MiMeDB: Showing metabocard for Mannosyl phosphoryl dolichol (MMDBc0057162)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2022-11-09 19:19:56 UTC

Update Date

2025-10-07 16:09:53 UTC

Metabolite ID

MMDBc0057162

Metabolite Identification

Common Name

Mannosyl phosphoryl dolichol

Description

Mannosyl phosphoryl dolichol is a glycosyl carrier lipid that belongs to the class of glycolipids. Its chemical structure comprises a long hydrophobic dolichol chain linked to a mannosyl phosphate moiety, facilitating the transfer of mannose residues during glycosylation processes. This compound plays a critical role in the biosynthesis of glycoproteins, particularly in the endoplasmic reticulum, where it participates in the assembly of oligosaccharides onto nascent polypeptides. Notably, mannosyl phosphoryl dolichol is involved in the stereoselective transbilayer translocation mediated by an endoplasmic reticulum flippase, which is essential for proper glycoprotein maturation and function (PMID:20534553 ). Additionally, its structural analogs have been developed to possess photoreactive and clickable properties, or to enable fluorescence readouts, showcasing its potential utility in biochemical assays and studies (PMID:32765793 ). Overall, mannosyl phosphoryl dolichol serves as a crucial intermediate in the intricate pathways of protein glycosylation, contributing to cellular processes that depend on glycoprotein function.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
Alpha-D-Mannopyranosyl phosphate, dolichyl	MeSH
D Mannopyranosyldolichyl	MeSH
D-Mannopyranosyldolichyl	MeSH
Dolichol monophosphate mannose	MeSH
Dolichol, mannosyl phosphoryl	MeSH
Dolicholphosphate mannose	MeSH
Dolichyl Alpha D mannopyranosyl phosphate	MeSH
Dolichyl Alpha-D-mannopyranosyl phosphate	MeSH
Dolichyl mannopyranosyl phosphate	MeSH
Dolichyl mannosyl phosphate	MeSH
Mannolipid	MeSH
Mannopyranosyl phosphate, dolichyl	MeSH
Mannose, dolichol monophosphate	MeSH
Mannose, dolicholphosphate	MeSH
Mannosyl phosphate, dolichyl	MeSH
monoPhosphate mannose, dolichol	MeSH
Phosphate, dolichyl Alpha-D-mannopyranosyl	MeSH
Phosphate, dolichyl mannopyranosyl	MeSH
Phosphate, dolichyl mannosyl	MeSH
Phosphoryl dolichol, mannosyl	MeSH

Molecular Formula

C₈₆H₁₄₂O₉P

Average Mass

1351.047

Monoisotopic Mass

1350.03969673

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

Not Available

InChI Identifier

Not Available

InChI Key

YRJQNWAWJNIMPJ-NWNWEXASSA-M

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Not Available

Predicted Properties

Not Available

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

146037247

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

Bansal P, Morgat A, Axelsen KB, Muthukrishnan V, Coudert E, Aimo L, Hyka-Nouspikel N, Gasteiger E, Kerhornou A, Neto TB, Pozzato M, Blatter MC, Ignatchenko A, Redaschi N, Bridge A: Rhea, the reaction knowledgebase in 2022. Nucleic Acids Res. 2022 Jan 7;50(D1):D693-D700. doi: 10.1093/nar/gkab1016. [PubMed:34755880 ]

Showing metabocard for Mannosyl phosphoryl dolichol (MMDBc0057162)

MOL for #<Metabolite:0x00007f8dea914a18>

3D MOL for #<Metabolite:0x00007f8dea914a18>

3D SDF for #<Metabolite:0x00007f8dea914a18>

3D-SDF for #<Metabolite:0x00007f8dea914a18>

PDB for #<Metabolite:0x00007f8dea914a18>

3D PDB for #<Metabolite:0x00007f8dea914a18>

SMILES for #<Metabolite:0x00007f8dea914a18>

INCHI for #<Metabolite:0x00007f8dea914a18>

Structure for #<Metabolite:0x00007f8dea914a18>

3D Structure for #<Metabolite:0x00007f8dea914a18>