MiMeDB: Showing metabocard for N-stearoylphytosphingosine (MMDBc0047869)

Microbial

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-11-19 15:46:47 UTC

Update Date

2025-10-07 16:08:07 UTC

Metabolite ID

MMDBc0047869

Metabolite Identification

Common Name

N-stearoylphytosphingosine

Description

N-stearoylphytosphingosine is a ceramide, specifically a sphingolipid, characterized by the attachment of a stearoyl group to the phytosphingosine backbone. This compound features a long-chain fatty acid moiety, which contributes to its structural properties and biological functions. Chemically, N-stearoylphytosphingosine can form multilamellar and unilamellar vesicles, influencing membrane dynamics and stability, as evidenced by studies demonstrating its impact on the structure and properties of dimyristoylphosphatidylcholine vesicles (PMID:16202987 ). Additionally, it has been shown to participate in cellular responses to UVB irradiation, where it acts as a co-stimulator in keratinocytes at low concentrations, highlighting its role in skin biology (PMID:25078364 ). The presence of N-stearoylphytosphingosine in cellular membranes suggests its involvement in various signaling pathways and cellular processes, particularly in the context of skin health and integrity.

Structure

MOL SDF PDB SMILES InChI


  Mrv1572012291519292D          

 44 43  0  0  0  0            999 V2000
   12.3970    1.6391    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.3970   -1.6391    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7346    1.1473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.7346   -1.1473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9775    1.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.9775   -1.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3151    0.9834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.3151   -0.9834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5580    1.3112    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.5580   -1.3112    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8955    0.8195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8955   -0.8195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1385    1.1473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.1385   -1.1473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4760    0.6556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4760   -0.6556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7190    0.9834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0565    0.4917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2995    0.8195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7190   -0.9834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6370    0.3278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0565   -0.4917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8799    0.6556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2995   -0.8195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2175    0.1639    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6370   -0.3278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4604    0.4917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8799   -0.6556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7980    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2175   -0.1639    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0409    0.3278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9463   -1.1473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0409   -0.3278    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.4604   -0.4917    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.3785   -0.1639    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7980    0.0000    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.3785    0.1639    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6087   -1.6391    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3658   -1.3112    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4731   -0.9834    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8926    0.8195    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7034   -0.8195    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5551    0.3278    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1356    0.4917    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  3  1  1  0  0  0  0
  4  2  1  0  0  0  0
  5  3  1  0  0  0  0
  6  4  1  0  0  0  0
  7  5  1  0  0  0  0
  8  6  1  0  0  0  0
  9  7  1  0  0  0  0
 10  8  1  0  0  0  0
 11  9  1  0  0  0  0
 12 10  1  0  0  0  0
 13 11  1  0  0  0  0
 14 12  1  0  0  0  0
 15 13  1  0  0  0  0
 16 14  1  0  0  0  0
 17 15  1  0  0  0  0
 18 17  1  0  0  0  0
 19 18  1  0  0  0  0
 20 16  1  0  0  0  0
 21 19  1  0  0  0  0
 22 20  1  0  0  0  0
 23 21  1  0  0  0  0
 24 22  1  0  0  0  0
 25 23  1  0  0  0  0
 26 24  1  0  0  0  0
 27 25  1  0  0  0  0
 28 26  1  0  0  0  0
 29 27  1  0  0  0  0
 30 28  1  0  0  0  0
 31 29  1  0  0  0  0
 33 32  1  0  0  0  0
 34 30  1  0  0  0  0
 35 31  1  0  0  0  0
 36 33  1  0  0  0  0
 36 34  1  0  0  0  0
 33 37  1  6  0  0  0
 37 35  2  0  0  0  0
 38 32  1  0  0  0  0
 34 39  1  1  0  0  0
 35 40  1  4  0  0  0
 36 41  1  1  0  0  0
 33 42  1  6  0  0  0
 34 43  1  1  0  0  0
 36 44  1  6  0  0  0
M  END


