MiMeDB: Showing metabocard for phosphinothricin (MMDBc0054635)

Xenobiotic

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2022-06-05 23:21:55 UTC

Update Date

2025-10-07 16:08:36 UTC

Metabolite ID

MMDBc0054635

Metabolite Identification

Common Name

phosphinothricin

Description

Phosphinothricin is a member of the chemical class of phosphonic acids, specifically known for its role as a broad-spectrum herbicide. Its chemical structure features a phosphinic acid moiety, which is critical for its herbicidal activity. Phosphinothricin acts by inhibiting the enzyme glutamine synthetase, leading to the accumulation of ammonia and subsequent plant death. In biochemical pathways, it is involved in the synthesis of L-phosphinothricin (L-PPT) through a multi-enzyme cascade process, where engineered strains of Escherichia coli are utilized to convert D-phosphinothricin (D-PPT) into the desired L-PPT via the intermediate 2-oxo-4-[(hydroxymethylphosphonyl)] butyric acid (PPO) (PMID:40994337 ). Additionally, the compound is related to other biologically active substances, including the antibiotic fosfomycin and the herbicide glyphosate, highlighting its significance within a broader context of phosphonic acid derivatives (PMID:40652902 ). Furthermore, research has identified novel D-amino acid oxidases that facilitate the deracemization of D, L-phosphinothricin, showcasing its potential for further applications in biochemistry (PMID:40782217 ).

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Molecular Formula

C₅H₁₂NO₄P

Average Mass

181.1268

Monoisotopic Mass

181.0503944

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

Not Available

InChI Identifier

InChI=1S/C5H12NO4P/c1-11(9,10)3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)(H,9,10)

InChI Key

IAJOBQBIJHVGMQ-UHFFFAOYSA-N

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Not Available

Predicted Properties

Not Available

Spectra

Not Available

Chromatographic Retention Times and Retention Indices

Retention Times

Chromatography Type	Technique	Column	Deposition Date	Retention Time (s)
Liquid Chromatography	HILIC	Waters Acquity UPLC-BEH Amide column (retained)	2025-10-24	567.7
Liquid Chromatography	HILIC	Accucore 150 Amide HILIC (eluted)	2025-10-24	458.5
Liquid Chromatography	Reversed-phase	Hypersil Gold 1.9 µm C18 (void)	2025-10-24	41.1
Liquid Chromatography	Reversed-phase	Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) (eluted)	2025-10-24	228.0
Liquid Chromatography	Reversed-phase	XBridge C18 3.5u 2.1x50 mm (eluted)	2025-10-24	295.4
Liquid Chromatography	Reversed-phase	Ascentis Express C18 (void)	2025-10-24	286.4
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (void)	2025-10-24	386.4
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-24	950.0
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC (eluted)	2025-10-24	786.8
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-24	171.7
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-24	660.5
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (void)	2025-10-24	180.8
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (void)	2025-10-24	39.4
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-24	477.9
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-24	818.1
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (void)	2025-10-24	71.9
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (void)	2025-10-24	308.5
Liquid Chromatography	Reversed-phase	Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex (eluted)	2025-10-24	613.5
Liquid Chromatography	Reversed-phase	Waters Atlantis T3 (2.1 x 150 mm, 5 um) (eluted)	2025-10-24	547.8

