MiMeDB: Showing metabocard for 2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine (MMDBc0032960)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-11-19 04:28:58 UTC

Update Date

2025-01-15 22:18:27 UTC

Metabolite ID

MMDBc0032960

Metabolite Identification

Common Name

2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine

Description

2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine is an unusual amino acid that results from the post-translational modification of histidine in certain proteins. In particular, it is a post-translational derivative of histidine that exists in protein synthesis elongation factor 2 (EF2) at the site of diphtheria toxin-catalyzed ADP-ribosylation of elongation factor 2. It is a precursor for diphthamide. This compound is a substrate for the enzyme diphthine synthase (EC 2.1.1.98). This enzyme catalyzes the chemical reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-[3-carboxy-3-(methylammonio)propyl]-L-histidine.

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

HMDB0011654
     RDKit          3D
2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine
 38 38  0  0  0  0  0  0  0  0999 V2000
   -4.7995    0.0815   -0.6151 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5821   -0.6627   -0.4968 N   0  0  0  0  0  4  0  0  0  0  0  0
   -2.9884   -0.5450    0.8327 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5230    0.8330    1.0900 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5427    1.4593    0.1971 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2166    0.8227    0.1019 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3324   -0.2281    0.7054 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5926   -0.4444    0.2961 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637    0.5408   -0.6349 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1145    0.7491   -1.3829 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1755   -0.2560   -1.0009 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.8019   -1.6212   -1.2288 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7416   -0.0354    0.3434 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8997   -0.9976    1.1141 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0864    1.2495    0.7179 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7543    1.2852   -0.7274 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0908   -1.6626    1.0622 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6442   -1.9086    2.2102 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7081   -2.4833    0.0186 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4738   -0.2198    0.2344 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6304    1.1709   -0.6461 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2886   -0.2070   -1.5605 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8186   -1.6820   -0.6476 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9143   -0.3027   -1.2188 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9149   -0.6592    1.5298 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1337    0.9242    2.1514 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4418    1.4890    1.1192 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3379    2.4963    0.6249 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9427    1.7054   -0.8220 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2343   -1.2396    0.6440 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4895    1.7628   -1.1051 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9258    0.7531   -2.4717 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0311   -0.0666   -1.7303 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9208   -1.8693   -2.2218 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1856   -2.2918   -0.5528 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5058    2.0574    0.6405 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6360    2.1219   -1.3562 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2993   -2.1192   -0.8432 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 11 13  1  0
 13 14  2  0
 13 15  1  0
  9 16  1  0
  3 17  1  0
 17 18  2  0
 17 19  1  0
 16  6  1  0
  1 20  1  0
  1 21  1  0
  1 22  1  0
  2 23  1  0
  2 24  1  0
  3 25  1  0
  4 26  1  0
  4 27  1  0
  5 28  1  0
  5 29  1  0
  8 30  1  0
 10 31  1  0
 10 32  1  0
 11 33  1  6
 12 34  1  0
 12 35  1  0
 15 36  1  0
 16 37  1  0
 19 38  1  0
M  CHG  1   2   1
M  END


  Mrv0541 02241201492D          

 19 19  0  0  1  0            999 V2000
   13.4887   -8.2250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.2338   -7.4410    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   13.7858   -6.8275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5309   -6.0429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0830   -5.4301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.8280   -4.6454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.3125   -3.9780    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.8280   -3.3106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.0434   -3.5655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.0434   -4.3905    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.3760   -3.0804    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6224   -3.4160    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   10.9549   -2.9310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0411   -2.1109    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.2013   -3.2665    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.5361   -4.2367    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   14.5928   -6.9994    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.8477   -7.7840    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.1449   -6.3859    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3 17  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6 10  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 16  1  6  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
M  CHG  1   2   1
M  END
> <DATABASE_ID>
MMDBc0032960

> <DATABASE_NAME>
MIME

> <SMILES>
C[NH2+]C(CCC1=NC=C(C[C@H](N)C(O)=O)N1)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C11H18N4O4/c1-13-8(11(18)19)2-3-9-14-5-6(15-9)4-7(12)10(16)17/h5,7-8,13H,2-4,12H2,1H3,(H,14,15)(H,16,17)(H,18,19)/p+1/t7-,8?/m0/s1

> <INCHI_KEY>
YBMOTEQVMANKGX-JAMMHHFISA-O

> <FORMULA>
C11H19N4O4

> <MOLECULAR_WEIGHT>
271.293

> <EXACT_MASS>
271.140630116

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_AVERAGE_POLARIZABILITY>
27.905161848285083

