MiMeDB: Showing metabocard for 3-amino-4-hydroxybenzoic acid (MMDBc0055344)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2022-06-17 19:49:41 UTC

Update Date

2025-10-07 16:04:20 UTC

Metabolite ID

MMDBc0055344

Metabolite Identification

Common Name

3-amino-4-hydroxybenzoic acid

Description

3-amino-4-hydroxybenzoic acid is a γ-amino acid and an aromatic compound that serves as a significant metabolite in various biochemical pathways. Its chemical structure features an amino group and a hydroxyl group attached to a benzoic acid framework, which contributes to its reactivity and functionality in biological systems. This compound has been identified as a characteristic metabolite for diagnosing mild cognitive impairment due to Alzheimer's disease (PMID:38069159 ). Additionally, it plays a role in the synthesis of coenzyme Q (UQ), which is essential for cellular growth, as demonstrated by studies using inhibitors like 3-amino-4-hydroxybenzoic acid (PMID:34543102 ). Furthermore, it has been utilized in the production of high-performance industrial plastics and thermostable bioplastics, highlighting its versatility in material science (PMID:35831135 , PMID:34949178 ). The compound also serves as a functional monomer in the electropolymerization process for creating molecularly imprinted polymers (MIPs) (PMID:33470260 ). Overall, 3-amino-4-hydroxybenzoic acid is a compound of interest in both chemistry and biology, with applications ranging from diagnostics to materials development.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
3-Amino-4-hydroxybenzoate anion	ChEBI
3-Amino-4-hydroxybenzoic acid anion	Generator
3-Amino-4-hydroxybenzoic acid	Generator

Molecular Formula

C₇H₆NO₃

Average Mass

152.13

Monoisotopic Mass

152.035316637

IUPAC Name

2-amino-4-carboxybenzen-1-olate

Traditional Name

2-amino-4-carboxybenzenolate

CAS Registry Number

Not Available

SMILES

NC1=C([O-])C=CC(=C1)C(O)=O

InChI Identifier

InChI=1S/C7H7NO3/c8-5-3-4(7(10)11)1-2-6(5)9/h1-3,9H,8H2,(H,10,11)/p-1

InChI Key

MRBKRZAPGUCWOS-UHFFFAOYSA-M

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as aminobenzoic acids. These are benzoic acids containing an amine group attached to the benzene moiety.

Kingdom

Organic compounds

Super Class

Benzenoids

Class

Benzene and substituted derivatives

Sub Class

Benzoic acids and derivatives

Direct Parent

Aminobenzoic acids

Alternative Parents

Substituents

Aminobenzoic acid
Benzoic acid
Benzoyl
Aniline or substituted anilines
Phenoxide
Amino acid or derivatives
Amino acid
Carboxylic acid derivative
Carboxylic acid
Monocarboxylic acid or derivatives
Amine
Organic nitrogen compound
Organooxygen compound
Organonitrogen compound
Primary amine
Hydrocarbon derivative
Organic oxide
Organopnictogen compound
Organic oxygen compound
Organic anion
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

monohydroxybenzoate (CHEBI:60005 )
aromatic amino-acid anion (CHEBI:60005 )

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
logP	0.35	ChemAxon
pKa (Strongest Acidic)	5.09	ChemAxon
pKa (Strongest Basic)	3.38	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	86.38 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	50.55 m³·mol⁻¹	ChemAxon
Polarizability	13.94 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, H₂O, predicted)	2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, H₂O, predicted)	2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, H₂O, predicted)	2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, predicted)	2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, H₂O, predicted)	2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, H₂O, predicted)	2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, H₂O, predicted)	2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, H₂O, predicted)	2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, H₂O, predicted)	2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	2022-08-22	View Spectrum

Chromatographic Retention Times and Retention Indices

Retention Times

Not Available

Retention Indices

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria/Eubacteria	Actinobacteria	2

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

5305846

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

6931691

PDB ID

Not Available

ChEBI ID

60005

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

Bansal P, Morgat A, Axelsen KB, Muthukrishnan V, Coudert E, Aimo L, Hyka-Nouspikel N, Gasteiger E, Kerhornou A, Neto TB, Pozzato M, Blatter MC, Ignatchenko A, Redaschi N, Bridge A: Rhea, the reaction knowledgebase in 2022. Nucleic Acids Res. 2022 Jan 7;50(D1):D693-D700. doi: 10.1093/nar/gkab1016. [PubMed:34755880 ]

Showing metabocard for 3-amino-4-hydroxybenzoic acid (MMDBc0055344)

MOL for #<Metabolite:0x00007fadcc1243d8>

3D MOL for #<Metabolite:0x00007fadcc1243d8>

3D SDF for #<Metabolite:0x00007fadcc1243d8>

3D-SDF for #<Metabolite:0x00007fadcc1243d8>

PDB for #<Metabolite:0x00007fadcc1243d8>

3D PDB for #<Metabolite:0x00007fadcc1243d8>

SMILES for #<Metabolite:0x00007fadcc1243d8>

INCHI for #<Metabolite:0x00007fadcc1243d8>

Structure for #<Metabolite:0x00007fadcc1243d8>

3D Structure for #<Metabolite:0x00007fadcc1243d8>