Showing metabocard for Commendamide (MMDBc0060750)
Microbial
| Record Information | |||||||||||||
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| Version | 1.0 | ||||||||||||
| Status | Detected and Quantified | ||||||||||||
| Creation Date | 2025-10-02 22:38:25 UTC | ||||||||||||
| Update Date | 2025-10-08 21:35:18 UTC | ||||||||||||
| Metabolite ID | MMDBc0060750 | ||||||||||||
| Metabolite Identification | |||||||||||||
| Common Name | Commendamide | ||||||||||||
| Description | Commendamide is a bioactive metabolite classified as a long-chain N-acyl-amino acid, specifically N-(3-hydroxypalmitoyl)glycine. It is derived from gut microbiota and is structurally similar to endogenous compounds within the endocannabinoidome, a complex lipid signaling system that influences various physiological and pathological processes in mammals. The chemical structure of commendamide features a hydroxypalmitoyl group attached to a glycine backbone, which is critical for its interaction with biological systems. Commendamide has been shown to activate G-protein-coupled receptors (GPCRs), particularly the G2A/132 subtype, which are involved in signaling pathways that regulate numerous biological functions (PMID:35300384 ). Additionally, commendamide's production by gut bacteria, such as Bacteroides, highlights its role in the microbiome's contribution to metabolic processes, particularly following dietary interventions like BO supplementation (PMID:38695302 ). The first separation of commendamide enantiomers using enantioselective high-performance liquid chromatography (HPLC) has also been documented, emphasizing its significance in analytical chemistry (PMID:39700865 ). Overall, commendamide represents a fascinating intersection of microbiology, chemistry, and pharmacology. | ||||||||||||
| Structure |  | ||||||||||||
| Synonyms | Not Available | ||||||||||||
| Molecular Formula | C18H35NO4 | ||||||||||||
| Average Mass | 329.481 | ||||||||||||
| Monoisotopic Mass | 329.256608611 | ||||||||||||
| IUPAC Name | Not Available | ||||||||||||
| Traditional Name | Not Available | ||||||||||||
| CAS Registry Number | Not Available | ||||||||||||
| SMILES | Not Available | ||||||||||||
| InChI Identifier | Not Available | ||||||||||||
| InChI Key | MZUHHHSFDVDBCZ-UHFFFAOYNA-N | ||||||||||||
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| State | Not Available | ||||||||||||
| Predicted Properties | Not Available | ||||||||||||
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| Cellular Locations | Not Available | ||||||||||||
| Biospecimen Locations | Not Available | ||||||||||||
| Tissue Locations | Not Available | ||||||||||||
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| Pathways | This table shows at most 5 pathways. For the full list of associated pathways: See All Associated Bacterial Pathways
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Reactions This table shows at most 20 reactions. For the full list of associated reactions: See All Associated Reactions
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| External Links | |||||||||||||
| CMMC Knowledgebase | MZUHHHSFDVDBCZ-UHFFFAOYSA-N | ||||||||||||
| References | |||||||||||||
| Synthesis Reference | Not Available | ||||||||||||
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