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
5

> <JCHEM_FORMAL_CHARGE>
1

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(3-{5-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-2-yl}-1-carboxypropyl)(methyl)azanium

> <ALOGPS_LOGP>
-1.31

> <JCHEM_LOGP>
-6.256054221514534

> <ALOGPS_LOGS>
-2.41

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
2.091107228921873

> <JCHEM_PKA_STRONGEST_ACIDIC>
1.4249838958401044

> <JCHEM_PKA_STRONGEST_BASIC>
10.592317287195943

> <JCHEM_POLAR_SURFACE_AREA>
145.91

> <JCHEM_REFRACTIVITY>
77.33319999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
8

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.20e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(3-{4-[(2S)-2-amino-2-carboxyethyl]-3H-imidazol-2-yl}-1-carboxypropyl)(methyl)azanium

> <JCHEM_VEBER_RULE>
0

$$$$

HMDB0011654
     RDKit          3D
2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine
 38 38  0  0  0  0  0  0  0  0999 V2000
   -4.7995    0.0815   -0.6151 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5821   -0.6627   -0.4968 N   0  0  0  0  0  4  0  0  0  0  0  0
   -2.9884   -0.5450    0.8327 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5230    0.8330    1.0900 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5427    1.4593    0.1971 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2166    0.8227    0.1019 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3324   -0.2281    0.7054 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5926   -0.4444    0.2961 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637    0.5408   -0.6349 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1145    0.7491   -1.3829 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1755   -0.2560   -1.0009 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.8019   -1.6212   -1.2288 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7416   -0.0354    0.3434 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8997   -0.9976    1.1141 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0864    1.2495    0.7179 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7543    1.2852   -0.7274 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0908   -1.6626    1.0622 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6442   -1.9086    2.2102 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7081   -2.4833    0.0186 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4738   -0.2198    0.2344 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6304    1.1709   -0.6461 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2886   -0.2070   -1.5605 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8186   -1.6820   -0.6476 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9143   -0.3027   -1.2188 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9149   -0.6592    1.5298 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1337    0.9242    2.1514 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4418    1.4890    1.1192 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3379    2.4963    0.6249 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9427    1.7054   -0.8220 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2343   -1.2396    0.6440 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4895    1.7628   -1.1051 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9258    0.7531   -2.4717 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0311   -0.0666   -1.7303 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9208   -1.8693   -2.2218 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1856   -2.2918   -0.5528 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5058    2.0574    0.6405 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6360    2.1219   -1.3562 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2993   -2.1192   -0.8432 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 11 13  1  0
 13 14  2  0
 13 15  1  0
  9 16  1  0
  3 17  1  0
 17 18  2  0
 17 19  1  0
 16  6  1  0
  1 20  1  0
  1 21  1  0
  1 22  1  0
  2 23  1  0
  2 24  1  0
  3 25  1  0
  4 26  1  0
  4 27  1  0
  5 28  1  0
  5 29  1  0
  8 30  1  0
 10 31  1  0
 10 32  1  0
 11 33  1  6
 12 34  1  0
 12 35  1  0
 15 36  1  0
 16 37  1  0
 19 38  1  0
M  CHG  1   2   1
M  END

HEADER    PROTEIN                                 24-FEB-12   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-FEB-12         0                                  
HETATM    1  C   UNK     0      25.179 -15.353   0.000  0.00  0.00           C+0
HETATM    2  N   UNK     0      24.703 -13.890   0.000  0.00  0.00           N+1
HETATM    3  C   UNK     0      25.733 -12.745   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      25.258 -11.280   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      26.288 -10.136   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      25.812  -8.671   0.000  0.00  0.00           C+0
HETATM    7  N   UNK     0      26.717  -7.426   0.000  0.00  0.00           N+0
HETATM    8  C   UNK     0      25.812  -6.180   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      24.348  -6.656   0.000  0.00  0.00           C+0
HETATM   10  N   UNK     0      24.348  -8.196   0.000  0.00  0.00           N+0
HETATM   11  C   UNK     0      23.102  -5.750   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      21.695  -6.377   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      20.449  -5.471   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0      20.610  -3.940   0.000  0.00  0.00           O+0
HETATM   15  O   UNK     0      19.042  -6.097   0.000  0.00  0.00           O+0
HETATM   16  N   UNK     0      21.534  -7.909   0.000  0.00  0.00           N+0
HETATM   17  C   UNK     0      27.240 -13.066   0.000  0.00  0.00           C+0
HETATM   18  O   UNK     0      27.716 -14.530   0.000  0.00  0.00           O+0
HETATM   19  O   UNK     0      28.270 -11.920   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4   17                                                  
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7   10                                                  
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10   11                                                  
CONECT   10    6    9                                                       
CONECT   11    9   12                                                       
CONECT   12   11   13   16                                                  
CONECT   13   12   14   15                                                  
CONECT   14   13                                                            
CONECT   15   13                                                            
CONECT   16   12                                                            
CONECT   17    3   18   19                                                  
CONECT   18   17                                                            
CONECT   19   17                                                            
MASTER        0    0    0    0    0    0    0    0   19    0   38    0
END

