MiMeDB: Showing metabocard for Homoisocitric acid (MMDBc0032930)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-11-19 04:27:47 UTC

Update Date

2025-10-07 16:07:52 UTC

Metabolite ID

MMDBc0032930

Metabolite Identification

Common Name

Homoisocitric acid

Description

Homoisocitric acid is a tricarboxylic acid, classified within the chemical class of organic acids. Its chemical structure features three carboxyl groups (-COOH) attached to a six-carbon backbone, making it a derivative of citric acid. This metabolite plays a role in various biochemical pathways, particularly in the context of the citric acid cycle and related metabolic processes. Notably, homoisocitric acid is involved in the enzymatic activity of homoaconitase, which has been shown to exhibit an apparent K(m) of 1.1 mM toward homoisocitric acid (PMID:9268014 ). This interaction highlights its significance in metabolic pathways that involve the interconversion of citric acid cycle intermediates, suggesting a potential role in energy production and biosynthesis within cells. The presence of homoisocitric acid in metabolic pathways underscores its importance in cellular metabolism, although its specific biological functions and implications remain an area of ongoing research.

Structure

MOL SDF PDB SMILES InChI

 
  Mrv0541 02241222072D          
 
 14 13  0  0  1  0            999 V2000
   15.4768  -12.2978    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   16.1879  -11.8795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.7239  -11.8795    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   15.4768  -13.1344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.9408  -12.2978    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0128  -12.2978    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.1879  -13.5526    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.7239  -13.5526    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   17.6519  -11.8795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0128  -13.0925    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.3017  -11.8795    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   17.6519  -11.0429    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   18.3630  -12.2978    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.7239  -11.0429    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  1  4  1  6  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  2  0  0  0  0
  6 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
  3 14  1  6  0  0  0
M  END
> <DATABASE_ID>
MMDBc0032930

> <DATABASE_NAME>
MIME

> <SMILES>
O[C@H]([C@H](CCC(O)=O)C(O)=O)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C7H10O7/c8-4(9)2-1-3(6(11)12)5(10)7(13)14/h3,5,10H,1-2H2,(H,8,9)(H,11,12)(H,13,14)/t3-,5+/m0/s1

> <INCHI_KEY>
OEJZZCGRGVFWHK-WVZVXSGGSA-N

> <FORMULA>
C7H10O7

> <MOLECULAR_WEIGHT>
206.1501

> <EXACT_MASS>
206.042652674

> <JCHEM_ACCEPTOR_COUNT>
7

> <JCHEM_AVERAGE_POLARIZABILITY>
17.626131533372334

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylic acid

> <ALOGPS_LOGP>
-0.54

> <JCHEM_LOGP>
-1.0017595846666665

> <ALOGPS_LOGS>
-0.90

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-3

> <JCHEM_PKA>
3.9340746844137886

> <JCHEM_PKA_STRONGEST_ACIDIC>
3.12028269600076

> <JCHEM_PKA_STRONGEST_BASIC>
-4.012518164144468

> <JCHEM_POLAR_SURFACE_AREA>
132.13

> <JCHEM_REFRACTIVITY>
40.3171

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.62e+01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(-)-homoisocitric acid

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 24-FEB-12   NONE
TITLE     NULL                                                        
COMPND    MOLECULE:                                                   
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-FEB-12         0                                  
HETATM    1  C   UNK     0      28.890 -22.956   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      30.217 -22.175   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      27.485 -22.175   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      28.890 -24.518   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      31.623 -22.956   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      26.157 -22.956   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0      30.217 -25.298   0.000  0.00  0.00           O+0
HETATM    8  O   UNK     0      27.485 -25.298   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0      32.950 -22.175   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0      26.157 -24.439   0.000  0.00  0.00           O+0
HETATM   11  O   UNK     0      24.830 -22.175   0.000  0.00  0.00           O+0
HETATM   12  O   UNK     0      32.950 -20.613   0.000  0.00  0.00           O+0
HETATM   13  O   UNK     0      34.278 -22.956   0.000  0.00  0.00           O+0
HETATM   14  O   UNK     0      27.485 -20.613   0.000  0.00  0.00           O+0
CONECT    1    2    3    4                                                  
CONECT    2    1    5                                                       
CONECT    3    1    6   14                                                  
CONECT    4    1    7    8                                                  
CONECT    5    2    9                                                       
CONECT    6    3   10   11                                                  
CONECT    7    4                                                            
CONECT    8    4                                                            
CONECT    9    5   12   13                                                  
CONECT   10    6                                                            
CONECT   11    6                                                            
CONECT   12    9                                                            
CONECT   13    9                                                            
CONECT   14    3                                                            
MASTER        0    0    0    0    0    0    0    0   14    0   26    0
END

