MiMeDB: Showing metabocard for D-arabinitol 1-phosphate (MMDBc0055850)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2022-06-17 20:08:44 UTC

Update Date

2025-10-07 16:09:25 UTC

Metabolite ID

MMDBc0055850

Metabolite Identification

Common Name

D-arabinitol 1-phosphate

Description

D-arabinitol 1-phosphate is a sugar phosphate belonging to the class of carbohydrate metabolites. Its chemical structure features a phosphate group attached to the D-arabinitol backbone, which is involved in various metabolic pathways, particularly in plant physiology. D-arabinitol 1-phosphate is known for its role in the regulation of Rubisco, a key enzyme in the photosynthetic process. It acts as a precursor to 2-carboxy-D-arabinitol 1-phosphate (CA1P), a potent nocturnal inhibitor of Rubisco that accumulates in plants during periods of darkness or low light, progressively binding to the enzyme and modulating its activity (PMID:36173669 ). This compound, along with other metabolites such as 2-phosphoglyceric acid, demonstrates significant inhibitory effects on Rubisco with sub-nanomolar affinities (PMID:35661591 ). The regulation of Rubisco by CA1P is further highlighted by studies indicating the role of CA1P phosphatase in this regulatory mechanism, suggesting a broader involvement of D-arabinitol 1-phosphate in plant metabolic pathways (PMID:22132794 ).

Structure

MOL SDF PDB SMILES InChI


  Mrv1652306172222082D          

 17 16  0  0  1  0            999 V2000
   -1.1270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -0.7145    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.0164   -0.7145    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.3020   -0.3020    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.8414   -0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -1.5395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -1.5395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    0.5230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743    0.1105    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.0164    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.7474    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1599   -0.3020    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    0.1105    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164    0.1105    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -1.1270    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  3  1  1  0  0  0  0
  4  2  1  0  0  0  0
  5  3  1  0  0  0  0
  5  4  1  0  0  0  0
  6  1  1  0  0  0  0
  3  7  1  1  0  0  0
  4  8  1  6  0  0  0
  5  9  1  6  0  0  0
 13  2  1  0  0  0  0
 14 10  1  0  0  0  0
 14 11  1  0  0  0  0
 14 12  2  0  0  0  0
 14 13  1  0  0  0  0
  3 15  1  1  0  0  0
  4 16  1  6  0  0  0
  5 17  1  6  0  0  0
M  CHG  2  10  -1  11  -1
M  END
> <DATABASE_ID>
MMDBc0055850

> <DATABASE_NAME>
MIME

> <SMILES>
[H][C@@](O)(CO)[C@@]([H])(O)[C@]([H])(O)COP([O-])([O-])=O

> <INCHI_IDENTIFIER>
InChI=1S/C5H13O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h3-9H,1-2H2,(H2,10,11,12)/p-2/t3-,4-,5-/m1/s1

> <INCHI_KEY>
VJDOAZKNBQCAGE-UOWFLXDJSA-L

> <FORMULA>
C5H11O8P

> <MOLECULAR_WEIGHT>
230.11

> <EXACT_MASS>
230.020251472

> <JCHEM_ACCEPTOR_COUNT>
7

> <JCHEM_ATOM_COUNT>
25

> <JCHEM_AVERAGE_POLARIZABILITY>
18.294585454764977

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
-2

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2R,3R,4R)-5-(phosphonooxy)pentane-1,2,3,4-tetrol

> <JCHEM_LOGP>
-3.2232499379999995

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-2

> <JCHEM_PKA>
6.517789357699702

> <JCHEM_PKA_STRONGEST_ACIDIC>
1.4919789137158341

> <JCHEM_PKA_STRONGEST_BASIC>
-2.974203813611499

> <JCHEM_POLAR_SURFACE_AREA>
153.34

> <JCHEM_REFRACTIVITY>
41.0706

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(2R,3R,4R)-5-(phosphonooxy)pentane-1,2,3,4-tetrol