COMPND    HMDB0011654
HETATM    1  C1  UNL     1      -4.799   0.082  -0.615  1.00  0.00           C  
HETATM    2  N1  UNL     1      -3.582  -0.663  -0.497  1.00  0.00           N1+
HETATM    3  C2  UNL     1      -2.988  -0.545   0.833  1.00  0.00           C  
HETATM    4  C3  UNL     1      -2.523   0.833   1.090  1.00  0.00           C  
HETATM    5  C4  UNL     1      -1.543   1.459   0.197  1.00  0.00           C  
HETATM    6  C5  UNL     1      -0.217   0.823   0.102  1.00  0.00           C  
HETATM    7  N2  UNL     1       0.332  -0.228   0.705  1.00  0.00           N  
HETATM    8  C6  UNL     1       1.593  -0.444   0.296  1.00  0.00           C  
HETATM    9  C7  UNL     1       1.864   0.541  -0.635  1.00  0.00           C  
HETATM   10  C8  UNL     1       3.115   0.749  -1.383  1.00  0.00           C  
HETATM   11  C9  UNL     1       4.176  -0.256  -1.001  1.00  0.00           C  
HETATM   12  N3  UNL     1       3.802  -1.621  -1.229  1.00  0.00           N  
HETATM   13  C10 UNL     1       4.742  -0.035   0.343  1.00  0.00           C  
HETATM   14  O1  UNL     1       4.900  -0.998   1.114  1.00  0.00           O  
HETATM   15  O2  UNL     1       5.086   1.250   0.718  1.00  0.00           O  
HETATM   16  N4  UNL     1       0.754   1.285  -0.727  1.00  0.00           N  
HETATM   17  C11 UNL     1      -2.091  -1.663   1.062  1.00  0.00           C  
HETATM   18  O3  UNL     1      -1.644  -1.909   2.210  1.00  0.00           O  
HETATM   19  O4  UNL     1      -1.708  -2.483   0.019  1.00  0.00           O  
HETATM   20  H1  UNL     1      -5.474  -0.220   0.234  1.00  0.00           H  
HETATM   21  H2  UNL     1      -4.630   1.171  -0.646  1.00  0.00           H  
HETATM   22  H3  UNL     1      -5.289  -0.207  -1.560  1.00  0.00           H  
HETATM   23  H4  UNL     1      -3.819  -1.682  -0.648  1.00  0.00           H  
HETATM   24  H5  UNL     1      -2.914  -0.303  -1.219  1.00  0.00           H  
HETATM   25  H6  UNL     1      -3.915  -0.659   1.530  1.00  0.00           H  
HETATM   26  H7  UNL     1      -2.134   0.924   2.151  1.00  0.00           H  
HETATM   27  H8  UNL     1      -3.442   1.489   1.119  1.00  0.00           H  
HETATM   28  H9  UNL     1      -1.338   2.496   0.625  1.00  0.00           H  
HETATM   29  H10 UNL     1      -1.943   1.705  -0.822  1.00  0.00           H  
HETATM   30  H11 UNL     1       2.234  -1.240   0.644  1.00  0.00           H  
HETATM   31  H12 UNL     1       3.489   1.763  -1.105  1.00  0.00           H  
HETATM   32  H13 UNL     1       2.926   0.753  -2.472  1.00  0.00           H  
HETATM   33  H14 UNL     1       5.031  -0.067  -1.730  1.00  0.00           H  
HETATM   34  H15 UNL     1       3.921  -1.869  -2.222  1.00  0.00           H  
HETATM   35  H16 UNL     1       4.186  -2.292  -0.553  1.00  0.00           H  
HETATM   36  H17 UNL     1       4.506   2.057   0.640  1.00  0.00           H  
HETATM   37  H18 UNL     1       0.636   2.122  -1.356  1.00  0.00           H  
HETATM   38  H19 UNL     1      -1.299  -2.119  -0.843  1.00  0.00           H  
CONECT    1    2   20   21   22
CONECT    2    3   23   24
CONECT    3    4   17   25
CONECT    4    5   26   27
CONECT    5    6   28   29
CONECT    6    7    7   16
CONECT    7    8
CONECT    8    9    9   30
CONECT    9   10   16
CONECT   10   11   31   32
CONECT   11   12   13   33
CONECT   12   34   35
CONECT   13   14   14   15
CONECT   15   36
CONECT   16   37
CONECT   17   18   18   19
CONECT   19   38
END

