MiMeDB: Showing metabocard for Protein tyrosine (MMDBc0031933)

Human

Pharmaceutical

Xenobiotic

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-11-18 01:55:35 UTC

Update Date

2025-11-05 17:12:58 UTC

Metabolite ID

MMDBc0031933

Metabolite Identification

Common Name

Protein tyrosine

Description

Protein tyrosine is a non-essential amino acid that falls under the class of proteinogenic amino acids, characterized by the presence of a phenolic hydroxyl group on its aromatic ring. This unique chemical structure allows protein tyrosine to participate in various biochemical pathways, particularly in the phosphorylation processes mediated by protein tyrosine kinases (PTKs). These enzymes play a crucial role in signal transduction, influencing cellular processes such as growth, differentiation, and metabolism. For instance, in studies involving betulinic acid, it was demonstrated that this compound inhibited collagen-induced platelet activation by decreasing the phosphorylation of SYK, a protein tyrosine kinase, thereby highlighting the importance of protein tyrosine in modulating signaling pathways related to platelet function (PMID:41170229 ). The ability of protein tyrosine to undergo phosphorylation and dephosphorylation reactions is central to its role in cellular signaling, making it a vital component in the regulation of various physiological processes.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Molecular Formula

C₂₀H₃₂O₅

Average Mass

352.4651

Monoisotopic Mass

352.224974134

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

Not Available

InChI Identifier

InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1

InChI Key

XEYBRNLFEZDVAW-ARSRFYASSA-N

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Not Available

Spectra

Not Available

Chromatographic Retention Times and Retention Indices

Retention Times

Chromatography Type	Technique	Column	Deposition Date	Retention Time (s)
Liquid Chromatography	HILIC	Waters Acquity UPLC-BEH Amide column (void)	2025-10-23	188.8
Liquid Chromatography	HILIC	Accucore 150 Amide HILIC (eluted)	2025-10-23	83.7
Liquid Chromatography	Reversed-phase	Hypersil Gold 1.9 µm C18 (eluted)	2025-10-23	474.9
Liquid Chromatography	Reversed-phase	Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) (eluted)	2025-10-23	457.7
Liquid Chromatography	Reversed-phase	XBridge C18 3.5u 2.1x50 mm (eluted)	2025-10-23	467.0
Liquid Chromatography	Reversed-phase	Ascentis Express C18 (eluted)	2025-10-23	188.4
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	2468.7
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (void)	2025-10-23	178.3
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC (eluted)	2025-10-23	342.9
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	351.5
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-23	149.0
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	165.3
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	157.4
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (void)	2025-10-23	64.6
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-23	369.8
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	149.6
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	371.2
Liquid Chromatography	Reversed-phase	Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex (eluted)	2025-10-23	1407.5
Liquid Chromatography	Reversed-phase	Waters Atlantis T3 (2.1 x 150 mm, 5 um) (eluted)	2025-10-23	1052.0