  Mrv1572012291519292D          

 44 43  0  0  0  0            999 V2000
   12.3970    1.6391    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.3970   -1.6391    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7346    1.1473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.7346   -1.1473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9775    1.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.9775   -1.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3151    0.9834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.3151   -0.9834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5580    1.3112    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.5580   -1.3112    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8955    0.8195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8955   -0.8195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1385    1.1473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.1385   -1.1473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4760    0.6556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4760   -0.6556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7190    0.9834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0565    0.4917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2995    0.8195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7190   -0.9834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6370    0.3278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0565   -0.4917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8799    0.6556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2995   -0.8195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2175    0.1639    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6370   -0.3278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4604    0.4917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8799   -0.6556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7980    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2175   -0.1639    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0409    0.3278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9463   -1.1473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0409   -0.3278    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.4604   -0.4917    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.3785   -0.1639    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7980    0.0000    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.3785    0.1639    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6087   -1.6391    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3658   -1.3112    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4731   -0.9834    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8926    0.8195    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7034   -0.8195    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5551    0.3278    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1356    0.4917    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  3  1  1  0  0  0  0
  4  2  1  0  0  0  0
  5  3  1  0  0  0  0
  6  4  1  0  0  0  0
  7  5  1  0  0  0  0
  8  6  1  0  0  0  0
  9  7  1  0  0  0  0
 10  8  1  0  0  0  0
 11  9  1  0  0  0  0
 12 10  1  0  0  0  0
 13 11  1  0  0  0  0
 14 12  1  0  0  0  0
 15 13  1  0  0  0  0
 16 14  1  0  0  0  0
 17 15  1  0  0  0  0
 18 17  1  0  0  0  0
 19 18  1  0  0  0  0
 20 16  1  0  0  0  0
 21 19  1  0  0  0  0
 22 20  1  0  0  0  0
 23 21  1  0  0  0  0
 24 22  1  0  0  0  0
 25 23  1  0  0  0  0
 26 24  1  0  0  0  0
 27 25  1  0  0  0  0
 28 26  1  0  0  0  0
 29 27  1  0  0  0  0
 30 28  1  0  0  0  0
 31 29  1  0  0  0  0
 33 32  1  0  0  0  0
 34 30  1  0  0  0  0
 35 31  1  0  0  0  0
 36 33  1  0  0  0  0
 36 34  1  0  0  0  0
 33 37  1  6  0  0  0
 37 35  2  0  0  0  0
 38 32  1  0  0  0  0
 34 39  1  1  0  0  0
 35 40  1  4  0  0  0
 36 41  1  1  0  0  0
 33 42  1  6  0  0  0
 34 43  1  1  0  0  0
 36 44  1  6  0  0  0
M  END
> <DATABASE_ID>
MMDBc0047869

> <DATABASE_NAME>
MIME

> <SMILES>
[H][C@@](O)(CCCCCCCCCCCCCC)[C@@]([H])(O)[C@]([H])(CO)N=C(O)CCCCCCCCCCCCCCCCC

> <INCHI_IDENTIFIER>
InChI=1S/C36H73NO4/c1-3-5-7-9-11-13-15-17-18-19-21-23-25-27-29-31-35(40)37-33(32-38)36(41)34(39)30-28-26-24-22-20-16-14-12-10-8-6-4-2/h33-34,36,38-39,41H,3-32H2,1-2H3,(H,37,40)/t33-,34+,36-/m0/s1