HMDB0011654
     RDKit          3D
2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine
 38 38  0  0  0  0  0  0  0  0999 V2000
   -4.7995    0.0815   -0.6151 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5821   -0.6627   -0.4968 N   0  0  0  0  0  4  0  0  0  0  0  0
   -2.9884   -0.5450    0.8327 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5230    0.8330    1.0900 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5427    1.4593    0.1971 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2166    0.8227    0.1019 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3324   -0.2281    0.7054 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5926   -0.4444    0.2961 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637    0.5408   -0.6349 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1145    0.7491   -1.3829 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1755   -0.2560   -1.0009 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.8019   -1.6212   -1.2288 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7416   -0.0354    0.3434 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8997   -0.9976    1.1141 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0864    1.2495    0.7179 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7543    1.2852   -0.7274 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0908   -1.6626    1.0622 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6442   -1.9086    2.2102 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7081   -2.4833    0.0186 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4738   -0.2198    0.2344 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6304    1.1709   -0.6461 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2886   -0.2070   -1.5605 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8186   -1.6820   -0.6476 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9143   -0.3027   -1.2188 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9149   -0.6592    1.5298 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1337    0.9242    2.1514 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4418    1.4890    1.1192 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3379    2.4963    0.6249 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9427    1.7054   -0.8220 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2343   -1.2396    0.6440 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4895    1.7628   -1.1051 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9258    0.7531   -2.4717 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0311   -0.0666   -1.7303 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9208   -1.8693   -2.2218 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1856   -2.2918   -0.5528 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5058    2.0574    0.6405 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6360    2.1219   -1.3562 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2993   -2.1192   -0.8432 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 11 13  1  0
 13 14  2  0
 13 15  1  0
  9 16  1  0
  3 17  1  0
 17 18  2  0
 17 19  1  0
 16  6  1  0
  1 20  1  0
  1 21  1  0
  1 22  1  0
  2 23  1  0
  2 24  1  0
  3 25  1  0
  4 26  1  0
  4 27  1  0
  5 28  1  0
  5 29  1  0
  8 30  1  0
 10 31  1  0
 10 32  1  0
 11 33  1  6
 12 34  1  0
 12 35  1  0
 15 36  1  0
 16 37  1  0
 19 38  1  0
M  CHG  1   2   1
M  END

Synonyms

Value	Source
EF-2 2-[3-carboxy-3-(methylammonio)propyl]-L-histidine	ChEBI
Elongation factor 2 2-[3-carboxy-3-(methylammonio)propyl]-L-histidine	ChEBI
1-Carboxy-3-(L-histidin-2-yl)-N-methylpropan-1-aminium	HMDB
2-[3-Carboxy-3-(methylammonio)propyl]-his	HMDB
2-[3-Carboxy-3-(methylammonio)propyl]-histidine	HMDB
[3-[[4-(2-amino-2-Carboxy-ethyl)-1H-imidazol-2-yl]]-1-carboxy- propyl]-methyl-ammonium	HMDB

Molecular Formula

C₁₁H₁₉N₄O₄

Average Mass

271.293

Monoisotopic Mass

271.140630116

IUPAC Name

(3-{5-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-2-yl}-1-carboxypropyl)(methyl)azanium

Traditional Name

(3-{4-[(2S)-2-amino-2-carboxyethyl]-3H-imidazol-2-yl}-1-carboxypropyl)(methyl)azanium

CAS Registry Number

Not Available

SMILES

C[NH2+]C(CCC1=NC=C(C[C@H](N)C(O)=O)N1)C(O)=O

InChI Identifier

InChI=1S/C11H18N4O4/c1-13-8(11(18)19)2-3-9-14-5-6(15-9)4-7(12)10(16)17/h5,7-8,13H,2-4,12H2,1H3,(H,14,15)(H,16,17)(H,18,19)/p+1/t7-,8?/m0/s1

