Showing metabocard for arthrobactin (MMDBc0060737)
Microbial
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| Version | 1.0 | ||||||||||||
| Status | Detected and Quantified | ||||||||||||
| Creation Date | 2025-10-02 22:27:56 UTC | ||||||||||||
| Update Date | 2025-10-08 21:35:17 UTC | ||||||||||||
| Metabolite ID | MMDBc0060737 | ||||||||||||
| Metabolite Identification | |||||||||||||
| Common Name | arthrobactin | ||||||||||||
| Description | Arthrobactin is a hydroxamate-type siderophore, a class of chemical compounds known for their ability to chelate iron. Its chemical structure features hydroxamate groups which are crucial for binding iron(III) ions, facilitating uptake in iron-limited environments. Arthrobactin is synthesized via a biosynthetic pathway that includes cadaverine as an intermediate, highlighting its metabolic origins (PMID:354550 ). This siderophore is involved in various transport mechanisms, being recognized by transport proteins such as ChtA and an unidentified TonB-dependent transporter (TBDT) for its ferric form (PMID:37758521 ). Additionally, the uptake of arthrobactin is at least partially dependent on the YfhA YfiYZ importer and the YusV ATPase, indicating its role in cellular iron acquisition (PMID:16672620 ). In experimental settings, ferrated forms of arthrobactin have been shown to stimulate growth in iron-limited conditions and enhance virulence in certain microbial organisms (PMID:6454658 , PMID:6454660 ). Moreover, it shares structural similarities with other siderophores like ferrioxamine B and aerobactin, underscoring its significance in microbial iron metabolism (PMID:1541550 ). | ||||||||||||
| Structure |  | ||||||||||||
| Synonyms | Not Available | ||||||||||||
| Molecular Formula | C20H36N4O9 | ||||||||||||
| Average Mass | 476.527 | ||||||||||||
| Monoisotopic Mass | 476.248228755 | ||||||||||||
| IUPAC Name | Not Available | ||||||||||||
| Traditional Name | Not Available | ||||||||||||
| CAS Registry Number | Not Available | ||||||||||||
| SMILES | Not Available | ||||||||||||
| InChI Identifier | Not Available | ||||||||||||
| InChI Key | BPEXJHGGARTCIR-UHFFFAOYSA-N | ||||||||||||
| Chemical Taxonomy | |||||||||||||
| Description | Belongs to the class of organic compounds known as hydroxy fatty acids. These are fatty acids in which the chain bears a hydroxyl group. | ||||||||||||
| Kingdom | Organic compounds | ||||||||||||
| Super Class | Lipids and lipid-like molecules | ||||||||||||
| Class | Fatty Acyls | ||||||||||||
| Sub Class | Fatty acids and conjugates | ||||||||||||
| Direct Parent | Hydroxy fatty acids | ||||||||||||
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| Substituents |
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| Molecular Framework | Aliphatic acyclic compounds | ||||||||||||
| External Descriptors | Not Available | ||||||||||||
| Functional Ontology | |||||||||||||
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| Physical Properties | |||||||||||||
| State | Not Available | ||||||||||||
| Predicted Properties | Not Available | ||||||||||||
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| Biological Properties | |||||||||||||
| Cellular Locations | Not Available | ||||||||||||
| Biospecimen Locations | Not Available | ||||||||||||
| Tissue Locations | Not Available | ||||||||||||
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| Pathways |
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| Microbial Pathways | |||||||||||||
| Pathways | This table shows at most 5 pathways. For the full list of associated pathways: See All Associated Bacterial Pathways
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| Metabolic Reactions | |||||||||||||
Reactions This table shows at most 20 reactions. For the full list of associated reactions: See All Associated Reactions
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| External Links | |||||||||||||
| HMDB ID | Not Available | ||||||||||||
| DrugBank ID | Not Available | ||||||||||||
| Phenol Explorer Compound ID | Not Available | ||||||||||||
| FooDB ID | Not Available | ||||||||||||
| KNApSAcK ID | Not Available | ||||||||||||
| Chemspider ID | Not Available | ||||||||||||
| KEGG Compound ID | Not Available | ||||||||||||
| BioCyc ID | Not Available | ||||||||||||
| BiGG ID | Not Available | ||||||||||||
| Wikipedia Link | Not Available | ||||||||||||
| METLIN ID | Not Available | ||||||||||||
| PubChem Compound | 193781 | ||||||||||||
| PDB ID | Not Available | ||||||||||||
| ChEBI ID | Not Available | ||||||||||||
| Food Biomarker Ontology | Not Available | ||||||||||||
| CMMC Knowledgebase | BPEXJHGGARTCIR-UHFFFAOYSA-N | ||||||||||||
| References | |||||||||||||
| Synthesis Reference | Not Available | ||||||||||||
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