MiMeDB: Showing metabocard for (9Z)-hexadecenoic acid (MMDBc0054080)

Microbial

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2022-06-05 22:51:46 UTC

Update Date

2025-10-07 16:08:22 UTC

Metabolite ID

MMDBc0054080

Metabolite Identification

Common Name

(9Z)-hexadecenoic acid

Description

(9Z)-hexadecenoic acid is a monounsaturated fatty acid belonging to the class of fatty acids. Its chemical structure features a 16-carbon chain with a cis double bond at the 9th position, making it an important component in various metabolic pathways. This fatty acid, also known as palmitoleic acid (C16:1 n-7), is involved in lipid metabolism and has been identified as an antibacterial compound, indicating its potential role in host defense mechanisms. (9Z)-hexadecenoic acid is synthesized from palmitic acid through the action of stearoyl-CoA desaturase, which introduces the double bond. Additionally, it can influence cellular signaling pathways and membrane fluidity, impacting various physiological processes. The presence of (9Z)-hexadecenoic acid in biological systems highlights its significance in maintaining lipid homeostasis and its potential implications in health and disease. Its antibacterial properties further suggest a role in modulating microbial interactions within the host environment. The identification of this fatty acid alongside other compounds, such as (6Z, 9Z, 12Z)-hexadecatrienoic acid, underscores its relevance in the study of fatty acid profiles in biological contexts (PMID:18813920 ).

Structure

MOL SDF PDB SMILES InChI


  Mrv0541 02241222512D          

 18 17  0  0  0  0            999 V2000
   -0.5743    6.2684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1401    5.8559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1401    5.0309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8546    4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8546    3.7934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5691    3.3809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5691    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2836    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9980    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7125    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1414    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8559    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2849    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9993    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7138    2.5559    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    7.9993    1.3184    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
M  CHG  1  17  -1
M  END
> <DATABASE_ID>
MMDBc0054080

> <DATABASE_NAME>
MIME

> <SMILES>
CCCCCC\C=C/CCCCCCCC([O-])=O

> <INCHI_IDENTIFIER>
InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7-

> <INCHI_KEY>
SECPZKHBENQXJG-FPLPWBNLSA-M

> <FORMULA>
C16H29O2

> <MOLECULAR_WEIGHT>
253.4003

> <EXACT_MASS>
253.216755172

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_AVERAGE_POLARIZABILITY>
32.396689377040076

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
-1

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(9Z)-hexadec-9-enoate

> <ALOGPS_LOGP>
6.78

> <JCHEM_LOGP>
5.894661121

> <ALOGPS_LOGS>
-6.22

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.988167283903808

> <JCHEM_POLAR_SURFACE_AREA>
40.129999999999995

> <JCHEM_REFRACTIVITY>
89.03729999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
13

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
1.65e-04 g/l

> <JCHEM_TRADITIONAL_IUPAC>
palmitoleate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 24-FEB-12   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-FEB-12         0                                  
HETATM    1  C   UNK     0      -1.072  11.701   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       0.262  10.931   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       0.262   9.391   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       1.595   8.621   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       1.595   7.081   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       2.929   6.311   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       2.929   4.771   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       4.263   4.001   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       5.596   4.771   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       6.930   4.001   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       8.264   4.771   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       9.597   4.001   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      10.931   4.771   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      12.265   4.001   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      13.598   4.771   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      14.932   4.001   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0      16.266   4.771   0.000  0.00  0.00           O-1
HETATM   18  O   UNK     0      14.932   2.461   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   17   18                                                  
CONECT   17   16                                                            
CONECT   18   16                                                            
MASTER        0    0    0    0    0    0    0    0   18    0   34    0
END

Synonyms

Value	Source
(16:1n7)	ChEBI
(9Z)-Hexadecenoate	ChEBI
(Z)-9-Hexadecenoate	ChEBI
(Z)-Hexadec-9-enoate	ChEBI
9-cis-Hexadecenoate	ChEBI
cis-9-Hexadecenoate	ChEBI
cis-Delta(9)-Hexadecenoate	ChEBI
Palmitolinoleate	ChEBI
Zoomarate	ChEBI
(9Z)-Hexadecenoic acid	Generator
(Z)-9-Hexadecenoic acid	Generator
(Z)-Hexadec-9-enoic acid	Generator
9-cis-Hexadecenoic acid	Generator
cis-9-Hexadecenoic acid	Generator
cis-delta(9)-Hexadecenoic acid	Generator
cis-Δ(9)-hexadecenoate	Generator
cis-Δ(9)-hexadecenoic acid	Generator
Palmitolinoleic acid	Generator
Zoomaric acid	Generator
Palmitoleic acid	Generator