InChI Key

YBMOTEQVMANKGX-JAMMHHFISA-O

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as histidine and derivatives. Histidine and derivatives are compounds containing cysteine or a derivative thereof resulting from reaction of cysteine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Histidine and derivatives

Alternative Parents

Substituents

Histidine or derivatives
Alpha-amino acid
L-alpha-amino acid
Aralkylamine
Dicarboxylic acid or derivatives
Azole
Imidazole
Heteroaromatic compound
Amino acid
Carboxylic acid
Secondary aliphatic amine
Secondary amine
Organoheterocyclic compound
Azacycle
Primary amine
Organooxygen compound
Organonitrogen compound
Primary aliphatic amine
Organic oxide
Organopnictogen compound
Amine
Organic nitrogen compound
Organic oxygen compound
Hydrocarbon derivative
Carbonyl group
Organic cation
Aromatic heteromonocyclic compound

Molecular Framework

Aromatic heteromonocyclic compounds

External Descriptors

ammonium ion (CHEBI:16475 )

Functional Ontology

Not Available

Physical Properties

State

Solid

Predicted Properties

Property	Value	Source
Water Solubility	1.2 g/L	ALOGPS
logP	-1.3	ALOGPS
logP	-6.3	ChemAxon
logS	-2.4	ALOGPS
pKa (Strongest Acidic)	1.42	ChemAxon
pKa (Strongest Basic)	10.59	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	5	ChemAxon
Polar Surface Area	145.91 Å²	ChemAxon
Rotatable Bond Count	8	ChemAxon
Refractivity	77.33 m³·mol⁻¹	ChemAxon
Polarizability	27.91 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	splash10-00c3-5950000000-8d8531a8962d98bce733	2016-09-22	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (2 TMS) - 70eV, Positive	splash10-0uk9-6396000000-dad13bde2626e3b2434e	2017-10-06	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-00di-0090000000-1f393c0ea0a92d6031e1	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-01q9-0090000000-0c7cb2be23e59d69e473	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-02e9-9630000000-8921612205d259e1d741	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-00di-8090000000-becfe845d15fd5c1b0e7	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-00di-9080000000-4b8c28900abb9566d066	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-00dl-9010000000-e1ea27f3e9093efbaac5	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-00fr-0090000000-66a1fe26570d43a0aba7	2021-09-24	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-004j-0490000000-fae35f1d1ac38709f83f	2021-09-24	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-002s-2900000000-0ca514fb76d9df5640eb	2021-09-24	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)		2021-09-25	View Spectrum

Chromatographic Retention Times and Retention Indices

Retention Times

Chromatography Type	Technique	Column	Deposition Date	Retention Time (s)
Liquid Chromatography	HILIC	Waters Acquity UPLC-BEH Amide column (eluted)	2025-10-24	711.4
Liquid Chromatography	HILIC	Accucore 150 Amide HILIC (eluted)	2025-10-24	664.0
Liquid Chromatography	Reversed-phase	Hypersil Gold 1.9 µm C18 (void)	2025-10-24	52.3
Liquid Chromatography	Reversed-phase	Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) (eluted)	2025-10-24	244.3
Liquid Chromatography	Reversed-phase	XBridge C18 3.5u 2.1x50 mm (eluted)	2025-10-24	372.6
Liquid Chromatography	Reversed-phase	Ascentis Express C18 (eluted)	2025-10-24	291.4
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (void)	2025-10-24	393.2
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-24	1412.5
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC (eluted)	2025-10-24	946.5
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-24	174.4
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-24	1009.5
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-24	178.6
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (void)	2025-10-24	23.3
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-24	653.1
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-24	989.0
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (void)	2025-10-24	99.1
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-24	402.4
Liquid Chromatography	Reversed-phase	Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex (eluted)	2025-10-24	658.0
Liquid Chromatography	Reversed-phase	Waters Atlantis T3 (2.1 x 150 mm, 5 um) (eluted)	2025-10-24	589.6

