;370(1):17-25. doi: 10.1016/j.ab.2007.07.022. Epub 2007 Aug 1. [PubMed:17765195 ]
Winder CL, Dunn WB, Schuler S, Broadhurst D, Jarvis R, Stephens GM, Goodacre R: Global metabolic profiling of Escherichia coli cultures: an evaluation of methods for quenching and extraction of intracellular metabolites. Anal Chem. 2008 Apr 15;80(8):2939-48. doi: 10.1021/ac7023409. Epub 2008 Mar 11. [PubMed:18331064 ]
Keseler IM, Collado-Vides J, Santos-Zavaleta A, Peralta-Gil M, Gama-Castro S, Muniz-Rascado L, Bonavides-Martinez C, Paley S, Krummenacker M, Altman T, Kaipa P, Spaulding A, Pacheco J, Latendresse M, Fulcher C, Sarker M, Shearer AG, Mackie A, Paulsen I, Gunsalus RP, Karp PD: EcoCyc: a comprehensive database of Escherichia coli biology. Nucleic Acids Res. 2011 Jan;39(Database issue):D583-90. doi: 10.1093/nar/gkq1143. Epub 2010 Nov 21. [PubMed:21097882 ]

Showing metabocard for 5-Methylaminomethyl-2-thiouridine (MMDBc0030124)

MOL for #<Metabolite:0x00007fadb84f1588>

3D MOL for #<Metabolite:0x00007fadb84f1588>

3D SDF for #<Metabolite:0x00007fadb84f1588>

3D-SDF for #<Metabolite:0x00007fadb84f1588>

PDB for #<Metabolite:0x00007fadb84f1588>

3D PDB for #<Metabolite:0x00007fadb84f1588>

SMILES for #<Metabolite:0x00007fadb84f1588>

INCHI for #<Metabolite:0x00007fadb84f1588>

Structure for #<Metabolite:0x00007fadb84f1588>

3D Structure for #<Metabolite:0x00007fadb84f1588>