Molecular Formula

C₁₆H₂₉O₂

Average Mass

253.4003

Monoisotopic Mass

253.216755172

IUPAC Name

(9Z)-hexadec-9-enoate

Traditional Name

palmitoleate

CAS Registry Number

Not Available

SMILES

CCCCCC\C=C/CCCCCCCC([O-])=O

InChI Identifier

InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7-

InChI Key

SECPZKHBENQXJG-FPLPWBNLSA-M

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as long-chain fatty acids. These are fatty acids with an aliphatic tail that contains between 13 and 21 carbon atoms.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Fatty Acyls

Sub Class

Fatty acids and conjugates

Direct Parent

Long-chain fatty acids

Alternative Parents

Substituents

Long-chain fatty acid
Unsaturated fatty acid
Straight chain fatty acid
Monocarboxylic acid or derivatives
Carboxylic acid
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Organic anion
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

hexadec-9-enoate (CHEBI:32372 )

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.00016 g/L	ALOGPS
logP	6.78	ALOGPS
logP	5.89	ChemAxon
logS	-6.2	ALOGPS
pKa (Strongest Acidic)	4.99	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	40.13 Å²	ChemAxon
Rotatable Bond Count	13	ChemAxon
Refractivity	89.04 m³·mol⁻¹	ChemAxon
Polarizability	32.4 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0udi-0090000000-aa7d6ed9c31cbce5ee58	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0udl-3190000000-6d0251511acf821e8e66	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-052f-9200000000-676a924b797a70d5ce97	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0udi-0090000000-21512e834cec47e3f3f2	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0zfr-0090000000-0a19d0f4cb7164d25355	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0a4l-9680000000-1b103427dd6ff86926d5	2016-09-12	View Spectrum

