MiMeDB: Showing metabocard for versicolorin B (MMDBc0056379)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2022-06-17 20:24:09 UTC

Update Date

2025-10-07 16:09:46 UTC

Metabolite ID

MMDBc0056379

Metabolite Identification

Common Name

versicolorin B

Description

Versicolorin B is a secondary metabolite belonging to the chemical class of anthraquinones. It plays a significant role in the biosynthetic pathways of various fungal metabolites, particularly in the synthesis of aflatoxins, where versicolorin B synthase acts as a key catalytic enzyme for heterochrome B synthesis during aflatoxin production (PMID:36566904 ). Additionally, versicolorin B has been identified as a promising candidate in molecular docking studies, demonstrating superior binding affinities to the SD protein, outperforming conventional fungicides (PMID:39681474 ). The stability of the docked complexes involving versicolorin B was confirmed through molecular dynamics simulations, indicating favorable binding free energies (PMID:39681474 ). Furthermore, it has been isolated from various fungal cultures, including Aspergillus species, highlighting its prevalence in the fungal metabolome (PMID:34722462 ; PMID:36970635 ). Versicolorin B has also shown inhibitory effects on the mycelial growth and conidial germination of certain fungi, suggesting its potential utility in biocontrol applications (PMID:36970635 ). Overall, versicolorin B is a crucial compound in fungal secondary metabolism with implications for both chemical and biological research.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652306172222242D          

 27 31  0  0  1  0            999 V2000
    3.2351    3.9124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4906    3.5570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3179    2.4044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8644    3.7247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4846    2.0306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9723    2.9068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8032    3.3141    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    7.5556    2.7199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1390    2.5330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1021    4.0402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7223    2.3461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4477    3.5378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6144    3.1640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0311    3.3509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9013    2.2175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6854    3.8533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2688    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4097    2.5890    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    9.7346    2.5913    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    7.9942    4.8581    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0092    1.3996    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5775    4.6712    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1608    4.4843    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5985    2.7391    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9778    1.9907    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1966    4.0392    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0163    1.8638    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  6  3  2  0  0  0  0
  6  4  1  0  0  0  0
  7  1  1  0  0  0  0
  8  3  1  0  0  0  0
  9  5  2  0  0  0  0
 10  4  2  0  0  0  0
 11  5  1  0  0  0  0
 12  8  2  0  0  0  0
 12 10  1  0  0  0  0
 13  7  1  0  0  0  0
 13 11  2  0  0  0  0
 14  9  1  0  0  0  0
 15  8  1  0  0  0  0
 15  9  1  0  0  0  0
 16 12  1  0  0  0  0
 16 14  1  0  0  0  0
 17 13  1  0  0  0  0
 17 14  2  0  0  0  0
 18  7  1  0  0  0  0
 19  6  1  0  0  0  0
 20 10  1  0  0  0  0
 21 15  2  0  0  0  0
 22 16  2  0  0  0  0
 23 17  1  0  0  0  0
 24  2  1  0  0  0  0
 24 18  1  0  0  0  0
 25 11  1  0  0  0  0
 25 18  1  0  0  0  0
  7 26  1  6  0  0  0
 18 27  1  6  0  0  0
M  CHG  1  19  -1
M  END


  Mrv1652306172222242D          

 27 31  0  0  1  0            999 V2000
    3.2351    3.9124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4906    3.5570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3179    2.4044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8644    3.7247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4846    2.0306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9723    2.9068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8032    3.3141    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    7.5556    2.7199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1390    2.5330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1021    4.0402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7223    2.3461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4477    3.5378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6144    3.1640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0311    3.3509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9013    2.2175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6854    3.8533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2688    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4097    2.5890    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    9.7346    2.5913    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    7.9942    4.8581    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0092    1.3996    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5775    4.6712    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1608    4.4843    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5985    2.7391    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9778    1.9907    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1966    4.0392    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0163    1.8638    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  6  3  2  0  0  0  0
  6  4  1  0  0  0  0
  7  1  1  0  0  0  0
  8  3  1  0  0  0  0
  9  5  2  0  0  0  0
 10  4  2  0  0  0  0
 11  5  1  0  0  0  0
 12  8  2  0  0  0  0
 12 10  1  0  0  0  0
 13  7  1  0  0  0  0
 13 11  2  0  0  0  0
 14  9  1  0  0  0  0
 15  8  1  0  0  0  0
 15  9  1  0  0  0  0
 16 12  1  0  0  0  0
 16 14  1  0  0  0  0
 17 13  1  0  0  0  0
 17 14  2  0  0  0  0
 18  7  1  0  0  0  0
 19  6  1  0  0  0  0
 20 10  1  0  0  0  0
 21 15  2  0  0  0  0
 22 16  2  0  0  0  0
 23 17  1  0  0  0  0
 24  2  1  0  0  0  0
 24 18  1  0  0  0  0
 25 11  1  0  0  0  0
 25 18  1  0  0  0  0
  7 26  1  6  0  0  0
 18 27  1  6  0  0  0
M  CHG  1  19  -1
M  END
> <DATABASE_ID>
MMDBc0056379