> <INCHI_KEY>
IEZRNEGTKRQRFV-LFBNJJMOSA-N

> <FORMULA>
C36H73NO4

> <MOLECULAR_WEIGHT>
583.983

> <EXACT_MASS>
583.553959835

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
114

> <JCHEM_AVERAGE_POLARIZABILITY>
79.86918728120804

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]octadecanimidic acid

> <ALOGPS_LOGP>
9.24

> <JCHEM_LOGP>
11.705207190333333

> <ALOGPS_LOGS>
-6.70

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
13.447358522928397

> <JCHEM_PKA_STRONGEST_ACIDIC>
6.090449998537554

> <JCHEM_PKA_STRONGEST_BASIC>
3.03413668353801

> <JCHEM_POLAR_SURFACE_AREA>
93.28000000000002

> <JCHEM_REFRACTIVITY>
175.89830000000003

> <JCHEM_ROTATABLE_BOND_COUNT>
33

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
1.16e-04 g/l

> <JCHEM_TRADITIONAL_IUPAC>
N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]octadecanimidic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 29-DEC-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   29-DEC-15         0                                  
HETATM    1  C   UNK     0      23.141   3.060   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0     -23.141  -3.060   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      21.905   2.142   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0     -21.905  -2.142   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      20.491   2.754   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0     -20.491  -2.754   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      19.255   1.836   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0     -19.255  -1.836   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      17.842   2.448   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0     -17.842  -2.448   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      16.605   1.530   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0     -16.605  -1.530   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      15.192   2.142   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0     -15.192  -2.142   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      13.955   1.224   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0     -13.955  -1.224   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      12.542   1.836   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      11.305   0.918   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       9.892   1.530   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0     -12.542  -1.836   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       8.656   0.612   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0     -11.305  -0.918   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       7.242   1.224   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      -9.892  -1.530   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       6.006   0.306   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      -8.656  -0.612   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       4.593   0.918   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      -7.242  -1.224   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       3.356   0.000   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0      -6.006  -0.306   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       1.943   0.612   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0      -1.766  -2.142   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0      -1.943  -0.612   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0      -4.593  -0.918   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0       0.707  -0.306   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0      -3.356   0.000   0.000  0.00  0.00           C+0
HETATM   37  N   UNK     0      -0.707   0.306   0.000  0.00  0.00           N+0
HETATM   38  O   UNK     0      -3.003  -3.060   0.000  0.00  0.00           O+0
HETATM   39  O   UNK     0      -4.416  -2.448   0.000  0.00  0.00           O+0
HETATM   40  O   UNK     0       0.883  -1.836   0.000  0.00  0.00           O+0
HETATM   41  O   UNK     0      -3.533   1.530   0.000  0.00  0.00           O+0
HETATM   42  H   UNK     0      -3.180  -1.530   0.000  0.00  0.00           H+0
HETATM   43  H   UNK     0      -4.770   0.612   0.000  0.00  0.00           H+0
HETATM   44  H   UNK     0      -2.120   0.918   0.000  0.00  0.00           H+0
CONECT    1    3                                                            
CONECT    2    4                                                            
CONECT    3    1    5                                                       
CONECT    4    2    6                                                       
CONECT    5    3    7                                                       
CONECT    6    4    8                                                       
CONECT    7    5    9                                                       
CONECT    8    6   10                                                       
CONECT    9    7   11                                                       
CONECT   10    8   12                                                       
CONECT   11    9   13                                                       
CONECT   12   10   14                                                       
CONECT   13   11   15                                                       
CONECT   14   12   16                                                       
CONECT   15   13   17                                                       
CONECT   16   14   20                                                       
CONECT   17   15   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   21                                                       
CONECT   20   16   22                                                       
CONECT   21   19   23                                                       
CONECT   22   20   24                                                       
CONECT   23   21   25                                                       
CONECT   24   22   26                                                       
CONECT   25   23   27                                                       
CONECT   26   24   28                                                       
CONECT   27   25   29                                                       
CONECT   28   26   30                                                       
CONECT   29   27   31                                                       
CONECT   30   28   34                                                       
CONECT   31   29   35                                                       
CONECT   32   33   38                                                       
CONECT   33   32   36   37   42                                             
CONECT   34   30   36   39   43                                             
CONECT   35   31   37   40                                                  
CONECT   36   33   34   41   44                                             
CONECT   37   33   35                                                       
CONECT   38   32                                                            
CONECT   39   34                                                            
CONECT   40   35                                                            
CONECT   41   36                                                            
CONECT   42   33                                                            
CONECT   43   34                                                            
CONECT   44   36                                                            
MASTER        0    0    0    0    0    0    0    0   44    0   86    0
END