Retention Indices

Chromatography Type	Peak Label	SMILES	Stationary Phase	Deposition Date	Retention Index
Gas Chromatography	Protein tyrosine_TMS_1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O[Si](C)(C)C	standard non polar	2025-10-24	2144.38
Gas Chromatography	Protein tyrosine_TMS_2	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O[Si](C)(C)C)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	standard non polar	2025-10-24	1911.25
Gas Chromatography	Protein tyrosine_TMS_3	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C	standard non polar	2025-10-24	1870.83
Gas Chromatography	Protein tyrosine_TMS_4	CCCCC[C@H](O)/C=C/[C@@H]1C(C/C=C\CCCC(=O)O)=C(O[Si](C)(C)C)C[C@H]1O	standard non polar	2025-10-24	2201.7
Gas Chromatography	Protein tyrosine_TMS_5	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C=C(O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O	standard non polar	2025-10-24	1841.04
Gas Chromatography	Protein tyrosine_TMS_6	CCCCC[C@@H](/C=C/[C@H]1[C@H](O[Si](C)(C)C)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O[Si](C)(C)C	standard non polar	2025-10-24	1395.0
Gas Chromatography	Protein tyrosine_TMS_7	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C	standard non polar	2025-10-24	1826.59
Gas Chromatography	Protein tyrosine_TMS_8	CCCCC[C@@H](/C=C/[C@@H]1C(C/C=C\CCCC(=O)O)=C(O[Si](C)(C)C)C[C@H]1O)O[Si](C)(C)C	standard non polar	2025-10-24	1892.15
Gas Chromatography	Protein tyrosine_TMS_9	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C=C(O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O)O[Si](C)(C)C	standard non polar	2025-10-24	1777.96
Gas Chromatography	Protein tyrosine_TMS_10	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O[Si](C)(C)C)CC(=O)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C	standard non polar	2025-10-24	1700.75
Gas Chromatography	Protein tyrosine_TMS_11	CCCCC[C@H](O)/C=C/[C@@H]1C(C/C=C\CCCC(=O)O)=C(O[Si](C)(C)C)C[C@H]1O[Si](C)(C)C	standard non polar	2025-10-24	1347.2
Gas Chromatography	Protein tyrosine_TMS_12	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O[Si](C)(C)C)C=C(O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O	standard non polar	2025-10-24	2686.68
Gas Chromatography	Protein tyrosine_TMS_13	CCCCC[C@H](O)/C=C/[C@@H]1C(C/C=C\CCCC(=O)O[Si](C)(C)C)=C(O[Si](C)(C)C)C[C@H]1O	standard non polar	2025-10-24	2152.86
Gas Chromatography	Protein tyrosine_TMS_14	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C=C(O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C	standard non polar	2025-10-24	1407.38
Gas Chromatography	Protein tyrosine_TMS_15	CCCCC[C@@H](/C=C/[C@H]1[C@H](O[Si](C)(C)C)CC(=O)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C	standard non polar	2025-10-24	968.318
Gas Chromatography	Protein tyrosine_TMS_16	CCCCC[C@@H](/C=C/[C@@H]1C(C/C=C\CCCC(=O)O)=C(O[Si](C)(C)C)C[C@H]1O[Si](C)(C)C)O[Si](C)(C)C	standard non polar	2025-10-24	1716.06
Gas Chromatography	Protein tyrosine_TMS_17	CCCCC[C@@H](/C=C/[C@H]1[C@H](O[Si](C)(C)C)C=C(O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O)O[Si](C)(C)C	standard non polar	2025-10-24	1785.2
Gas Chromatography	Protein tyrosine_TMS_18	CCCCC[C@@H](/C=C/[C@@H]1C(C/C=C\CCCC(=O)O[Si](C)(C)C)=C(O[Si](C)(C)C)C[C@H]1O)O[Si](C)(C)C	standard non polar	2025-10-24	1816.73
Gas Chromatography	Protein tyrosine_TMS_19	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C=C(O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C	standard non polar	2025-10-24	1434.7
Gas Chromatography	Protein tyrosine_TMS_20	CCCCC[C@H](O)/C=C/[C@@H]1C(C/C=C\CCCC(=O)O[Si](C)(C)C)=C(O[Si](C)(C)C)C[C@H]1O[Si](C)(C)C	standard non polar	2025-10-24	2434.71
Gas Chromatography	Protein tyrosine_TMS_21	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O[Si](C)(C)C)C=C(O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C	standard non polar	2025-10-24	444.769
Gas Chromatography	Protein tyrosine_TMS_22	CCCCC[C@@H](/C=C/[C@@H]1C(C/C=C\CCCC(=O)O[Si](C)(C)C)=C(O[Si](C)(C)C)C[C@H]1O[Si](C)(C)C)O[Si](C)(C)C	standard non polar	2025-10-24	2656.91
Gas Chromatography	Protein tyrosine_TMS_23	CCCCC[C@@H](/C=C/[C@H]1[C@H](O[Si](C)(C)C)C=C(O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C	standard non polar	2025-10-24	1839.86
