Showing metabocard for Angolamycin (MMDBc0060734)
Microbial
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| Version | 1.0 | ||||||||||||
| Status | Detected and Quantified | ||||||||||||
| Creation Date | 2025-10-02 22:25:32 UTC | ||||||||||||
| Update Date | 2025-10-08 21:35:17 UTC | ||||||||||||
| Metabolite ID | MMDBc0060734 | ||||||||||||
| Metabolite Identification | |||||||||||||
| Common Name | Angolamycin | ||||||||||||
| Description | Angolamycin is a macrolide antibiotic that belongs to the chemical class of polyketides. It was isolated from the culture broth of a Streptomyces strain, with its structure elucidated through NMR and mass spectrometry, revealing derivatives such as the 18-dihydro- and 18-deoxo-18-dihydro forms (PMID:1399843 ). Angolamycin exhibits significant antimicrobial properties, although its derivatives, including angolamycin P1, demonstrate reduced potency compared to the parent compound (PMID:6706849 ). The compound is involved in various biochemical pathways, including deepoxidation processes, which enhance the plasma levels of certain macrolides in vivo, although angolamycin's derivatives showed only moderate improvements (PMID:6706849 ). Additionally, angolamycin can be subjected to structural modifications, such as des-mycarosyl derivatives, as indicated by mass spectrometry comparisons (PMID:541251 ). The proposed structure of angolamycin has been supported by mass spectrometric analysis, highlighting its complex chemical nature and the potential for further exploration of its analogues (PMID:4648491 ). Overall, angolamycin represents a significant compound within the macrolide class, with ongoing research into its structural variants and biological activities. | ||||||||||||
| Structure |  | ||||||||||||
| Synonyms | Not Available | ||||||||||||
| Molecular Formula | C46H77NO17 | ||||||||||||
| Average Mass | 916.112 | ||||||||||||
| Monoisotopic Mass | 915.519150023 | ||||||||||||
| IUPAC Name | Not Available | ||||||||||||
| Traditional Name | Not Available | ||||||||||||
| CAS Registry Number | Not Available | ||||||||||||
| SMILES | Not Available | ||||||||||||
| InChI Identifier | Not Available | ||||||||||||
| InChI Key | KZXDKUWSAVUSKI-UHFFFAOYNA-N | ||||||||||||
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| State | Not Available | ||||||||||||
| Predicted Properties | Not Available | ||||||||||||
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| Cellular Locations | Not Available | ||||||||||||
| Biospecimen Locations | Not Available | ||||||||||||
| Tissue Locations | Not Available | ||||||||||||
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| Pathways | This table shows at most 5 pathways. For the full list of associated pathways: See All Associated Bacterial Pathways
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Reactions This table shows at most 20 reactions. For the full list of associated reactions: See All Associated Reactions
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| External Links | |||||||||||||
| CMMC Knowledgebase | KZXDKUWSAVUSKI-UHFFFAOYSA-N | ||||||||||||
| References | |||||||||||||
| Synthesis Reference | Not Available | ||||||||||||
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