Synonyms

Value	Source
Cer(t18:0/18:0)	ChEBI
N-(Octadecanoyl)-4-hydroxysphinganine	ChEBI
N-(Octadecanoyl)-4R-hydroxysphinganine	ChEBI
N-(Octadecanoyl)-phytoceramide	ChEBI
N-(Stearoyl)-phytoceramide	ChEBI
N-Octadecanoylphytoceramide	ChEBI
N-Octadecanoylphytosphingosine	ChEBI
N-Stearoyl-4-hydroxysphinganine	ChEBI
N-Stearoylphytoceramide	ChEBI
PHC-b 18:0/18:0	ChEBI
N-Stearoylphytosphingosine	ChEBI

Molecular Formula

C₃₆H₇₃NO₄

Average Mass

583.983

Monoisotopic Mass

583.553959835

IUPAC Name

N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]octadecanimidic acid

Traditional Name

N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]octadecanimidic acid

CAS Registry Number

Not Available

SMILES

[H][C@@](O)(CCCCCCCCCCCCCC)[C@@]([H])(O)[C@]([H])(CO)N=C(O)CCCCCCCCCCCCCCCCC

InChI Identifier

InChI=1S/C36H73NO4/c1-3-5-7-9-11-13-15-17-18-19-21-23-25-27-29-31-35(40)37-33(32-38)36(41)34(39)30-28-26-24-22-20-16-14-12-10-8-6-4-2/h33-34,36,38-39,41H,3-32H2,1-2H3,(H,37,40)/t33-,34+,36-/m0/s1

InChI Key

IEZRNEGTKRQRFV-LFBNJJMOSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as phytoceramides. These are n-acylated 4-hydroxysphinganine.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Sphingolipids

Sub Class

Ceramides

Direct Parent

Phytoceramides

Alternative Parents

Substituents

N-acyl-4-hydroxysphinganine
Fatty amide
N-acyl-amine
Fatty acyl
Carboxamide group
Secondary alcohol
Secondary carboxylic acid amide
Carboxylic acid derivative
Polyol
Organic oxide
Organooxygen compound
Organonitrogen compound
Organopnictogen compound
Organic oxygen compound
Alcohol
Organic nitrogen compound
Carbonyl group
Primary alcohol
Hydrocarbon derivative
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

phytoceramide (CHEBI:67035 )
N-acyl-4-hydroxysphinganines (phytoceramides) (LMSP02030006 )

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.00012 g/L	ALOGPS
logP	9.24	ALOGPS
logP	11.71	ChemAxon
logS	-6.7	ALOGPS
pKa (Strongest Acidic)	6.09	ChemAxon
pKa (Strongest Basic)	3.03	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	93.28 Å²	ChemAxon
Rotatable Bond Count	33	ChemAxon
Refractivity	175.9 m³·mol⁻¹	ChemAxon
Polarizability	79.87 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_6) - 70eV, Positive	Not Available	2022-08-08	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-014i-0015090000-a6e02bfaa802f7e59d89	2016-09-14	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0929-8249010000-d7944b72f4d4acdf1529	2016-09-14	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-00os-7957000000-d85a10fc559cff778892	2016-09-14	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-053r-0043090000-a59d891183b63dd6c0d7	2016-09-14	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0a4i-1097030000-eb54f5fca379b34dbccf	2016-09-14	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0a4l-9160000000-2a68a5ad5490a4d2f889	2016-09-14	View Spectrum