Retention Indices

Chromatography Type	Peak Label	SMILES	Stationary Phase	Deposition Date	Retention Index
Gas Chromatography	phosphinothricin_TMS_1	C[Si](C)(C)OC(=O)C(N)CCP(C)(=O)O	standard non polar	2025-10-24	1682.85
Gas Chromatography	phosphinothricin_TMS_2	C[Si](C)(C)OP(C)(=O)CCC(N)C(=O)O	standard non polar	2025-10-24	1855.65
Gas Chromatography	phosphinothricin_TMS_3	C[Si](C)(C)NC(CCP(C)(=O)O)C(=O)O	standard non polar	2025-10-24	2234.38
Gas Chromatography	phosphinothricin_TMS_4	C[Si](C)(C)OC(=O)C(N)CCP(C)(=O)O[Si](C)(C)C	standard non polar	2025-10-24	2225.62
Gas Chromatography	phosphinothricin_TMS_5	C[Si](C)(C)NC(CCP(C)(=O)O)C(=O)O[Si](C)(C)C	standard non polar	2025-10-24	1977.82
Gas Chromatography	phosphinothricin_TMS_6	C[Si](C)(C)NC(CCP(C)(=O)O[Si](C)(C)C)C(=O)O	standard non polar	2025-10-24	1868.14
Gas Chromatography	phosphinothricin_TMS_7	C[Si](C)(C)N(C(CCP(C)(=O)O)C(=O)O)[Si](C)(C)C	standard non polar	2025-10-24	2339.37
Gas Chromatography	phosphinothricin_TMS_8	C[Si](C)(C)NC(CCP(C)(=O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard non polar	2025-10-24	1771.37
Gas Chromatography	phosphinothricin_TMS_9	C[Si](C)(C)OC(=O)C(CCP(C)(=O)O)N([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1938.85
Gas Chromatography	phosphinothricin_TMS_10	C[Si](C)(C)OP(C)(=O)CCC(C(=O)O)N([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	1284.19
Gas Chromatography	phosphinothricin_TMS_11	C[Si](C)(C)OC(=O)C(CCP(C)(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C	standard non polar	2025-10-24	2104.19
Gas Chromatography	phosphinothricin_TMS_1	C[Si](C)(C)OC(=O)C(N)CCP(C)(=O)O	standard polar	2025-10-24	1655.21
Gas Chromatography	phosphinothricin_TMS_2	C[Si](C)(C)OP(C)(=O)CCC(N)C(=O)O	standard polar	2025-10-24	2078.76
Gas Chromatography	phosphinothricin_TMS_3	C[Si](C)(C)NC(CCP(C)(=O)O)C(=O)O	standard polar	2025-10-24	2082.52
Gas Chromatography	phosphinothricin_TMS_4	C[Si](C)(C)OC(=O)C(N)CCP(C)(=O)O[Si](C)(C)C	standard polar	2025-10-24	2601.19
Gas Chromatography	phosphinothricin_TMS_5	C[Si](C)(C)NC(CCP(C)(=O)O)C(=O)O[Si](C)(C)C	standard polar	2025-10-24	2376.04
Gas Chromatography	phosphinothricin_TMS_6	C[Si](C)(C)NC(CCP(C)(=O)O[Si](C)(C)C)C(=O)O	standard polar	2025-10-24	2198.78
Gas Chromatography	phosphinothricin_TMS_7	C[Si](C)(C)N(C(CCP(C)(=O)O)C(=O)O)[Si](C)(C)C	standard polar	2025-10-24	1682.57
Gas Chromatography	phosphinothricin_TMS_8	C[Si](C)(C)NC(CCP(C)(=O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	standard polar	2025-10-24	2008.63
Gas Chromatography	phosphinothricin_TMS_9	C[Si](C)(C)OC(=O)C(CCP(C)(=O)O)N([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2439.79
Gas Chromatography	phosphinothricin_TMS_10	C[Si](C)(C)OP(C)(=O)CCC(C(=O)O)N([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2252.37
Gas Chromatography	phosphinothricin_TMS_11	C[Si](C)(C)OC(=O)C(CCP(C)(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C	standard polar	2025-10-24	2223.33

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites
Bacteria/Eubacteria	Proteobacteria	1	Human
Bacteria/Eubacteria	Actinobacteria	1
Bacteria	Actinobacteria	2
Bacteria/Eubacteria	Firmicutes	1	Human feces

Exposure Sources

Other Exposures

Source Type	Data Source	Reference
Cosmetics	U.S. Environmental Protection Agency	CompTox
Domestics	U.S. Environmental Protection Agency	CompTox
Water	U.S. Environmental Protection Agency	CompTox

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

Barupal DK, Fiehn O: Generating the Blood Exposome Database Using a Comprehensive Text Mining and Database Fusion Approach. Environ Health Perspect. 2019 Sep;127(9):97008. doi: 10.1289/EHP4713. Epub 2019 Sep 26. [PubMed:31557052 ]

Showing metabocard for phosphinothricin (MMDBc0054635)

MOL for #<Metabolite:0x00007f9ad4ea7830>

3D MOL for #<Metabolite:0x00007f9ad4ea7830>

3D SDF for #<Metabolite:0x00007f9ad4ea7830>

3D-SDF for #<Metabolite:0x00007f9ad4ea7830>

PDB for #<Metabolite:0x00007f9ad4ea7830>

3D PDB for #<Metabolite:0x00007f9ad4ea7830>

SMILES for #<Metabolite:0x00007f9ad4ea7830>

INCHI for #<Metabolite:0x00007f9ad4ea7830>

Structure for #<Metabolite:0x00007f9ad4ea7830>

3D Structure for #<Metabolite:0x00007f9ad4ea7830>