Gas Chromatography	Protein tyrosine_TMS_1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O[Si](C)(C)C	standard polar	2025-10-24	1629.73
Gas Chromatography	Protein tyrosine_TMS_2	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O[Si](C)(C)C)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	standard polar	2025-10-24	1688.43
Gas Chromatography	Protein tyrosine_TMS_3	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C	standard polar	2025-10-24	1686.76
Gas Chromatography	Protein tyrosine_TMS_4	CCCCC[C@H](O)/C=C/[C@@H]1C(C/C=C\CCCC(=O)O)=C(O[Si](C)(C)C)C[C@H]1O	standard polar	2025-10-24	1896.87
Gas Chromatography	Protein tyrosine_TMS_5	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C=C(O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O	standard polar	2025-10-24	1272.88
Gas Chromatography	Protein tyrosine_TMS_6	CCCCC[C@@H](/C=C/[C@H]1[C@H](O[Si](C)(C)C)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O[Si](C)(C)C	standard polar	2025-10-24	2172.8
Gas Chromatography	Protein tyrosine_TMS_7	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C	standard polar	2025-10-24	2379.47
Gas Chromatography	Protein tyrosine_TMS_8	CCCCC[C@@H](/C=C/[C@@H]1C(C/C=C\CCCC(=O)O)=C(O[Si](C)(C)C)C[C@H]1O)O[Si](C)(C)C	standard polar	2025-10-24	2579.33
Gas Chromatography	Protein tyrosine_TMS_9	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C=C(O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O)O[Si](C)(C)C	standard polar	2025-10-24	1838.15
Gas Chromatography	Protein tyrosine_TMS_10	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O[Si](C)(C)C)CC(=O)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C	standard polar	2025-10-24	1498.23
Gas Chromatography	Protein tyrosine_TMS_11	CCCCC[C@H](O)/C=C/[C@@H]1C(C/C=C\CCCC(=O)O)=C(O[Si](C)(C)C)C[C@H]1O[Si](C)(C)C	standard polar	2025-10-24	1958.61
Gas Chromatography	Protein tyrosine_TMS_12	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O[Si](C)(C)C)C=C(O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O	standard polar	2025-10-24	1453.18
Gas Chromatography	Protein tyrosine_TMS_13	CCCCC[C@H](O)/C=C/[C@@H]1C(C/C=C\CCCC(=O)O[Si](C)(C)C)=C(O[Si](C)(C)C)C[C@H]1O	standard polar	2025-10-24	3395.38
Gas Chromatography	Protein tyrosine_TMS_14	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C=C(O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C	standard polar	2025-10-24	1503.86
Gas Chromatography	Protein tyrosine_TMS_15	CCCCC[C@@H](/C=C/[C@H]1[C@H](O[Si](C)(C)C)CC(=O)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C	standard polar	2025-10-24	1431.1
Gas Chromatography	Protein tyrosine_TMS_16	CCCCC[C@@H](/C=C/[C@@H]1C(C/C=C\CCCC(=O)O)=C(O[Si](C)(C)C)C[C@H]1O[Si](C)(C)C)O[Si](C)(C)C	standard polar	2025-10-24	1974.97
Gas Chromatography	Protein tyrosine_TMS_17	CCCCC[C@@H](/C=C/[C@H]1[C@H](O[Si](C)(C)C)C=C(O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O)O[Si](C)(C)C	standard polar	2025-10-24	2561.74
Gas Chromatography	Protein tyrosine_TMS_18	CCCCC[C@@H](/C=C/[C@@H]1C(C/C=C\CCCC(=O)O[Si](C)(C)C)=C(O[Si](C)(C)C)C[C@H]1O)O[Si](C)(C)C	standard polar	2025-10-24	3151.17
Gas Chromatography	Protein tyrosine_TMS_19	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C=C(O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C	standard polar	2025-10-24	1259.94
Gas Chromatography	Protein tyrosine_TMS_20	CCCCC[C@H](O)/C=C/[C@@H]1C(C/C=C\CCCC(=O)O[Si](C)(C)C)=C(O[Si](C)(C)C)C[C@H]1O[Si](C)(C)C	standard polar	2025-10-24	2325.69
Gas Chromatography	Protein tyrosine_TMS_21	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O[Si](C)(C)C)C=C(O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C	standard polar	2025-10-24	1577.12
Gas Chromatography	Protein tyrosine_TMS_22	CCCCC[C@@H](/C=C/[C@@H]1C(C/C=C\CCCC(=O)O[Si](C)(C)C)=C(O[Si](C)(C)C)C[C@H]1O[Si](C)(C)C)O[Si](C)(C)C	standard polar	2025-10-24	1340.43
Gas Chromatography	Protein tyrosine_TMS_23	CCCCC[C@@H](/C=C/[C@H]1[C@H](O[Si](C)(C)C)C=C(O[Si](C)(C)C)[C@@H]1C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C	standard polar	2025-10-24	1480.3

