MiMeDB: Showing metabocard for D-erythrulose 4-phosphate (MMDBc0055860)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2022-06-17 20:09:00 UTC

Update Date

2025-10-07 16:09:25 UTC

Metabolite ID

MMDBc0055860

Metabolite Identification

Common Name

D-erythrulose 4-phosphate

Description

D-erythrulose 4-phosphate is a carbohydrate metabolite belonging to the class of phosphorylated sugars. Its chemical structure features a four-carbon backbone with a phosphate group attached to the fourth carbon, making it a crucial intermediate in various metabolic pathways. D-erythrulose 4-phosphate is synthesized from glycolaldehyde through a series of enzymatic reactions involving transketolase and kinase, leading to its eventual conversion to D-erythrose 4-phosphate (PMID:3987693 ). The enzyme responsible for the interconversion of D-erythrose 4-phosphate and D-erythrulose 4-phosphate has been isolated from beef liver, highlighting its significance in metabolic processes (PMID:3987693 ). Analytical techniques such as gas chromatography/mass spectrometry have demonstrated that D-erythrulose 4-phosphate constitutes approximately 90% of the total tetrose 4-phosphate present after equilibration, indicating its predominance in the equilibrium state (PMID:6547672 ). Furthermore, this compound can also be formed from D-threose 4-phosphate, showcasing its role in the dynamic interconversion of tetrose phosphates (PMID:6547672 ). Overall, D-erythrulose 4-phosphate plays a pivotal role in carbohydrate metabolism and serves as an important precursor in various biosynthetic pathways.

Structure

MOL SDF PDB SMILES InChI

HEADER    PROTEIN                                 17-JUN-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   17-JUN-22         0                                  
HETATM    1  C   UNK     0       6.160  -2.667   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       2.310  -1.334   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       4.620  -2.667   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       3.850  -1.334   0.000  0.00  0.00           C+0
HETATM    5  O   UNK     0       6.930  -4.001   0.000  0.00  0.00           O+0
HETATM    6  O   UNK     0       3.850  -4.001   0.000  0.00  0.00           O+0
HETATM    7  O   UNK     0       4.620  -0.000   0.000  0.00  0.00           O+0
HETATM    8  O   UNK     0      -1.540   0.000   0.000  0.00  0.00           O-1
HETATM    9  O   UNK     0       0.000   1.540   0.000  0.00  0.00           O-1
HETATM   10  O   UNK     0       0.000  -1.540   0.000  0.00  0.00           O+0
HETATM   11  O   UNK     0       1.540   0.000   0.000  0.00  0.00           O+0
HETATM   12  P   UNK     0       0.000   0.000   0.000  0.00  0.00           P+0
HETATM   13  H   UNK     0       3.080  -2.667   0.000  0.00  0.00           H+0
CONECT    1    3    5                                                       
CONECT    2    4   11                                                       
CONECT    3    1    4    6                                                  
CONECT    4    2    3    7   13                                             
CONECT    5    1                                                            
CONECT    6    3                                                            
CONECT    7    4                                                            
CONECT    8   12                                                            
CONECT    9   12                                                            
CONECT   10   12                                                            
CONECT   11    2   12                                                       
CONECT   12    8    9   10   11                                             
CONECT   13    4                                                            
MASTER        0    0    0    0    0    0    0    0   13    0   24    0
END

Synonyms

Value	Source
(2R)-2,4-Dihydroxy-3-oxobutyl phosphate	ChEBI
D-Erythrulose 4-phosphate	ChEBI
(2R)-2,4-Dihydroxy-3-oxobutyl phosphoric acid	Generator
D-Erythrulose 4-phosphoric acid	Generator
D-Erythrulose 4-phosphoric acid(2-)	Generator

Molecular Formula

C₄H₇O₇P

Average Mass

198.068

Monoisotopic Mass

197.994036723

IUPAC Name

(3R)-1,3-dihydroxy-4-(phosphonooxy)butan-2-one

Traditional Name

(3R)-1,3-dihydroxy-4-(phosphonooxy)butan-2-one

CAS Registry Number

Not Available

SMILES

[H][C@@](O)(COP([O-])([O-])=O)C(=O)CO

InChI Identifier

InChI=1S/C4H9O7P/c5-1-3(6)4(7)2-11-12(8,9)10/h4-5,7H,1-2H2,(H2,8,9,10)/p-2/t4-/m1/s1

InChI Key

WUVPHPUDYOVMOE-SCSAIBSYSA-L

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as monosaccharides. Monosaccharides are compounds containing one carbohydrate unit not glycosidically linked to another such unit, and no set of two or more glycosidically linked carbohydrate units. Monosaccharides have the general formula CnH2nOn.