> <DATABASE_NAME>
MIME

> <SMILES>
[H][C@]12OCC[C@@]1([H])C1=C(O2)C=C2C(=O)C3=C(C(O)=CC([O-])=C3)C(=O)C2=C1O

> <INCHI_IDENTIFIER>
InChI=1S/C18H12O7/c19-6-3-8-12(10(20)4-6)16(22)14-9(15(8)21)5-11-13(17(14)23)7-1-2-24-18(7)25-11/h3-5,7,18-20,23H,1-2H2/p-1/t7-,18+/m0/s1

> <INCHI_KEY>
BABJNKGTTYCTOO-ULCDLSAGSA-M

> <FORMULA>
C18H11O7

> <MOLECULAR_WEIGHT>
339.28

> <EXACT_MASS>
339.051026274

> <JCHEM_ACCEPTOR_COUNT>
7

> <JCHEM_ATOM_COUNT>
36

> <JCHEM_AVERAGE_POLARIZABILITY>
32.55725927887592

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
-1

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(4S,8R)-2,18-dihydroxy-13,20-dioxo-7,9-dioxapentacyclo[10.8.0.0^{3,10}.0^{4,8}.0^{14,19}]icosa-1,3(10),11,14(19),15,17-hexaen-16-olate

> <JCHEM_LOGP>
3.246219122666666

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
8.342603442881286

> <JCHEM_PKA_STRONGEST_ACIDIC>
7.2928948350166936

> <JCHEM_PKA_STRONGEST_BASIC>
-4.245109368777737

> <JCHEM_POLAR_SURFACE_AREA>
116.12000000000002

> <JCHEM_REFRACTIVITY>
95.9931

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(4S,8R)-2,18-dihydroxy-13,20-dioxo-7,9-dioxapentacyclo[10.8.0.0^{3,10}.0^{4,8}.0^{14,19}]icosa-1,3(10),11,14(19),15,17-hexaen-16-olate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 17-JUN-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   17-JUN-22         0                                  
HETATM    1  C   UNK     0       6.039   7.303   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       4.649   6.640   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      15.527   4.488   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      16.547   6.953   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      10.238   3.790   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      16.748   5.426   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       7.099   6.186   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      14.104   5.077   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      11.459   4.728   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      15.124   7.542   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       8.815   4.379   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      13.902   6.604   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       8.614   5.906   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      11.258   6.255   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      12.882   4.139   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      12.479   7.193   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       9.835   6.844   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       6.365   4.833   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0      18.171   4.837   0.000  0.00  0.00           O-1
HETATM   20  O   UNK     0      14.922   9.068   0.000  0.00  0.00           O+0
HETATM   21  O   UNK     0      13.084   2.613   0.000  0.00  0.00           O+0
HETATM   22  O   UNK     0      12.278   8.720   0.000  0.00  0.00           O+0
HETATM   23  O   UNK     0       9.634   8.371   0.000  0.00  0.00           O+0
HETATM   24  O   UNK     0       4.850   5.113   0.000  0.00  0.00           O+0
HETATM   25  O   UNK     0       7.425   3.716   0.000  0.00  0.00           O+0
HETATM   26  H   UNK     0       7.834   7.540   0.000  0.00  0.00           H+0
HETATM   27  H   UNK     0       5.630   3.479   0.000  0.00  0.00           H+0
CONECT    1    2    7                                                       
CONECT    2    1   24                                                       
CONECT    3    6    8                                                       
CONECT    4    6   10                                                       
CONECT    5    9   11                                                       
CONECT    6    3    4   19                                                  
CONECT    7    1   13   18   26                                             
CONECT    8    3   12   15                                                  
CONECT    9    5   14   15                                                  
CONECT   10    4   12   20                                                  
CONECT   11    5   13   25                                                  
CONECT   12    8   10   16                                                  
CONECT   13    7   11   17                                                  
CONECT   14    9   16   17                                                  
CONECT   15    8    9   21                                                  
CONECT   16   12   14   22                                                  
CONECT   17   13   14   23                                                  
CONECT   18    7   24   25   27                                             
CONECT   19    6                                                            
CONECT   20   10                                                            
CONECT   21   15                                                            
CONECT   22   16                                                            
CONECT   23   17                                                            
CONECT   24    2   18                                                       
CONECT   25   11   18                                                       
CONECT   26    7                                                            
CONECT   27   18                                                            
MASTER        0    0    0    0    0    0    0    0   27    0   62    0
END