Biological Properties

Cellular Locations

Cytoplasm
Endoplasmic reticulum
Extracellular
Membrane

Biospecimen Locations

Blood
Brain
Cerebrospinal Fluid (CSF)
Epidermis
Feces
Fibroblasts
Placenta
Urine

Tissue Locations

Brain
Epidermis
Fibroblasts
Placenta

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species
MMDBp0191748	Carbonyl reductase [NADPH] 1	Enzyme	P16152	Homo sapiens
MMDBp0191750	Carbonyl reductase [NADPH] 3	Enzyme	O75828	Homo sapiens
MMDBp0191751	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Unknown	P15428	Homo sapiens
MMDBp0191752	Prostaglandin E synthase	Enzyme	O14684	Homo sapiens
MMDBp0192115	Solute carrier organic anion transporter family member 1B1	Transporter	Q9Y6L6	Homo sapiens
MMDBp0193303	Aryl hydrocarbon receptor	Unknown	P35869	Homo sapiens
MMDBp0193519	Prostaglandin E2 receptor EP1 subtype	Unknown	P34995	Homo sapiens
MMDBp0193676	Prostaglandin E2 receptor EP4 subtype	Enzyme	P35408	Homo sapiens
MMDBp0194011	Prostaglandin E synthase 2	Enzyme	Q9H7Z7	Homo sapiens
MMDBp0194709	Prostaglandin E2 receptor EP3 subtype	Unknown	P43115	Homo sapiens
MMDBp0194927	Prostaglandin E2 receptor EP2 subtype	Unknown	P43116	Homo sapiens
MMDBp0195820	Solute carrier family 22 member 7	Transporter	Q9Y694	Homo sapiens
MMDBp0196262	Prostaglandin E synthase 3	Enzyme	Q15185	Homo sapiens
MMDBp0196331	CUGBP Elav-like family member 2	Unknown	O95319	Homo sapiens

Human Pathways

Pathways

Name	SMPDB/PathBank
Succinate Signalling During Inflammation

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Evidence Type	Host and Biospecimen	Data Source	Reference
Amyotrophic lateral sclerosis	Association	Human Cerebrospinal Fluid (CSF)	HMDB	11971099
Hydrocephalus	Association	Human Cerebrospinal Fluid (CSF)	HMDB	2835791
Meningitis	Association	Human Cerebrospinal Fluid (CSF)	HMDB	2835791

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria/Eubacteria	Proteobacteria	1	Human ; Human feces; Human feces; pleural fluid plaque; bal	Unknown

Exposure Sources

Other Exposures

Source Type	Data Source	Reference
Drugs	U.S. Environmental Protection Agency	CompTox
Drugs - Antimicrobial	U.S. Environmental Protection Agency	CompTox
Cosmetics	U.S. Environmental Protection Agency	CompTox
Domestics	U.S. Environmental Protection Agency	CompTox
Domestics	U.S. Environmental Protection Agency	CompTox