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Carbohydrates and carbohydrate conjugates

Direct Parent

Monosaccharides

Alternative Parents

Substituents

Alkyl phosphate
Phosphoric acid ester
Organic phosphoric acid derivative
Monosaccharide
Acyloin
Alpha-hydroxy ketone
Secondary alcohol
Ketone
Organic oxide
Hydrocarbon derivative
Primary alcohol
Carbonyl group
Alcohol
Organic anion
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
logP	-2.1	ChemAxon
pKa (Strongest Acidic)	1.38	ChemAxon
pKa (Strongest Basic)	-3.3	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	129.95 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	34.27 m³·mol⁻¹	ChemAxon
Polarizability	14.96 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Chromatographic Retention Times and Retention Indices

Retention Times

Chromatography Type	Technique	Column	Deposition Date	Retention Time (s)
Liquid Chromatography	HILIC	Waters Acquity UPLC-BEH Amide column (eluted)	2025-10-24	374.5
Liquid Chromatography	HILIC	Accucore 150 Amide HILIC (eluted)	2025-10-24	248.4
Liquid Chromatography	Reversed-phase	Hypersil Gold 1.9 µm C18 (void)	2025-10-24	56.4
Liquid Chromatography	Reversed-phase	Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) (eluted)	2025-10-24	324.7
Liquid Chromatography	Reversed-phase	XBridge C18 3.5u 2.1x50 mm (eluted)	2025-10-24	261.0
Liquid Chromatography	Reversed-phase	Ascentis Express C18 (void)	2025-10-24	336.2
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (void)	2025-10-24	801.4
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-24	532.6
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC (eluted)	2025-10-24	910.5
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-24	174.0
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-24	251.8
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-24	195.6
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-24	45.7
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-24	390.8
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-24	708.1
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (void)	2025-10-24	69.0
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (void)	2025-10-24	225.5
Liquid Chromatography	Reversed-phase	Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex (eluted)	2025-10-24	841.5
Liquid Chromatography	Reversed-phase	Waters Atlantis T3 (2.1 x 150 mm, 5 um) (eluted)	2025-10-24	621.9