Retention Indices

Chromatography Type	Peak Label	SMILES	Stationary Phase	Deposition Date	Retention Index
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_1	C[NH2+]C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O	standard non polar	2025-10-24	2848.65
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_2	C[NH2+]C(CCC1=NC=C(C[C@H](N)C(=O)O)[NH]1)C(=O)O[Si](C)(C)C	standard non polar	2025-10-24	1949.64
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_3	C[NH+](C(CCC1=NC=C(C[C@H](N)C(=O)O)[NH]1)C(=O)O)[Si](C)(C)C	standard non polar	2025-10-24	2119.54
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_4	C[NH2+]C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)[NH]1)C(=O)O	standard non polar	2025-10-24	2521.3
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_5	C[NH2+]C(CCC1=NC=C(C[C@H](N)C(=O)O)N1[Si](C)(C)C)C(=O)O	standard non polar	2025-10-24	2022.63
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_6	C[NH2+]C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C	standard non polar	2025-10-24	2387.83
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_7	C[NH+](C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O)[Si](C)(C)C	standard non polar	2025-10-24	2201.78
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_8	C[NH2+]C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O	standard non polar	2025-10-24	1850.37
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_9	C[NH2+]C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O	standard non polar	2025-10-24	2343.23
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_10	C[NH+](C(CCC1=NC=C(C[C@H](N)C(=O)O)[NH]1)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1899.49
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_11	C[NH2+]C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)[NH]1)C(=O)O[Si](C)(C)C	standard non polar	2025-10-24	1310.88
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_12	C[NH2+]C(CCC1=NC=C(C[C@H](N)C(=O)O)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-24	1453.86
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_13	C[NH+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)[NH]1)C(=O)O)[Si](C)(C)C	standard non polar	2025-10-24	1694.73
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_14	C[N+](C(CCC1=NC=C(C[C@H](N)C(=O)O)[NH]1)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	2263.73
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_15	C[NH+](C(CCC1=NC=C(C[C@H](N)C(=O)O)N1[Si](C)(C)C)C(=O)O)[Si](C)(C)C	standard non polar	2025-10-24	2166.27
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_16	C[NH2+]C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O	standard non polar	2025-10-24	2274.91
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_17	C[NH2+]C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)N1[Si](C)(C)C)C(=O)O	standard non polar	2025-10-24	2131.69
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_18	C[NH+](C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	839.016
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_19	C[NH2+]C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C	standard non polar	2025-10-24	1937.53
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_20	C[NH2+]C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-24	2268.34
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_21	C[NH+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O)[Si](C)(C)C	standard non polar	2025-10-24	1430.5
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_22	C[N+](C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	2278.31
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_23	C[NH+](C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O)[Si](C)(C)C	standard non polar	2025-10-24	2376.57
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_24	C[NH2+]C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O	standard non polar	2025-10-24	2330.53
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_25	C[NH2+]C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O	standard non polar	2025-10-24	1552.22
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_26	C[NH+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)[NH]1)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1769.49
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_27	C[N+](C(CCC1=NC=C(C[C@H](N)C(=O)O)[NH]1)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	2086.36
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_28	C[NH+](C(CCC1=NC=C(C[C@H](N)C(=O)O)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	2046.31
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_29	C[NH2+]C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C	standard non polar	2025-10-24	2460.2
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_30	C[NH2+]C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-24	3066.86
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_31	C[N+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)[NH]1)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1994.85
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_32	C[NH+](C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O)[Si](C)(C)C	standard non polar	2025-10-24	2099.59
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_33	C[NH+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)N1[Si](C)(C)C)C(=O)O)[Si](C)(C)C	standard non polar	2025-10-24	1553.6
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_34	C[N+](C(CCC1=NC=C(C[C@H](N)C(=O)O)N1[Si](C)(C)C)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	2004.21
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_35	C[NH2+]C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O	standard non polar	2025-10-24	2230.62
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_36	C[NH+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1856.63
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_37	C[N+](C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1681.87
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_38	C[NH+](C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1861.45
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_39	C[NH2+]C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C	standard non polar	2025-10-24	2784.87
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_40	C[NH2+]C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-24	3536.83
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_41	C[N+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1354.83
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_42	C[NH+](C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O)[Si](C)(C)C	standard non polar	2025-10-24	1295.25
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_43	C[NH+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O)[Si](C)(C)C	standard non polar	2025-10-24	1911.35
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_44	C[N+](C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	2041.66
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_45	C[NH2+]C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O	standard non polar	2025-10-24	2821.32
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_46	C[N+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)[NH]1)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	2615.77
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_47	C[NH+](C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	2069.77
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_48	C[NH+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1946.92
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_49	C[N+](C(CCC1=NC=C(C[C@H](N)C(=O)O)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	2056.69
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_50	C[NH2+]C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-24	2442.16
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_51	C[N+](C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	2027.75
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_52	C[N+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)N1[Si](C)(C)C)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1603.23
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_53	C[NH+](C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O)[Si](C)(C)C	standard non polar	2025-10-24	1122.09
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_54	C[N+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	2128.68
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_55	C[NH+](C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	2423.41
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_56	C[NH+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	892.181
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_57	C[N+](C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	2991.93
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_58	C[NH2+]C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-24	2034.59
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_59	C[N+](C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	2634.84
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_60	C[N+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1498.62
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_61	C[NH+](C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O)[Si](C)(C)C	standard non polar	2025-10-24	2365.46
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_62	C[N+](C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	707.079
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_63	C[N+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	3166.74
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_64	C[NH+](C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1842.98
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_65	C[N+](C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1101.41
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_66	C[N+](C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	2820.58
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_67	C[N+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1592.67
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_68	C[NH+](C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1664.98
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_69	C[N+](C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1585.73
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_70	C[N+](C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	3005.92
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_71	C[N+](C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	2377.12
