MiMeDB: Showing metabocard for O-succinyl-L-serine (MMDBc0056232)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2022-06-17 20:20:11 UTC

Update Date

2025-10-07 16:09:40 UTC

Metabolite ID

MMDBc0056232

Metabolite Identification

Common Name

O-succinyl-L-serine

Description

O-succinyl-L-serine is a non-proteinogenic amino acid that belongs to the class of metabolites known as amino acid derivatives. Its chemical structure features a succinyl group attached to the serine backbone, which plays a critical role in various metabolic pathways. O-succinyl-L-serine is involved in the biosynthesis of L-cysteine, where it acts as a substrate for specific enzymes. Notably, research has identified a divergent subgroup of MetX enzymes in fungi that function exclusively as O-succinyl-L-serine transferases, thereby facilitating the conversion of this compound in the context of L-cysteine production (PMID:28581482 ). This highlights its significance in the metabolic networks that contribute to amino acid synthesis, particularly in certain fungal species. The understanding of O-succinyl-L-serine's role in these pathways not only sheds light on amino acid metabolism but also provides insights into the enzymatic mechanisms that govern the synthesis of essential biomolecules.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652306172222202D          

 15 14  0  0  1  0            999 V2000
    2.3349    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6204    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5230    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375    0.7145    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.0493    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9059    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9520    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375   -0.1105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7638    1.1270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0493   -0.1105    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.9059    1.9520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6664    0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9520    1.9520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1914    0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375    1.5395    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  4  3  1  0  0  0  0
  5  1  1  0  0  0  0
  6  2  1  0  0  0  0
  7  4  1  0  0  0  0
  4  8  1  1  0  0  0
  9  5  2  0  0  0  0
 10  5  1  0  0  0  0
 11  6  2  0  0  0  0
 12  7  2  0  0  0  0
 13  7  1  0  0  0  0
 14  3  1  0  0  0  0
 14  6  1  0  0  0  0
  4 15  1  1  0  0  0
M  CHG  1  10  -1
M  END
> <DATABASE_ID>
MMDBc0056232

> <DATABASE_NAME>
MIME

> <SMILES>
[H][C@](N)(COC(=O)CCC([O-])=O)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C7H11NO6/c8-4(7(12)13)3-14-6(11)2-1-5(9)10/h4H,1-3,8H2,(H,9,10)(H,12,13)/p-1/t4-/m0/s1

> <INCHI_KEY>
ZAHSBRLHJRVFAU-BYPYZUCNSA-M

> <FORMULA>
C7H10NO6

> <MOLECULAR_WEIGHT>
204.159

> <EXACT_MASS>
204.051360626

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
24

> <JCHEM_AVERAGE_POLARIZABILITY>
18.15396592716357

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
-1

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
4-[(2S)-2-amino-2-carboxyethoxy]-4-oxobutanoate