Chromatographic Retention Times and Retention Indices

Retention Times

Chromatography Type	Technique	Column	Deposition Date	Retention Time (s)
Liquid Chromatography	HILIC	Waters Acquity UPLC-BEH Amide column (eluted)	2025-10-24	156.8
Liquid Chromatography	HILIC	Accucore 150 Amide HILIC (eluted)	2025-10-24	69.3
Liquid Chromatography	Reversed-phase	Hypersil Gold 1.9 µm C18 (eluted)	2025-10-24	931.0
Liquid Chromatography	Reversed-phase	Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) (eluted)	2025-10-24	1258.6
Liquid Chromatography	Reversed-phase	XBridge C18 3.5u 2.1x50 mm (eluted)	2025-10-24	1428.2
Liquid Chromatography	Reversed-phase	Ascentis Express C18 (eluted)	2025-10-24	445.7
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-24	4668.8
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-24	164.2
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC (eluted)	2025-10-24	269.4
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-24	1045.2
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-24	370.1
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-24	203.9
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-24	334.0
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-24	8.8
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (void)	2025-10-24	525.9
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-24	943.7
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-24	657.7
Liquid Chromatography	Reversed-phase	Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex (eluted)	2025-10-24	2804.3
Liquid Chromatography	Reversed-phase	Waters Atlantis T3 (2.1 x 150 mm, 5 um) (eluted)	2025-10-24	2786.6