Chromatographic Retention Times and Retention Indices

Retention Times

Not Available

Retention Indices

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference
MMDBr0027947	CL(10:0/16:1(9Z)/10:0/16:1(9Z))	2-MLCL(10:0/0:0/10:0/16:1(9Z))	Cardiolipin-specific deacylase 1, mitochondrial	Deacylation	RHEA	34755880
MMDBr0027948	CL(10:0/16:1(9Z)/16:1(11Z)/18:0)	2-MLCL(10:0/0:0/16:1(11Z)/18:0)	Cardiolipin-specific deacylase 1, mitochondrial	Deacylation	RHEA	34755880
MMDBr0027949	CL(10:0/16:1(9Z)/16:1(11Z)/18:1(11Z))	2-MLCL(10:0/0:0/16:1(11Z)/18:1(11Z))	Cardiolipin-specific deacylase 1, mitochondrial	Deacylation	RHEA	34755880
MMDBr0027950	CL(10:0/16:1(9Z)/16:1(11Z)/18:1(9Z))	2-MLCL(10:0/0:0/16:1(11Z)/18:1(9Z))	Cardiolipin-specific deacylase 1, mitochondrial	Deacylation	RHEA	34755880
MMDBr0027951	CL(10:0/16:1(9Z)/16:1(11Z)/20:0)	2-MLCL(10:0/0:0/16:1(11Z)/20:0)	Cardiolipin-specific deacylase 1, mitochondrial	Deacylation	RHEA	34755880
MMDBr0027952	CL(10:0/16:1(9Z)/16:1(11Z)/20:1(11Z))	2-MLCL(10:0/0:0/16:1(11Z)/20:1(11Z))	Cardiolipin-specific deacylase 1, mitochondrial	Deacylation	RHEA	34755880
MMDBr0027953	CL(10:0/16:1(9Z)/16:1(11Z)/20:1(13Z))	2-MLCL(10:0/0:0/16:1(11Z)/20:1(13Z))	Cardiolipin-specific deacylase 1, mitochondrial	Deacylation	RHEA	34755880
MMDBr0027954	CL(10:0/16:1(9Z)/16:1(11Z)/22:0)	2-MLCL(10:0/0:0/16:1(11Z)/22:0)	Cardiolipin-specific deacylase 1, mitochondrial	Deacylation	RHEA	34755880
MMDBr0027955	CL(10:0/16:1(9Z)/16:1(11Z)/22:1(11Z))	2-MLCL(10:0/0:0/16:1(11Z)/22:1(11Z))	Cardiolipin-specific deacylase 1, mitochondrial	Deacylation	RHEA	34755880
MMDBr0027956	CL(10:0/16:1(9Z)/16:1(11Z)/22:1(9Z))	2-MLCL(10:0/0:0/16:1(11Z)/22:1(9Z))	Cardiolipin-specific deacylase 1, mitochondrial	Deacylation	RHEA	34755880
MMDBr0027957	CL(10:0/16:1(9Z)/16:1(11Z)/24:0)	2-MLCL(10:0/0:0/16:1(11Z)/24:0)	Cardiolipin-specific deacylase 1, mitochondrial	Deacylation	RHEA	34755880
MMDBr0027958	CL(10:0/16:1(9Z)/16:1(11Z)/24:1(11Z))	2-MLCL(10:0/0:0/16:1(11Z)/24:1(11Z))	Cardiolipin-specific deacylase 1, mitochondrial	Deacylation	RHEA	34755880
MMDBr0027959	CL(10:0/16:1(9Z)/16:1(11Z)/24:1(9Z))	2-MLCL(10:0/0:0/16:1(11Z)/24:1(9Z))	Cardiolipin-specific deacylase 1, mitochondrial	Deacylation	RHEA	34755880
MMDBr0027960	CL(10:0/16:1(9Z)/16:1(11Z)/26:0)	2-MLCL(10:0/0:0/16:1(11Z)/26:0)	Cardiolipin-specific deacylase 1, mitochondrial	Deacylation	RHEA	34755880
MMDBr0027961	CL(10:0/16:1(9Z)/16:1(11Z)/26:1(11Z))	2-MLCL(10:0/0:0/16:1(11Z)/26:1(11Z))	Cardiolipin-specific deacylase 1, mitochondrial	Deacylation	RHEA	34755880
MMDBr0027962	CL(10:0/16:1(9Z)/16:1(11Z)/28:0)	2-MLCL(10:0/0:0/16:1(11Z)/28:0)	Cardiolipin-specific deacylase 1, mitochondrial	Deacylation	RHEA	34755880
MMDBr0027963	CL(10:0/16:1(9Z)/16:1(11Z)/28:1(11Z))	2-MLCL(10:0/0:0/16:1(11Z)/28:1(11Z))	Cardiolipin-specific deacylase 1, mitochondrial	Deacylation	RHEA	34755880
MMDBr0027964	CL(10:0/16:1(9Z)/16:1(11Z)/30:0)	2-MLCL(10:0/0:0/16:1(11Z)/30:0)	Cardiolipin-specific deacylase 1, mitochondrial	Deacylation	RHEA	34755880
MMDBr0027965	CL(10:0/16:1(9Z)/16:1(9Z)/18:0)	2-MLCL(10:0/0:0/16:1(9Z)/18:0)	Cardiolipin-specific deacylase 1, mitochondrial	Deacylation	RHEA	34755880
MMDBr0027966	CL(10:0/16:1(9Z)/16:1(9Z)/18:1(11Z))	2-MLCL(10:0/0:0/16:1(9Z)/18:1(11Z))	Cardiolipin-specific deacylase 1, mitochondrial	Deacylation	RHEA	34755880

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites
Eukaryota/Fungi	Ascomycota	2
Bacteria/Eubacteria	Proteobacteria	1	Human ; Human feces
Bacteria	Proteobacteria	1	Human ; Human feces

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Palmitoleic acid

METLIN ID

Not Available

PubChem Compound

5461012

PDB ID

Not Available

ChEBI ID

32372

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

Bansal P, Morgat A, Axelsen KB, Muthukrishnan V, Coudert E, Aimo L, Hyka-Nouspikel N, Gasteiger E, Kerhornou A, Neto TB, Pozzato M, Blatter MC, Ignatchenko A, Redaschi N, Bridge A: Rhea, the reaction knowledgebase in 2022. Nucleic Acids Res. 2022 Jan 7;50(D1):D693-D700. doi: 10.1093/nar/gkab1016. [PubMed:34755880 ]

Showing metabocard for (9Z)-hexadecenoic acid (MMDBc0054080)

MOL for #<Metabolite:0x00007fadd0143770>

3D MOL for #<Metabolite:0x00007fadd0143770>

3D SDF for #<Metabolite:0x00007fadd0143770>

3D-SDF for #<Metabolite:0x00007fadd0143770>

PDB for #<Metabolite:0x00007fadd0143770>

3D PDB for #<Metabolite:0x00007fadd0143770>

SMILES for #<Metabolite:0x00007fadd0143770>

INCHI for #<Metabolite:0x00007fadd0143770>

Structure for #<Metabolite:0x00007fadd0143770>

3D Structure for #<Metabolite:0x00007fadd0143770>