MiMeDB: Showing metabocard for LysoPC(0:0/12:0) (MMDBc0060117)

Microbial

Human

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2023-02-02 20:23:32 UTC

Update Date

2025-10-07 20:14:14 UTC

Metabolite ID

MMDBc0060117

Metabolite Identification

Common Name

LysoPC(0:0/12:0)

Description

LysoPC(0:0/12:0) contains one acyl chain of 12:0 at the sn-2. LysoPC(0:0/12:0) is a lysophosphatidylcholine (LysoPC), a type of lysophospholipid (LyP). LysoPCs are monoglycerophospholipids in which a phosphorylcholine group occupies one of the glycerol substitution sites. They contain a single fatty acyl chain at either the sn-1 or sn-2 position and a free hydroxyl group at the other. The most common acyl chains contain 16, 18, or 20 carbons with varying degrees of unsaturation. LysoPCs are formed primarily by hydrolysis of phosphatidylcholine by phospholipase A₂ and can be produced in plasma by LCAT activity. They circulate bound mainly to albumin and act as signaling molecules via lysophospholipid (GPR) receptors.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
2-Lauroyl-sn-glycero-3-phosphocholine	ChEBI
LPC(0:0/12:0)	ChEBI
Lysophosphatidylcholine 0:0/12:0	ChEBI
PC(0:0/12:0)	ChEBI

Molecular Formula

C₂₀H₄₂NO₇P

Average Mass

439.53

Monoisotopic Mass

439.269889694

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

Not Available

InChI Identifier

Not Available

InChI Key

GLSCDHQUIDQFRP-LJQANCHMSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as 2-acyl-sn-glycero-3-phosphocholines. These are glycerophosphocholines in which the glycerol is esterified with a fatty acid at O-2 position, and linked at position 3 to a phosphocholine.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Glycerophospholipids

Sub Class

Glycerophosphocholines

Direct Parent

2-acyl-sn-glycero-3-phosphocholines

Alternative Parents

Substituents

2-acyl-sn-glycero-3-phosphocholine
Phosphocholine
Dialkyl phosphate
Fatty acid ester
Fatty acyl
Alkyl phosphate
Phosphoric acid ester
Organic phosphoric acid derivative
Tetraalkylammonium salt
Quaternary ammonium salt
Carboxylic acid ester
Monocarboxylic acid or derivatives
Carboxylic acid derivative
Organic nitrogen compound
Organic oxygen compound
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Organic salt
Primary alcohol
Organooxygen compound
Organonitrogen compound
Carbonyl group
Amine
Alcohol
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Not Available

Predicted Properties

Not Available

Spectra

Not Available

Chromatographic Retention Times and Retention Indices

Retention Times

Chromatography Type	Technique	Column	Deposition Date	Retention Time (s)
Liquid Chromatography	HILIC	Waters Acquity UPLC-BEH Amide column (eluted)	2025-10-24	381.8
Liquid Chromatography	HILIC	Accucore 150 Amide HILIC (eluted)	2025-10-24	111.3
Liquid Chromatography	Reversed-phase	Hypersil Gold 1.9 µm C18 (eluted)	2025-10-24	481.2
Liquid Chromatography	Reversed-phase	Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) (eluted)	2025-10-24	634.6
Liquid Chromatography	Reversed-phase	XBridge C18 3.5u 2.1x50 mm (eluted)	2025-10-24	654.8
Liquid Chromatography	Reversed-phase	Ascentis Express C18 (eluted)	2025-10-24	167.7
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (retained)	2025-10-24	2178.5
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-24	614.3
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC (eluted)	2025-10-24	304.4
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-24	483.1
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-24	69.5
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-24	169.5
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-24	203.6
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-24	42.6
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (void)	2025-10-24	250.8
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-24	219.3
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-24	405.5
Liquid Chromatography	Reversed-phase	Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex (eluted)	2025-10-24	1760.8
Liquid Chromatography	Reversed-phase	Waters Atlantis T3 (2.1 x 150 mm, 5 um) (eluted)	2025-10-24	1441.5

Retention Indices

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference
MMDBr0036805	PC(12:0/12:0)	Dodecanoate (N-C12:0)	cGAMP-activated phospholipase	Hydrolysis	RHEA	34755880
MMDBr0036827	PC(10:0/12:0)	Decanoate (N-C10:0)	cGAMP-activated phospholipase	Hydrolysis	RHEA	34755880

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

76963147

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

132282515

PDB ID

Not Available

ChEBI ID

140088

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

Showing metabocard for LysoPC(0:0/12:0) (MMDBc0060117)

MOL for #<Metabolite:0x00007f9ac4e005e0>

3D MOL for #<Metabolite:0x00007f9ac4e005e0>

3D SDF for #<Metabolite:0x00007f9ac4e005e0>

3D-SDF for #<Metabolite:0x00007f9ac4e005e0>

PDB for #<Metabolite:0x00007f9ac4e005e0>

3D PDB for #<Metabolite:0x00007f9ac4e005e0>

SMILES for #<Metabolite:0x00007f9ac4e005e0>

INCHI for #<Metabolite:0x00007f9ac4e005e0>

Structure for #<Metabolite:0x00007f9ac4e005e0>

3D Structure for #<Metabolite:0x00007f9ac4e005e0>