Retention Indices

Chromatography Type	Peak Label	SMILES	Stationary Phase	Deposition Date	Retention Index
Gas Chromatography	N-stearoylphytosphingosine_TMS_1	CCCCCCCCCCCCCCCCCC(O)=N[C@@H](CO)[C@H](O)[C@@H](CCCCCCCCCCCCCC)O[Si](C)(C)C	standard non polar	2025-10-24	1959.82
Gas Chromatography	N-stearoylphytosphingosine_TMS_2	CCCCCCCCCCCCCCCCCC(O)=N[C@@H](CO)[C@H](O[Si](C)(C)C)[C@H](O)CCCCCCCCCCCCCC	standard non polar	2025-10-24	2598.52
Gas Chromatography	N-stearoylphytosphingosine_TMS_3	CCCCCCCCCCCCCCCCCC(O)=N[C@@H](CO[Si](C)(C)C)[C@H](O)[C@H](O)CCCCCCCCCCCCCC	standard non polar	2025-10-24	2188.27
Gas Chromatography	N-stearoylphytosphingosine_TMS_4	CCCCCCCCCCCCCCCCCC(=N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC)O[Si](C)(C)C	standard non polar	2025-10-24	2797.3
Gas Chromatography	N-stearoylphytosphingosine_TMS_5	CCCCCCCCCCCCCCCCCC(=N[C@@H](CO)[C@H](O)[C@@H](CCCCCCCCCCCCCC)O[Si](C)(C)C)O[Si](C)(C)C	standard non polar	2025-10-24	1654.78
Gas Chromatography	N-stearoylphytosphingosine_TMS_6	CCCCCCCCCCCCCCCCCC(O)=N[C@@H](CO[Si](C)(C)C)[C@H](O)[C@@H](CCCCCCCCCCCCCC)O[Si](C)(C)C	standard non polar	2025-10-24	3063.05
Gas Chromatography	N-stearoylphytosphingosine_TMS_7	CCCCCCCCCCCCCCCCCC(O)=N[C@@H](CO)[C@H](O[Si](C)(C)C)[C@@H](CCCCCCCCCCCCCC)O[Si](C)(C)C	standard non polar	2025-10-24	2298.92
Gas Chromatography	N-stearoylphytosphingosine_TMS_8	CCCCCCCCCCCCCCCCCC(=N[C@@H](CO)[C@H](O[Si](C)(C)C)[C@H](O)CCCCCCCCCCCCCC)O[Si](C)(C)C	standard non polar	2025-10-24	1312.47
Gas Chromatography	N-stearoylphytosphingosine_TMS_9	CCCCCCCCCCCCCCCCCC(O)=N[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@H](O)CCCCCCCCCCCCCC	standard non polar	2025-10-24	1539.55
Gas Chromatography	N-stearoylphytosphingosine_TMS_10	CCCCCCCCCCCCCCCCCC(=N[C@@H](CO[Si](C)(C)C)[C@H](O)[C@H](O)CCCCCCCCCCCCCC)O[Si](C)(C)C	standard non polar	2025-10-24	554.443
Gas Chromatography	N-stearoylphytosphingosine_TMS_11	CCCCCCCCCCCCCCCCCC(=N[C@@H](CO[Si](C)(C)C)[C@H](O)[C@@H](CCCCCCCCCCCCCC)O[Si](C)(C)C)O[Si](C)(C)C	standard non polar	2025-10-24	2214.32
Gas Chromatography	N-stearoylphytosphingosine_TMS_12	CCCCCCCCCCCCCCCCCC(=N[C@@H](CO)[C@H](O[Si](C)(C)C)[C@@H](CCCCCCCCCCCCCC)O[Si](C)(C)C)O[Si](C)(C)C	standard non polar	2025-10-24	1805.05
Gas Chromatography	N-stearoylphytosphingosine_TMS_13	CCCCCCCCCCCCCCCCCC(O)=N[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H](CCCCCCCCCCCCCC)O[Si](C)(C)C	standard non polar	2025-10-24	2265.35
Gas Chromatography	N-stearoylphytosphingosine_TMS_14	CCCCCCCCCCCCCCCCCC(=N[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@H](O)CCCCCCCCCCCCCC)O[Si](C)(C)C	standard non polar	2025-10-24	1584.17
Gas Chromatography	N-stearoylphytosphingosine_TMS_15	CCCCCCCCCCCCCCCCCC(=N[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H](CCCCCCCCCCCCCC)O[Si](C)(C)C)O[Si](C)(C)C	standard non polar	2025-10-24	336.806
Gas Chromatography	N-stearoylphytosphingosine_TMS_1	CCCCCCCCCCCCCCCCCC(O)=N[C@@H](CO)[C@H](O)[C@@H](CCCCCCCCCCCCCC)O[Si](C)(C)C	standard polar	2025-10-24	1542.14
Gas Chromatography	N-stearoylphytosphingosine_TMS_2	CCCCCCCCCCCCCCCCCC(O)=N[C@@H](CO)[C@H](O[Si](C)(C)C)[C@H](O)CCCCCCCCCCCCCC	standard polar	2025-10-24	4270.47
Gas Chromatography	N-stearoylphytosphingosine_TMS_3	CCCCCCCCCCCCCCCCCC(O)=N[C@@H](CO[Si](C)(C)C)[C@H](O)[C@H](O)CCCCCCCCCCCCCC	standard polar	2025-10-24	3405.06
Gas Chromatography	N-stearoylphytosphingosine_TMS_4	CCCCCCCCCCCCCCCCCC(=N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC)O[Si](C)(C)C	standard polar	2025-10-24	2198.34
Gas Chromatography	N-stearoylphytosphingosine_TMS_5	CCCCCCCCCCCCCCCCCC(=N[C@@H](CO)[C@H](O)[C@@H](CCCCCCCCCCCCCC)O[Si](C)(C)C)O[Si](C)(C)C	standard polar	2025-10-24	1599.58
Gas Chromatography	N-stearoylphytosphingosine_TMS_6	CCCCCCCCCCCCCCCCCC(O)=N[C@@H](CO[Si](C)(C)C)[C@H](O)[C@@H](CCCCCCCCCCCCCC)O[Si](C)(C)C	standard polar	2025-10-24	1794.02
Gas Chromatography	N-stearoylphytosphingosine_TMS_7	CCCCCCCCCCCCCCCCCC(O)=N[C@@H](CO)[C@H](O[Si](C)(C)C)[C@@H](CCCCCCCCCCCCCC)O[Si](C)(C)C	standard polar	2025-10-24	1721.16
Gas Chromatography	N-stearoylphytosphingosine_TMS_8	CCCCCCCCCCCCCCCCCC(=N[C@@H](CO)[C@H](O[Si](C)(C)C)[C@H](O)CCCCCCCCCCCCCC)O[Si](C)(C)C	standard polar	2025-10-24	2000.17
Gas Chromatography	N-stearoylphytosphingosine_TMS_9	CCCCCCCCCCCCCCCCCC(O)=N[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@H](O)CCCCCCCCCCCCCC	standard polar	2025-10-24	2866.94
Gas Chromatography	N-stearoylphytosphingosine_TMS_10	CCCCCCCCCCCCCCCCCC(=N[C@@H](CO[Si](C)(C)C)[C@H](O)[C@H](O)CCCCCCCCCCCCCC)O[Si](C)(C)C	standard polar	2025-10-24	1187.89
Gas Chromatography	N-stearoylphytosphingosine_TMS_11	CCCCCCCCCCCCCCCCCC(=N[C@@H](CO[Si](C)(C)C)[C@H](O)[C@@H](CCCCCCCCCCCCCC)O[Si](C)(C)C)O[Si](C)(C)C	standard polar	2025-10-24	2225.33
Gas Chromatography	N-stearoylphytosphingosine_TMS_12	CCCCCCCCCCCCCCCCCC(=N[C@@H](CO)[C@H](O[Si](C)(C)C)[C@@H](CCCCCCCCCCCCCC)O[Si](C)(C)C)O[Si](C)(C)C	standard polar	2025-10-24	484.154
Gas Chromatography	N-stearoylphytosphingosine_TMS_13	CCCCCCCCCCCCCCCCCC(O)=N[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H](CCCCCCCCCCCCCC)O[Si](C)(C)C	standard polar	2025-10-24	2990.42
Gas Chromatography	N-stearoylphytosphingosine_TMS_14	CCCCCCCCCCCCCCCCCC(=N[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@H](O)CCCCCCCCCCCCCC)O[Si](C)(C)C	standard polar	2025-10-24	1800.22
Gas Chromatography	N-stearoylphytosphingosine_TMS_15	CCCCCCCCCCCCCCCCCC(=N[C@@H](CO[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@@H](CCCCCCCCCCCCCC)O[Si](C)(C)C)O[Si](C)(C)C	standard polar	2025-10-24	1718.92