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_1	C[NH2+]C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O	standard polar	2025-10-24	2255.84
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_2	C[NH2+]C(CCC1=NC=C(C[C@H](N)C(=O)O)[NH]1)C(=O)O[Si](C)(C)C	standard polar	2025-10-24	2001.73
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_3	C[NH+](C(CCC1=NC=C(C[C@H](N)C(=O)O)[NH]1)C(=O)O)[Si](C)(C)C	standard polar	2025-10-24	1874.94
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_4	C[NH2+]C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)[NH]1)C(=O)O	standard polar	2025-10-24	1414.33
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_5	C[NH2+]C(CCC1=NC=C(C[C@H](N)C(=O)O)N1[Si](C)(C)C)C(=O)O	standard polar	2025-10-24	2174.88
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_6	C[NH2+]C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C	standard polar	2025-10-24	1978.45
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_7	C[NH+](C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O)[Si](C)(C)C	standard polar	2025-10-24	2277.38
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_8	C[NH2+]C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O	standard polar	2025-10-24	1706.89
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_9	C[NH2+]C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O	standard polar	2025-10-24	2235.34
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_10	C[NH+](C(CCC1=NC=C(C[C@H](N)C(=O)O)[NH]1)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2260.39
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_11	C[NH2+]C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)[NH]1)C(=O)O[Si](C)(C)C	standard polar	2025-10-24	1634.52
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_12	C[NH2+]C(CCC1=NC=C(C[C@H](N)C(=O)O)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-24	1993.28
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_13	C[NH+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)[NH]1)C(=O)O)[Si](C)(C)C	standard polar	2025-10-24	2677.9
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_14	C[N+](C(CCC1=NC=C(C[C@H](N)C(=O)O)[NH]1)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2111.47
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_15	C[NH+](C(CCC1=NC=C(C[C@H](N)C(=O)O)N1[Si](C)(C)C)C(=O)O)[Si](C)(C)C	standard polar	2025-10-24	1874.14
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_16	C[NH2+]C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O	standard polar	2025-10-24	2193.15
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_17	C[NH2+]C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)N1[Si](C)(C)C)C(=O)O	standard polar	2025-10-24	2024.66
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_18	C[NH+](C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2827.41
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_19	C[NH2+]C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C	standard polar	2025-10-24	2872.13
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_20	C[NH2+]C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-24	2610.5
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_21	C[NH+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O)[Si](C)(C)C	standard polar	2025-10-24	1868.44
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_22	C[N+](C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	1964.12
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_23	C[NH+](C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O)[Si](C)(C)C	standard polar	2025-10-24	2397.13
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_24	C[NH2+]C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O	standard polar	2025-10-24	2412.71
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_25	C[NH2+]C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O	standard polar	2025-10-24	1606.97
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_26	C[NH+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)[NH]1)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2736.43
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_27	C[N+](C(CCC1=NC=C(C[C@H](N)C(=O)O)[NH]1)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2041.57
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_28	C[NH+](C(CCC1=NC=C(C[C@H](N)C(=O)O)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	1284.56
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_29	C[NH2+]C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C	standard polar	2025-10-24	1681.22
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_30	C[NH2+]C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-24	1546.36
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_31	C[N+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)[NH]1)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2057.64
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_32	C[NH+](C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O)[Si](C)(C)C	standard polar	2025-10-24	2769.4
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_33	C[NH+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)N1[Si](C)(C)C)C(=O)O)[Si](C)(C)C	standard polar	2025-10-24	2780.05
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_34	C[N+](C(CCC1=NC=C(C[C@H](N)C(=O)O)N1[Si](C)(C)C)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2310.53
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_35	C[NH2+]C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O	standard polar	2025-10-24	2207.05
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_36	C[NH+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	867.28
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_37	C[N+](C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2466.24
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_38	C[NH+](C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2067.26
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_39	C[NH2+]C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C	standard polar	2025-10-24	2770.95
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_40	C[NH2+]C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-24	1716.15
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_41	C[N+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	3795.76
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_42	C[NH+](C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O)[Si](C)(C)C	standard polar	2025-10-24	2801.52
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_43	C[NH+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O)[Si](C)(C)C	standard polar	2025-10-24	2336.3
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_44	C[N+](C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	1690.3
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_45	C[NH2+]C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O	standard polar	2025-10-24	2337.82
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_46	C[N+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)[NH]1)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	1858.93
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_47	C[NH+](C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2483.58
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_48	C[NH+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2700.03
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_49	C[N+](C(CCC1=NC=C(C[C@H](N)C(=O)O)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	1775.71
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_50	C[NH2+]C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-24	1936.72
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_51	C[N+](C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2165.61
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_52	C[N+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)N1[Si](C)(C)C)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2276.45
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_53	C[NH+](C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O)[Si](C)(C)C	standard polar	2025-10-24	1977.86
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_54	C[N+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2628.18
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_55	C[NH+](C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2141.69
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_56	C[NH+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2959.43
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_57	C[N+](C(CCC1=NC=C(C[C@H](N)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	328.104
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_58	C[NH2+]C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-24	1291.3
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_59	C[N+](C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	1293.47
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_60	C[N+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	1314.76
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_61	C[NH+](C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O)[Si](C)(C)C	standard polar	2025-10-24	2623.93
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_62	C[N+](C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2102.36
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_63	C[N+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	1710.02
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_64	C[NH+](C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2259.44
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_65	C[N+](C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2132.81
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_66	C[N+](C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)[NH]1)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	1898.33
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_67	C[N+](C(CCC1=NC=C(C[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	1547.95
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_68	C[NH+](C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2102.53
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_69	C[N+](C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	302.3
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_70	C[N+](C(CCC1=NC=C(C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2619.69
Gas Chromatography	2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine_TMS_71	C[N+](C(CCC1=NC=C(C[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)N1[Si](C)(C)C)C(=O)O[Si](C)(C)C)([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	1577.65