Synonyms

Value	Source
3-Carboxy-2-hydroxyadipate	Kegg
(-)-1-Hydroxy-1,2,4-butanetricarboxylate	Kegg
(1R,2S)-1-Hydroxybutane-1,2,4-tricarboxylate	Kegg
(-)-Threo-homoisocitrate	Kegg
3-Carboxy-2-hydroxyadipic acid	Generator
(-)-1-Hydroxy-1,2,4-butanetricarboxylic acid	Generator
(1R,2S)-1-Hydroxybutane-1,2,4-tricarboxylic acid	Generator
(-)-Threo-homoisocitric acid	Generator
Homoisocitrate	Generator
Homoisocitric acid	Generator
1-Hydroxy-1,2,4-butanetricarboxylic acid	MeSH

Molecular Formula

C₇H₁₀O₇

Average Mass

206.1501

Monoisotopic Mass

206.042652674

IUPAC Name

(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylic acid

Traditional Name

(-)-homoisocitric acid

CAS Registry Number

Not Available

SMILES

O[C@H]([C@H](CCC(O)=O)C(O)=O)C(O)=O

InChI Identifier

InChI=1S/C7H10O7/c8-4(9)2-1-3(6(11)12)5(10)7(13)14/h3,5,10H,1-2H2,(H,8,9)(H,11,12)(H,13,14)/t3-,5+/m0/s1

InChI Key

OEJZZCGRGVFWHK-WVZVXSGGSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as tricarboxylic acids and derivatives. These are carboxylic acids containing exactly three carboxyl groups.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Tricarboxylic acids and derivatives

Direct Parent

Tricarboxylic acids and derivatives

Alternative Parents

Substituents

Tricarboxylic acid or derivatives
Beta-hydroxy acid
Monosaccharide
Hydroxy acid
Alpha-hydroxy acid
Secondary alcohol
Carboxylic acid
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Alcohol
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

homoisocitric acid (CHEBI:30903 )

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	26.2 g/L	ALOGPS
logP	-0.54	ALOGPS
logP	-1	ChemAxon
logS	-0.9	ALOGPS
pKa (Strongest Acidic)	3.12	ChemAxon
pKa (Strongest Basic)	-4	ChemAxon
Physiological Charge	-3	ChemAxon
Hydrogen Acceptor Count	7	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	132.13 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	40.32 m³·mol⁻¹	ChemAxon
Polarizability	17.63 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	splash10-040c-4900000000-245ee743f483524a8b03	2016-09-22	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-06yc-0910000000-5c3dafa2c882be609ea5	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-044u-3900000000-844b0dbd7ceda195cc3c	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0079-9500000000-a9250a420bcaa09a94ec	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0bt9-1930000000-53a9e446f7ec93873520	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-090r-3900000000-9b3c3bafb9f9e3cfbfdd	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0aor-9500000000-7e7a6c4a5222720a30e9	2016-09-12	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-20	View Spectrum

Chromatographic Retention Times and Retention Indices

Retention Times

Chromatography Type	Technique	Column	Deposition Date	Retention Time (s)
Liquid Chromatography	HILIC	Waters Acquity UPLC-BEH Amide column (eluted)	2025-10-24	495.4
Liquid Chromatography	HILIC	Accucore 150 Amide HILIC (eluted)	2025-10-24	334.4
Liquid Chromatography	Reversed-phase	Hypersil Gold 1.9 µm C18 (void)	2025-10-24	56.1
Liquid Chromatography	Reversed-phase	Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) (eluted)	2025-10-24	244.2
Liquid Chromatography	Reversed-phase	XBridge C18 3.5u 2.1x50 mm (eluted)	2025-10-24	275.2
Liquid Chromatography	Reversed-phase	Ascentis Express C18 (void)	2025-10-24	309.9
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-24	698.4
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-24	692.1
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC (eluted)	2025-10-24	934.5
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-24	167.2
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-24	305.1
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-24	180.9
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-24	43.4
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-24	501.6
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-24	711.6
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-24	79.0
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (void)	2025-10-24	213.1
Liquid Chromatography	Reversed-phase	Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex (eluted)	2025-10-24	849.6
Liquid Chromatography	Reversed-phase	Waters Atlantis T3 (2.1 x 150 mm, 5 um) (eluted)	2025-10-24	604.4