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference
MMDBr0019620	Phytosphingosine	N-stearoylphytosphingosine	Ceramide synthase subunit LIP1	Synthesis	PathBank	31602464
MMDBr0036129	N-stearoylphytosphingosine	Octadecanoate (N-C18:0)	Alkaline ceramidase YPC1	Hydrolysis	RHEA	34755880

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	1	Human feces; Human saliva	Unknown

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

67035

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

Wishart DS, Li C, Marcu A, Badran H, Pon A, Budinski Z, Patron J, Lipton D, Cao X, Oler E, Li K, Paccoud M, Hong C, Guo AC, Chan C, Wei W, Ramirez-Gaona M: PathBank: a comprehensive pathway database for model organisms. Nucleic Acids Res. 2020 Jan 8;48(D1):D470-D478. doi: 10.1093/nar/gkz861. [PubMed:31602464 ]

Showing metabocard for N-stearoylphytosphingosine (MMDBc0047869)

MOL for #<Metabolite:0x00007f2e25aea588>

3D MOL for #<Metabolite:0x00007f2e25aea588>

3D SDF for #<Metabolite:0x00007f2e25aea588>

3D-SDF for #<Metabolite:0x00007f2e25aea588>

PDB for #<Metabolite:0x00007f2e25aea588>

3D PDB for #<Metabolite:0x00007f2e25aea588>

SMILES for #<Metabolite:0x00007f2e25aea588>

INCHI for #<Metabolite:0x00007f2e25aea588>

Structure for #<Metabolite:0x00007f2e25aea588>

3D Structure for #<Metabolite:0x00007f2e25aea588>