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Feces

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species
MMDBp0192074	Diphthine synthase	Unknown	Q9H2P9	Homo sapiens

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	1	Human feces; Human saliva	Unknown

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified									HMDB

External Links

HMDB ID

HMDB0011654

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB028345

KNApSAcK ID

Not Available

Chemspider ID

389379

KEGG Compound ID

C04692

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

440443

PDB ID

Not Available

ChEBI ID

16475

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

Noronha A, Modamio J, Jarosz Y, Guerard E, Sompairac N, Preciat G, Danielsdottir AD, Krecke M, Merten D, Haraldsdottir HS, Heinken A, Heirendt L, Magnusdottir S, Ravcheev DA, Sahoo S, Gawron P, Friscioni L, Garcia B, Prendergast M, Puente A, Rodrigues M, Roy A, Rouquaya M, Wiltgen L, Zagare A, John E, Krueger M, Kuperstein I, Zinovyev A, Schneider R, Fleming RMT, Thiele I: The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease. Nucleic Acids Res. 2019 Jan 8;47(D1):D614-D624. doi: 10.1093/nar/gky992. [PubMed:30371894 ]

Showing metabocard for 2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine (MMDBc0032960)

MOL for #<Metabolite:0x00007f9ac7e3a378>

3D MOL for #<Metabolite:0x00007f9ac7e3a378>

3D SDF for #<Metabolite:0x00007f9ac7e3a378>

3D-SDF for #<Metabolite:0x00007f9ac7e3a378>

PDB for #<Metabolite:0x00007f9ac7e3a378>

3D PDB for #<Metabolite:0x00007f9ac7e3a378>

SMILES for #<Metabolite:0x00007f9ac7e3a378>

INCHI for #<Metabolite:0x00007f9ac7e3a378>

Structure for #<Metabolite:0x00007f9ac7e3a378>

3D Structure for #<Metabolite:0x00007f9ac7e3a378>