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified									HMDB
Human Cerebrospinal fluid (csf)	Detected and Quantified	35.0	10.0			uM	Adult (>18 years old)	Not Specified	Amyotrophic lateral sclerosis	HMDB	11971099
Human Cerebrospinal fluid (csf)	Detected and Quantified	0.00006246	0.000165			uM	Not Specified	Not Specified	hydrocephalus	HMDB	2835791
Human Cerebrospinal fluid (csf)	Detected and Quantified	0.00716		0.000116	0.0142	uM	Not Specified	Not Specified	meningitis	HMDB	2835791
Human Cerebrospinal fluid (csf)	Detected and Quantified	<0.00005110				uM	Adult (>18 years old)	Both	Normal	HMDB	6593432
Human Cerebrospinal fluid (csf)	Detected and Quantified			0	0.02	uM	Adult (>18 years old)	Both	Normal	HMDB	11971099
Human Blood	Detected and Quantified	0.000037	0.000012			uM	Adult (>18 years old)	Both	Normal	HMDB	20671299
Human Blood	Detected and Quantified	0.0000967	0.000012			uM	Adult (>18 years old)	Both	Normal	HMDB	21359215
Human Blood	Detected and Quantified	0.000172	0.00013			uM	Adult (>18 years old)	Both	Normal	HMDB	21359215
Human Urine	Detected and Quantified	0.0002	0.0002			umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	24817352
Human Blood	Detected and Quantified	0.0009	0.000060			uM	Adult (>18 years old)	Female	Normal	HMDB	12840179
Human Blood	Detected and Quantified	0.001	0.000053			uM	Adult (>18 years old)	Male	Normal	HMDB	12840179
Human Blood	Detected and Quantified	0.00218	0.00287			uM	Adult (>18 years old)	Both	Normal	HMDB	18953024
Human Blood	Detected and Quantified	0.00218	0.00287			uM	Adult (>18 years old)	Both	Normal	HMDB	21359215
Human Urine	Detected and Quantified	0.0098	0.0011			umol/mmol creatinine	Adult (>18 years old)	Female	Normal	HMDB	9373880
Human Urine	Detected and Quantified	0.015	0.002			umol/mmol creatinine	Adult (>18 years old)	Female	Normal	HMDB	9373880
Human Urine	Detected and Quantified	0.000057	0.000020			umol/mmol creatinine	Adult (>18 years old)	Female	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Urine	Detected and Quantified	0.00012	0.000025			umol/mmol creatinine	Adult (>18 years old)	Male	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Cerebrospinal fluid (csf)	Detected and Quantified	0.0013	0.0020			uM	Adult (>18 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Brain	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Epidermis	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Fibroblasts	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Placenta	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	19636438