Synonyms

Value	Source
Versicolorin b	ChEBI

Molecular Formula

C₁₈H₁₁O₇

Average Mass

339.28

Monoisotopic Mass

339.051026274

IUPAC Name

(4S,8R)-2,18-dihydroxy-13,20-dioxo-7,9-dioxapentacyclo[10.8.0.0^{3,10}.0^{4,8}.0^{14,19}]icosa-1,3(10),11,14(19),15,17-hexaen-16-olate

Traditional Name

(4S,8R)-2,18-dihydroxy-13,20-dioxo-7,9-dioxapentacyclo[10.8.0.0^{3,10}.0^{4,8}.0^{14,19}]icosa-1,3(10),11,14(19),15,17-hexaen-16-olate

CAS Registry Number

Not Available

SMILES

[H][C@]12OCC[C@@]1([H])C1=C(O2)C=C2C(=O)C3=C(C(O)=CC([O-])=C3)C(=O)C2=C1O

InChI Identifier

InChI=1S/C18H12O7/c19-6-3-8-12(10(20)4-6)16(22)14-9(15(8)21)5-11-13(17(14)23)7-1-2-24-18(7)25-11/h3-5,7,18-20,23H,1-2H2/p-1/t7-,18+/m0/s1

InChI Key

BABJNKGTTYCTOO-ULCDLSAGSA-M

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as hydroxyanthraquinones. Hydroxyanthraquinones are compounds containing a hydroxyanthraquinone moiety, which consists of an anthracene bearing a quinone, and hydroxyl group.

Kingdom

Super Class

Class

Sub Class

Direct Parent

Hydroxyanthraquinones

Alternative Parents

Substituents

Hydroxyanthraquinone
Naphthofuran
Coumaran
Aryl ketone
Phenoxide
1-hydroxy-2-unsubstituted benzenoid
1-hydroxy-4-unsubstituted benzenoid
Vinylogous acid
Tetrahydrofuran
Ketone
Oxacycle
Organoheterocyclic compound
Acetal
Organic oxygen compound
Hydrocarbon derivative
Organooxygen compound
Organic oxide
Organic anion
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

phenolate anion (CHEBI:77951 )

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
logP	3.25	ChemAxon
pKa (Strongest Acidic)	7.29	ChemAxon
pKa (Strongest Basic)	-4.2	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	7	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	116.12 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	95.99 m³·mol⁻¹	ChemAxon
Polarizability	32.56 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Chromatographic Retention Times and Retention Indices

Retention Times

Not Available

Retention Indices

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	4

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

31150445

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

25203123

PDB ID

Not Available

ChEBI ID

77951

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

Bansal P, Morgat A, Axelsen KB, Muthukrishnan V, Coudert E, Aimo L, Hyka-Nouspikel N, Gasteiger E, Kerhornou A, Neto TB, Pozzato M, Blatter MC, Ignatchenko A, Redaschi N, Bridge A: Rhea, the reaction knowledgebase in 2022. Nucleic Acids Res. 2022 Jan 7;50(D1):D693-D700. doi: 10.1093/nar/gkab1016. [PubMed:34755880 ]

Showing metabocard for versicolorin B (MMDBc0056379)

MOL for #<Metabolite:0x00007fadd85bdbe0>

3D MOL for #<Metabolite:0x00007fadd85bdbe0>

3D SDF for #<Metabolite:0x00007fadd85bdbe0>

3D-SDF for #<Metabolite:0x00007fadd85bdbe0>

PDB for #<Metabolite:0x00007fadd85bdbe0>

3D PDB for #<Metabolite:0x00007fadd85bdbe0>

SMILES for #<Metabolite:0x00007fadd85bdbe0>

INCHI for #<Metabolite:0x00007fadd85bdbe0>

Structure for #<Metabolite:0x00007fadd85bdbe0>

3D Structure for #<Metabolite:0x00007fadd85bdbe0>