Record Information
Version2.0
StatusDetected and Quantified
Creation Date2022-11-09 19:26:20 UTC
Update Date2025-10-07 16:09:55 UTC
Metabolite IDMMDBc0057181
Metabolite Identification
Common NameN6-Stearoyl-L-lysine
DescriptionN6-Stearoyl-L-lysine is a synthetic muramyl dipeptide derivative belonging to the class of immunomodulatory compounds. Its chemical structure features a stearoyl group attached to the nitrogen at the sixth position of L-lysine, contributing to its lipophilicity and biological activity. This compound, also known as MDP-Lys or romurtide, functions as a macrophage activator, enhancing the immune response by stimulating cells of the monocyte-macrophage lineage (PMID:11061343 ). It has been shown to induce the production of various cytokines, including interleukin-1 (IL-1) and tumor necrosis factor (TNF), which are critical in inflammatory pathways (PMID:10688489 ). Additionally, repeated subcutaneous administration of MDP-Lys has been observed to increase the counts of peripheral neutrophils and monocytes, indicating its role in modulating immune cell populations (PMID:2049113 ). Furthermore, it has been reported to augment the production of complement components, such as C1q, which are essential for the opsonization and clearance of pathogens (PMID:2340001 ). Overall, N6-stearoyl-L-lysine exemplifies the intersection of synthetic chemistry and immunology, with significant implications for therapeutic applications.
Structure
SynonymsNot Available
Molecular FormulaC24H48N2O3
Average Mass412.659
Monoisotopic Mass412.366493414
IUPAC NameNot Available
Traditional NameNot Available
CAS Registry NumberNot Available
SMILESNot Available
InChI Identifier
Not Available
InChI KeyPQOQDGZTLPYXJD-QFIPXVFZSA-N