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

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BiGG ID

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General References

Greaves MW: Does ultraviolet-evoked prostaglandin formation protect skin from actinic cancer? Lancet. 1978 Jan 28;1(8057):189. doi: 10.1016/s0140-6736(78)90618-9. [PubMed:74611 ]
Catanzarite VA: Prophylactic intramyometrial carboprost tromethamine does not substantially reduce blood loss relative to intramyometrial oxytocin at routine cesarean section. Am J Perinatol. 1990 Jan;7(1):39-42. doi: 10.1055/s-2007-999443. [PubMed:2403792 ]
Iizuka H, Ohkawara A, Ishibashi Y: Human skin epidermal adenylate cyclase systems: defective beta-adrenergic responsiveness in the involved epidermis of Darier's disease. Curr Probl Dermatol. 1983;11:45-58. doi: 10.1159/000408663. [PubMed:6317292 ]
Schmitz T, Dallot E, Leroy MJ, Breuiller-Fouche M, Ferre F, Cabrol D: EP(4) receptors mediate prostaglandin E(2)-stimulated glycosaminoglycan synthesis in human cervical fibroblasts in culture. Mol Hum Reprod. 2001 Apr;7(4):397-402. doi: 10.1093/molehr/7.4.397. [PubMed:11279302 ]
Amato F, Rizzuto G, Nicoletti A, Senatore M, Roberti R: [Isolated peripheral arterial ischaemia and medullary neurostimulation: case report]. G Ital Nefrol. 2003 Mar-Apr;20(2):200-4. [PubMed:12746806 ]
Ilzecka J: Prostaglandin E2 is increased in amyotrophic lateral sclerosis patients. Acta Neurol Scand. 2003 Aug;108(2):125-9. doi: 10.1034/j.1600-0404.2003.00102.x. [PubMed:12859290 ]
Seo JY, Kim EK, Lee SH, Park KC, Kim KH, Eun HC, Chung JH: Enhanced expression of cylooxygenase-2 by UV in aged human skin in vivo. Mech Ageing Dev. 2003 Aug-Sep;124(8-9):903-10. doi: 10.1016/s0047-6374(03)00150-7. [PubMed:14499495 ]
Konopka T, Rutkowska M, Hirnle L, Kopec W, Karolewska E: The secretion of prostaglandin E2 and interleukin 1-beta in women with periodontal diseases and preterm low-birth-weight. Bull Group Int Rech Sci Stomatol Odontol. 2003 Jan-Apr;45(1):18-28. [PubMed:14535055 ]
Yamada M, Ogata M, Kawai M, Mashima Y, Nishida T: Substance P in human tears. Cornea. 2003 Oct;22(7 Suppl):S48-54. doi: 10.1097/00003226-200310001-00007. [PubMed:14703707 ]
Laitinen K, Arvola T, Moilanen E, Lampi AM, Ruuska T, Isolauri E: Characterization of breast milk received by infants with gross blood in stools. Biol Neonate. 2005;87(1):66-72. doi: 10.1159/000081955. Epub 2004 Nov 9. [PubMed:15542928 ]
Christidis N, Kopp S, Ernberg M: The effect on mechanical pain threshold over human muscles by oral administration of granisetron and diclofenac-sodium. Pain. 2005 Feb;113(3):265-270. doi: 10.1016/j.pain.2004.10.016. [PubMed:15661432 ]
Waschbisch A, Fiebich BL, Akundi RS, Schmitz ML, Hoozemans JJ, Candelario-Jalil E, Virtainen N, Veerhuis R, Slawik H, Yrjanheikki J, Hull M: Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB. J Neurochem. 2006 Feb;96(3):680-93. doi: 10.1111/j.1471-4159.2005.03599.x. Epub 2006 Jan 9. [PubMed:16405508 ]
Choi SH, Langenbach R, Bosetti F: Cyclooxygenase-1 and -2 enzymes differentially regulate the brain upstream NF-kappa B pathway and downstream enzymes involved in prostaglandin biosynthesis. J Neurochem. 2006 Aug;98(3):801-11. doi: 10.1111/j.1471-4159.2006.03926.x. Epub 2006 Jun 19. [PubMed:16787416 ]
Harizi H, Gualde N: Pivotal role of PGE2 and IL-10 in the cross-regulation of dendritic cell-derived inflammatory mediators. Cell Mol Immunol. 2006 Aug;3(4):271-7. [PubMed:16978535 ]
Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]

Showing metabocard for Protein tyrosine (MMDBc0031933)

MOL for #<Metabolite:0x00007f9ac5e03aa0>

3D MOL for #<Metabolite:0x00007f9ac5e03aa0>

3D SDF for #<Metabolite:0x00007f9ac5e03aa0>

3D-SDF for #<Metabolite:0x00007f9ac5e03aa0>

PDB for #<Metabolite:0x00007f9ac5e03aa0>

3D PDB for #<Metabolite:0x00007f9ac5e03aa0>

SMILES for #<Metabolite:0x00007f9ac5e03aa0>

INCHI for #<Metabolite:0x00007f9ac5e03aa0>

Structure for #<Metabolite:0x00007f9ac5e03aa0>

3D Structure for #<Metabolite:0x00007f9ac5e03aa0>