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 17-JUN-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   17-JUN-22         0                                  
HETATM    1  C   UNK     0      -2.104  -0.564   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       3.231  -0.564   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -0.770  -1.334   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       1.897  -1.334   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       0.564  -0.564   0.000  0.00  0.00           C+0
HETATM    6  O   UNK     0      -3.437  -1.334   0.000  0.00  0.00           O+0
HETATM    7  O   UNK     0      -0.770  -2.874   0.000  0.00  0.00           O+0
HETATM    8  O   UNK     0       1.897  -2.874   0.000  0.00  0.00           O+0
HETATM    9  O   UNK     0       0.564   0.976   0.000  0.00  0.00           O+0
HETATM   10  O   UNK     0       7.232   0.206   0.000  0.00  0.00           O-1
HETATM   11  O   UNK     0       6.668  -1.897   0.000  0.00  0.00           O-1
HETATM   12  O   UNK     0       5.128   0.770   0.000  0.00  0.00           O+0
HETATM   13  O   UNK     0       4.565  -1.334   0.000  0.00  0.00           O+0
HETATM   14  P   UNK     0       5.898  -0.564   0.000  0.00  0.00           P+0
HETATM   15  H   UNK     0      -0.770   0.206   0.000  0.00  0.00           H+0
HETATM   16  H   UNK     0       1.897   0.206   0.000  0.00  0.00           H+0
HETATM   17  H   UNK     0       0.564  -2.104   0.000  0.00  0.00           H+0
CONECT    1    3    6                                                       
CONECT    2    4   13                                                       
CONECT    3    1    5    7   15                                             
CONECT    4    2    5    8   16                                             
CONECT    5    3    4    9   17                                             
CONECT    6    1                                                            
CONECT    7    3                                                            
CONECT    8    4                                                            
CONECT    9    5                                                            
CONECT   10   14                                                            
CONECT   11   14                                                            
CONECT   12   14                                                            
CONECT   13    2   14                                                       
CONECT   14   10   11   12   13                                             
CONECT   15    3                                                            
CONECT   16    4                                                            
CONECT   17    5                                                            
MASTER        0    0    0    0    0    0    0    0   17    0   32    0
END

Synonyms

Value	Source
1-O-Phosphonato-D-arabinitol	ChEBI
D-Arabinitol 1-phosphate	ChEBI
D-Arabinitol 1-phosphoric acid	Generator
D-Arabinitol 1-phosphoric acid(2-)	Generator

Molecular Formula

C₅H₁₁O₈P

Average Mass

230.11

Monoisotopic Mass

230.020251472

IUPAC Name

(2R,3R,4R)-5-(phosphonooxy)pentane-1,2,3,4-tetrol

Traditional Name

(2R,3R,4R)-5-(phosphonooxy)pentane-1,2,3,4-tetrol

CAS Registry Number

Not Available

SMILES

[H][C@@](O)(CO)[C@@]([H])(O)[C@]([H])(O)COP([O-])([O-])=O

InChI Identifier

InChI=1S/C5H13O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h3-9H,1-2H2,(H2,10,11,12)/p-2/t3-,4-,5-/m1/s1

InChI Key

VJDOAZKNBQCAGE-UOWFLXDJSA-L

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as monosaccharide phosphates. These are monosaccharides comprising a phosphated group linked to the carbohydrate unit.

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Carbohydrates and carbohydrate conjugates

Direct Parent

Monosaccharide phosphates

Alternative Parents

Substituents

Pentose monosaccharide
Monosaccharide phosphate
Alkyl phosphate
Sugar alcohol
Phosphoric acid ester
Organic phosphoric acid derivative
Secondary alcohol
Polyol
Organic oxide
Hydrocarbon derivative
Primary alcohol
Alcohol
Organic anion
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

organophosphate oxoanion (CHEBI:58566 )

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
logP	-3.2	ChemAxon
pKa (Strongest Acidic)	1.49	ChemAxon
pKa (Strongest Basic)	-3	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	7	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	153.34 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	41.07 m³·mol⁻¹	ChemAxon
Polarizability	18.29 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Chromatographic Retention Times and Retention Indices

Retention Times

Not Available

Retention Indices

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria/Eubacteria	Firmicutes	1	Human

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

26331248

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

25201710

PDB ID

Not Available

ChEBI ID

58566

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

Bansal P, Morgat A, Axelsen KB, Muthukrishnan V, Coudert E, Aimo L, Hyka-Nouspikel N, Gasteiger E, Kerhornou A, Neto TB, Pozzato M, Blatter MC, Ignatchenko A, Redaschi N, Bridge A: Rhea, the reaction knowledgebase in 2022. Nucleic Acids Res. 2022 Jan 7;50(D1):D693-D700. doi: 10.1093/nar/gkab1016. [PubMed:34755880 ]

Showing metabocard for D-arabinitol 1-phosphate (MMDBc0055850)

MOL for #<Metabolite:0x000056153396fac0>

3D MOL for #<Metabolite:0x000056153396fac0>

3D SDF for #<Metabolite:0x000056153396fac0>

3D-SDF for #<Metabolite:0x000056153396fac0>

PDB for #<Metabolite:0x000056153396fac0>

3D PDB for #<Metabolite:0x000056153396fac0>

SMILES for #<Metabolite:0x000056153396fac0>

INCHI for #<Metabolite:0x000056153396fac0>

Structure for #<Metabolite:0x000056153396fac0>

3D Structure for #<Metabolite:0x000056153396fac0>