Retention Indices

Chromatography Type	Peak Label	SMILES	Stationary Phase	Deposition Date	Retention Index
Gas Chromatography	Homoisocitric acid_TMS_1	C[Si](C)(C)O[C@@H](C(=O)O)[C@H](CCC(=O)O)C(=O)O	standard non polar	2025-10-24	1847.28
Gas Chromatography	Homoisocitric acid_TMS_2	C[Si](C)(C)OC(=O)CC[C@H](C(=O)O)[C@@H](O)C(=O)O	standard non polar	2025-10-24	2136.57
Gas Chromatography	Homoisocitric acid_TMS_3	C[Si](C)(C)OC(=O)[C@@H](CCC(=O)O)[C@@H](O)C(=O)O	standard non polar	2025-10-24	2219.1
Gas Chromatography	Homoisocitric acid_TMS_4	C[Si](C)(C)OC(=O)[C@H](O)[C@H](CCC(=O)O)C(=O)O	standard non polar	2025-10-24	1768.83
Gas Chromatography	Homoisocitric acid_TMS_5	C[Si](C)(C)OC(=O)[C@H](O[Si](C)(C)C)[C@H](CCC(=O)O)C(=O)O	standard non polar	2025-10-24	2013.0
Gas Chromatography	Homoisocitric acid_TMS_6	C[Si](C)(C)OC(=O)CC[C@H](C(=O)O)[C@@H](O[Si](C)(C)C)C(=O)O	standard non polar	2025-10-24	1856.55
Gas Chromatography	Homoisocitric acid_TMS_7	C[Si](C)(C)OC(=O)[C@@H](CCC(=O)O)[C@@H](O[Si](C)(C)C)C(=O)O	standard non polar	2025-10-24	1473.28
Gas Chromatography	Homoisocitric acid_TMS_8	C[Si](C)(C)OC(=O)CC[C@H](C(=O)O[Si](C)(C)C)[C@@H](O)C(=O)O	standard non polar	2025-10-24	1630.05
Gas Chromatography	Homoisocitric acid_TMS_9	C[Si](C)(C)OC(=O)CC[C@H](C(=O)O)[C@@H](O)C(=O)O[Si](C)(C)C	standard non polar	2025-10-24	1555.62
Gas Chromatography	Homoisocitric acid_TMS_10	C[Si](C)(C)OC(=O)[C@@H](CCC(=O)O)[C@@H](O)C(=O)O[Si](C)(C)C	standard non polar	2025-10-24	2045.0
Gas Chromatography	Homoisocitric acid_TMS_11	C[Si](C)(C)OC(=O)CC[C@H](C(=O)O)[C@@H](O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-24	2252.06
Gas Chromatography	Homoisocitric acid_TMS_12	C[Si](C)(C)OC(=O)[C@@H](CCC(=O)O)[C@@H](O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-24	1988.83
Gas Chromatography	Homoisocitric acid_TMS_13	C[Si](C)(C)OC(=O)CC[C@H](C(=O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)C(=O)O	standard non polar	2025-10-24	2158.05
Gas Chromatography	Homoisocitric acid_TMS_14	C[Si](C)(C)OC(=O)CC[C@H](C(=O)O[Si](C)(C)C)[C@@H](O)C(=O)O[Si](C)(C)C	standard non polar	2025-10-24	1888.05
Gas Chromatography	Homoisocitric acid_TMS_15	C[Si](C)(C)OC(=O)CC[C@H](C(=O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-24	2706.88
Gas Chromatography	Homoisocitric acid_TMS_1	C[Si](C)(C)O[C@@H](C(=O)O)[C@H](CCC(=O)O)C(=O)O	standard polar	2025-10-24	2603.47
Gas Chromatography	Homoisocitric acid_TMS_2	C[Si](C)(C)OC(=O)CC[C@H](C(=O)O)[C@@H](O)C(=O)O	standard polar	2025-10-24	1877.35
Gas Chromatography	Homoisocitric acid_TMS_3	C[Si](C)(C)OC(=O)[C@@H](CCC(=O)O)[C@@H](O)C(=O)O	standard polar	2025-10-24	2645.55
Gas Chromatography	Homoisocitric acid_TMS_4	C[Si](C)(C)OC(=O)[C@H](O)[C@H](CCC(=O)O)C(=O)O	standard polar	2025-10-24	2712.1
Gas Chromatography	Homoisocitric acid_TMS_5	C[Si](C)(C)OC(=O)[C@H](O[Si](C)(C)C)[C@H](CCC(=O)O)C(=O)O	standard polar	2025-10-24	2084.85
Gas Chromatography	Homoisocitric acid_TMS_6	C[Si](C)(C)OC(=O)CC[C@H](C(=O)O)[C@@H](O[Si](C)(C)C)C(=O)O	standard polar	2025-10-24	1391.85
Gas Chromatography	Homoisocitric acid_TMS_7	C[Si](C)(C)OC(=O)[C@@H](CCC(=O)O)[C@@H](O[Si](C)(C)C)C(=O)O	standard polar	2025-10-24	1705.66
Gas Chromatography	Homoisocitric acid_TMS_8	C[Si](C)(C)OC(=O)CC[C@H](C(=O)O[Si](C)(C)C)[C@@H](O)C(=O)O	standard polar	2025-10-24	2074.4
Gas Chromatography	Homoisocitric acid_TMS_9	C[Si](C)(C)OC(=O)CC[C@H](C(=O)O)[C@@H](O)C(=O)O[Si](C)(C)C	standard polar	2025-10-24	2315.81
Gas Chromatography	Homoisocitric acid_TMS_10	C[Si](C)(C)OC(=O)[C@@H](CCC(=O)O)[C@@H](O)C(=O)O[Si](C)(C)C	standard polar	2025-10-24	1753.77
Gas Chromatography	Homoisocitric acid_TMS_11	C[Si](C)(C)OC(=O)CC[C@H](C(=O)O)[C@@H](O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-24	1978.84
Gas Chromatography	Homoisocitric acid_TMS_12	C[Si](C)(C)OC(=O)[C@@H](CCC(=O)O)[C@@H](O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-24	2498.93
Gas Chromatography	Homoisocitric acid_TMS_13	C[Si](C)(C)OC(=O)CC[C@H](C(=O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)C(=O)O	standard polar	2025-10-24	2033.59
Gas Chromatography	Homoisocitric acid_TMS_14	C[Si](C)(C)OC(=O)CC[C@H](C(=O)O[Si](C)(C)C)[C@@H](O)C(=O)O[Si](C)(C)C	standard polar	2025-10-24	2484.54
Gas Chromatography	Homoisocitric acid_TMS_15	C[Si](C)(C)OC(=O)CC[C@H](C(=O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-24	2814.19