> <JCHEM_LOGP>
-3.675699988274044

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
4.007762124033174

> <JCHEM_PKA_STRONGEST_ACIDIC>
1.6349274092133426

> <JCHEM_PKA_STRONGEST_BASIC>
8.603146122997607

> <JCHEM_POLAR_SURFACE_AREA>
129.75

> <JCHEM_REFRACTIVITY>
52.922900000000006

> <JCHEM_ROTATABLE_BOND_COUNT>
7

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
4-[(2S)-2-amino-2-carboxyethoxy]-4-oxobutanoate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 17-JUN-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   17-JUN-22         0                                  
HETATM    1  C   UNK     0       4.358   2.104   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       3.025   1.334   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -0.976   2.104   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -2.310   1.334   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       5.692   1.334   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       1.691   2.104   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -3.644   2.104   0.000  0.00  0.00           C+0
HETATM    8  N   UNK     0      -2.310  -0.206   0.000  0.00  0.00           N+0
HETATM    9  O   UNK     0       7.026   2.104   0.000  0.00  0.00           O+0
HETATM   10  O   UNK     0       5.692  -0.206   0.000  0.00  0.00           O-1
HETATM   11  O   UNK     0       1.691   3.644   0.000  0.00  0.00           O+0
HETATM   12  O   UNK     0      -4.977   1.334   0.000  0.00  0.00           O+0
HETATM   13  O   UNK     0      -3.644   3.644   0.000  0.00  0.00           O+0
HETATM   14  O   UNK     0       0.357   1.334   0.000  0.00  0.00           O+0
HETATM   15  H   UNK     0      -2.310   2.874   0.000  0.00  0.00           H+0
CONECT    1    2    5                                                       
CONECT    2    1    6                                                       
CONECT    3    4   14                                                       
CONECT    4    3    7    8   15                                             
CONECT    5    1    9   10                                                  
CONECT    6    2   11   14                                                  
CONECT    7    4   12   13                                                  
CONECT    8    4                                                            
CONECT    9    5                                                            
CONECT   10    5                                                            
CONECT   11    6                                                            
CONECT   12    7                                                            
CONECT   13    7                                                            
CONECT   14    3    6                                                       
CONECT   15    4                                                            
MASTER        0    0    0    0    0    0    0    0   15    0   28    0
END

Synonyms

Not Available

Molecular Formula

C₇H₁₀NO₆

Average Mass

204.159

Monoisotopic Mass

204.051360626

IUPAC Name

4-[(2S)-2-amino-2-carboxyethoxy]-4-oxobutanoate

Traditional Name

4-[(2S)-2-amino-2-carboxyethoxy]-4-oxobutanoate

CAS Registry Number

Not Available

SMILES

[H][C@](N)(COC(=O)CCC([O-])=O)C(O)=O

InChI Identifier

InChI=1S/C7H11NO6/c8-4(7(12)13)3-14-6(11)2-1-5(9)10/h4H,1-3,8H2,(H,9,10)(H,12,13)/p-1/t4-/m0/s1

InChI Key

ZAHSBRLHJRVFAU-BYPYZUCNSA-M

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

L-alpha-amino acids

Alternative Parents

Substituents

L-alpha-amino acid
Tricarboxylic acid or derivatives
Fatty acid ester
Fatty acyl
Amino acid
Carboxylic acid ester
Carboxylic acid
Organic nitrogen compound
Organic oxygen compound
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Primary amine
Organooxygen compound
Organonitrogen compound
Primary aliphatic amine
Carbonyl group
Amine
Organic anion
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
logP	-3.7	ChemAxon
pKa (Strongest Acidic)	1.63	ChemAxon
pKa (Strongest Basic)	8.6	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	129.75 Å²	ChemAxon
Rotatable Bond Count	7	ChemAxon
Refractivity	52.92 m³·mol⁻¹	ChemAxon
Polarizability	18.15 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Chromatographic Retention Times and Retention Indices

Retention Times

Not Available

Retention Indices

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites
Eukaryota/Fungi	Ascomycota	4	Human feces
Bacteria	Proteobacteria	2	Human
Bacteria/Eubacteria	Proteobacteria	13	Human

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

76962916

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

126843518

PDB ID

Not Available

ChEBI ID

136856

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

Bansal P, Morgat A, Axelsen KB, Muthukrishnan V, Coudert E, Aimo L, Hyka-Nouspikel N, Gasteiger E, Kerhornou A, Neto TB, Pozzato M, Blatter MC, Ignatchenko A, Redaschi N, Bridge A: Rhea, the reaction knowledgebase in 2022. Nucleic Acids Res. 2022 Jan 7;50(D1):D693-D700. doi: 10.1093/nar/gkab1016. [PubMed:34755880 ]

Showing metabocard for O-succinyl-L-serine (MMDBc0056232)

MOL for #<Metabolite:0x00007fade1c85b68>

3D MOL for #<Metabolite:0x00007fade1c85b68>

3D SDF for #<Metabolite:0x00007fade1c85b68>

3D-SDF for #<Metabolite:0x00007fade1c85b68>

PDB for #<Metabolite:0x00007fade1c85b68>

3D PDB for #<Metabolite:0x00007fade1c85b68>

SMILES for #<Metabolite:0x00007fade1c85b68>

INCHI for #<Metabolite:0x00007fade1c85b68>

Structure for #<Metabolite:0x00007fade1c85b68>

3D Structure for #<Metabolite:0x00007fade1c85b68>