Retention Indices

Chromatography Type	Peak Label	SMILES	Stationary Phase	Deposition Date	Retention Index
Gas Chromatography	D-erythrulose 4-phosphate_TMS_1	C[Si](C)(C)O[C@H](COP(=O)([O-])[O-])C(=O)CO	standard non polar	2025-10-24	2190.95
Gas Chromatography	D-erythrulose 4-phosphate_TMS_2	C[Si](C)(C)OCC(=O)[C@H](O)COP(=O)([O-])[O-]	standard non polar	2025-10-24	1897.57
Gas Chromatography	D-erythrulose 4-phosphate_TMS_3	C[Si](C)(C)OC(CO)=C(O)COP(=O)([O-])[O-]	standard non polar	2025-10-24	2099.38
Gas Chromatography	D-erythrulose 4-phosphate_TMS_4	C[Si](C)(C)OC(=CO)[C@H](O)COP(=O)([O-])[O-]	standard non polar	2025-10-24	2086.21
Gas Chromatography	D-erythrulose 4-phosphate_TMS_5	C[Si](C)(C)OCC(=O)[C@@H](COP(=O)([O-])[O-])O[Si](C)(C)C	standard non polar	2025-10-24	1756.47
Gas Chromatography	D-erythrulose 4-phosphate_TMS_6	C[Si](C)(C)OC(CO)=C(COP(=O)([O-])[O-])O[Si](C)(C)C	standard non polar	2025-10-24	1866.84
Gas Chromatography	D-erythrulose 4-phosphate_TMS_7	C[Si](C)(C)OC(=CO)[C@@H](COP(=O)([O-])[O-])O[Si](C)(C)C	standard non polar	2025-10-24	1737.35
Gas Chromatography	D-erythrulose 4-phosphate_TMS_8	C[Si](C)(C)OCC(O[Si](C)(C)C)=C(O)COP(=O)([O-])[O-]	standard non polar	2025-10-24	2184.93
Gas Chromatography	D-erythrulose 4-phosphate_TMS_9	C[Si](C)(C)OC=C(O[Si](C)(C)C)[C@H](O)COP(=O)([O-])[O-]	standard non polar	2025-10-24	2366.79
Gas Chromatography	D-erythrulose 4-phosphate_TMS_10	C[Si](C)(C)OCC(O[Si](C)(C)C)=C(COP(=O)([O-])[O-])O[Si](C)(C)C	standard non polar	2025-10-24	2166.23
Gas Chromatography	D-erythrulose 4-phosphate_TMS_11	C[Si](C)(C)OC=C(O[Si](C)(C)C)[C@@H](COP(=O)([O-])[O-])O[Si](C)(C)C	standard non polar	2025-10-24	1780.83
Gas Chromatography	D-erythrulose 4-phosphate_TMS_1	C[Si](C)(C)O[C@H](COP(=O)([O-])[O-])C(=O)CO	standard polar	2025-10-24	2161.55
Gas Chromatography	D-erythrulose 4-phosphate_TMS_2	C[Si](C)(C)OCC(=O)[C@H](O)COP(=O)([O-])[O-]	standard polar	2025-10-24	1875.76
Gas Chromatography	D-erythrulose 4-phosphate_TMS_3	C[Si](C)(C)OC(CO)=C(O)COP(=O)([O-])[O-]	standard polar	2025-10-24	2080.14
Gas Chromatography	D-erythrulose 4-phosphate_TMS_4	C[Si](C)(C)OC(=CO)[C@H](O)COP(=O)([O-])[O-]	standard polar	2025-10-24	2003.05
Gas Chromatography	D-erythrulose 4-phosphate_TMS_5	C[Si](C)(C)OCC(=O)[C@@H](COP(=O)([O-])[O-])O[Si](C)(C)C	standard polar	2025-10-24	1942.51
Gas Chromatography	D-erythrulose 4-phosphate_TMS_6	C[Si](C)(C)OC(CO)=C(COP(=O)([O-])[O-])O[Si](C)(C)C	standard polar	2025-10-24	1876.0
Gas Chromatography	D-erythrulose 4-phosphate_TMS_7	C[Si](C)(C)OC(=CO)[C@@H](COP(=O)([O-])[O-])O[Si](C)(C)C	standard polar	2025-10-24	2181.38
Gas Chromatography	D-erythrulose 4-phosphate_TMS_8	C[Si](C)(C)OCC(O[Si](C)(C)C)=C(O)COP(=O)([O-])[O-]	standard polar	2025-10-24	2070.87
Gas Chromatography	D-erythrulose 4-phosphate_TMS_9	C[Si](C)(C)OC=C(O[Si](C)(C)C)[C@H](O)COP(=O)([O-])[O-]	standard polar	2025-10-24	1353.48
Gas Chromatography	D-erythrulose 4-phosphate_TMS_10	C[Si](C)(C)OCC(O[Si](C)(C)C)=C(COP(=O)([O-])[O-])O[Si](C)(C)C	standard polar	2025-10-24	2308.95
Gas Chromatography	D-erythrulose 4-phosphate_TMS_11	C[Si](C)(C)OC=C(O[Si](C)(C)C)[C@@H](COP(=O)([O-])[O-])O[Si](C)(C)C	standard polar	2025-10-24	1805.65

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria/Eubacteria	Actinobacteria	1	Human
Bacteria/Eubacteria	Proteobacteria	9	Human ; Pig ; Human feces

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

58164088

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

102571803

PDB ID

Not Available

ChEBI ID

90796

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

Bansal P, Morgat A, Axelsen KB, Muthukrishnan V, Coudert E, Aimo L, Hyka-Nouspikel N, Gasteiger E, Kerhornou A, Neto TB, Pozzato M, Blatter MC, Ignatchenko A, Redaschi N, Bridge A: Rhea, the reaction knowledgebase in 2022. Nucleic Acids Res. 2022 Jan 7;50(D1):D693-D700. doi: 10.1093/nar/gkab1016. [PubMed:34755880 ]

Showing metabocard for D-erythrulose 4-phosphate (MMDBc0055860)

MOL for #<Metabolite:0x00007fae02d0c598>

3D MOL for #<Metabolite:0x00007fae02d0c598>

3D SDF for #<Metabolite:0x00007fae02d0c598>

3D-SDF for #<Metabolite:0x00007fae02d0c598>

PDB for #<Metabolite:0x00007fae02d0c598>

3D PDB for #<Metabolite:0x00007fae02d0c598>

SMILES for #<Metabolite:0x00007fae02d0c598>

INCHI for #<Metabolite:0x00007fae02d0c598>

Structure for #<Metabolite:0x00007fae02d0c598>

3D Structure for #<Metabolite:0x00007fae02d0c598>