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	1	Human feces; Human saliva	Unknown

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

C05662

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Homoisocitric acid

METLIN ID

Not Available

PubChem Compound

5460287

PDB ID

Not Available

ChEBI ID

30903

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

Strassman M, Ceci LN: Enzymatic formation of alpha-ketoadipic acid from homoisocitric acid. J Biol Chem. 1965 Nov;240(11):4357-61. [PubMed:4284830 ]
Zabriskie TM, Jackson MD: Lysine biosynthesis and metabolism in fungi. Nat Prod Rep. 2000 Feb;17(1):85-97. doi: 10.1039/a801345d. [PubMed:10714900 ]
Herrgard MJ, Swainston N, Dobson P, Dunn WB, Arga KY, Arvas M, Bluthgen N, Borger S, Costenoble R, Heinemann M, Hucka M, Le Novere N, Li P, Liebermeister W, Mo ML, Oliveira AP, Petranovic D, Pettifer S, Simeonidis E, Smallbone K, Spasic I, Weichart D, Brent R, Broomhead DS, Westerhoff HV, Kirdar B, Penttila M, Klipp E, Palsson BO, Sauer U, Oliver SG, Mendes P, Nielsen J, Kell DB: A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology. Nat Biotechnol. 2008 Oct;26(10):1155-60. doi: 10.1038/nbt1492. [PubMed:18846089 ]
Authors unspecified: Ongoing and future developments at the Universal Protein Resource. Nucleic Acids Res. 2011 Jan;39(Database issue):D214-9. doi: 10.1093/nar/gkq1020. Epub 2010 Nov 4. [PubMed:21051339 ]
Scheer M, Grote A, Chang A, Schomburg I, Munaretto C, Rother M, Sohngen C, Stelzer M, Thiele J, Schomburg D: BRENDA, the enzyme information system in 2011. Nucleic Acids Res. 2011 Jan;39(Database issue):D670-6. doi: 10.1093/nar/gkq1089. Epub 2010 Nov 9. [PubMed:21062828 ]

Showing metabocard for Homoisocitric acid (MMDBc0032930)

MOL for #<Metabolite:0x00007f9af2270008>

3D MOL for #<Metabolite:0x00007f9af2270008>

3D SDF for #<Metabolite:0x00007f9af2270008>

3D-SDF for #<Metabolite:0x00007f9af2270008>

PDB for #<Metabolite:0x00007f9af2270008>

3D PDB for #<Metabolite:0x00007f9af2270008>

SMILES for #<Metabolite:0x00007f9af2270008>

INCHI for #<Metabolite:0x00007f9af2270008>

Structure for #<Metabolite:0x00007f9af2270008>

3D Structure for #<Metabolite:0x00007f9af2270008>